公开(公告)号：KR101150967B1

公开(公告)日：2012-07-11

申请号：KR1020100024274

申请日：2010-03-18

Applicant: 서울대학교산학협력단

Inventor： 박승범 ,  이향연 ,  박종민

IPC: C07H5/04 ,  C07H5/10 ,  G01N33/50 ,  A61P3/00

Abstract: 본 발명은 신규한 형광 글루코스 유사체 및 그 용도에 관한 것으로, 보다 상세하게는 다양한 링커를 통해 형광염료를 표지한 새로운 형광 글루코스 유사체 및 상기 유사체를 바이오프로브로서 이용하는 방법 및 용도에 관한 것이다.

公开(公告)号：KR1020120060957A

公开(公告)日：2012-06-12

申请号：KR1020100092520

申请日：2010-09-20

Applicant: 서울대학교산학협력단

Inventor： 박승범 ,  김성환 ,  주명언 ,  이상희

IPC: C07D491/147 ,  A61K31/5025 ,  A61P19/10 ,  A61P19/08

Abstract: PURPOSE: A novel benzopyranyl tetracycle compound and a method for preparing the same are provided to effectively inhibit RANKL-induced osteoclastogenesis. CONSTITUTION: A novel benzopyranyl tetracycle compound is denoted by chemical formula 1. In chemical formula 1, R1 is hydrogen atom or hydroxyl; R2 and R'2 are identical or different methyl or cyclopentyl; and R3 is phenyl or p-methyl phenyl. A therapeutic agent for treating bone diseases contains the benzopyranyl tetracycle compounds as an active ingredient. The effective dose of the benzopyranyl tetracycle compounds is 1-50mg/kg/day.

Abstract translation: 目的：提供新的苯并吡喃基四环化合物及其制备方法，以有效抑制RANKL诱导的破骨细胞发生。 构成：化学式1表示新的苯并吡喃基四环化合物。在化学式1中，R 1为氢原子或羟基; R2和R'2是相同或不同的甲基或环戊基; 并且R 3是苯基或对甲基苯基。 用于治疗骨疾病的治疗剂含有苯并吡喃基四环化合物作为活性成分。 苯并吡喃基四环化合物的有效剂量为1-50mg / kg /天。

公开(公告)号：KR1020100028998A

公开(公告)日：2010-03-15

申请号：KR1020080125891

申请日：2008-12-11

Applicant: 서울대학교산학협력단

Inventor： 박승범

IPC: B82B1/00 ,  B82Y5/00

CPC classification number: A61K38/1875 ,  A61K47/59 ,  A61K47/593 ,  A61K47/595 ,  A61K47/60 ,  A61K47/62 ,  A61K47/6953 ,  B82Y5/00

Abstract: PURPOSE: A biodegradable BMP nanofiber and uses thereof are provided to obtain a more efficient method and direct method for BMP treatment. CONSTITUTION: A nanofiber includes one or more bone morphogentic protein(BMP) combined with the nanofiber or bone morphogentic protein fractions. The nanofiber is selected from a group of carbon nano fiber, polymer nanofiber, organic crystalline nanofiber, inorganic phosphate nanofiber, copolymer nanofiber, and core-shell type nanofiber. The polymer nanofiber is selected from a group of nylon, polystyrene, poly acrylonitrile, polycarbonate, poly(ethylene oxide), polyethylene terephthalate, and water-soluble polymer.

Abstract translation: 目的：提供可生物降解的BMP纳米纤维及其用途，以获得更有效的BMP治疗方法和直接方法。 构成：纳米纤维包括与纳米纤维或骨形态发生蛋白质组分组合的一种或多种骨形态发生蛋白（BMP）。 纳米纤维选自碳纳米纤维，聚合物纳米纤维，有机结晶纳米纤维，无机磷酸盐纳米纤维，共聚物纳米纤维和核壳型纳米纤维。 聚合物纳米纤维选自尼龙，聚苯乙烯，聚丙烯腈，聚碳酸酯，聚（环氧乙烷），聚对苯二甲酸乙二醇酯和水溶性聚合物。