公开(公告)号：LU79350A1

公开(公告)日：1978-11-27

申请号：LU79350

申请日：1978-03-31

Applicant: HOECHST AG

Inventor： DUERCKHEIMER W ,  SCHRINNER E ,  HEYMES R ,  EHLERS E ,  BORMANN D

IPC: A61K31/397 ,  A61K31/435 ,  A61K31/505 ,  A61K31/535 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  B25J15/08 ,  C07D205/08 ,  C07D277/20 ,  C07D277/40 ,  C07D277/42 ,  C07D277/50 ,  C07D463/00 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D501/20 ,  C07D501/24 ,  C07D501/36 ,  C07D505/00 ,  C07D519/06 ,  C07F9/6561 ,  C07D ,  A61K

公开(公告)号：SE404796B

公开(公告)日：1978-10-30

申请号：SE7504841

申请日：1975-04-25

Applicant: HOECHST AG

Inventor： BORMANN D ,  MERKEL W ,  MUSCHAWECK R ,  MANIA D

IPC: C07D207/04 ,  A61K20060101 ,  A61K31/125 ,  A61K31/18 ,  A61K31/33 ,  A61K31/395 ,  A61K31/40 ,  A61K31/402 ,  A61K31/445 ,  A61K31/45 ,  A61K31/635 ,  A61P7/10 ,  C07C20060101 ,  C07D20060101 ,  C07D205/04 ,  C07D207/02 ,  C07D207/06 ,  C07D207/08 ,  C07D207/10 ,  C07D207/18 ,  C07D207/20 ,  C07D207/32 ,  C07D207/327 ,  C07D207/40 ,  C07D207/404 ,  C07D207/44 ,  C07D209/00 ,  C07D209/44 ,  C07D209/48 ,  C07D209/52 ,  C07D209/94 ,  C07D211/04 ,  C07D211/14 ,  C07D211/18 ,  C07D211/30 ,  C07D211/32 ,  C07D211/34 ,  C07D211/38 ,  C07D211/70 ,  C07D211/88 ,  C07D265/32 ,  C07D295/00 ,  C07D295/02 ,  C07D295/04 ,  C07D295/08 ,  C07D295/10 ,  C07D295/116 ,  C07D295/12 ,  C07D295/14 ,  C07D295/155 ,  C07D295/18 ,  C07D295/192 ,  C07D403/10 ,  C07D405/10 ,  C07D407/10 ,  C07D413/10 ,  C07D405/12 ,  C07D409/12

公开(公告)号：SE7803660L

公开(公告)日：1978-10-03

申请号：SE7803660

申请日：1978-03-31

Applicant: HOECHST AG

Inventor： DURCKHEIMER W ,  BORMANN D ,  EHLERS E ,  SCHRINNER E ,  HAYMES R

IPC: A61K31/397 ,  A61K31/435 ,  A61K31/505 ,  A61K31/535 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  B25J15/08 ,  C07D205/08 ,  C07D277/20 ,  C07D277/40 ,  C07D277/42 ,  C07D277/50 ,  C07D463/00 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D501/20 ,  C07D501/24 ,  C07D501/36 ,  C07D505/00 ,  C07D519/06 ,  C07F9/6561 ,  C07D501/34 ,  C07D487/02

Abstract: Cephem derivatives of the general formula in which the R2O group is in the syn-position, a process for their manufacture and pharmaceutical formulations which are active against bacterial infections and contain these compounds.

公开(公告)号：SE7802175L

公开(公告)日：1978-02-27

申请号：SE7802175

申请日：1978-02-27

Applicant: HOECHST AG

Inventor： BORMANN D ,  MERKEL W ,  MUSCHAWECK R ,  MANIA D

IPC: C07D207/04 ,  A61K20060101 ,  A61K31/125 ,  A61K31/18 ,  A61K31/33 ,  A61K31/395 ,  A61K31/397 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/402 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/445 ,  A61K31/45 ,  A61K31/635 ,  A61P7/10 ,  C07C20060101 ,  C07D20060101 ,  C07D205/04 ,  C07D205/10 ,  C07D207/02 ,  C07D207/06 ,  C07D207/08 ,  C07D207/10 ,  C07D207/18 ,  C07D207/20 ,  C07D207/32 ,  C07D207/327 ,  C07D207/40 ,  C07D207/404 ,  C07D207/44 ,  C07D207/452 ,  C07D209/00 ,  C07D209/44 ,  C07D209/48 ,  C07D209/52 ,  C07D209/94 ,  C07D211/04 ,  C07D211/14 ,  C07D211/18 ,  C07D211/30 ,  C07D211/32 ,  C07D211/34 ,  C07D211/38 ,  C07D211/70 ,  C07D211/88 ,  C07D265/32 ,  C07D265/33 ,  C07D295/00 ,  C07D295/02 ,  C07D295/04 ,  C07D295/08 ,  C07D295/10 ,  C07D295/116 ,  C07D295/12 ,  C07D295/14 ,  C07D295/155 ,  C07D295/18 ,  C07D295/192 ,  C07D317/00 ,  C07D403/10 ,  C07D405/10 ,  C07D407/10 ,  C07D413/10

Abstract: 1504505 Sulphonamides HOECHST AG 25 April 1975 [25 April 1974 27 Dec 1974] 17337/75 Heading C2C The invention comprises novel compounds (I) (including salts thereof) in which R 1 and R 2 , which may be identical or different, each represents a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms, and, if R 1 represents a hydrogen atom, R 2 may also represent an alkoxymethyl group having from 1 to 4 carbon atoms in the alkoxy radical, a phenoxymethyl group or a phenylthiomethyl group, R 3 represents a hydrogen atom, a straight or branched chain alkyl group having from 1 to 4 carbon atoms, a cycloalkyl group, having 5 or 6 ring members, one of which may be replaced by an oxygen or sulphur atom, a phenyl or benzyl group which may be substituted in the phenyl nucleus by one or more substituents selected from nitro groups, alkyl groups having from 1 to 3 carbon atoms, alkoxy groups having from 1 to 5 carbon atoms and halogen atoms, or represents a benzhydryl group or an alkanoyloxymethyl group having 2 to 4 carbon atoms in the alkanoyl part, X represents a halogen atom, a CF 3 or CCl 3 group, a straight or branched chain, saturated or unsaturated alkyl group having from 1 to 6 carbon atoms, a benzyl group which may be substituted in the phenyl nucleus by one or more substituents selected from halogen atoms, hydroxy and amino groups, and alkyl and alkoxy groups, or represents one of the groups -O-R 4 , -S-R 4 , SO-R 4 , SO 2 -R 4 and NR 4 R 5 , in which R 4 represents a phenyl group which may be substituted by one or more substituents selected from halogen atoms, CF 3 , OH and amino groups, alkyl and alkoxy groups having from 1 to 4 carbon atoms, and SO 2 NH 2 groups, or represents a straight or branched chain alkyl group having from 1 to 4 carbon atoms which may be substituted by a phenyl, pyridyl, furyl or thienyl group, and R 5 represents a hydrogen atom, a straight or branched chain alkyl group having from 1 to 4 carbon atoms, and the group NR 4 R 5 may represent a saturated, heterocyclic, 5- or 6-membered ring which may be interrupted by an O-, N- or S- atom, A represents a single bond, or an alkylene chain of 1 to 3 carbon atoms which may be unsaturated, interrupted by O-, N- or S-atoms or substituted by halogen atoms and/or substituted by alkyl, aralkyl, aryl groups or by mono-nuclear hetero-aromatic rings, or A represents an ortho-phenylene radical or the grouping in which Y represents a single bond or an alkylene group having from 1 to 4 carbon atoms, and R 6 and R 7 , which may be identical or different, each represents a hydrogen or halogen atom or an alkyl group having from 1 to 4 carbon atoms. They are made by standard methods. Pharmaceutical preparations having diuretic and saluretic action contain (I) as active ingredient. Administration is enterally or parenterally.

公开(公告)号：SE7604940L

公开(公告)日：1976-10-30

申请号：SE7604940

申请日：1976-04-29

Applicant: HOECHST AG

Inventor： BORMANN D ,  MERKEL W ,  MANIA D

IPC: C07D295/14 ,  C07C67/00 ,  C07C301/00 ,  C07C303/40 ,  C07C311/39 ,  C07C313/00 ,  C07C315/00 ,  C07C315/04 ,  C07C317/48 ,  C07C319/14 ,  C07C323/67 ,  C07D207/09 ,  C07D213/71 ,  C07D295/155 ,  C07D307/52 ,  C07D333/34 ,  C07C143/80

公开(公告)号：SE7504841L

公开(公告)日：1975-10-27

申请号：SE7504841

申请日：1975-04-25

Applicant: HOECHST AG

Inventor： BORMANN D ,  MERKEL W ,  MUSCHAWECK R ,  MANIA D

IPC: C07D207/04 ,  A61K20060101 ,  A61K31/125 ,  A61K31/18 ,  A61K31/33 ,  A61K31/395 ,  A61K31/40 ,  A61K31/402 ,  A61K31/445 ,  A61K31/45 ,  A61K31/635 ,  A61P7/10 ,  C07C20060101 ,  C07D20060101 ,  C07D205/04 ,  C07D207/02 ,  C07D207/06 ,  C07D207/08 ,  C07D207/10 ,  C07D207/18 ,  C07D207/20 ,  C07D207/32 ,  C07D207/327 ,  C07D207/40 ,  C07D207/404 ,  C07D207/44 ,  C07D209/00 ,  C07D209/44 ,  C07D209/48 ,  C07D209/52 ,  C07D209/94 ,  C07D211/04 ,  C07D211/14 ,  C07D211/18 ,  C07D211/30 ,  C07D211/32 ,  C07D211/34 ,  C07D211/38 ,  C07D211/70 ,  C07D211/88 ,  C07D265/32 ,  C07D295/00 ,  C07D295/02 ,  C07D295/04 ,  C07D295/08 ,  C07D295/10 ,  C07D295/116 ,  C07D295/12 ,  C07D295/14 ,  C07D295/155 ,  C07D295/18 ,  C07D295/192 ,  C07D403/10 ,  C07D405/10 ,  C07D407/10 ,  C07D413/10 ,  C07D405/12 ,  C07D409/12

公开(公告)号：DK179875A

公开(公告)日：1975-10-26

申请号：DK179875

申请日：1975-04-24

Applicant: HOECHST AG

Inventor： BORMANN D ,  MERKEL W ,  MUSCHAWECK R ,  MANIA D

IPC: C07D207/04 ,  A61K20060101 ,  A61K31/125 ,  A61K31/18 ,  A61K31/33 ,  A61K31/395 ,  A61K31/40 ,  A61K31/402 ,  A61K31/445 ,  A61K31/45 ,  A61K31/635 ,  A61P7/10 ,  C07C20060101 ,  C07D20060101 ,  C07D205/04 ,  C07D207/02 ,  C07D207/06 ,  C07D207/08 ,  C07D207/10 ,  C07D207/18 ,  C07D207/20 ,  C07D207/32 ,  C07D207/327 ,  C07D207/40 ,  C07D207/404 ,  C07D207/44 ,  C07D209/00 ,  C07D209/44 ,  C07D209/48 ,  C07D209/52 ,  C07D209/94 ,  C07D211/04 ,  C07D211/14 ,  C07D211/18 ,  C07D211/30 ,  C07D211/32 ,  C07D211/34 ,  C07D211/38 ,  C07D211/70 ,  C07D211/88 ,  C07D265/32 ,  C07D295/00 ,  C07D295/02 ,  C07D295/04 ,  C07D295/08 ,  C07D295/10 ,  C07D295/116 ,  C07D295/12 ,  C07D295/14 ,  C07D295/155 ,  C07D295/18 ,  C07D295/192 ,  C07D403/10 ,  C07D405/10 ,  C07D407/10 ,  C07D413/10 ,  C07D

公开(公告)号：FI343374A

公开(公告)日：1975-05-30

申请号：FI343374

申请日：1974-11-27

Applicant: HOECHST AG

Inventor： BORMANN D ,  KNABE B ,  SCHRINNER E ,  WORM M

IPC: A61K20060101 ,  A61K31/43 ,  A61K31/545 ,  C01D20060101 ,  C07D20060101 ,  C07D501/04 ,  C07D501/06 ,  C07D501/20 ,  C07D501/24 ,  C07D501/36 ,  C07D501/40 ,  C07D501/42 ,  C07D501/46 ,  C07D501/48 ,  C07D501/56 ,  C07D501/60 ,  C07D519/00 ,  C07D521/00 ,  C07D

公开(公告)号：NO752250L

公开(公告)日：1975-03-10

申请号：NO752250

申请日：1975-06-24

Applicant: HOECHST AG

Inventor： BORMANN D ,  MERKEL W

IPC: C07C20060101 ,  C07C

公开(公告)号：FI259974A

公开(公告)日：1975-03-08

申请号：FI259974

申请日：1974-09-05

Applicant: HOECHST AG

Inventor： BORMANN D ,  MERKEL W

IPC: C07C311/46 ,  C07C67/00 ,  C07C301/00 ,  C07C311/37 ,  C07C313/00 ,  C07C319/20 ,  C07C323/67 ,  C07C

Abstract: 3-Alkylamino-5-sulfamyl benzoic acid derivatives are prepared by reducing 3-acylamino-5-sulfamyl-benzoic acid derivatives by means of boron hydrides or complex boron hydrides in the presence of Lewis acids.