公开(公告)号：KR1020110134358A

公开(公告)日：2011-12-14

申请号：KR1020110124402

申请日：2011-11-25

Applicant: 전남대학교산학협력단

Inventor： 안태호 ,  윤철호

IPC: C07K7/08 ,  C07K14/47 ,  C07K16/18 ,  A61K39/395

Abstract: PURPOSE: A method for preparing a peptide antigen with enhanced immunogenicity is provided to enhance antibody-producing efficiency. CONSTITUTION: A polypeptide contains an amino acid sequence with two or more tandem repeat LEDTQKH amino active sequences and additionally contains one or two praline between the repeat amino acid sequences. The polypeptide is linked to polystyrene or polylactic-glycolic acid polymers or bovine serum albumin(BSA) or ovalbumin. A vaccine composition contains: the polypeptide with two or more tandem repeat LEDTQKH amino active sequences; the polypeptide with LEDTQKH sequences and proline; the polypeptide linked by the polystyrene or polylactic-glycolic acid polymers or bovine serum albumin(BSA) or ovalbumin; a nucleic acid encoding one of polypeptides; and an antibody for one of the polypeptides.

Abstract translation: 目的：提供增强免疫原性制备肽抗原的方法，以提高抗体产生效率。 构成：多肽含有具有两个或多个串联重复LEDTQKH氨基活性序列的氨基酸序列，并且在重复氨基酸序列之间另外含有一个或两个脯氨酸。 多肽与聚苯乙烯或聚乳酸 - 乙醇酸聚合物或牛血清白蛋白（BSA）或卵清蛋白连接。 疫苗组合物包含：具有两个或更多个串联重复的LEDTQKH氨基活性序列的多肽; 该多肽与LEDTQKH序列和脯氨酸; 通过聚苯乙烯或聚乳酸 - 乙醇酸聚合物或牛血清白蛋白（BSA）或卵清蛋白连接的多肽; 编码多肽之一的核酸; 和一种多肽的抗体。

公开(公告)号：KR1020110086686A

公开(公告)日：2011-07-29

申请号：KR1020110071078

申请日：2011-07-18

Applicant: 전남대학교산학협력단

Inventor： 윤철호 ,  김건희 ,  김동현 ,  강지연

IPC: C12N15/09 ,  C12P7/02

Abstract: PURPOSE: A method for preparing human metabolites of simvastatin or lovastatin using bacterial cytochrome p450 is provided to selectively produce metabolic protucts. CONSTITUTION: A composition for preparing human metabolites of simvastatin or lovastatin has: 47th amino acid arginin(R) of wild type CYP102A1, which is substituted with alanine, valine, leucine, isoleucine, proline, methionine, phenylalanine, or tryptopane; 87th amino acid, phenylalaine(F) which is substituted with alanine, valine, leucine, isoleucine, proline, methionine, or tryptopane; 143th amino acid, gluamic acid(E), which is substituted with glycine, serine, threonine, cysteine, tyrosine, asparagine, or glutamine; and 188th amino acid, leucine(L), which is substituted with glycine, serine, threonine, cysteine, tyrosine, asparagine, or glutamine.

Abstract translation: 目的：提供使用细菌细胞色素p450制备辛伐他汀或洛伐他汀的人代谢产物的方法，以选择性地产生代谢产物。 构成：用于制备辛伐他汀或洛伐他汀的人代谢物的组合物具有：用丙氨酸，缬氨酸，亮氨酸，异亮氨酸，脯氨酸，甲硫氨酸，苯丙氨酸或三苯甲烷取代的野生型CYP102A1的第47位氨基酸精氨酸（R） 第八十八氨基酸，被丙氨酸，缬氨酸，亮氨酸，异亮氨酸，脯氨酸，甲硫氨酸或三苯甲烷取代的苯丙氨酸（F）; 由甘氨酸，丝氨酸，苏氨酸，半胱氨酸，酪氨酸，天冬酰胺或谷氨酰胺取代的第143位氨基酸，葡萄糖酸（E） 和第188位氨基酸，其被甘氨酸，丝氨酸，苏氨酸，半胱氨酸，酪氨酸，天冬酰胺或谷氨酰胺取代的亮氨酸（L）。

公开(公告)号：KR101048475B1

公开(公告)日：2011-07-11

申请号：KR1020080122029

申请日：2008-12-03

Applicant: 전남대학교산학협력단

Inventor： 윤철호 ,  김동현

IPC: C12P7/22 ,  C12N15/09

CPC classification number: C12P7/22 ,  C12N9/0071 ,  C12Y114/14001

Abstract: 본 발명은 피세아타놀(piceatannol)의 신규한 생산방법에 관한 것이다. 보다 상세하게는, 본 발명은 박테리아 시토크롬 P450 BM3(CYP102A1) 또는 그의 돌연변이체를 이용하여 레스베라트롤로부터 고가의 피세아타놀을 제조하는 방법 및 이를 위한 조성물 및 키트를 제공한다.
피세아타놀, piceatannol, 레스베라트롤, resveratrol, CYP102A1, 돌연변이체

Abstract translation: 本发明涉及用于生产海桧木醇的新型方法。 更具体地，本发明提供了一种使用细菌细胞色素P450 BM3（CYP102A1）或它的突变体和组合物和药盒为此从白藜芦醇生产高血佘tanol的方法。