公开(公告)号：ES2061531T3

公开(公告)日：1994-12-16

申请号：ES88101975

申请日：1988-02-11

Applicant: HOECHST AG

Inventor： URBACH HANSJORG DR ,  HENNING RAINER DR ,  SCHOLKENS BERNWARD DR ,  BECKER REINHARD DR

IPC: C07D223/32 ,  A61K31/395 ,  A61K31/445 ,  A61K31/55 ,  A61K38/00 ,  A61P9/00 ,  A61P9/12 ,  A61P27/02 ,  A61P27/06 ,  A61P43/00 ,  C07D225/04 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07K5/02 ,  C07K5/06 ,  A61K37/02

Abstract: Cyclopenta-azocine and -azepine derivs. of formula (I) and their salts are new. In (I) m = 1 or 2; n = 0-2; R1 and R2 = H; 1-6C alkyl (opt. substd. once by OH, SH, 1-2C alkoxy, 1-2C alkylthio, COOH, 1-2C alkoxycarbonyl, 3-indolyl, imidazolyl, CONH2, amino or guanidino); 2-6C alkenyl; 3-9C cycloalkyl or cycloalkenyl; 3-7C cycloalkyl (1-4C) alkyl; 6-12C aryl (opt. partially hydrogenated) or 6-12C aryl (1-4C) alkyl (opt. OH substd. in aryl); R3 and R4 = H, 1-6C alkyl, 2-6C alkenyl or 6-12C aryl (1-4C) alkyl, opt. substd. in aryl by one MeO or NO2; Y = H or OH; Z = H; or Y and Z are together oxo; X = 1-6C alkyl (opt. substd. by NH2, acylamino, 1-6C alkylamino and/or di(1-4C)alkylamino); 2-6C alkenyl; 5-9C cycloalkyl, 1-R1-piperidin-4-yl, 6-12C aryl (opt. substd. by 1-3 of 1-4C alkyl or alkoxy, OH, halo, NO2, NH2 (itself opt. substd. by 1 or 2 1-4C alkyl) and/or methylenedioxy) or 3-indolyl; any free OH, SH, COOH, amino or guanidino can be protected conventionally.

公开(公告)号：CZ89288A3

公开(公告)日：1994-12-15

申请号：CS89288

申请日：1988-02-12

Applicant: HOECHST AG

Inventor： URBACH HANSJORG DR ,  HENNING RAINER DR ,  SCHOLKENS BERNWARD DR ,  BECKER REINHARD DR

IPC: C07D223/32 ,  A61K31/395 ,  A61K31/445 ,  A61K31/55 ,  A61K38/00 ,  A61P9/00 ,  A61P9/12 ,  A61P27/02 ,  A61P27/06 ,  A61P43/00 ,  C07D225/04 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07K5/02 ,  C07K5/06

Abstract: Cyclopenta-azocine and -azepine derivs. of formula (I) and their salts are new. In (I) m = 1 or 2; n = 0-2; R1 and R2 = H; 1-6C alkyl (opt. substd. once by OH, SH, 1-2C alkoxy, 1-2C alkylthio, COOH, 1-2C alkoxycarbonyl, 3-indolyl, imidazolyl, CONH2, amino or guanidino); 2-6C alkenyl; 3-9C cycloalkyl or cycloalkenyl; 3-7C cycloalkyl (1-4C) alkyl; 6-12C aryl (opt. partially hydrogenated) or 6-12C aryl (1-4C) alkyl (opt. OH substd. in aryl); R3 and R4 = H, 1-6C alkyl, 2-6C alkenyl or 6-12C aryl (1-4C) alkyl, opt. substd. in aryl by one MeO or NO2; Y = H or OH; Z = H; or Y and Z are together oxo; X = 1-6C alkyl (opt. substd. by NH2, acylamino, 1-6C alkylamino and/or di(1-4C)alkylamino); 2-6C alkenyl; 5-9C cycloalkyl, 1-R1-piperidin-4-yl, 6-12C aryl (opt. substd. by 1-3 of 1-4C alkyl or alkoxy, OH, halo, NO2, NH2 (itself opt. substd. by 1 or 2 1-4C alkyl) and/or methylenedioxy) or 3-indolyl; any free OH, SH, COOH, amino or guanidino can be protected conventionally.

公开(公告)号：ES2054989T3

公开(公告)日：1994-08-16

申请号：ES89121499

申请日：1989-11-21

Applicant: HOECHST AG

Inventor： HENNING RAINER DR ,  URBACH HANSJORG DR ,  RUPPERT DIETER DR ,  SCHOLKENS BERNWARD DR

IPC: C07D213/40 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/4433 ,  A61K38/00 ,  A61K38/55 ,  A61P9/12 ,  C07D233/64 ,  C07D401/12 ,  C07D409/12 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81 ,  A61K37/64

Abstract: The invention relates to compounds of the formula I in which A is a radical of the formula II in which E is a CH2 group or a radical NR , G is a radical from the group comprising S, SO, SO2, O, CO, CS or a direct bond, B is an amino acid, D is a heterocycle, and R , R , R , R , R , R and R are defined in the description, and the salts thereof. The invention also relates to a process for preparing the compounds of the formula I and to the use thereof as medicines.

公开(公告)号：CZ9104162A3

公开(公告)日：1993-09-15

申请号：CS416291

申请日：1991-12-30

Applicant: HOECHST AG

Inventor： TEETZ VOLKER DR ,  GEIGER ROLF PROF DR ,  URBACH HANSJORG DR ,  BECKER REINHARD DR ,  SCHOLKENS BERNWARD DR

IPC: C07C227/08 ,  A61K31/40 ,  A61K31/403 ,  A61K38/00 ,  A61P9/12 ,  C07C227/10 ,  C07C227/16 ,  C07C229/36 ,  C07C237/06 ,  C07D209/52 ,  C07D451/04 ,  C07K5/02 ,  C07K5/06

CPC classification number: C07K5/0222 ,  A61K38/00 ,  C07D209/52

公开(公告)号：CS9104094A3

公开(公告)日：1992-05-13

申请号：CS409491

申请日：1991-12-27

Applicant: HOECHST AG

Inventor： GEIGER ROLF PROF DR ,  TEETZ VOLKER DR ,  URBACH HANSJORG DR ,  SCHOLKENS BERNWARD DR ,  HENNING RAINER DR

IPC: A61K38/00 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/47 ,  A61K31/472 ,  A61P9/12 ,  C07D209/42 ,  C07D217/26 ,  C07D233/64 ,  C07D241/20 ,  C07D307/54 ,  C07D309/10 ,  C07D317/66 ,  C07D333/24 ,  C07D335/02 ,  C07D339/08 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07K1/02 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/062 ,  C07K5/065 ,  C07K5/078 ,  C07K14/81 ,  C07D405/06

CPC classification number: C07K5/0222 ,  A61K38/00 ,  C07D217/26

公开(公告)号：CZ8800892A3

公开(公告)日：1994-12-15

申请号：CS89288

申请日：1988-02-12

Applicant: HOECHST AG

Inventor： URBACH HANSJORG DR ,  HENNING RAINER DR ,  SCHOLKENS BERNWARD DR ,  BECKER REINHARD DR

IPC: C07D223/32 ,  A61K31/395 ,  A61K31/445 ,  A61K31/55 ,  A61K38/00 ,  A61P9/00 ,  A61P9/12 ,  A61P27/02 ,  A61P27/06 ,  A61P43/00 ,  C07D225/04 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07K5/02

CPC classification number: C07K5/0222 ,  A61K38/00

公开(公告)号：CS409491A3

公开(公告)日：1992-05-13

申请号：CS409491

申请日：1991-12-27

Applicant: HOECHST AG

Inventor： GEIGER ROLF PROF DR ,  TEETZ VOLKER DR ,  URBACH HANSJORG DR ,  SCHOLKENS BERNWARD DR ,  HENNING RAINER DR

IPC: C07D209/42 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/47 ,  A61K31/472 ,  A61K38/00 ,  A61P9/12 ,  C07D217/26 ,  C07D233/64 ,  C07D241/20 ,  C07D307/54 ,  C07D309/10 ,  C07D317/66 ,  C07D333/24 ,  C07D335/02 ,  C07D339/08 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07K1/02 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/062 ,  C07K5/065 ,  C07K5/078 ,  C07K14/81

Abstract: Amino acid derivatives of the formula I in which n, R , R and R have the meanings given, and salts thereof are used as medicaments.

公开(公告)号：DE3072064D1

公开(公告)日：1988-02-11

申请号：DE3072064

申请日：1980-09-13

Applicant: HOECHST AG

Inventor： GEIGER ROLF PROF DR ,  TEETZ VOLKER DR ,  SCHOLKENS BERNWARD DR ,  WISSMANN HANS DR

IPC: A61K31/40 ,  A61K31/405 ,  A61K31/45 ,  A61K31/47 ,  A61K31/472 ,  A61P9/12 ,  C07D209/42 ,  C07D215/48 ,  C07D217/26 ,  C07D339/04 ,  C07D401/12 ,  C07D409/06 ,  C07K5/06

公开(公告)号：DE2861236D1

公开(公告)日：1981-12-10

申请号：DE2861236

申请日：1978-09-13

Applicant: HOECHST AG

Inventor： BARTMANN WILHELM DR ,  BECK GERARD DR ,  LERCH ULRICH DR ,  SCHOLKENS BERNWARD DR

IPC: A61K31/20 ,  A61K31/215 ,  A61K31/557 ,  A61P43/00 ,  C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07C177/00

公开(公告)号：CZ8904906A3

公开(公告)日：1997-03-12

申请号：CS490689

申请日：1989-08-21

Applicant: HOECHST AG

Inventor： HENKE STEPHAN DR ,  ANAGNOSTOPULOS HIRISTO ,  BREIPOHL GERHARD DR ,  KNOLLE JOCHEN DR ,  STECHL JENS DR ,  SCHOLKENS BERNWARD DR ,  FEHLHABER HANS-WOLFRAM DR

IPC: A61K38/17 ,  A61K38/00 ,  A61K38/08 ,  A61P9/00 ,  A61P9/02 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P25/04 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07K1/06 ,  C07K7/06 ,  C07K7/08 ,  C07K7/18

CPC classification number: C07K7/18 ,  A61K38/00