公开(公告)号：AU700883B2

公开(公告)日：1999-01-14

申请号：AU4442996

申请日：1996-02-08

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH DR ,  GERLACH UWE DR ,  CRAUSE PETER DR ,  MANIA DIETER DR ,  GOGELEIN HEINZ DR ,  KAISER JOACHIM DR

IPC: C07D333/20 ,  A61K31/18 ,  A61K31/34 ,  A61K31/35 ,  A61K31/38 ,  A61K31/381 ,  A61K31/395 ,  A61K31/40 ,  A61K31/425 ,  A61K31/426 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07C233/00 ,  C07C303/40 ,  C07C311/58 ,  C07C327/40 ,  C07C335/42 ,  C07D207/32 ,  C07D207/335 ,  C07D213/40 ,  C07D277/28 ,  C07D307/52 ,  C07C311/59 ,  A61K31/17

Abstract: Substd. benzenesulphonylurea or -thiourea cpds. of formula (I) are new: R1 = H, 1-6C alkyl, or 3-6C cycloalkyl; R2 = 1-6C alkyl, 1-6C alkoxy, 1-6C mercaptoalkyl, 3-6C cycloalkyl, or a 1-8C chain in which 1-3C may be replaced by O, NH or S; R3, R4 = H or 1-6C alkyl; or R3 + R4 = (CH2)p; p = 2-5; E, X = O or S; Y = ÄC(R5)2Üm; R5 = H, Me or Et; m = 1 or 2; Ar = phenyl, thienyl, furyl, pyrrolyl, thiazolyl, naphthyl or pyridyl (all opt. substd. by 1-3 Me, Et, MeO, EtO, Cl, Br or F).

公开(公告)号：AU700793B2

公开(公告)日：1999-01-14

申请号：AU4556096

申请日：1996-02-15

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH DR ,  GERLACH UWE DR ,  MANIA DIETER DR ,  GOGELEIN HEINZ DR ,  KAISER JOACHIM DR

IPC: A61K31/18 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07C233/00 ,  C07C303/40 ,  C07C311/58 ,  C07C311/59 ,  C07C327/40 ,  C07C335/42 ,  A61K31/17

Abstract: Substd. benzene sulphonyl urea and thiourea derivs. of formula (I) and their salts are new. R1 = H, Me or CF3; R2 = 4-10C alkoxy with 1-6C replaced by O, S or NH; Q = O or S; Y = ÄC(R3)2Üm; R3 = H, Me or Et; R' = H, halo or 1-6C alkyl; R" = halo, 1-4C alkoxy or 1-4C alkyl; and m = 1-4.

公开(公告)号：CZ284456B6

公开(公告)日：1998-12-16

申请号：CS403392

申请日：1992-12-31

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH DR ,  MANIA DIETER DR ,  LANG HANS-JOCHEN DR ,  SCHOLZ WOLFGANG DR ,  LINZ WOLFGANG DR ,  ALBUS UDO DR

IPC: A61K31/155 ,  A61K31/165 ,  A61K31/445 ,  A61P1/16 ,  A61P3/08 ,  A61P3/10 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P35/00 ,  C07C279/22 ,  C07D213/65 ,  C07D295/14 ,  C07D295/155

Abstract: There are described benzoylguanidines of the formula I in which R(1) or R(2) is an amino group -NR(3)R(4), where R(3) and R(4) are equal to H, (cyclo)alkyl or R(3) is equal to phenyl-(CH2)p- where p = 0, 1, 2, 3 or 4, or phenyl, or R(3) and R(4) together can also be a methylene chain, and in which the other substituent R(1) or R(2) in each case is H, F, Cl, alkyl, alkoxy, CF3, CmF2m+1-CH2-, benzyl or phenoxy, and their pharmaceutically tolerable salts. The compounds according to the invention have very good antiarrhythmic properties, such as they show, for example, in the case of oxygen deficiency symptoms. The compounds are used as antiarrhythmic medicaments having a cardioprotective component for infarct prophylaxis and infarct treatment and also for the treatment of angina pectoris, where they preventively inhibit or strongly decrease the pathophysiological processes during the formation of ischaemically induced damage, in particular during the induction of ischaemically induced cardiac arrhythmias.

公开(公告)号：CZ9703588A3

公开(公告)日：1998-06-17

申请号：CZ358897

申请日：1997-11-12

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN DR ,  GERLACH UWE DR ,  MANIA DIETER DR ,  LINZ WOLFGANG DR ,  GOEGELEIN HEINZ PROF DR ,  KLAUS ERIK DR

IPC: C07D311/04 ,  A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/355 ,  A61K31/40 ,  A61K31/4025 ,  A61P9/00 ,  A61P9/06 ,  C07D207/26 ,  C07D209/34 ,  C07D211/76 ,  C07D217/24 ,  C07D227/02 ,  C07D311/16 ,  C07D311/18 ,  C07D311/42 ,  C07D311/58 ,  C07D311/70 ,  C07D405/12 ,  C07D311/74 ,  A61K31/47 ,  C07D203/08 ,  C07D209/32 ,  C07D217/16

CPC classification number: C07D405/12 ,  C07D311/58 ,  C07D311/70

公开(公告)号：DE19647000A1

公开(公告)日：1998-05-20

申请号：DE19647000

申请日：1996-11-14

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH-CHRISTIAN DR ,  GERLACH UWE DR ,  MANIA DIETER DR ,  LINZ WOLFGANG DR ,  GOEGELEIN HEINZ PROF DR ,  KLAUS ERIK DR

IPC: C07D311/04 ,  A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/355 ,  A61K31/40 ,  A61K31/4025 ,  A61P9/00 ,  A61P9/06 ,  C07D207/26 ,  C07D209/34 ,  C07D211/76 ,  C07D217/24 ,  C07D227/02 ,  C07D311/16 ,  C07D311/18 ,  C07D311/42 ,  C07D311/58 ,  C07D311/70 ,  C07D405/12

Abstract: 3-Amido-chromanylsulphonyl-urea or -thiourea derivatives of formula (I), in all stereoisomer (or mixture) forms, and their salts are new. R1 = H, alkyl, alkoxy, alkoxyalkoxy, alkylthio, F, Cl, Br, I or CF3; R2 = H, Me or Et; R3 = H or alkyl; Z = O or S; A = phenyl (optionally substituted by 1-3 halo, Me, Et, OMe or OEt), lactam residue of formula (i), 1-oxo-1,2,3,4-tetrahydroisoquinolin-2-yl, 1-oxo-perhydroisoquinolin-2-yl, 1-oxo-2,3-isoindolin-2-yl or 1-oxo-perhydroisoindolin-2-yl; B = 3-6C alkylene or 3-6C alkenylene (both optionally substituted by 1-3 alkyl); all alkyl moieties have 1-4C.

公开(公告)号：ES2089600T3

公开(公告)日：1996-10-01

申请号：ES93101842

申请日：1993-02-05

Applicant: HOECHST AG

Inventor： LANG HANS-JOCHEN DR ,  MANIA DIETER DR ,  WEICHERT ANDREAS DR ,  SCHOLZ WOLFGANG DR ,  ALBUS UDO DR ,  ENGLERT HEINRICH DR

IPC: A61K31/155 ,  A61K31/18 ,  A61K31/275 ,  A61P1/16 ,  A61P3/08 ,  A61P3/10 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P35/00 ,  A61P35/04 ,  C07C217/44 ,  C07C311/16 ,  C07C311/37 ,  C07C311/39 ,  C07C311/47 ,  C07C317/42 ,  C07C317/44 ,  C07C323/65

Abstract: There are described benzoylguanidines of the formula I where R(1) is equal to R(4)-SOm or R(5)R(6)N-SO2-, where R(4) and R(5) are equal to alk(en)yl, -CnH2n-R(7), and where R(7) is equal to cycloalkyl or phenyl, where R(5) also denotes H, R(6) is equal to H or C1-C4-alkyl, R(2) is hydrogen, halogen, alkyl, -O-(CH2)mCpF2p+1, -X-R(10), where X is equal to O, S, NR(11), R(10) is equal to H, (cyclo)alkyl(methyl), -CnH2n-R(12) where R(12) is equal to phenyl, R(3), inter alia, is defined as R(1), and their pharmaceutically tolerable salts. The compounds I are prepared by reaction of compounds of the formula II in which L represents a leaving group which can be easily substituted nucleophilically, with guanidine. Compounds I are outstandingly suitable as antiarrhythmic medicaments having a cardioprotective component for infarct prophylaxis and infract treatment and for the treatment of angina pectoris, where they also preventively inhibit or strongly decrease the pathophysiological processes during the formation of ischaemically induced damage. They are moreover distinguished by a strong inhibitory action on cell proliferation. They can therefore be used as antiatherosclerotics, agents against diabetic late complications, cancers, fibrotic disorders such as pulmonary fibrosis, fibrosis of the liver or fibrosis of the kidneys. They are effective inhibitors of the cellular sodium/protons antiporter (Na /H exchanger).

公开(公告)号：CZ9600436A3

公开(公告)日：1996-09-11

申请号：CZ43696

申请日：1996-02-14

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH DR ,  GERLACH UWE DR ,  MANIA DIETER DR ,  GOGELEIN HEINZ DR ,  KAISER JOACHIM DR

IPC: A61K31/18 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07C233/00 ,  C07C303/40 ,  C07C311/58 ,  C07C311/59 ,  C07C327/40 ,  C07C335/42 ,  A61K31/17 ,  C07C303/36 ,  C07C311/54

CPC classification number: C07C311/58 ,  C07C335/42 ,  Y10S514/821

公开(公告)号：DE59302959D1

公开(公告)日：1996-07-25

申请号：DE59302959

申请日：1993-02-05

Applicant: HOECHST AG

Inventor： LANG HANS-JOCHEN DR ,  MANIA DIETER DR ,  WEICHERT ANDREAS DR ,  SCHOLZ WOLFGANG DR ,  ALBUS UDO DR ,  ENGLERT HEINRICH DR ,  LANG FLORIAN PROF DR

IPC: A61K31/155 ,  A61K31/18 ,  A61K31/275 ,  A61P1/16 ,  A61P3/08 ,  A61P3/10 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P35/00 ,  A61P35/04 ,  C07C217/44 ,  C07C311/16 ,  C07C311/37 ,  C07C311/39 ,  C07C311/47 ,  C07C317/42 ,  C07C317/44 ,  C07C323/65

Abstract: There are described benzoylguanidines of the formula I where R(1) is equal to R(4)-SOm or R(5)R(6)N-SO2-, where R(4) and R(5) are equal to alk(en)yl, -CnH2n-R(7), and where R(7) is equal to cycloalkyl or phenyl, where R(5) also denotes H, R(6) is equal to H or C1-C4-alkyl, R(2) is hydrogen, halogen, alkyl, -O-(CH2)mCpF2p+1, -X-R(10), where X is equal to O, S, NR(11), R(10) is equal to H, (cyclo)alkyl(methyl), -CnH2n-R(12) where R(12) is equal to phenyl, R(3), inter alia, is defined as R(1), and their pharmaceutically tolerable salts. The compounds I are prepared by reaction of compounds of the formula II in which L represents a leaving group which can be easily substituted nucleophilically, with guanidine. Compounds I are outstandingly suitable as antiarrhythmic medicaments having a cardioprotective component for infarct prophylaxis and infract treatment and for the treatment of angina pectoris, where they also preventively inhibit or strongly decrease the pathophysiological processes during the formation of ischaemically induced damage. They are moreover distinguished by a strong inhibitory action on cell proliferation. They can therefore be used as antiatherosclerotics, agents against diabetic late complications, cancers, fibrotic disorders such as pulmonary fibrosis, fibrosis of the liver or fibrosis of the kidneys. They are effective inhibitors of the cellular sodium/protons antiporter (Na /H exchanger).

公开(公告)号：DK0547523T3

公开(公告)日：1995-09-11

申请号：DK92121155

申请日：1992-12-11

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH DR ,  MANIA DIETER DR ,  KIBAT PAUL-GERHARD DR ,  GEHRING DORIS ,  PAULUS ERICH DR

IPC: A61K31/35 ,  A61K9/12 ,  A61K31/352 ,  A61K31/353 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/445 ,  A61P11/00 ,  A61P11/06 ,  A61P11/08 ,  C07D207/12 ,  C07D311/68 ,  C07D311/74 ,  C07D405/04

Abstract: The invention relates to ethanol adducts of the compounds of the formula I I to a process for their preparation and to their use as inhalants in diseases, in particular in asthma.

公开(公告)号：ES2061816T3

公开(公告)日：1994-12-16

申请号：ES89112897

申请日：1989-07-14

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN DR ,  KLAUS ERIK DR ,  MANIA DIETER DR ,  SCHOLKENS BERNWARD DR

IPC: C07D311/22 ,  A61K31/40 ,  A61K31/415 ,  A61K31/42 ,  A61K31/425 ,  A61K31/44 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/495 ,  A61K31/50 ,  A61K31/505 ,  A61K31/535 ,  A61K31/54 ,  A61P11/00 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  C07D405/04 ,  C07D409/12 ,  C07D413/04 ,  C07D417/04

Abstract: The use of 3,4-dihydro-2H-benzo[b]pyrans of the formula I in which R is H, OH, (C1-C2)-alkoxy, (C1-C2)-alkyl or NR R , where R and R are identical or different and are H, (C1-C2)-alkyl or (C1-C3)-alkylcarbonyl, R and R are identical or different and are alkyl with 1-4 C atoms, Ar is an aromatic or heteroaromatic system which is unsubstituted or substituted by 1 to 3 identical or different radicals (C1-C2)-alkyl, (C1-C2)-alkoxy, halogen, trifluoromethyl, CN, NO2, CO-(C1-C2)-alkyl or SOm-(C1-C2)-alkyl with m = 1 or 2, n is 1 or 2, X is a chain (CH2)r which can be interrupted by a heteroatom O, S or NR where R is H or (C1-C4)-alkyl and r is the numbers 2, 3, 4 or 5, for the production of a medicament for urinary tract disorders.