公开(公告)号：WO1989003041A2

公开(公告)日：1989-04-06

申请号：PCT/US1988003368

申请日：1988-09-30

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  OH, Chan, S. ,  STERNBERG, James, C.

IPC: G01N33/531

CPC classification number: G01N33/54353 ,  G01N33/531 ,  G01N33/532 ,  G01N33/539 ,  G01N33/54313 ,  G01N33/94 ,  Y10S435/964 ,  Y10S436/819 ,  Y10S530/81 ,  Y10S530/812 ,  Y10S530/816

Abstract: A tridentate conjugate has three chemical moieties, or tridentate members, attached through an appropriate spacer moiety. At least two of the tridentate members are relatively small molecules, usually less than about 7,000 Daltons in size. The particular appropriate spacer moiety selected for a tridentate imparts certain steric properties to the tridentate conjugate. In one embodiment, the binding of a macromolecular specific binding partner to one of the tridentate members sterically inhibits the binding of a different macromolecule to another tridentate member. In another embodiment, the binding of a first tridentate member to a macromolecule restricts the subsequent binding of a second tridentate member to a proximate location on the same macromolecule.

Abstract translation: 具有三个化学部分或三齿元素的三齿共轭物通过适当的间隔半部连接。 至少两个三齿元素是相对小的分子，其大小通常小于7000道尔顿。 为三齿选择适当的半粒径赋予三齿偶联物一定的空间性质。 在一个实施方案中，将特定大分子结合配偶体与三齿元件之一结合，从空间上防止不同大分子与另一三齿元件的结合。 在另一个实施方案中，第一三齿元素与大分子的结合限制了第二三齿元素随后与同一分子上的附近位置的结合。

公开(公告)号：WO1989002088A2

公开(公告)日：1989-03-09

申请号：PCT/US1988001657

申请日：1988-05-16

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  WUNDERLY, Stephen, W. ,  QUINT, Joseph, F.

IPC: G01T01/20

CPC classification number: G01T1/204 ,  G01T1/20

Abstract: A sample counting support for scintillation counting of a radioactive labeled sample comprises a base material covered with a thin layer of dry solid scintillator in a substantially permanent form so that the support may receive the sample and produce light emissions in response to particles emitted by a radioactive substance labelling said sample.

Abstract translation: 对于放射性标记的样品的闪烁计数样品计数支撑件包括以基本上永久形状涂覆有干固体闪烁体的薄的层的基材，使得所述支撑件可以接收样本 并响应由标记所述样本的放射性物质发射的粒子产生光发射。

公开(公告)号：WO1989000688A1

公开(公告)日：1989-01-26

申请号：PCT/US1988002417

申请日：1988-07-15

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  SOHN, Chul, Ho ,  BLESSUM, Cynthia, R. ,  GAGE, Steven, C.

IPC: G01N27/26

CPC classification number: G01N27/44708

Abstract: An electrophoretic gel cooled cell including a gel supporting surface. The cell includes members for holding gels against the supporting surface such that gels of either of two dimensions may be used with the cell. A reservoir adapted to hold a cooling medium shares a common wall with the supporting surface to cool the gel retained by the members. The reservoir has a large opening which may be closed by a cover for easy insertion and removal of the cooling medium from the reservoir. A venting valve in the reservoir cover vents gas in the reservoir to atmosphere and closes when the cover is in an inverted position to prevent condensate leakage through the vent.

公开(公告)号：WO1988010158A1

公开(公告)日：1988-12-29

申请号：PCT/US1988001953

申请日：1988-06-08

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  SOHN, Chul, Ho ,  GOODALE, David, Leo

IPC: B08B03/10

CPC classification number: G01N35/1004 ,  B01L99/00 ,  G01N35/08 ,  Y10S261/74 ,  Y10T137/7782 ,  Y10T137/87676

Abstract: A device for generating a plurality of gas bubbles in a liquid. The device includes a conduit (58) adapted to carry the liquid. A first gas chamber (96) is formed near the conduit and an orifice (53) proximate a side wall of the conduit defines a passageway (60) between the first gas chamber and the conduit. A valve member (50) is adapted to seat against and close the orifice. The device may include a second gas chamber (86) and a diaphragm (36) responsive to gas pressure in the second gas chamber. A conduit (98) connecting the first and second chambers may include a variable vent (104) for controlling the size and number of gas bubbles injected into the liquid flowing in the conduit.

Abstract translation: 一种用于在液体中产生多个气泡的装置。 该装置包括适于承载液体的导管（58）。 在导管附近形成有第一气室（96），靠近导管侧壁的孔（53）在第一气室和导管之间形成通道（60）。 阀构件（50）适于抵靠和关闭孔口。 该装置可以包括响应于第二气体室中的气体压力的第二气体室（86）和隔膜（36）。 连接第一和第二室的管道（98）可以包括用于控制喷射到在管道中流动的液体中的气泡的尺寸和数量的可变排气口（104）。

公开(公告)号：WO1988009217A1

公开(公告)日：1988-12-01

申请号：PCT/US1988001426

申请日：1988-05-02

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  GIEBELER, Robert

IPC: B04B09/10

CPC classification number: B04B13/003 ,  B04B9/10 ,  Y10S388/903 ,  Y10S388/904 ,  Y10S388/93 ,  Y10S388/933

Abstract: An apparatus and method of protecting a centrifuge from rotor overspeed and resultant mishap by computation of the rotor moment of inertia is disclosed. In the preferred embodiment, a centrifuge is driven by a rotor (10) mounted on a shaft (14) which shaft is in turn driven by a constant current motor (16). A tachometer (20) for detecting angular velocity of the drive shaft is used. A desired and ultimate centrifuge operating speed is selected by the operator. The times at which the rotor passes through discrete speeds are recorded and from the time difference the moment of inertia is computed. The moment of inertia can thereafter be utilized to discretely identify or ''finger print'' rotors to disqualify certain rotors from use in particular centrifuge protocols and establish gross limits of centrifuge operating speed.

公开(公告)号：WO1988008535A1

公开(公告)日：1988-11-03

申请号：PCT/US1988001277

申请日：1988-04-13

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  TUNG, Ker-Kong ,  CRAGLE, Linda, Katherine ,  ROOD, Frederick, William, Jr. ,  LEE, Shih-Yun

IPC: G01N33/543

CPC classification number: G01N33/74 ,  G01N33/54306 ,  G01N33/68 ,  Y10S436/801 ,  Y10S436/803 ,  Y10S436/817 ,  Y10S436/82 ,  Y10S436/827

Abstract: A method for obtaining an actual linear standard curve in a sandwich type of immunoassay where a first antibody bound to an insoluble support and a second unbound labelled antibody complex with the antigen contained in a test sample to form an insoluble antibody:antigen:labelled antibody complex which is then detected. Unbound unlabelled first antibody and/or unbound unlabelled second antibody are added to the reaction mixture to divert excess antigen away from the desired end-product complex, thus rendering the antigen of interest the rate-limiting factor in the overall immunoreaction. This results in a pseudo first-order reaction which produces an actual linear standard curve.

公开(公告)号：WO1987003962A1

公开(公告)日：1987-07-02

申请号：PCT/US1986002778

申请日：1986-12-22

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  SEYMOUR, Daniel, B. ,  THEOBALD, Paul, E. ,  LILLIG, John, E.

IPC: G01N21/82

CPC classification number: G01N33/557 ,  G01N21/47 ,  G01N21/82 ,  G01N2201/122 ,  Y10S436/805 ,  Y10S436/909

Abstract: The peak verify time for kinetic nephelometric measurements of reactions between antigens and antibodies is adjusted as a function of the magnitude of the peak rate in order to reduce the time required for peak verification. The scatter signal is zeroed following the end of the peak verification period and the reaction is tested for antigen excess. Reactions during the antigen excess check having rates that exceed a threshold value are accepted as being valid, and no additional measurements are made for such samples. Reactions during the antigen excess check having rates that are less than the threshold value are rejected as being in antigen excess. Samples found to be in antigen excess are diluted and then reanalyzed.

公开(公告)号：WO1986001451A1

公开(公告)日：1986-03-13

申请号：PCT/US1985001642

申请日：1985-08-27

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  WRIGHT, Herschel, Eugene ,  WEDEMEYER, Robert, Carl ,  GIEBELER, Robert, Henry, Jr.

IPC: B26D03/16

CPC classification number: B01L99/00 ,  B26D3/16 ,  G01N1/28 ,  Y10T83/0596 ,  Y10T83/323 ,  Y10T83/7533 ,  Y10T83/828

Abstract: A tube-cutting apparatus and method for separating centrifuged materials in which a resilient axial compressive force is exerted on tube (50) during cutting by spaced tube-holding members (52) and (102); and the cutting knife (18) has flat upper (84) and lower (82) sides against which the severed portions of the tube (50) are held in sealing engagement by the axial force. Independent adjustment is provided for (a) the relative positions of the tube (50) and the cutting knife (18), and (b) the relative positions of the spaced tube-holding members (52) and (102).

公开(公告)号：WO1985005567A1

公开(公告)日：1985-12-19

申请号：PCT/US1985001028

申请日：1985-05-31

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  LAM, Kin, C. ,  WILLIAMS, Ronald, K.

IPC: B04B05/04

CPC classification number: B04B5/0414 ,  B04B2005/0435

Abstract: A centrifuge rotor (10) is provided with a plurality of cavities (20) having a non-circular cross-section for receiving mating multi-angle adapters (24), which may be inserted in the cavities (20) with selected rotational alignment about the cavity axes (m-m'), to determine a plurality of select angle receiving chambers (26) in the rotor (10) for sample containers.

公开(公告)号：WO1985005459A1

公开(公告)日：1985-12-05

申请号：PCT/US1985000915

申请日：1985-05-15

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  KEENAN, Charles, A. ,  HORROCKS, Donald, L.

IPC: G01T01/204

CPC classification number: G01T1/2045 ,  G02F1/1313

Abstract: Apparatus for the optical quench of a sample (10) including a photodetector (12, 14), means for positioning the sample in an operative relationship with the photodetector, and a liquid crystal light valve (15) disposed between the sample and the photodetector when the sample is in the operative relationship. The light transmission characteristics of the liquid crystal light valve are varied in response to an attenuation signal generated by a power supply. The apparatus may further include means responsive to the photodetector means for generating a control signal and the power supply means may further be responsive to the control signal for varying the attenuation signal with respect thereto.

Abstract translation: 用于包括光电检测器（12,14）的样品（10）的光淬灭的装置，用于将样品与光电检测器操作的关系定位的装置和设置在样品和光电检测器之间的液晶光阀（15） 样本处于操作关系。 液晶光阀的透光特性响应于由电源产生的衰减信号而变化。 该装置还可以包括响应于光电检测器装置产生控制信号的装置，并且电源装置还可以响应于控制信号来改变相对于其的衰减信号。