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公开(公告)号：JPH0267300A
公开(公告)日：1990-03-07
申请号：JP13937889
申请日：1989-06-02
Applicant: HOECHST AG
Inventor： CRAUSE PETER , HABERMANN PAUL , KRAMER MARTIN , OBERMEIER RAINER , SAUBER KLAUS , TRIPIER DOMINIQUE
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公开(公告)号：CA1340197C
公开(公告)日：1998-12-15
申请号：CA601593
申请日：1989-06-02
Applicant: HOECHST AG
Inventor： CRAUSE PETER , HABERMANN PAUL , KRAMER MARTIN , OBERMEIER RAINER , SAUBER KLAUS , TRIPIER DOMINIQUE
IPC: C12N9/99 , A61K38/00 , A61K38/55 , A61K47/00 , A61K47/48 , A61P7/02 , C07K1/113 , C07K1/20 , C07K1/22 , C07K14/81 , C07K14/815 , C07K17/10 , C12P21/02 , C12R1/645 , A61K38/58
Abstract: The present invention relates to hirudin derivatives which are formed from hirudin or the physiologically acceptable salt thereof and a carrier, to a process for the preparation thereof, and to the use thereof as thrombin inhibitor.
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公开(公告)号：DE58909493D1
公开(公告)日：1995-12-21
申请号：DE58909493
申请日：1989-05-30
Applicant: HOECHST AG
Inventor： CRAUSE PETER , HABERMANN PAUL , KRAMER MARTIN , OBERMEIER RAINER , SAUBER KLAUS , TRIPIER DOMINIQUE
IPC: C12N9/99 , A61K38/00 , A61K38/55 , A61K47/00 , A61K47/48 , A61P7/02 , C07K1/113 , C07K1/20 , C07K1/22 , C07K14/81 , C07K14/815 , C07K17/10 , C12P21/02 , C12R1/645
Abstract: The present invention relates to hirudin derivatives which are formed from hirudin or its physiologically acceptable salt and of a carrier, to a process for the preparation thereof and to the use thereof as thrombin inhibitor.
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公开(公告)号：IE61569B1
公开(公告)日：1994-11-16
申请号：IE190286
申请日：1986-07-16
Applicant: HOECHST AG
Inventor： KRAMER MARTIN , TRIPIER DOMINIQUE
IPC: C07K1/06 , A61K35/62 , A61K38/00 , A61K38/55 , A61P7/02 , C07K1/00 , C07K1/12 , C07K1/14 , C07K1/20 , C07K1/22 , C07K14/00 , C07K14/435 , C07K14/81 , C07K14/815 , A61K37/02 , C07K1/04 , C07K7/10
Abstract: The invention relates to a polypeptide of the formula (I) +TR in which R represents phenoloic hydrogen or a phenolic ester group and m, n, X, Z, A, B, C, D, E, F, G, I and J have the meanings given, and in which the 6 Cys radicals are linked in pairs via disulfide bridges, processes for the preparation or isolation thereof, their use and agents containing them.
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公开(公告)号：FI935707A
公开(公告)日：1993-12-17
申请号：FI935707
申请日：1993-12-17
Applicant: HOECHST AG
Inventor： CRAUSE PETER , HABERMANN PAUL , KRAMER MARTIN , OBERMEIER RAINER , SAUBER KLAUS , TRIPIER DOMINIQUE
IPC: A61K20060101 , A61K38/58 , A61K47/26 , A61K47/38 , C07K14/815
Abstract: The invention relates to the use of dextran-bound or Sepharose-bound hirudin as thrombin inhibitor.
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Patent Agency Ranking
公开(公告)号：DE3819079A1
公开(公告)日：1989-12-07
申请号：DE3819079
申请日：1988-06-04
Applicant: HOECHST AG
Inventor： CRAUSE PETER , HABERMANN PAUL , KRAMER MARTIN , OBERMEIER RAINER , SAUBER KLAUS , TRIPIER DOMINIQUE
IPC: C12N9/99 , A61K38/00 , A61K38/55 , A61K47/00 , A61K47/48 , A61P7/02 , C07K1/113 , C07K1/20 , C07K1/22 , C07K14/81 , C07K14/815 , C07K17/10 , C12P21/02 , C12R1/645
Abstract: The present invention relates to hirudin derivatives which are formed from hirudin or its physiologically acceptable salt and of a carrier, to a process for the preparation thereof and to the use thereof as thrombin inhibitor.
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公开(公告)号：DK270789A
公开(公告)日：1989-12-05
申请号：DK270789
申请日：1989-06-02
Applicant: HOECHST AG
Inventor： CRAUSE PETER , HABERMANN PAUL , KRAMER MARTIN , OBERMEIER RAINER , SAUBER KLAUS , TRIPIER DOMINIQUE
IPC: C12N9/99 , A61K38/00 , A61K38/55 , A61K47/00 , A61K47/48 , A61P7/02 , C07K1/113 , C07K1/20 , C07K1/22 , C07K14/81 , C07K14/815 , C07K17/10 , C12P21/02 , C12R1/645 , C07K7/10
Abstract: The present invention relates to hirudin derivatives which are formed from hirudin or its physiologically acceptable salt and of a carrier, to a process for the preparation thereof and to the use thereof as thrombin inhibitor.
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公开(公告)号：DK270789D0
公开(公告)日：1989-06-02
申请号：DK270789
申请日：1989-06-02
Applicant: HOECHST AG
Inventor： CRAUSE PETER , HABERMANN PAUL , KRAMER MARTIN , OBERMEIER RAINER , SAUBER KLAUS , TRIPIER DOMINIQUE
IPC: C12N9/99 , A61K38/00 , A61K38/55 , A61K47/00 , A61K47/48 , A61P7/02 , C07K1/113 , C07K1/20 , C07K1/22 , C07K14/81 , C07K14/815 , C07K17/10 , C12P21/02 , C12R1/645 , C07K7/10
Abstract: The present invention relates to hirudin derivatives which are formed from hirudin or its physiologically acceptable salt and of a carrier, to a process for the preparation thereof and to the use thereof as thrombin inhibitor.
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公开(公告)号：FI892686A0
公开(公告)日：1989-06-01
申请号：FI892686
申请日：1989-06-01
Applicant: HOECHST AG
Inventor： CRAUSE PETER , HABERMANN PAUL , KRAMER MARTIN , OBERMEIER RAINER , SAUBER KLAUS , TRIPIER DOMINIQUE
IPC: C12N9/99 , A61K38/00 , A61K38/55 , A61K47/00 , A61K47/48 , A61P7/02 , C07K1/113 , C07K1/20 , C07K1/22 , C07K14/81 , C07K14/815 , C07K17/10 , C12P21/02 , C12R1/645 , C07K
Abstract: The present invention relates to hirudin derivatives which are formed from hirudin or its physiologically acceptable salt and of a carrier, to a process for the preparation thereof and to the use thereof as thrombin inhibitor.
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公开(公告)号：NO862876L
公开(公告)日：1987-01-19
申请号：NO862876
申请日：1986-07-16
Applicant: HOECHST AG
Inventor： KRAMER MARTIN , TRIPIER DOMINIQUE
IPC: A61K35/62 , C07K1/06 , A61K38/00 , A61K38/55 , A61P7/02 , C07K1/00 , C07K1/12 , C07K1/14 , C07K1/20 , C07K1/22 , C07K14/00 , C07K14/435 , C07K14/81 , C07K14/815 , C07K
Abstract: The invention relates to a polypeptide of the formula (I) +TR in which R represents phenoloic hydrogen or a phenolic ester group and m, n, X, Z, A, B, C, D, E, F, G, I and J have the meanings given, and in which the 6 Cys radicals are linked in pairs via disulfide bridges, processes for the preparation or isolation thereof, their use and agents containing them.
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