公开(公告)号：AU664059B2

公开(公告)日：1995-11-02

申请号：AU3020892

申请日：1992-12-17

Applicant: HOECHST AG

Inventor： ENHSEN ALFONS ,  GLOMBIK HEINER ,  MULLNER STEFAN ,  WESS GUNTHER

IPC: A61K31/575 ,  A61P1/16 ,  A61P3/06 ,  C07J9/00 ,  C07J31/00 ,  C07J41/00 ,  C07J43/00 ,  C07J51/00 ,  C08F122/40 ,  C08F110/02 ,  C08F110/06 ,  C08F116/18 ,  C08F116/20 ,  C08F118/04 ,  C08F120/54 ,  C08F126/02

公开(公告)号：AU663592B2

公开(公告)日：1995-10-12

申请号：AU4018093

申请日：1993-06-11

Applicant: HOECHST AG

Inventor： ENHSEN ALFONS ,  GLOMBIK HEINER ,  KRAMER WERNER ,  WESS GUNTHER

IPC: A61K31/575 ,  A61P1/00 ,  A61P3/00 ,  A61P3/06 ,  A61P7/00 ,  C07H9/00 ,  C07J9/00 ,  C07J41/00 ,  A61K31/56

Abstract: Bile acid derivatives of the formula I Z(X-GS)n in which GS, X, Z and n have the stated meanings, and a process for the production of these compounds are described. The compounds have pharmacological activity and can therefore be used as pharmaceuticals, in particular as hypolipidaemic.

公开(公告)号：AU660248B2

公开(公告)日：1995-06-15

申请号：AU6189294

申请日：1994-05-04

Applicant: HOECHST AG

Inventor： WEITHMANN KLAUS-ULRICH ,  WESS GUNTHER ,  SEIFFGE DIRK

IPC: A61K31/35 ,  A61K31/352 ,  A61P9/00 ,  C07D311/58 ,  C07D311/66 ,  C07D319/06 ,  C07D339/00 ,  C07D339/04 ,  C07D339/08 ,  C07F9/655 ,  C07F9/6558 ,  C07J9/00 ,  C07J11/00 ,  C07J17/00 ,  C07J31/00 ,  C07J33/00 ,  C07J41/00 ,  C09K15/04 ,  A61K31/58 ,  A61K31/165 ,  A61K31/57 ,  A61K31/05 ,  A61K31/23 ,  C07F9/40 ,  A23L3/349 ,  A23L3/3544 ,  C07D307/62

Abstract: Lipid-selective antioxidants of the general formula I (A)a(L)(X)a(I> in which A = antioxidant component, L = linker, X = lipophilic component, a and a' = independently of one another the numbers 1 or 2. The compounds are used to protect lipid-containing substances from oxidation and in pharmaceutical compositions for the prophylaxis and therapy of diseases in which bioradicals are involved, in particular diseases of the heart, circulation and vessels.

公开(公告)号：PT87928B

公开(公告)日：1995-05-04

申请号：PT8792888

申请日：1988-07-07

Applicant: HOECHST AG

Inventor： BECK GERHARD ,  GRANZER ERNOLD ,  BARTMANN WILHELM ,  WESS GUNTHER

IPC: C12N9/99 ,  A61K31/19 ,  A61K31/22 ,  A61K31/34 ,  A61K31/341 ,  A61K31/365 ,  A61K31/366 ,  A61K31/38 ,  A61K31/381 ,  A61P3/06 ,  A61P9/10 ,  A61P43/00 ,  C07C27/00 ,  C07C31/125 ,  C07C31/13 ,  C07C31/135 ,  C07C31/137 ,  C07C33/025 ,  C07C33/12 ,  C07C33/14 ,  C07C33/28 ,  C07C33/38 ,  C07C33/46 ,  C07C33/48 ,  C07C41/00 ,  C07C43/13 ,  C07C43/178 ,  C07C47/00 ,  C07C47/21 ,  C07C51/00 ,  C07C51/09 ,  C07C59/42 ,  C07C59/48 ,  C07C59/54 ,  C07C59/56 ,  C07C59/58 ,  C07C59/64 ,  C07C67/00 ,  C07C69/65 ,  C07C69/66 ,  C07C69/675 ,  C07C69/732 ,  C07C69/738 ,  C07C253/00 ,  C07D307/34 ,  C07D307/54 ,  C07D309/30 ,  C07D333/02 ,  C07D333/38 ,  C07D405/06 ,  C07D407/02 ,  C07D407/06 ,  C07D409/02 ,  C07D409/06 ,  A01N43/54 ,  C07F7/08

Abstract: 3,5-dihydroxycarboxylic acids of formula (I) and their lactones of formula (II) are new: A-B = CH-CH or C=C; X-Y = CH2CH2 or CH=CH; R1 and R2 are each up to 20C, opt. unsatd., alkyl (opt. substd. by 1-6C alkoxy or OCOR5); 3-7C cycloalkyl; phenyl, thiophene, furan or naphthalene residue (these all opt. substd. by 1-3 of halo, 1-6C alkyl or alkoxy, 3-7C cycloalkyl or OCOR5) or pyridyl, opt. substd. by 1-3, 1-4C alkyl; R5 = 1-8C alkyl; R3 = up to 8C alkyl (opt. unsatd.); benzyl, phenyl, thiophene, furan or naphthalene residue (all opt. substd. as above), or 3-7C cycloalkyl; R4 = H, 1-8C alkyl, metal cation, ammonium ion, phenyl, benzyl or 2,3-dihydroxypropyl. Also new are the intermediates of formula (III), (IV), (VI), (VII), (VIII), (IX) or (XII): Q-X-Y-CHO (III); Q-X-Y-CHOH-CH2-CO-CH2-COOR4 (IV); Q-Z; Z = -X-Y-CN (cpds. (VI)); -CHO (cpds. (VII)); -CH2OH (cpds. (VIII)); or COOR7 (cpds. (IX)); R4 = 1-8C alkyl; R7 = protecting gp.; Q = a gp. of formula (i).

公开(公告)号：NZ260471A

公开(公告)日：1995-04-27

申请号：NZ26047194

申请日：1994-05-06

Applicant: HOECHST AG

Inventor： GLOMBIK HEINER ,  ENHSEN ALFONS ,  KRAMER WERNER ,  WESS GUNTHER

IPC: A61K31/575 ,  A61K31/58 ,  A61P3/06 ,  A61P9/10 ,  C07J9/00 ,  C07J31/00 ,  C07J41/00 ,  C07J43/00 ,  C07J51/00 ,  C07J17/00

Abstract: Monomeric bile acid derivatives of the formula I Z-X-GS I, in which GS, X and Z have the stated meanings, and processes for their preparation are described. The compounds have valuable pharmacological properties and can therefore be used as medicines.

公开(公告)号：NO941679D0

公开(公告)日：1994-05-06

申请号：NO941679

申请日：1994-05-06

Applicant: HOECHST AG

Inventor： WESS GUNTHER ,  ENHSEN ALFONS ,  GLOMBIK HEINER ,  KRAMER WERNER

IPC: A61K31/575 ,  A61P3/06 ,  A61P43/00 ,  C07J9/00 ,  C07J41/00

公开(公告)号：NO941678D0

公开(公告)日：1994-05-06

申请号：NO941678

申请日：1994-05-06

Applicant: HOECHST AG

Inventor： ENHSEN ALFONS ,  GLOMBIK HEINER ,  KRAMER WERNER ,  WESS GUNTHER

IPC: A61P3/06 ,  A61P9/00 ,  A61K31/575 ,  C07J3/00 ,  C07J7/00 ,  C07J9/00 ,  C07J31/00 ,  C07J41/00 ,  C07J51/00

Abstract: nor-Bile acid derivatives of the formula I G1 - X - G2 I, in which G1, G2 and X have the stated meanings, processes for preparing these compounds and medicines are described. On the basis of their pharmacological action, they can be used as antihyperlipidaemic.

公开(公告)号：AU4018093A

公开(公告)日：1993-12-16

申请号：AU4018093

申请日：1993-06-11

Applicant: HOECHST AG

Inventor： ENHSEN ALFONS ,  GLOMBIK HEINER ,  KRAMER WERNER ,  WESS GUNTHER

IPC: A61K31/575 ,  A61P1/00 ,  A61P3/00 ,  A61P3/06 ,  A61P7/00 ,  C07H9/00 ,  C07J9/00 ,  C07J41/00 ,  A61K31/56

Abstract: Bile acid derivatives of the formula I Z(X-GS)n in which GS, X, Z and n have the stated meanings, and a process for the production of these compounds are described. The compounds have pharmacological activity and can therefore be used as pharmaceuticals, in particular as hypolipidaemic.

公开(公告)号：PH26336A

公开(公告)日：1992-04-29

申请号：PH37923

申请日：1988-12-14

Applicant: HOECHST AG

Inventor： WESS GUNTHER ,  KEBELER KURT ,  BAADER EKKHARD ,  BECK GERHARD

IPC: C07D405/06 ,  C07D405/14 ,  C07D409/14

公开(公告)号：AU616224B2

公开(公告)日：1991-10-24

申请号：AU2662688

申请日：1988-12-07

Applicant: HOECHST AG

Inventor： WESS GUNTHER ,  KESSELER KURT ,  BAADER EKKEHARD ,  BECK GERHARD

IPC: C07D213/55 ,  C07B31/00 ,  C07B53/00 ,  C07C51/00 ,  C07C51/09 ,  C07C51/367 ,  C07C59/01 ,  C07C59/125 ,  C07C59/42 ,  C07C59/58 ,  C07C67/00 ,  C07C69/63 ,  C07D309/30 ,  C07D319/06 ,  C07D405/06 ,  C07D239/26 ,  C07D319/08

Abstract: A process for the preparation of optically active 3-de-methylmevalonic acid derivatives, and intermediates A process for the preparation of optically active 3-de-methylmevalonic acid derivatives of the formula I I (3,5-dihydroxy carboxylic acid derivatives) or of the formula II II ( beta -hydroxy lactones) in which R, R1 and Y have the indicated meanings, is described. The invention furthermore relates to aldehydes of the formula XII XII in which M represents the indicated protective groups. The 3-demethylmevalonic acid derivatives of this invention are useful for lowering cholesterol levels of a host.