公开(公告)号：US08656958B2

公开(公告)日：2014-02-25

申请号：US11932263

申请日：2007-10-31

Applicant: Marc A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer ,  Stephen R. Quake ,  Markus M. Enzelberger ,  Mark L. Adams ,  Carl L. Hansen

Inventor： Marc A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer ,  Stephen R. Quake ,  Markus M. Enzelberger ,  Mark L. Adams ,  Carl L. Hansen

IPC: F15C3/00

CPC classification number: B05D3/04 ,  B01J2219/00355 ,  B01J2219/00378 ,  B01J2219/00396 ,  B01J2219/00398 ,  B01J2219/00439 ,  B01J2219/005 ,  B01J2219/00527 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00659 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L7/54 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/10 ,  B01L2300/0681 ,  B01L2300/0861 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2300/14 ,  B01L2300/18 ,  B01L2400/046 ,  B01L2400/0481 ,  B01L2400/06 ,  B01L2400/0655 ,  B01L2400/0688 ,  B32B2037/1081 ,  B65B31/00 ,  B81B2201/036 ,  B81B2201/054 ,  B81C1/00119 ,  B81C2201/019 ,  C12Q1/6832 ,  C12Q1/6874 ,  C30B29/54 ,  F04B43/043 ,  F15C1/06 ,  F15C3/00 ,  F15C5/00 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0046 ,  F16K99/0051 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/0078 ,  F16K2099/008 ,  F16K2099/0084 ,  F16K2099/0094 ,  Y10T137/0324 ,  Y10T137/0379 ,  Y10T137/0424 ,  Y10T137/206 ,  Y10T137/2082 ,  Y10T137/2164 ,  Y10T137/2169 ,  Y10T137/2174 ,  Y10T137/2202 ,  Y10T137/2224 ,  Y10T137/3084 ,  Y10T137/7837 ,  Y10T137/86027 ,  Y10T156/10 ,  Y10T428/24479 ,  Y10T428/24612 ,  C12Q2535/125

Abstract: A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

公开(公告)号：US08569741B2

公开(公告)日：2013-10-29

申请号：US13286008

申请日：2011-10-31

Applicant: Axel Scherer ,  Sameer Walavalkar ,  Michael D. Henry ,  Andrew P. Homyk

Inventor： Axel Scherer ,  Sameer Walavalkar ,  Michael D. Henry ,  Andrew P. Homyk

IPC: H01L29/772 ,  B82Y99/00

CPC classification number: H01L29/0665 ,  B82Y10/00 ,  B82Y40/00 ,  H01L29/0676 ,  H01L29/413 ,  H01L29/66439 ,  H01L29/66666 ,  H01L29/775 ,  H01L29/7827 ,  H01L33/18 ,  Y10S977/762

Abstract: Methods for fabricating passivated silicon nanowires and an electronic arrangement thus obtained are described. Such arrangements may comprise a metal-oxide-semiconductor (MOS) structure such that the arrangements may be utilized for MOS field-effect transistors (MOSFETs) or opto-electronic switches.

Abstract translation: 描述了制造钝化硅纳米线的方法和由此获得的电子布置。 这种布置可以包括金属氧化物半导体（MOS）结构，使得这些布置可以用于MOS场效应晶体管（MOSFET）或光电开关。

公开(公告)号：US08557613B2

公开(公告)日：2013-10-15

申请号：US13159335

申请日：2011-06-13

Applicant: Michael Shearn ,  Michael David Henry ,  Axel Scherer

Inventor： Michael Shearn ,  Michael David Henry ,  Axel Scherer

IPC: H01L21/00

CPC classification number: H01L21/3065 ,  B81B2207/056 ,  B81C1/00111 ,  H01L21/30608 ,  H01L21/3081 ,  H01L21/32137 ,  H01L21/32139 ,  H01L21/32155

Abstract: A method for designing, fabricating, and predicting a desired structure in and/or on a host material through defining etch masks and etching the host material is provided. The desired structure can be micro- or nanoscale structures, such as suspended nanowires and corresponding supporting pillars, and can be defined one layer at a time. Arbitrary desired structures can also be defined and obtained through etching. Further, given the desired structure, a starting structure can be predicted where etching of the starting structure yields the desired structure.

Abstract translation: 提供了一种通过限定蚀刻掩模和蚀刻主体材料来设计，制造和预测主体材料中和/或主体材料上的所需结构的方法。 所需的结构可以是微结构或纳米级结构，例如悬浮的纳米线和相应的支撑柱，并且可以一次定义一层。 也可以通过蚀刻来定义和获得任意的所需结构。 此外，给定所需的结构，可以预测起始结构的蚀刻产生所需结构的起始结构。

公开(公告)号：US08557612B2

公开(公告)日：2013-10-15

申请号：US12824128

申请日：2010-06-25

Applicant: Michael David Henry ,  Michael Shearn ,  Axel Scherer

Inventor： Michael David Henry ,  Michael Shearn ,  Axel Scherer

IPC: H01L21/00

CPC classification number: H01L21/3086 ,  B81B2203/0361 ,  B81C1/00031 ,  H01L21/3065 ,  H01L21/3081

Abstract: A method to determine minimum etch mask dosage or thickness as a function of etch depth or maximum etch depth as a function of etch mask implantation dosage or thickness, for fabricating structures in or on a substrate through etch masking via addition or removal of a masking material and subsequent etching.

Abstract translation: 确定作为蚀刻深度或最大蚀刻深度的函数的最小蚀刻掩模剂量或厚度作为蚀刻掩模注入剂量或厚度的函数的方法，用于通过添加或除去掩蔽材料通过蚀刻掩模来制造在衬底中或衬底上的结构 和随后的蚀刻。

公开(公告)号：US08241547B2

公开(公告)日：2012-08-14

申请号：US12572036

申请日：2009-10-01

Applicant: Axel Scherer ,  Aditya Rajagopal

Inventor： Axel Scherer ,  Aditya Rajagopal

IPC: B29C45/16

CPC classification number: B32B38/10 ,  B32B2038/047 ,  B81B2203/0307 ,  B81C1/0038 ,  Y10T156/1057

Abstract: A method for adhering two layers of materials is described. An additional layer of material deposited on one of the layers is used. The additional layer of material is perforated and undercut by etching away one of the layers thereby generating anchor shaped holes. The other layer is then deposited on the additional layer filling the anchor shaped holes therefore, providing adhesion.

Abstract translation: 描述了粘合两层材料的方法。 使用沉积在其中一层上的附加材料层。 附加的材料层通过蚀刻掉一个层而被穿孔和底切，从而产生锚定孔。 然后将另一层沉积在填充锚定孔的附加层上，从而提供粘附。

公开(公告)号：US08232091B2

公开(公告)日：2012-07-31

申请号：US11750326

申请日：2007-05-17

Applicant: George Maltezos ,  Matthew Johnston ,  David Goodwin ,  Axel Scherer ,  Christopher I. Walker

Inventor： George Maltezos ,  Matthew Johnston ,  David Goodwin ,  Axel Scherer ,  Christopher I. Walker

IPC: C12M1/00 ,  C12P19/34

CPC classification number: G01N21/645 ,  B01L3/50851 ,  B01L3/50853 ,  B01L7/52 ,  B01L7/54 ,  B01L2200/147 ,  B01L2300/0829 ,  B01L2300/0838 ,  B01L2300/12 ,  B01L2300/168 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/185 ,  B01L2300/1861

Abstract: This invention provides a system for performing PCR, and real time PCR in particular with great speed and specificity. The system employs a heat block containing a liquid composition to rapidly transfer heat to and from reaction vessels. The system makes use of the reflective properties of the liquid metal to reflect signal from the PCR into the vessel and out the top. In this way, the signal can be measured by an optical assembly in real time without removing the vessels from the heat block.

Abstract translation: 本发明提供了一种用于特别快速和特异性地进行PCR和实时PCR的系统。 该系统采用含有液体组合物的热块来快速地将热量传递到反应容器和从其返回。 该系统利用液态金属的反射特性，将来自PCR的信号反射入容器并排出顶部。 以这种方式，可以通过光学组件实时地测量信号，而不从容器中取出容器。

公开(公告)号：US20120118739A1

公开(公告)日：2012-05-17

申请号：US13248994

申请日：2011-09-29

Applicant: Sameer Walavalkar ,  Axel Scherer ,  Thomas A. Tombrello ,  Aditya Rajagopal ,  Andrew P. Homyk ,  Erika Garcia

Inventor： Sameer Walavalkar ,  Axel Scherer ,  Thomas A. Tombrello ,  Aditya Rajagopal ,  Andrew P. Homyk ,  Erika Garcia

IPC: G01N27/447 ,  H01L29/92 ,  H01L21/02 ,  B82Y15/00

CPC classification number: G01N27/447 ,  B82Y30/00 ,  C12Q1/6869 ,  G01N33/48721 ,  C12Q2563/116 ,  C12Q2565/631

Abstract: Methods and devices for sequencing nucleic acids are disclosed herein. Devices are also provided herein for measuring DNA with nano-pores sized to allow DNA to pass through the nano-pore. The capacitance can be measured for the DNA molecule passing through the nano-pore. The capacitance measurements can be correlated to determine the sequence of base pairs passing through the nano-pore to sequence the DNA.

Abstract translation: 本文公开了用于测序核酸的方法和装置。 本文还提供了用于测量具有大小允许DNA穿过纳米孔的纳米孔的DNA的装置。 可以测量通过纳米孔的DNA分子的电容。 电容测量可以相关，以确定通过纳米孔的碱基对序列来对DNA进行排序。

公开(公告)号：US08123192B2

公开(公告)日：2012-02-28

申请号：US11874211

申请日：2007-10-18

Applicant: George Maltezos ,  Axel Scherer

Inventor： George Maltezos ,  Axel Scherer

IPC: F16K31/02

CPC classification number: F16K99/0026 ,  B01L3/502707 ,  B01L3/502738 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2400/0487 ,  B01L2400/0655 ,  F16K99/0001 ,  F16K99/0034 ,  F16K99/0046 ,  F16K2099/0084 ,  Y10T156/1093

Abstract: Communication between microchannels of a microfluidic circuit is controlled through a combination between a membrane and a pin-actuated valve arrangement. The deformable membrane contributes to the formation of the surface of the microchannels. Alternatively, or in addition, the valve arrangement is operated through combination of the membrane with a control fluid. Systems, devices and methods based on such communication are shown. Also shown are methods to manufacture a system having a fluidic circuit and a control arrangement.

Abstract translation: 微流体电路的微通道之间的通信通过膜和引脚致动阀装置之间的组合来控制。 可变形膜有助于微通道表面的形成。 或者或另外，通过膜与控制流体的组合来操作阀装置。 显示了基于这种通信的系统，设备和方法。 还示出了制造具有流体回路和控制装置的系统的方法。

公开(公告)号：US08104515B2

公开(公告)日：2012-01-31

申请号：US12540994

申请日：2009-08-13

Applicant: Marc A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer ,  Stephen R. Quake

Inventor： Marc A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer ,  Stephen R. Quake

IPC: F15C1/06

CPC classification number: B29C51/00 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2300/0861 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/046 ,  B01L2400/0481 ,  B01L2400/0655 ,  B33Y80/00 ,  B81B5/00 ,  B81B2201/036 ,  B81B2201/054 ,  B81C1/00119 ,  B81C2201/019 ,  B81C2201/034 ,  C12Q1/6874 ,  F04B43/043 ,  F15C1/06 ,  F15C5/00 ,  F16K11/20 ,  F16K13/00 ,  F16K31/126 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0046 ,  F16K99/0048 ,  F16K99/0051 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/0078 ,  F16K2099/008 ,  F16K2099/0094 ,  Y10T137/0491 ,  Y10T137/0497 ,  Y10T137/2224 ,  Y10T137/87249 ,  Y10T156/10 ,  Y10T428/24479 ,  Y10T428/24744 ,  C12Q2535/125

Abstract: A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

公开(公告)号：US08100672B2

公开(公告)日：2012-01-24

申请号：US12349365

申请日：2009-01-06

Applicant: Sameer Walavalkar ,  Axel Scherer

Inventor： Sameer Walavalkar ,  Axel Scherer

IPC: F04B17/00 ,  F17D1/16 ,  F15C1/04 ,  B21D39/03

CPC classification number: F04B19/006 ,  B01L3/50273 ,  B01L2300/0816 ,  B01L2300/0874 ,  B01L2300/10 ,  B01L2300/1827 ,  B01L2400/0421 ,  B01L2400/046 ,  Y10T29/494 ,  Y10T29/49826 ,  Y10T137/0391 ,  Y10T137/2191 ,  Y10T137/2213 ,  Y10T137/2224

Abstract: A microfluidic structure with an electrically controlled pressure source is shown. The pressure source is an electrolyte connected with electrodes. Dissociation of the electrolyte generates the pressure, which is used to obtain a valve-like or pump-like behavior inside the microfluidic structure. A process for manufacturing the microfluidic structure and a method to circulate fluids in a microfluidic channel are also described.

Abstract translation: 示出了具有电控压力源的微流体结构。 压力源是与电极连接的电解质。 电解质的离解产生压力，其用于在微流体结构内获得阀状或泵状行为。 还描述了用于制造微流体结构的方法和在微流体通道中循环流体的方法。