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公开(公告)号：JPH0232100A
公开(公告)日：1990-02-01
申请号：JP13937789
申请日：1989-06-02
Applicant: HOECHST AG
Inventor： BONIN WERNER , HABERMANN PAUL , TRIPIER DOMINIQUE , WOEHNER ELISABET
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公开(公告)号：JPH0267300A
公开(公告)日：1990-03-07
申请号：JP13937889
申请日：1989-06-02
Applicant: HOECHST AG
Inventor： CRAUSE PETER , HABERMANN PAUL , KRAMER MARTIN , OBERMEIER RAINER , SAUBER KLAUS , TRIPIER DOMINIQUE
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公开(公告)号：JPS60233098A
公开(公告)日：1985-11-19
申请号：JP8043085
申请日：1985-04-17
Applicant: HOECHST AG
Inventor： TRIPIER DOMINIQUE
IPC: C07K1/113 , A61K35/56 , A61K35/62 , A61K38/00 , A61K38/46 , A61K38/55 , A61P7/02 , C07C20060101 , C07G20060101 , C07K1/20 , C07K14/00 , C07K14/815
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公开(公告)号：CA2084552C
公开(公告)日：2007-03-27
申请号：CA2084552
申请日：1992-12-04
Applicant: HOECHST AG
Inventor： CRAUSE PETER , HABERMANN PAUL , TRIPIER DOMINIQUE , ULMER WOLFGANG , SCHMID GERHARD
IPC: A61K38/55 , C12N15/15 , A61K38/00 , A61K38/58 , A61P7/02 , C07K1/14 , C07K14/00 , C07K14/815 , C12N15/09 , C12N15/12 , C12P21/02 , C12R1/19
Abstract: HOE 91/F 379 of the disclosure Novel synthetic isohirudins with improved stability The invention relates to novel synthetic isohirudins which have improved stability owing to exchange in the region of the Asp-Gly motif. This results, on the one hand, in an increase in the yield during workup and, on the other hand, in making possible pharmaceutical formu- lation as directly injectable solution ready for use.
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公开(公告)号：CA1340197C
公开(公告)日：1998-12-15
申请号：CA601593
申请日：1989-06-02
Applicant: HOECHST AG
Inventor： CRAUSE PETER , HABERMANN PAUL , KRAMER MARTIN , OBERMEIER RAINER , SAUBER KLAUS , TRIPIER DOMINIQUE
IPC: C12N9/99 , A61K38/00 , A61K38/55 , A61K47/00 , A61K47/48 , A61P7/02 , C07K1/113 , C07K1/20 , C07K1/22 , C07K14/81 , C07K14/815 , C07K17/10 , C12P21/02 , C12R1/645 , A61K38/58
Abstract: The present invention relates to hirudin derivatives which are formed from hirudin or the physiologically acceptable salt thereof and a carrier, to a process for the preparation thereof, and to the use thereof as thrombin inhibitor.
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Patent Agency Ranking
公开(公告)号：NO303784B1
公开(公告)日：1998-08-31
申请号：NO924681
申请日：1992-12-04
Applicant: HOECHST AG
Inventor： CRAUSE PETER , HEBERMANN PAUL , TRIPIER DOMINIQUE , ULMER WOLFGANG , SCHMID GERHARD
IPC: A61K38/00 , A61P7/02 , A61K38/55 , C07K1/14 , C07K14/00 , C07K14/815 , C12N15/09 , C12N15/12 , C12P21/02 , C12R1/19 , C07K1/36
Abstract: Novel synthetic isohirudins with improved stability The invention relates to novel synthetic isohirudins which have improved stability owing to exchange in the region of the Asp-Gly motif. This results, on the one hand, in an increase in the yield during workup and, on the other hand, in making possible pharmaceutical formulation as directly injectable solution ready for use.
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公开(公告)号：DE58909493D1
公开(公告)日：1995-12-21
申请号：DE58909493
申请日：1989-05-30
Applicant: HOECHST AG
Inventor： CRAUSE PETER , HABERMANN PAUL , KRAMER MARTIN , OBERMEIER RAINER , SAUBER KLAUS , TRIPIER DOMINIQUE
IPC: C12N9/99 , A61K38/00 , A61K38/55 , A61K47/00 , A61K47/48 , A61P7/02 , C07K1/113 , C07K1/20 , C07K1/22 , C07K14/81 , C07K14/815 , C07K17/10 , C12P21/02 , C12R1/645
Abstract: The present invention relates to hirudin derivatives which are formed from hirudin or its physiologically acceptable salt and of a carrier, to a process for the preparation thereof and to the use thereof as thrombin inhibitor.
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公开(公告)号：HUT70452A
公开(公告)日：1995-10-30
申请号：HU9203838
申请日：1992-12-04
Applicant: HOECHST AG
Inventor： HABERMANN PAUL , TRIPIER DOMINIQUE , CRAUSE PETER , SCHMID GERHARD , ULMER WOLFGANG
IPC: A61K38/55 , A61K38/00 , A61P7/02 , C07K1/14 , C07K14/00 , C07K14/815 , C12N15/09 , C12N15/12 , C12P21/02 , C12R1/19 , C12N15/15
Abstract: Novel synthetic isohirudins with improved stability The invention relates to novel synthetic isohirudins which have improved stability owing to exchange in the region of the Asp-Gly motif. This results, on the one hand, in an increase in the yield during workup and, on the other hand, in making possible pharmaceutical formulation as directly injectable solution ready for use.
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公开(公告)号：IE61569B1
公开(公告)日：1994-11-16
申请号：IE190286
申请日：1986-07-16
Applicant: HOECHST AG
Inventor： KRAMER MARTIN , TRIPIER DOMINIQUE
IPC: C07K1/06 , A61K35/62 , A61K38/00 , A61K38/55 , A61P7/02 , C07K1/00 , C07K1/12 , C07K1/14 , C07K1/20 , C07K1/22 , C07K14/00 , C07K14/435 , C07K14/81 , C07K14/815 , A61K37/02 , C07K1/04 , C07K7/10
Abstract: The invention relates to a polypeptide of the formula (I) +TR in which R represents phenoloic hydrogen or a phenolic ester group and m, n, X, Z, A, B, C, D, E, F, G, I and J have the meanings given, and in which the 6 Cys radicals are linked in pairs via disulfide bridges, processes for the preparation or isolation thereof, their use and agents containing them.
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公开(公告)号：PT90739B
公开(公告)日：1994-10-31
申请号：PT9073989
申请日：1989-06-02
Applicant: HOECHST AG
Inventor： HABERMANN PAUL , TRIPIER DOMINIQUE , BONIN WERNER , WOHNER ELISABET
IPC: A61K38/55 , A61K35/56 , A61K38/00 , A61P7/02 , C07K1/14 , C07K1/16 , C07K14/00 , C07K14/435 , C07K14/44 , C07K14/81 , C07K15/08 , A61K37/02
Abstract: The invention relates to a new active substance-amblyommin-for anticoagulant therapy and to a process for the isolation thereof from hard ticks. The isolated protein having a thrombin-inhibitory action has a molecular weight of 20000 to 30000 dalton, an isoelectric point between 5.05 and 5.65 and the partial amino acid sequences Ile-Leu-Phe-Thr-Gln-Gly-Asn-X-Gly-Glu-Leu-Glu-Asn-X-Phe-Glu-, Lys-Ile-Leu-Phe-X-Gln-Gly- and Ala-Ser-Tyr-Ile-Val-X-Ser-Glu-Ser-Ile-Gln-Ile-Leu-X-Leu-Ser-Glu-Gly-Ile- in which each radical X can be identical or different and each represents a naturally occurring amino acid.
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