公开(公告)号：DE2210169A1

公开(公告)日：1973-09-13

申请号：DE2210169

申请日：1972-03-03

Applicant: BASF AG

Inventor： RUECKARDT CHRISTOPH PROF DR ,  HASSMANN VOLKER DIPL CHEM ,  QUADBECK-SEEGER HANS-JUERGEN D ,  ARMBRUST HERBERT

IPC: C07D231/56 ,  C07D249/10 ,  C07D49/02

Abstract: Prepn. of indazoles of formula: where R1 gps. are the same or diff. and are H, aliphatic, cycloaliphatic, araliphatic or aromatic gp., or halogen; R2 is H or aliphatic gp is by reaction of a cpd. of formula: in presence of acetic acid, an alkali metal alkanoate and an inert solvent with an alkyl nitrile, an ester of glycol or a deriv. with nitrous acid and/or nitrous gases and removing in known manner the acetyl gp. from the 1-acetylindazole. The simple, economica process is applicable to industrial scale and gives high yields of good quality prodt., used as inters. for dyes. drugs and pesticides.

公开(公告)号：DE2155545A1

公开(公告)日：1973-05-17

申请号：DE2155545

申请日：1971-11-09

Applicant: BASF AG

Inventor： RUECHARDT CHRISTOPF PROF DR ,  HASSMANN VOLKER DIPL CHEM ,  QUADBECK-SEEGER HANSJUERGEN DR ,  ARMBRUST HERBERT

IPC: C07D231/56 ,  C07D249/10 ,  C07D49/02

Abstract: Indazoles of formula (I): (where each R1 (same or different) is H, an aliphatic, cycloaliphatic or aromatic residue, or halogen, and R2 is H or an aliphatic residue), which are starting materials for dyes, pharmaceuticals and pesticides, are prepd. by (a) reacting o-toluidines of formula (II) with alkyl nitrite and/or nitrous gases in the presence of acetic anhydride, an alkali salts of a lower alkanoic acid and an inert organic solvent, and (b) removing the acetyl group from the resulting l-acetyl-indazole in a conventional manner. The process is simple and economical, is suitable for industrial use, and gives (I) in better yields and purity than by known processes.