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公开(公告)号:DE2623169A1
公开(公告)日:1977-11-24
申请号:DE2623169
申请日:1976-05-22
Applicant: BASF AG
Inventor: ARMBRUST HERBERT
IPC: C07C301/00 , C07D239/48 , C07D317/60 , C07C137/00
Abstract: Prepn. of 5-benzyl-2,4-diaminopyrimidines (I) (opt. substd. substd. on the phenyl ring) comprises reacting the bisulphite deriv. (II) of an alpha-benzyl-alpha-cyanoacetaldehyde with guanidine in a basic medium. (I) have biological properties and are obtd. in good yields from easily available starting materials. (II) of high purity is prepd. from an alpha-benzyl-alpha-cyanoacetaldehyde and NaHSO3 which avoids the need for subsequent purificn. of (I). In an example, reaction of 17.5 pts. bisulphite deriv. of beta-3,4,5-trimethoxyphenyl-alpha-cyanopropionaldehyde and 9.5 pts. guanidine hydrochloride at 130-135 degrees C gave 14.6 pts. crude 5-(3,4,5-trimethoxybenzyl)-2,4-diaminopyrimidine.
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公开(公告)号:CA995238A
公开(公告)日:1976-08-17
申请号:CA94956
申请日:1970-10-06
Applicant: BASF AG
Inventor: STURM HANS-JUERGEN , KEMPTER FRITZ E , ARMBRUST HERBERT
IPC: C07C67/00 , C07C227/00 , C07C227/04 , C07C227/22 , C07C229/56 , C07D265/26
Abstract: 1316332 Production of anthranilic acid and isatoic anhydride BADISCHE ANILIN- & SODA-FABRIK AG 5 Oct 1970 [6 Oct 1969 8 Jan 1970] 47200/70 Heading C2C Anthranilic acid and/or isatoic anhydride alkali metal salts are continuously produced by reacting alkali metal salts of phthalamic acid and/or phthalimide with a hypohalite in an aqueous medium, wherein the first reaction stage, i.e. the reaction of the starting material to form the alkali metal salt of phenyl isocyanate- 2-carboxylic acid, is effected under substantially adiabatic conditions while substantially avoiding the occurrence of back mixing and the reaction mixture formed is immediately withdrawn from the reaction zone of the first stage and supplied substantially without back mixing to the reaction zone of the following stage, i.e. the reaction to form the end product. The first stage of the reaction is suitably carried out at 10-50 C. and the second stage at 60-80 C. under atmospheric or elevated pressure, and a reducing agent, e.g. a 10-40% by wt. sodium bisulphite solution, may be added to the reaction mixture after it has left the reaction zone of the first stage and before the reaction has been completed. The alkali metal salts produced may be acidified to give the free anthranilic acid or isatoic anhydride. The starting materials may be aqueous solutions of 10-50 wt. per cent of phthalimide and/or phthalamide which contain from 1 to 1À1 mole of alkali metal hydroxide per mole of phthalimide/phthalamide, and the aqueous hypohalite solutions suitably contain 8-15% by wt. of hypohalite and 0À02 to 2À1 moles of alkali metal hydroxide per mole of phthalimic/phthalamic acid.
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公开(公告)号:DE2160781A1
公开(公告)日:1973-09-13
申请号:DE2160781
申请日:1971-12-08
Applicant: BASF AG
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公开(公告)号:DE2160378A1
公开(公告)日:1973-06-14
申请号:DE2160378
申请日:1971-12-06
Applicant: BASF AG
Inventor: ARMBRUST HERBERT , KILPPER GERHARD DR , QUADBECK-SEEGER HANS-JUERGEN D , STURM HANS-JUERGEN DR , KOEHLER WALDEMAR DR , SCHECKER HANSGEORG DR
IPC: C07C17/26 , C07C1/00 , C07C2/42 , C07C13/465 , C07C17/00 , C07C17/281 , C07C25/22 , C07C67/00 , C07C13/46
Abstract: 1403077 Dimerizing styrenes BADISCHE ANILIN- & SODA-FABRIK AG 5 Dec 1972 [6 Dec 1971] 55987/72 Addition to 1343445 Heading C5E 1-Alkyl-3-phenylindans are prepared by catalytically dimerizing a styrene optionally containing alkyl substituents in the presence of a surfactant and optionally a polymerization inhibitor. Suitable reaction conditions are as in the parent Specification 1,343,445. The surfactant may be anionic (e.g. carboxylates, sulphuric acid esters, alkyl sulphates, sulphated fatty acid monoglycerides or fatty acid alkylolamides, sulphated ethers, salts of lignin sulphonic acid, alkylsulphonates, alkaryl sulphonates, alkyl phosphates and salts of alkyl benzene phosphonic acids) cationic, e.g. (amine of quaternary ammonium salts, phosphonium salts and sulphonium salts) amphoteric (e.g. betaines, sulphobetaines and sulphatobetaines) or non-ionic, e.g. ethylene oxide adducts fatty acid monoglycerides, anhydrosorbitol fatty acid esters, fatty acid alkylolamides, saccharose fatty acid esters and reaction products of ethylene oxide and amines or amides). The surfactant may be used in amount 10- 5 to 10 -1 moles per mole styrene.
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公开(公告)号:DE2155545A1
公开(公告)日:1973-05-17
申请号:DE2155545
申请日:1971-11-09
Applicant: BASF AG
Inventor: RUECHARDT CHRISTOPF PROF DR , HASSMANN VOLKER DIPL CHEM , QUADBECK-SEEGER HANSJUERGEN DR , ARMBRUST HERBERT
IPC: C07D231/56 , C07D249/10 , C07D49/02
Abstract: Indazoles of formula (I): (where each R1 (same or different) is H, an aliphatic, cycloaliphatic or aromatic residue, or halogen, and R2 is H or an aliphatic residue), which are starting materials for dyes, pharmaceuticals and pesticides, are prepd. by (a) reacting o-toluidines of formula (II) with alkyl nitrite and/or nitrous gases in the presence of acetic anhydride, an alkali salts of a lower alkanoic acid and an inert organic solvent, and (b) removing the acetyl group from the resulting l-acetyl-indazole in a conventional manner. The process is simple and economical, is suitable for industrial use, and gives (I) in better yields and purity than by known processes.
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公开(公告)号:DE1768786A1
公开(公告)日:1972-02-24
申请号:DE1768786
申请日:1968-06-29
Applicant: BASF AG
Inventor: GOERTH HELMUT DR , ARMBRUST HERBERT
IPC: C07C121/78
Abstract: 1,262,593. o-Amino benzonitriles. BADISCHE ANILIN- & SODA-FABRIK A.G. 26 June, 1969 [29 June, 1968], No. 32351/69. Heading C2C. o-Aminobenzonitriles which may be substituted in the ring by one or two halogen atoms or aliphatic radicals are prepared by decomposing an isatin-#-oxime of the formula where R 1 and R 2 , which may be the same or different, each denotes a hydrogen or halogen atom or an aliphatic radical, in the presence of a basic compound e.g. alkali metal hydroxides, carbonates, alcoholates, carboxylates at a temperature in the range 130-200 C. In examples, 2-aminobenzonitrile and 5-chloro- (or 5-methyl)-2-aminobenzonitrile are prepared. Starting materials include 5-isobutyl-, 5,7-dibromo and 4-methyl-5-chloroisatin #-oxime.
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公开(公告)号:DE2000698A1
公开(公告)日:1972-02-17
申请号:DE2000698
申请日:1970-01-08
Applicant: BASF AG
Inventor: JUERGEN DR STURM HANS , ARMBRUST HERBERT , ERDMANN DR KEMPTER FRITZ
IPC: C07D265/26 , C07C101/54
Abstract: Phthalamate and/or alkaline phthalimide are reacted with aqs. hypohalogenites by (1) performing the first reaction stage, i.e. conversion to an alkaline salt of phenyl isocyanato 2-carboxylic acid under adiabatic conditions, (2) immediately transferring the reaction mixture to a final reaction stage avoiding back mixing in stage (1). A reducer (hypohalogenite) may be added to the reaction mixture after (1) before (2). The product is produced more cheaply and simply than by known processes, and with higher yield and purity by eliminating the cooling at stage (1).
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公开(公告)号:DE2001043A1
公开(公告)日:1971-07-22
申请号:DE2001043
申请日:1970-01-12
Applicant: BASF AG
Inventor: JUERGEN DR STURM HANS , ARMBRUST HERBERT , KILPPER GERHARD DR
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公开(公告)号:DE1544378A1
公开(公告)日:1970-03-19
申请号:DE1544378
申请日:1965-07-03
Applicant: BASF AG
Inventor: JOHANNES DEHNERT DR , MATTHIAS SEEFELDER DR , ARMBRUST HERBERT
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公开(公告)号:AT256279B
公开(公告)日:1967-08-10
申请号:AT554366
申请日:1966-06-10
Applicant: BASF AG
Inventor: SEEFELDER MATTHIAS DR , ARMBRUST HERBERT , WIPPEL HANS GUENTER DR
IPC: C09B44/20
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