Abstract:
The present invention relates to: a graft material having a super-hydrophobic surface which includes a biocompatible material and a super-hydrophobic nanostructure loaded on the surface of the biocompatible material for preventing the contact with protein, water, and thrombocyte when the graft material is applied to blood vessels, thereby preventing thrombosis; and a method for manufacturing the same.
Abstract:
The present invention relates to a stereocomplex of biodegradable copolymers and a manufacturing method thereof. The stereocomplex of biodegradable copolymers comprises D form polylactide copolymers consisting of D form polylactide and at least one type monomer, and L form polylactide copolymers consisting of L form polylactide and at least one type monomer and has excellent thermal stability and mechanical strength. Therefore, the stereocomplex of biodegradable copolymers can be applied to engineering plastics, general purpose plastic substitutes, highly efficient medical materials etc.
Abstract:
PURPOSE: A polypeptide with stem cell recruiting activity is provided to enable effective angiogenesis and tissue regeneration, thereby being used as a therapeutic agent for treating vasoocclusion-related diseases, especially ischemic diseases. CONSTITUTION: A polypeptide with stem cell recruiting activity contains self-assembly peptides with an amino acid sequence of general formula 1 ((alpha beta)_n) and substance P which are conjugated. Substance P has an amino acid sequence of sequence number 2. A spacer with 2-10 repetitive sequences including glycine (G) or glutamic acid (E) is conjugated at N-terminal of the amino acid sequence of sequence number 2.
Abstract:
PURPOSE: An in vitro bioreactor for artificial blood vessels is provided to simulate heart beat considering hymodynamic effects such as compliance, pressure, and flow rate. CONSTITUTION: An in vitro bioreactor for artificial blood vessels comprises: a substrate (10); a pair of connectors (20) which is placed on the substrate and fixes both ends of the artificial blood vessels which stretch along one direction and allow a fluid to flow along the inside; a first manometer (30) and a second manometer (32) which are attached to the pair of connectors, are applied to measure the pressure of the fluid, and are placed on the substrate; a current meter (40) which is applied to measure the flux of the fluid which has passed through the first manometer and is placed on the substrate; a centrifugal pump (50) which is placed to transfer the fluid to the second manometer and is placed on the substrate; a storage tank (60) which supplies the fluid to the centrifugal pump, collects the fluid which has passed through the manometers, is applied to store the fluid, and is placed on the substrate; a micrometer (70) which is applied to measure the thickness of the artificial blood vessels while the micrometer moves along the artificial blood vessels in one direction; and an indicator (80) which receives each measured signal from the first manometer, the second manometer, the current meter, and the micrometer.
Abstract:
본 발명은 간단하고 경제적이면서도 친환경적인 초임계 유체-유기용매 시스템을 이용하여 열적, 기계적 안정성이 향상된 파우더 또는 다공성 폼과 같은 일정한 형태를 가진 점토/고분자 복합체, 더욱 구체적으로는 점토/ 생분해성 고분자 입체이성질 나노 복합체의 제조방법 및 그 방법으로 제조된 점토/고분자 복합체에 관한 것으로서, 본 발명의 점토/고분자 복합체 제조방법은 (a) 반응기에 점토, 생분해성 단일상 D-형 / L-형 입체이성질체 고분자 및 유기용매를 도입하는 단계, (b) 상기 반응기에 초임계유체를 도입하여 입체이성질 복합체를 형성하고, 상기 입체이성질 복합체에 점토가 분산된 점토/고분자 복합체를 형성하는 단계 및 (c) 상기 점토/고분자 복합체를 회수하는 단계를 포함하는 것이고, 본 발명의 점토/고분자 복합체는 상기 제조방법으로 제조된 점토/고분자 복합체이다.
Abstract:
본 발명은 헤파린 결합 도메인(heparin-binding domain, HBD)을 이용한 지방줄기세포의 지방세포로의 분화방법에 관한 것으로서, 구체적으로 지방줄기세포(adipose-derived stem cells; ASCs)에 대한 접착활성을 갖는 HBP가 표면에 고정되어 있는 배양용기; 및 상기 배양용기에 지방줄기세포를 접종하여 지방줄기세포를 배양용기 표면에 접착된 상태로 배양하는 단계를 포함하는 지방줄기세포의 지방세포로의 분화방법에 관한 것이다. 본 발명에 따라 지방줄기세포에 대한 접착활성을 갖는 HBD를 배양용기에 고정시키면, HBD와 지방줄기세포의 상호작용에 의한 세포접착이 유도되어 지방줄기세포를 배양용기의 표면에 접착된 상태로 배양할 수 있어 지방세포로의 대량 분화를 효과적으로 유도할 수 있다. 따라서 본 발명은 지방줄기세포의 분화 및 증식 연구와, 조직공학 및 세포치료와 같은 재생 의료분야에 매우 유용하게 적용될 수 있다. 지방줄기세포, 지방세포, 세포접착, 헤파린-결합 도메인, 세포분화
Abstract:
PURPOSE: A method for transplanting a polymer support into a body for treatment of articular cartilage damage and the polymer support for tissue engineering are provided to effectively and rapidly reproduce articular cartilage with good biodegradability and biocompatibility. CONSTITUTION: A polymer support for tissue engineering is manufactured high elastic (lactide / glycolide) / ε - caprolactone copolymer. The (lactide / glycolide) / ε - caprolactone copolymer has average molecular weight (Mw) of 10,000 ~ 500,000. In the (lactide / glycolide) / ε - caprolactone copolymer, a molar ratio of the (lactide / glycolide) / ε - caprolactone copolymer is 65:35 ~ 35:65. A molar ratio of the lactide and glycolide is 0:10 ~10:0 respectively.