公开(公告)号：AU7018774A

公开(公告)日：1975-12-18

申请号：AU7018774

申请日：1974-06-18

Applicant: HOECHST AG

Inventor： BABEJ MILOS ,  BARTMANN WILHELM ,  BECK GERHARD ,  LERCH ULRICH

IPC: C07D307/16 ,  A61K31/22 ,  A61K31/557 ,  C07C51/08 ,  C07C53/19 ,  C07C59/68 ,  C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07D307/33 ,  C07D307/54 ,  C07D309/12 ,  C07C31/02 ,  C07C43/20 ,  C07C121/20 ,  C07C69/74 ,  C07C121/16 ,  A01K27/00 ,  C07C61/06

Abstract: The safety barrier, for protection against avalanches and falling rocks or trees comprises a net (1) mounted on pairs of cables (2 -5) at the front and back which are fitted with cable brakes (9) to improve energy absorption. Additional cables (15, 17, 19) fitted with cable brakes (16, 18) are attached to the rear of the net.

公开(公告)号：NZ230751A

公开(公告)日：1997-04-24

申请号：NZ23075189

申请日：1989-09-22

Applicant: HOECHST AG

Inventor： KESSELER KURT ,  BARTMANN WILHELM ,  WESS GUENTHER ,  GRANZER ERNOLD

IPC: A61K31/215 ,  A61K31/34 ,  A61K31/35 ,  A61K31/351 ,  A61K31/365 ,  A61K31/366 ,  A61K31/38 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/42 ,  A61K31/425 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/443 ,  A61K31/496 ,  A61K31/50 ,  A61K31/505 ,  A61P3/06 ,  A61P9/10 ,  A61P43/00 ,  C07C33/48 ,  C07C45/30 ,  C07C47/222 ,  C07C47/24 ,  C07C51/367 ,  C07C59/42 ,  C07C59/46 ,  C07C59/48 ,  C07C59/56 ,  C07C59/76 ,  C07C67/31 ,  C07C69/606 ,  C07C69/732 ,  C07C69/734 ,  C07D207/08 ,  C07D207/32 ,  C07D207/333 ,  C07D207/337 ,  C07D213/48 ,  C07D213/55 ,  C07D213/62 ,  C07D213/63 ,  C07D231/12 ,  C07D233/64 ,  C07D237/08 ,  C07D239/26 ,  C07D261/08 ,  C07D275/02 ,  C07D309/30 ,  C07D405/06 ,  C07C47/20 ,  A61K31/19 ,  A61K31/20

Abstract: 7-Substituted 3,5-dihydroxyhept-6-ynoic acids and the derivatives thereof of the formula I I as well as the corresponding lactones of the formula II II in which R and R DEG have the specified meanings, a process for the preparation of these compounds, the use thereof as pharmaceuticals and pharmaceutical products are described. In addition, new intermediates for the preparation of the compounds of the formula I or formula II are described.

公开(公告)号：PT87928B

公开(公告)日：1995-05-04

申请号：PT8792888

申请日：1988-07-07

Applicant: HOECHST AG

Inventor： BECK GERHARD ,  GRANZER ERNOLD ,  BARTMANN WILHELM ,  WESS GUNTHER

IPC: C12N9/99 ,  A61K31/19 ,  A61K31/22 ,  A61K31/34 ,  A61K31/341 ,  A61K31/365 ,  A61K31/366 ,  A61K31/38 ,  A61K31/381 ,  A61P3/06 ,  A61P9/10 ,  A61P43/00 ,  C07C27/00 ,  C07C31/125 ,  C07C31/13 ,  C07C31/135 ,  C07C31/137 ,  C07C33/025 ,  C07C33/12 ,  C07C33/14 ,  C07C33/28 ,  C07C33/38 ,  C07C33/46 ,  C07C33/48 ,  C07C41/00 ,  C07C43/13 ,  C07C43/178 ,  C07C47/00 ,  C07C47/21 ,  C07C51/00 ,  C07C51/09 ,  C07C59/42 ,  C07C59/48 ,  C07C59/54 ,  C07C59/56 ,  C07C59/58 ,  C07C59/64 ,  C07C67/00 ,  C07C69/65 ,  C07C69/66 ,  C07C69/675 ,  C07C69/732 ,  C07C69/738 ,  C07C253/00 ,  C07D307/34 ,  C07D307/54 ,  C07D309/30 ,  C07D333/02 ,  C07D333/38 ,  C07D405/06 ,  C07D407/02 ,  C07D407/06 ,  C07D409/02 ,  C07D409/06 ,  A01N43/54 ,  C07F7/08

Abstract: 3,5-dihydroxycarboxylic acids of formula (I) and their lactones of formula (II) are new: A-B = CH-CH or C=C; X-Y = CH2CH2 or CH=CH; R1 and R2 are each up to 20C, opt. unsatd., alkyl (opt. substd. by 1-6C alkoxy or OCOR5); 3-7C cycloalkyl; phenyl, thiophene, furan or naphthalene residue (these all opt. substd. by 1-3 of halo, 1-6C alkyl or alkoxy, 3-7C cycloalkyl or OCOR5) or pyridyl, opt. substd. by 1-3, 1-4C alkyl; R5 = 1-8C alkyl; R3 = up to 8C alkyl (opt. unsatd.); benzyl, phenyl, thiophene, furan or naphthalene residue (all opt. substd. as above), or 3-7C cycloalkyl; R4 = H, 1-8C alkyl, metal cation, ammonium ion, phenyl, benzyl or 2,3-dihydroxypropyl. Also new are the intermediates of formula (III), (IV), (VI), (VII), (VIII), (IX) or (XII): Q-X-Y-CHO (III); Q-X-Y-CHOH-CH2-CO-CH2-COOR4 (IV); Q-Z; Z = -X-Y-CN (cpds. (VI)); -CHO (cpds. (VII)); -CH2OH (cpds. (VIII)); or COOR7 (cpds. (IX)); R4 = 1-8C alkyl; R7 = protecting gp.; Q = a gp. of formula (i).

公开(公告)号：IE63491B1

公开(公告)日：1995-05-03

申请号：IE253989

申请日：1989-08-04

Applicant: HOECHST AG

Inventor： BECK GERHARD ,  BARTMANN WILHELM ,  GRANZER ERNOLD ,  WESS GUENTHER

IPC: A61K31/19 ,  A61K31/215 ,  A61K31/365 ,  A61K31/366 ,  A61K31/40 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4418 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/50 ,  A61K31/505 ,  A61P3/06 ,  A61P9/10 ,  A61P43/00 ,  C07C27/00 ,  C07C29/147 ,  C07C33/48 ,  C07C45/56 ,  C07C47/55 ,  C07C59/56 ,  C07C67/00 ,  C07C67/31 ,  C07C67/343 ,  C07C69/65 ,  C07C69/732 ,  C07C69/738 ,  C07D207/32 ,  C07D207/333 ,  C07D207/337 ,  C07D213/30 ,  C07D213/48 ,  C07D213/55 ,  C07D213/79 ,  C07D237/08 ,  C07D239/26 ,  C07D307/54 ,  C07D309/30 ,  C07D333/24 ,  C07D405/06 ,  C07D407/06 ,  C07D409/06 ,  C07C33/30 ,  C07C47/24

Abstract: 6-Fluoro-3,5-dihydroxy carboxylic acid derivatives of the formula I and the corresponding lactones of the formula II in which R1 and R2 have the specified meanings, a process for the preparation of these compounds, the use thereof as medicinal agents and pharmaceutical products are described. In addition, new intermediates for the preparation of the compounds of the formula I or formula II are described.

公开(公告)号：NO177004B

公开(公告)日：1995-03-27

申请号：NO893777

申请日：1989-09-22

Applicant: HOECHST AG

Inventor： KESSELER KURT ,  BARTMANN WILHELM ,  WESS GUENTHER ,  GRANZER ERNOLD

IPC: A61K31/215 ,  A61K31/34 ,  A61K31/35 ,  A61K31/351 ,  A61K31/365 ,  A61K31/366 ,  A61K31/38 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/42 ,  A61K31/425 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/443 ,  A61K31/496 ,  A61K31/50 ,  A61K31/505 ,  A61P3/06 ,  A61P9/10 ,  A61P43/00 ,  C07C33/48 ,  C07C45/30 ,  C07C47/222 ,  C07C47/24 ,  C07C51/367 ,  C07C59/42 ,  C07C59/46 ,  C07C59/48 ,  C07C59/56 ,  C07C59/76 ,  C07C67/31 ,  C07C69/606 ,  C07C69/732 ,  C07C69/734 ,  C07D207/08 ,  C07D207/32 ,  C07D207/333 ,  C07D207/337 ,  C07D213/48 ,  C07D213/55 ,  C07D213/62 ,  C07D213/63 ,  C07D231/12 ,  C07D233/64 ,  C07D237/08 ,  C07D239/26 ,  C07D261/08 ,  C07D275/02 ,  C07D309/30 ,  C07D405/06

Abstract: 7-Substituted 3,5-dihydroxyhept-6-ynoic acids and the derivatives thereof of the formula I I as well as the corresponding lactones of the formula II II in which R and R DEG have the specified meanings, a process for the preparation of these compounds, the use thereof as pharmaceuticals and pharmaceutical products are described. In addition, new intermediates for the preparation of the compounds of the formula I or formula II are described.

公开(公告)号：FI90412C

公开(公告)日：1994-02-10

申请号：FI883248

申请日：1988-07-07

Applicant: HOECHST AG

Inventor： WESS GUENTHER ,  BARTMANN WILHELM ,  BECK GERHARD ,  GRANZER ERNOLD

IPC: C12N9/99 ,  A61K31/19 ,  A61K31/22 ,  A61K31/34 ,  A61K31/341 ,  A61K31/365 ,  A61K31/366 ,  A61K31/38 ,  A61K31/381 ,  A61P3/06 ,  A61P9/10 ,  A61P43/00 ,  C07C27/00 ,  C07C31/125 ,  C07C31/13 ,  C07C31/135 ,  C07C31/137 ,  C07C33/025 ,  C07C33/12 ,  C07C33/14 ,  C07C33/28 ,  C07C33/38 ,  C07C33/46 ,  C07C33/48 ,  C07C41/00 ,  C07C43/13 ,  C07C43/178 ,  C07C47/00 ,  C07C47/21 ,  C07C51/00 ,  C07C51/09 ,  C07C59/42 ,  C07C59/48 ,  C07C59/54 ,  C07C59/56 ,  C07C59/58 ,  C07C59/64 ,  C07C67/00 ,  C07C69/65 ,  C07C69/66 ,  C07C69/675 ,  C07C69/732 ,  C07C69/738 ,  C07C253/00 ,  C07D307/34 ,  C07D307/54 ,  C07D309/30 ,  C07D333/02 ,  C07D333/38 ,  C07D405/06 ,  C07D407/02 ,  C07D407/06 ,  C07D409/02 ,  C07D409/06

公开(公告)号：FI90412B

公开(公告)日：1993-10-29

申请号：FI883248

申请日：1988-07-07

Applicant: HOECHST AG

Inventor： WESS GUENTHER ,  BARTMANN WILHELM ,  BECK GERHARD ,  GRANZER ERNOLD

IPC: C12N9/99 ,  A61K31/19 ,  A61K31/22 ,  A61K31/34 ,  A61K31/341 ,  A61K31/365 ,  A61K31/366 ,  A61K31/38 ,  A61K31/381 ,  A61P3/06 ,  A61P9/10 ,  A61P43/00 ,  C07C27/00 ,  C07C31/125 ,  C07C31/13 ,  C07C31/135 ,  C07C31/137 ,  C07C33/025 ,  C07C33/12 ,  C07C33/14 ,  C07C33/28 ,  C07C33/38 ,  C07C33/46 ,  C07C33/48 ,  C07C41/00 ,  C07C43/13 ,  C07C43/178 ,  C07C47/00 ,  C07C47/21 ,  C07C51/00 ,  C07C51/09 ,  C07C59/42 ,  C07C59/48 ,  C07C59/54 ,  C07C59/56 ,  C07C59/58 ,  C07C59/64 ,  C07C67/00 ,  C07C69/65 ,  C07C69/66 ,  C07C69/675 ,  C07C69/732 ,  C07C69/738 ,  C07C253/00 ,  C07D307/34 ,  C07D307/54 ,  C07D309/30 ,  C07D333/02 ,  C07D333/38 ,  C07D405/06 ,  C07D407/02 ,  C07D407/06 ,  C07D409/02 ,  C07D409/06

Abstract: 3,5-dihydroxycarboxylic acids of formula (I) and their lactones of formula (II) are new: A-B = CH-CH or C=C; X-Y = CH2CH2 or CH=CH; R1 and R2 are each up to 20C, opt. unsatd., alkyl (opt. substd. by 1-6C alkoxy or OCOR5); 3-7C cycloalkyl; phenyl, thiophene, furan or naphthalene residue (these all opt. substd. by 1-3 of halo, 1-6C alkyl or alkoxy, 3-7C cycloalkyl or OCOR5) or pyridyl, opt. substd. by 1-3, 1-4C alkyl; R5 = 1-8C alkyl; R3 = up to 8C alkyl (opt. unsatd.); benzyl, phenyl, thiophene, furan or naphthalene residue (all opt. substd. as above), or 3-7C cycloalkyl; R4 = H, 1-8C alkyl, metal cation, ammonium ion, phenyl, benzyl or 2,3-dihydroxypropyl. Also new are the intermediates of formula (III), (IV), (VI), (VII), (VIII), (IX) or (XII): Q-X-Y-CHO (III); Q-X-Y-CHOH-CH2-CO-CH2-COOR4 (IV); Q-Z; Z = -X-Y-CN (cpds. (VI)); -CHO (cpds. (VII)); -CH2OH (cpds. (VIII)); or COOR7 (cpds. (IX)); R4 = 1-8C alkyl; R7 = protecting gp.; Q = a gp. of formula (i).

公开(公告)号：FI90236B

公开(公告)日：1993-09-30

申请号：FI883249

申请日：1988-07-07

Applicant: HOECHST AG

Inventor： KESSELER KURT ,  BECK GERHARD ,  BARTMANN WILHELM ,  GRANZER ERNOLD

IPC: A61K31/44 ,  A61K31/365 ,  A61K31/4418 ,  A61K31/443 ,  A61K31/505 ,  A61P3/06 ,  A61P9/10 ,  C07D213/55 ,  C07D239/26 ,  C07D405/06 ,  C07D405/14 ,  C07F7/18

Abstract: 3-Desmethylmevalonic acid derivatives of the formula I ( delta -lactone) or II (corresponding dihydroxycarboxylic acid derivative) … … in which A-B, Z, R , R , R and R have the meanings given, are used as medicaments.

公开(公告)号：NO172537C

公开(公告)日：1993-08-04

申请号：NO883074

申请日：1988-07-08

Applicant: HOECHST AG

Inventor： BERGMANN ANDREAS ,  BARTMANN WILHELM ,  BECK GERHARD ,  LAU HANS-HERMANN

IPC: C07D213/30 ,  A61K31/365 ,  A61K31/366 ,  A61K31/38 ,  A61K31/40 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/50 ,  A61P3/06 ,  A61P9/10 ,  C07C45/68 ,  C07C47/55 ,  C07C51/00 ,  C07C51/09 ,  C07C59/00 ,  C07C59/125 ,  C07C59/48 ,  C07C59/68 ,  C07C59/72 ,  C07C59/90 ,  C07C67/00 ,  C07C313/00 ,  C07C323/52 ,  C07C333/04 ,  C07D213/55 ,  C07D239/26 ,  C07D309/10 ,  C07D309/30 ,  C07D405/06 ,  C07D405/10 ,  C07D405/12 ,  C07D407/06 ,  C07D407/12 ,  C07D409/06 ,  C07D409/12 ,  C07D493/04 ,  C07D493/14 ,  C07F7/18 ,  C07H15/18

Abstract: 3-Desmethyl-4-fluoromevalonic acid derivatives of the formula I and the corresponding dihydroxycarboxylic acid derivatives of the formula II … … in which R, X and Y have the meanings given, processes for the preparation of these compounds, their use as medicaments and pharmaceutical preparations are described. Novel intermediates for the preparation of the compounds of the formula I or formula II are additionally described.

公开(公告)号：CA1314873C

公开(公告)日：1993-03-23

申请号：CA571560

申请日：1988-07-08

Applicant: HOECHST AG

Inventor： KESSELER KURT ,  BECK GERHARD ,  BARTMANN WILHELM ,  GRANZER ERNOLD

IPC: A61K31/44 ,  A61K31/365 ,  A61K31/4418 ,  A61K31/443 ,  A61K31/505 ,  A61P3/06 ,  A61P9/10 ,  C07D213/55 ,  C07D239/26 ,  C07D405/06 ,  C07D405/14 ,  C07F7/18 ,  C07D409/14 ,  A61K31/395

Abstract: of the disclosure 3-Demethylmevalonic acid derivatives, a process for their preparation, pharmaceutical products based on these compounds, their use and intermediates 3-Demethylmevalonic acid derivatives of the formula I (.delta.lactone) and II (corresponding dihydroxy carboxylic acid derivative) in which A-B, Z, R1, R2, R3 and R4 have the indicated meanings, a process for the preparation of these compounds, their use as medicaments, and pharmaceutical products, are described. In addition, new intermediates for the preparation of the compounds of the formula I and formula II are described.