公开(公告)号：JPH02243650A

公开(公告)日：1990-09-27

申请号：JP24538189

申请日：1989-09-22

Applicant: HOECHST AG

Inventor： KESSELER KURT ,  BARTMANN WILHELM ,  WESS GUENTHER ,  GRANZER ERNOLD

IPC: A61K31/215 ,  A61K31/34 ,  A61K31/35 ,  A61K31/351 ,  A61K31/365 ,  A61K31/366 ,  A61K31/38 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/42 ,  A61K31/425 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/443 ,  A61K31/496 ,  A61K31/50 ,  A61K31/505 ,  A61P3/06 ,  A61P9/10 ,  A61P43/00 ,  C07C33/48 ,  C07C45/30 ,  C07C47/222 ,  C07C47/24 ,  C07C51/367 ,  C07C59/42 ,  C07C59/46 ,  C07C59/48 ,  C07C59/56 ,  C07C59/76 ,  C07C67/31 ,  C07C69/606 ,  C07C69/732 ,  C07C69/734 ,  C07D207/08 ,  C07D207/32 ,  C07D207/333 ,  C07D207/337 ,  C07D213/48 ,  C07D213/55 ,  C07D213/62 ,  C07D213/63 ,  C07D231/12 ,  C07D233/64 ,  C07D237/08 ,  C07D239/26 ,  C07D261/08 ,  C07D275/02 ,  C07D309/30 ,  C07D405/06

公开(公告)号：NO970616A

公开(公告)日：1997-08-13

申请号：NO970616

申请日：1997-02-11

Applicant: HOECHST AG

Inventor： RYBCZYNSKI WOLFGANG ,  KESSELER KURT

IPC: C07K1/06 ,  C07K1/107 ,  C07K1/113 ,  C07K5/027 ,  C07K5/083 ,  C07K5/087 ,  C07K5/09 ,  C07K5/107 ,  C07K5/10 ,  C07C45/30 ,  C07K5/08

CPC classification number: C07K5/0812 ,  C07K1/107

公开(公告)号：NZ230751A

公开(公告)日：1997-04-24

申请号：NZ23075189

申请日：1989-09-22

Applicant: HOECHST AG

Inventor： KESSELER KURT ,  BARTMANN WILHELM ,  WESS GUENTHER ,  GRANZER ERNOLD

IPC: A61K31/215 ,  A61K31/34 ,  A61K31/35 ,  A61K31/351 ,  A61K31/365 ,  A61K31/366 ,  A61K31/38 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/42 ,  A61K31/425 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/443 ,  A61K31/496 ,  A61K31/50 ,  A61K31/505 ,  A61P3/06 ,  A61P9/10 ,  A61P43/00 ,  C07C33/48 ,  C07C45/30 ,  C07C47/222 ,  C07C47/24 ,  C07C51/367 ,  C07C59/42 ,  C07C59/46 ,  C07C59/48 ,  C07C59/56 ,  C07C59/76 ,  C07C67/31 ,  C07C69/606 ,  C07C69/732 ,  C07C69/734 ,  C07D207/08 ,  C07D207/32 ,  C07D207/333 ,  C07D207/337 ,  C07D213/48 ,  C07D213/55 ,  C07D213/62 ,  C07D213/63 ,  C07D231/12 ,  C07D233/64 ,  C07D237/08 ,  C07D239/26 ,  C07D261/08 ,  C07D275/02 ,  C07D309/30 ,  C07D405/06 ,  C07C47/20 ,  A61K31/19 ,  A61K31/20

Abstract: 7-Substituted 3,5-dihydroxyhept-6-ynoic acids and the derivatives thereof of the formula I I as well as the corresponding lactones of the formula II II in which R and R DEG have the specified meanings, a process for the preparation of these compounds, the use thereof as pharmaceuticals and pharmaceutical products are described. In addition, new intermediates for the preparation of the compounds of the formula I or formula II are described.

公开(公告)号：NO177004B

公开(公告)日：1995-03-27

申请号：NO893777

申请日：1989-09-22

Applicant: HOECHST AG

Inventor： KESSELER KURT ,  BARTMANN WILHELM ,  WESS GUENTHER ,  GRANZER ERNOLD

IPC: A61K31/215 ,  A61K31/34 ,  A61K31/35 ,  A61K31/351 ,  A61K31/365 ,  A61K31/366 ,  A61K31/38 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/42 ,  A61K31/425 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/443 ,  A61K31/496 ,  A61K31/50 ,  A61K31/505 ,  A61P3/06 ,  A61P9/10 ,  A61P43/00 ,  C07C33/48 ,  C07C45/30 ,  C07C47/222 ,  C07C47/24 ,  C07C51/367 ,  C07C59/42 ,  C07C59/46 ,  C07C59/48 ,  C07C59/56 ,  C07C59/76 ,  C07C67/31 ,  C07C69/606 ,  C07C69/732 ,  C07C69/734 ,  C07D207/08 ,  C07D207/32 ,  C07D207/333 ,  C07D207/337 ,  C07D213/48 ,  C07D213/55 ,  C07D213/62 ,  C07D213/63 ,  C07D231/12 ,  C07D233/64 ,  C07D237/08 ,  C07D239/26 ,  C07D261/08 ,  C07D275/02 ,  C07D309/30 ,  C07D405/06

Abstract: 7-Substituted 3,5-dihydroxyhept-6-ynoic acids and the derivatives thereof of the formula I I as well as the corresponding lactones of the formula II II in which R and R DEG have the specified meanings, a process for the preparation of these compounds, the use thereof as pharmaceuticals and pharmaceutical products are described. In addition, new intermediates for the preparation of the compounds of the formula I or formula II are described.

公开(公告)号：FI92321B

公开(公告)日：1994-07-15

申请号：FI885651

申请日：1988-12-05

Applicant: HOECHST AG

Inventor： WESS GUENTHER ,  KESSELER KURT ,  BAADER EKKEHARD ,  BECK GERHARD

IPC: C07D213/55 ,  C07B31/00 ,  C07B53/00 ,  C07C51/00 ,  C07C51/09 ,  C07C51/367 ,  C07C59/01 ,  C07C59/125 ,  C07C59/42 ,  C07C59/58 ,  C07C67/00 ,  C07C69/63 ,  C07D309/30 ,  C07D319/06 ,  C07D405/06

Abstract: A process for the preparation of optically active 3-de-methylmevalonic acid derivatives, and intermediates A process for the preparation of optically active 3-de-methylmevalonic acid derivatives of the formula I I (3,5-dihydroxy carboxylic acid derivatives) or of the formula II II ( beta -hydroxy lactones) in which R, R1 and Y have the indicated meanings, is described. The invention furthermore relates to aldehydes of the formula XII XII in which M represents the indicated protective groups. The 3-demethylmevalonic acid derivatives of this invention are useful for lowering cholesterol levels of a host.

公开(公告)号：NO174201B

公开(公告)日：1993-12-20

申请号：NO885438

申请日：1988-12-07

Applicant: HOECHST AG

Inventor： WESS GUENTHER ,  KESSELER KURT ,  BAADER EKKEHARD ,  BECK GERHARD

IPC: C07D213/55 ,  C07B31/00 ,  C07B53/00 ,  C07C51/00 ,  C07C51/09 ,  C07C51/367 ,  C07C59/01 ,  C07C59/125 ,  C07C59/42 ,  C07C59/58 ,  C07C67/00 ,  C07C69/63 ,  C07D309/30 ,  C07D319/06 ,  C07D405/06 ,  C07D213/04 ,  C07D319/04

Abstract: A process for the preparation of optically active 3-de-methylmevalonic acid derivatives, and intermediates A process for the preparation of optically active 3-de-methylmevalonic acid derivatives of the formula I I (3,5-dihydroxy carboxylic acid derivatives) or of the formula II II ( beta -hydroxy lactones) in which R, R1 and Y have the indicated meanings, is described. The invention furthermore relates to aldehydes of the formula XII XII in which M represents the indicated protective groups. The 3-demethylmevalonic acid derivatives of this invention are useful for lowering cholesterol levels of a host.

公开(公告)号：FI90236B

公开(公告)日：1993-09-30

申请号：FI883249

申请日：1988-07-07

Applicant: HOECHST AG

Inventor： KESSELER KURT ,  BECK GERHARD ,  BARTMANN WILHELM ,  GRANZER ERNOLD

IPC: A61K31/44 ,  A61K31/365 ,  A61K31/4418 ,  A61K31/443 ,  A61K31/505 ,  A61P3/06 ,  A61P9/10 ,  C07D213/55 ,  C07D239/26 ,  C07D405/06 ,  C07D405/14 ,  C07F7/18

Abstract: 3-Desmethylmevalonic acid derivatives of the formula I ( delta -lactone) or II (corresponding dihydroxycarboxylic acid derivative) … … in which A-B, Z, R , R , R and R have the meanings given, are used as medicaments.

公开(公告)号：NO931133L

公开(公告)日：1993-09-29

申请号：NO931133

申请日：1993-03-26

Applicant: HOECHST AG

Inventor： KESSELER KURT ,  SCHMIDTBERGER RUDOLF ,  MUELLNER STEFAN ,  GRANZER ERNOLD

IPC: A61K31/765 ,  A61K31/77 ,  A61K31/795 ,  A61P3/06 ,  A61P9/10 ,  C08L29/04 ,  C08L33/00 ,  C08L33/02 ,  C08L71/02 ,  C08L79/08 ,  F02D41/26

Abstract: The invention relates to a medicament containing an effective content of a polyhydroxymethylene with grafted-on ethoxylated alcohols and/or ethoxylated carboxylic acids. The medicament is used for the treatment of dyslipoproteinaemias.

公开(公告)号：CA1314873C

公开(公告)日：1993-03-23

申请号：CA571560

申请日：1988-07-08

Applicant: HOECHST AG

Inventor： KESSELER KURT ,  BECK GERHARD ,  BARTMANN WILHELM ,  GRANZER ERNOLD

IPC: A61K31/44 ,  A61K31/365 ,  A61K31/4418 ,  A61K31/443 ,  A61K31/505 ,  A61P3/06 ,  A61P9/10 ,  C07D213/55 ,  C07D239/26 ,  C07D405/06 ,  C07D405/14 ,  C07F7/18 ,  C07D409/14 ,  A61K31/395

Abstract: of the disclosure 3-Demethylmevalonic acid derivatives, a process for their preparation, pharmaceutical products based on these compounds, their use and intermediates 3-Demethylmevalonic acid derivatives of the formula I (.delta.lactone) and II (corresponding dihydroxy carboxylic acid derivative) in which A-B, Z, R1, R2, R3 and R4 have the indicated meanings, a process for the preparation of these compounds, their use as medicaments, and pharmaceutical products, are described. In addition, new intermediates for the preparation of the compounds of the formula I and formula II are described.

公开(公告)号：HU207045B

公开(公告)日：1993-03-01

申请号：HU635188

申请日：1988-12-08

Applicant: HOECHST AG

Inventor： WELL GUENTHER ,  KESSELER KURT ,  BAADER EKKEHARD ,  BECK GERHARD

IPC: C07D213/55 ,  C07B31/00 ,  C07B53/00 ,  C07C51/00 ,  C07C51/09 ,  C07C51/367 ,  C07C59/01 ,  C07C59/125 ,  C07C59/42 ,  C07C59/58 ,  C07C67/00 ,  C07C69/63 ,  C07D309/30 ,  C07D319/06 ,  C07D405/06 ,  C07D409/14

Abstract: A process for the preparation of optically active 3-de-methylmevalonic acid derivatives, and intermediates A process for the preparation of optically active 3-de-methylmevalonic acid derivatives of the formula I I (3,5-dihydroxy carboxylic acid derivatives) or of the formula II II ( beta -hydroxy lactones) in which R, R1 and Y have the indicated meanings, is described. The invention furthermore relates to aldehydes of the formula XII XII in which M represents the indicated protective groups. The 3-demethylmevalonic acid derivatives of this invention are useful for lowering cholesterol levels of a host.