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    (5)-Benzyl-(2,4)-diamino-pyrimidines prepn. - from the bisulphite deriv. of an (alpha)-benzyl-(alpha)-cyano-acetaldehyde and guanidine
    51.
    发明专利
    (5)-Benzyl-(2,4)-diamino-pyrimidines prepn. - from the bisulphite deriv. of an (alpha)-benzyl-(alpha)-cyano-acetaldehyde and guanidine 未知

    公开(公告)号：DE2623169A1

    公开(公告)日：1977-11-24

    申请号：DE2623169

    申请日：1976-05-22

    Applicant: BASF AG

    Inventor： ARMBRUST HERBERT

    IPC: C07C301/00 ,  C07D239/48 ,  C07D317/60 ,  C07C137/00

    Abstract: Prepn. of 5-benzyl-2,4-diaminopyrimidines (I) (opt. substd. substd. on the phenyl ring) comprises reacting the bisulphite deriv. (II) of an alpha-benzyl-alpha-cyanoacetaldehyde with guanidine in a basic medium. (I) have biological properties and are obtd. in good yields from easily available starting materials. (II) of high purity is prepd. from an alpha-benzyl-alpha-cyanoacetaldehyde and NaHSO3 which avoids the need for subsequent purificn. of (I). In an example, reaction of 17.5 pts. bisulphite deriv. of beta-3,4,5-trimethoxyphenyl-alpha-cyanopropionaldehyde and 9.5 pts. guanidine hydrochloride at 130-135 degrees C gave 14.6 pts. crude 5-(3,4,5-trimethoxybenzyl)-2,4-diaminopyrimidine.

    CONTINUOUS PRODUCTION OF ANTHRANILIC ACID
    52.
    发明专利
    CONTINUOUS PRODUCTION OF ANTHRANILIC ACID 未知

    公开(公告)号：CA995238A

    公开(公告)日：1976-08-17

    申请号：CA94956

    申请日：1970-10-06

    Applicant: BASF AG

    Inventor： STURM HANS-JUERGEN ,  KEMPTER FRITZ E ,  ARMBRUST HERBERT

    IPC: C07C67/00 ,  C07C227/00 ,  C07C227/04 ,  C07C227/22 ,  C07C229/56 ,  C07D265/26

    Abstract: 1316332 Production of anthranilic acid and isatoic anhydride BADISCHE ANILIN- & SODA-FABRIK AG 5 Oct 1970 [6 Oct 1969 8 Jan 1970] 47200/70 Heading C2C Anthranilic acid and/or isatoic anhydride alkali metal salts are continuously produced by reacting alkali metal salts of phthalamic acid and/or phthalimide with a hypohalite in an aqueous medium, wherein the first reaction stage, i.e. the reaction of the starting material to form the alkali metal salt of phenyl isocyanate- 2-carboxylic acid, is effected under substantially adiabatic conditions while substantially avoiding the occurrence of back mixing and the reaction mixture formed is immediately withdrawn from the reaction zone of the first stage and supplied substantially without back mixing to the reaction zone of the following stage, i.e. the reaction to form the end product. The first stage of the reaction is suitably carried out at 10-50‹ C. and the second stage at 60-80‹ C. under atmospheric or elevated pressure, and a reducing agent, e.g. a 10-40% by wt. sodium bisulphite solution, may be added to the reaction mixture after it has left the reaction zone of the first stage and before the reaction has been completed. The alkali metal salts produced may be acidified to give the free anthranilic acid or isatoic anhydride. The starting materials may be aqueous solutions of 10-50 wt. per cent of phthalimide and/or phthalamide which contain from 1 to 1À1 mole of alkali metal hydroxide per mole of phthalimide/phthalamide, and the aqueous hypohalite solutions suitably contain 8-15% by wt. of hypohalite and 0À02 to 2À1 moles of alkali metal hydroxide per mole of phthalimic/phthalamic acid.

    54.
    发明专利
    未知

    公开(公告)号：DE2160378A1

    公开(公告)日：1973-06-14

    申请号：DE2160378

    申请日：1971-12-06

    Applicant: BASF AG

    Inventor： ARMBRUST HERBERT ,  KILPPER GERHARD DR ,  QUADBECK-SEEGER HANS-JUERGEN D ,  STURM HANS-JUERGEN DR ,  KOEHLER WALDEMAR DR ,  SCHECKER HANSGEORG DR

    IPC: C07C17/26 ,  C07C1/00 ,  C07C2/42 ,  C07C13/465 ,  C07C17/00 ,  C07C17/281 ,  C07C25/22 ,  C07C67/00 ,  C07C13/46

    Abstract: 1403077 Dimerizing styrenes BADISCHE ANILIN- & SODA-FABRIK AG 5 Dec 1972 [6 Dec 1971] 55987/72 Addition to 1343445 Heading C5E 1-Alkyl-3-phenylindans are prepared by catalytically dimerizing a styrene optionally containing alkyl substituents in the presence of a surfactant and optionally a polymerization inhibitor. Suitable reaction conditions are as in the parent Specification 1,343,445. The surfactant may be anionic (e.g. carboxylates, sulphuric acid esters, alkyl sulphates, sulphated fatty acid monoglycerides or fatty acid alkylolamides, sulphated ethers, salts of lignin sulphonic acid, alkylsulphonates, alkaryl sulphonates, alkyl phosphates and salts of alkyl benzene phosphonic acids) cationic, e.g. (amine of quaternary ammonium salts, phosphonium salts and sulphonium salts) amphoteric (e.g. betaines, sulphobetaines and sulphatobetaines) or non-ionic, e.g. ethylene oxide adducts fatty acid monoglycerides, anhydrosorbitol fatty acid esters, fatty acid alkylolamides, saccharose fatty acid esters and reaction products of ethylene oxide and amines or amides). The surfactant may be used in amount 10- 5 to 10 -1 moles per mole styrene.

    56.
    发明专利
    未知

    公开(公告)号：DE1768786A1

    公开(公告)日：1972-02-24

    申请号：DE1768786

    申请日：1968-06-29

    Applicant: BASF AG

    Inventor： GOERTH HELMUT DR ,  ARMBRUST HERBERT

    IPC: C07C121/78

    Abstract: 1,262,593. o-Amino benzonitriles. BADISCHE ANILIN- & SODA-FABRIK A.G. 26 June, 1969 [29 June, 1968], No. 32351/69. Heading C2C. o-Aminobenzonitriles which may be substituted in the ring by one or two halogen atoms or aliphatic radicals are prepared by decomposing an isatin-#-oxime of the formula where R 1 and R 2 , which may be the same or different, each denotes a hydrogen or halogen atom or an aliphatic radical, in the presence of a basic compound e.g. alkali metal hydroxides, carbonates, alcoholates, carboxylates at a temperature in the range 130-200‹ C. In examples, 2-aminobenzonitrile and 5-chloro- (or 5-methyl)-2-aminobenzonitrile are prepared. Starting materials include 5-isobutyl-, 5,7-dibromo and 4-methyl-5-chloroisatin #-oxime.

    Anthranilic acid prodn by continuous process
    57.
    发明专利
    Anthranilic acid prodn by continuous process 未知

    公开(公告)号：DE2000698A1

    公开(公告)日：1972-02-17

    申请号：DE2000698

    申请日：1970-01-08

    Applicant: BASF AG

    Inventor： JUERGEN DR STURM HANS ,  ARMBRUST HERBERT ,  ERDMANN DR KEMPTER FRITZ

    IPC: C07D265/26 ,  C07C101/54

    Abstract: Phthalamate and/or alkaline phthalimide are reacted with aqs. hypohalogenites by (1) performing the first reaction stage, i.e. conversion to an alkaline salt of phenyl isocyanato 2-carboxylic acid under adiabatic conditions, (2) immediately transferring the reaction mixture to a final reaction stage avoiding back mixing in stage (1). A reducer (hypohalogenite) may be added to the reaction mixture after (1) before (2). The product is produced more cheaply and simply than by known processes, and with higher yield and purity by eliminating the cooling at stage (1).

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