公开(公告)号：FI98309B

公开(公告)日：1997-02-14

申请号：FI925497

申请日：1992-12-03

Applicant: HOECHST AG

Inventor： CRAUSE PETER ,  HABERMANN PAUL ,  TRIPIER DOMINIQUE ,  ULMER WOLFGANG ,  SCHMID GERHARD

IPC: A61K38/55 ,  A61K38/00 ,  A61P7/02 ,  C07K1/14 ,  C07K14/00 ,  C07K14/815 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12R1/19 ,  C12N15/15 ,  C12N15/81

Abstract: Novel synthetic isohirudins with improved stability The invention relates to novel synthetic isohirudins which have improved stability owing to exchange in the region of the Asp-Gly motif. This results, on the one hand, in an increase in the yield during workup and, on the other hand, in making possible pharmaceutical formulation as directly injectable solution ready for use.

公开(公告)号：FI96956B

公开(公告)日：1996-06-14

申请号：FI890127

申请日：1989-01-11

Applicant: HOECHST AG

Inventor： CRAUSE PETER ,  HABERMANN PAUL ,  TRIPIER DOMINIQUE

IPC: A61K38/00 ,  C07K14/815 ,  C12N15/00 ,  C12P21/02 ,  A61K38/58

公开(公告)号：GR3018364T3

公开(公告)日：1996-03-31

申请号：GR950403492

申请日：1995-12-12

Applicant: HOECHST AG

Inventor： CRAUSE PETER ,  HABERMANN PAUL ,  KRAMER MARTIN ,  OBERMEIER RAINER ,  SAUBER KLAUS ,  TRIPIER DOMINIQUE

IPC: C12N9/99 ,  A61K38/00 ,  A61K38/55 ,  A61K47/00 ,  A61K47/48 ,  A61P7/02 ,  C07K1/113 ,  C07K1/20 ,  C07K1/22 ,  C07K14/81 ,  C07K14/815 ,  C07K17/10 ,  C12P21/02 ,  C12R1/645

Abstract: The present invention relates to hirudin derivatives which are formed from hirudin or its physiologically acceptable salt and of a carrier, to a process for the preparation thereof and to the use thereof as thrombin inhibitor.

公开(公告)号：ES2080732T3

公开(公告)日：1996-02-16

申请号：ES89109772

申请日：1989-05-30

Applicant: HOECHST AG

Inventor： CRAUSE PETER ,  HABERMANN PAUL ,  KRAMER MARTIN ,  OBERMEIER RAINER ,  SAUBER KLAUS ,  TRIPIER DOMINIQUE

IPC: C12N9/99 ,  A61K38/00 ,  A61K38/55 ,  A61K47/00 ,  A61K47/48 ,  A61P7/02 ,  C07K1/113 ,  C07K1/20 ,  C07K1/22 ,  C07K14/81 ,  C07K14/815 ,  C07K17/10 ,  C12P21/02 ,  C12R1/645

Abstract: The present invention relates to hirudin derivatives which are formed from hirudin or its physiologically acceptable salt and of a carrier, to a process for the preparation thereof and to the use thereof as thrombin inhibitor.

公开(公告)号：AU1163795A

公开(公告)日：1995-08-17

申请号：AU1163795

申请日：1995-02-08

Applicant: HOECHST AG

Inventor： OBERMEIER RAINER ,  LUDWIG JURGEN ,  TRIPIER DOMINIQUE ,  HROPOT MAX

IPC: C12P21/02 ,  A61K38/00 ,  A61K38/55 ,  A61K47/48 ,  A61P7/02 ,  C07K1/107 ,  C07K1/12 ,  C07K14/815 ,  C07K14/435

Abstract: Hirudin derivs. of formula (I) and (II) are new. A0-A1-A2-(Hirudin 3-36)-(Y), (Hirudin 37-65) (I) A0-A1-A2-(Hirudin 3-63)-Y (II) in (I) the comma indicates that the 2 hirudin fragments are connected by disulphide bridges. A0, A1 and A2=amino acid (AA) residue; AO may also be H; Y=residue of amines NH2-R-X (IIIa) or A-R1-X (IIIb); A=1-10 AA; R=1-10C alkyl (opt. substd. by 1 or more of phenyl (itself opt. substd. by 1 or more OH), indolyl or imidazolyl), phenyl or naphthyl; R1=H, covalent bond, 1-10 sugar residues (e.g. glucose, fructose, mannose, galactose, ribose, ribulose or xylose), or -(O-(CH2)m)n; m=2-5; n=1-100; X=H, OR2, SR2, NHR2, COOR2 or A; R2=H or as R.

公开(公告)号：CA2142173A1

公开(公告)日：1995-08-11

申请号：CA2142173

申请日：1995-02-09

Applicant: HOECHST AG

Inventor： OBERMEIER RAINER ,  LUDWIG JUERGEN ,  TRIPIER DOMINIQUE ,  HROPOT MAX

IPC: C12P21/02 ,  A61K38/00 ,  A61K38/55 ,  A61K47/48 ,  A61P7/02 ,  C07K1/107 ,  C07K1/12 ,  C07K14/815 ,  C12P21/06 ,  A61K38/58

Abstract: Hirudin derivatives can be prepared by the selective enzymic replacement of a part of the molecule with an amino derivative. The hirudin derivatives are suitable for preparing pharmaceuticals having an anticoagulatory effect.

公开(公告)号：NZ245374A

公开(公告)日：1995-04-27

申请号：NZ24537492

申请日：1992-12-04

Applicant: HOECHST AG

Inventor： CRAUSE PETER ,  HABERMANN PAUL ,  TRIPIER DOMINIQUE ,  ULMER WOLFGANG ,  SCHMID GERHARD

IPC: A61K38/00 ,  A61P7/02 ,  C07K1/14 ,  C07K14/00 ,  C07K14/815 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12R1/19 ,  A61K38/55 ,  C12N15/15 ,  C12N15/63 ,  C07K15/08 ,  C07K7/10 ,  C07K3/20 ,  C07K3/22 ,  A61K37/64

Abstract: Novel synthetic isohirudins with improved stability The invention relates to novel synthetic isohirudins which have improved stability owing to exchange in the region of the Asp-Gly motif. This results, on the one hand, in an increase in the yield during workup and, on the other hand, in making possible pharmaceutical formulation as directly injectable solution ready for use.

公开(公告)号：FI91167B

公开(公告)日：1994-02-15

申请号：FI892689

申请日：1989-06-01

Applicant: HOECHST AG

Inventor： SCHULZ ARNO ,  BARTSCH KLAUS ,  TRIPIER DOMINIQUE ,  SAUBER KLAUS

IPC: C12N9/10 ,  C12N11/02 ,  C12N11/08 ,  C12P13/00 ,  C12P13/04 ,  C12R1/19 ,  C12P9/00

Abstract: Transaminase, the preparation thereof and the use thereof. A transaminase can be isolated from E. coli DH-1 and can be used with great efficiency to prepare L-phosphinothricin and gamma -aminobutyric acid from the appropriate precursor by transfer of the amino group from glutamate.

公开(公告)号：ZA89215B

公开(公告)日：1993-12-23

申请号：ZA89215

申请日：1989-01-11

Applicant: HOECHST AG

Inventor： CRAUSE PETER ,  HABERMANN PAUL ,  TRIPIER DOMINIQUE

IPC: A22B7/00 ,  A61K38/00 ,  C07K14/815 ,  C12N ,  A61K ,  C07H ,  C07K ,  C12P

公开(公告)号：FI935707A0

公开(公告)日：1993-12-17

申请号：FI935707

申请日：1993-12-17

Applicant: HOECHST AG

Inventor： CRAUSE PETER ,  HABERMANN PAUL ,  KRAMER MARTIN ,  OBERMEIER RAINER ,  SAUBER KLAUS ,  TRIPIER DOMINIQUE

IPC: A61K20060101 ,  A61K38/58 ,  A61K47/26 ,  A61K47/38 ,  C07K14/815 ,  A61K