公开(公告)号：CA607415A

公开(公告)日：1960-10-25

申请号：CA607415D

Applicant: HOFFMANN LA ROCHE

Inventor： MONTAVON MARC ,  ISLER OTTO ,  ZELLER PAUL ,  RUEGG RUDOLF

公开(公告)号：CA607413A

公开(公告)日：1960-10-25

申请号：CA607413D

Applicant: HOFFMANN LA ROCHE

Inventor： ISLER OTTO ,  RUEGG RUDOLF ,  MONTAVON MARC ,  ZELLER PAUL

公开(公告)号：CA566469A

公开(公告)日：1958-11-25

申请号：CA566469D

Applicant: HOFFMANN LA ROCHE

Inventor： ZELLER PAUL ,  ISLER OTTO ,  MONTAVON MARC ,  RUEGG RUDOLF

公开(公告)号：CA566459A

公开(公告)日：1958-11-25

申请号：CA566459D

Applicant: HOFFMANN LA ROCHE

Inventor： ISLER OTTO ,  MONTAVON MARC ,  RUEGG RUDOLF ,  ZELLER PAUL

公开(公告)号：CA557015A

公开(公告)日：1958-05-06

申请号：CA557015D

Applicant: HOFFMANN LA ROCHE

Inventor： ISLER OTTO ,  MONTAVON MARC ,  LINDLAR HERBERT ,  RUEGG RUDOLF ,  ZELLER PAUL

公开(公告)号：LV5519A3

公开(公告)日：1994-03-10

申请号：LV930506

申请日：1993-06-08

Applicant: HOFFMANN LA ROCHE

Inventor： MONTAVON MARC ,  REINER ROLAND

IPC: A61K31/545 ,  C07D501/36

公开(公告)号：PT89080B

公开(公告)日：1993-04-30

申请号：PT8908088

申请日：1988-11-24

Applicant: HOFFMANN LA ROCHE

Inventor： FURLENMEIER ANDRE ,  HUBSCHWERLEN CHRISTIAN ,  MONTAVON MARC

IPC: C07D499/897 ,  A61K31/397 ,  A61K31/40 ,  A61K31/435 ,  A61K31/47 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D463/00 ,  C07D477/00 ,  C07D477/08 ,  C07D499/00 ,  C07D499/32 ,  C07D499/893 ,  C07D501/04 ,  C07D501/06 ,  C07D501/16 ,  C07D501/18 ,  C07D501/20 ,  C07D501/22 ,  C07D501/24 ,  C07D501/34 ,  C07D501/36 ,  C07D501/46 ,  C07D505/00 ,  C07D513/04

Abstract: Novel esters of pharmacologically active carboxylic acids, which can be cleaved under physiological conditions, in particular of antibiotically active carboxylic acids from the beta -lactam antibiotic field, are described, which are characterised in that the alcohol component of the ester is a group of the general formula in which R denotes hydrogen or lower alkyl, R denotes hydrogen, lower alkyl, lower haloalkyl, lower alkenyl, lower alkoxycarbonyl, aryl or heteroaryl or, together with R denotes lower alkylene, R denotes hydrogen, lower alkyl or lower alkoxycarbonyl, R denotes the group -COOR , -COR , -SO2-R , -CONR R or -PO(OR )2, R denotes a saturated or unsaturated hydrocarbon radical having up to 12 carbon atoms, in which up to two methylene groups can be replaced by oxygen atoms, or denotes aryl or aryl-lower alkyl, R denotes lower alkyl or aryl, R and R each denotes hydrogen or lower alkyl or together denotes lower alkylene in which a methylene group can be replaced by an oxygen or sulphur atom or by an imino or lower alkylimino group, and R denotes lower alkyl. If a basic substituent is present, these esters can also be present in the form of pharmaceutically acceptable acid addition salts.

公开(公告)号：NO170215C

公开(公告)日：1992-09-23

申请号：NO881199

申请日：1988-03-18

Applicant: HOFFMANN LA ROCHE

Inventor： KLOETZER WILHELM ,  MONTAVON MARC ,  MUESSNER RENATE ,  SINGEWALD NICOLAS

IPC: A61K31/415 ,  A61K31/4164 ,  C07D233/56 ,  A61K31/417 ,  A61P3/00 ,  A61P29/00 ,  C07D233/61 ,  C07D233/64 ,  C07D233/80 ,  C07D233/84 ,  C07D233/88 ,  C07D521/00 ,  C07D413/04

Abstract: Imidazole derivatives of the formula I wherein R1 and R2 each is lower alkyl, X is a residue of the formula R3 is hydrogen and R4 is hydrogen or lower alkyl or R3 and R4 taken together are an additional carbon-nitrogen bond; R5 is hydrogen or lower alkyl; R6 is hydrogen, lower alkyl, lower alkylthio or a residue of the formula -NR7R8; and R7 and R8 each is lower alkyl or taken together with the nitrogen atom are a 5- or 6-membered saturated heterocycle; and pharmaceutically acceptable acid addition salts thereof are described. The compounds of formula I possess valuable pharmacodynamic properties, especially inflammation-inhibiting and edema-inhibiting properties, so that they can be used for the control or prevention of illnesses, especially for the control or prevention of inflammations and edemas.

公开(公告)号：NO166229C

公开(公告)日：1991-06-19

申请号：NO803516

申请日：1980-11-20

Applicant: HOFFMANN LA ROCHE

Inventor： MONTAVON MARC ,  REINER ROLAND

IPC: C07D501/00 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07C20060101 ,  C07D20060101 ,  C07D501/04 ,  C07D501/16 ,  C07D501/36 ,  C07D501/46

Abstract: For the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE 1. A process for the manufacture of acyl derivatives of general formula I see diagramm : EP0030294,P12,F1 in which R represents hydrogen or a readily hydrolyzable ester group, as well as of salts of these compounds and hydrates of these compounds or of their salts by reating a halide of general formula II see diagramm : EP0030294,P12,F2 in which R has the significance given above and Y represents a halogen atom, or a salt of this compound with thiourea and, if desired, converting a compound of formula I obtained into a salt or hydrate or into a hydrate of this salt, characterized in that X signifies one of the groups see diagramm : EP0030294,P13,F3 in which R' represents hydrogen or a readily hydrolysable ether group.

公开(公告)号：NO166228B

公开(公告)日：1991-03-11

申请号：NO812083

申请日：1981-06-18

Applicant: HOFFMANN LA ROCHE

Inventor： MONTAVON MARC ,  REINER ROLAND

IPC: C07D501/00 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07C20060101 ,  C07D20060101 ,  C07D501/04 ,  C07D501/16 ,  C07D501/36 ,  C07D501/46

Abstract: For the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE 1. A process for the manufacture of acyl derivatives of general formula I see diagramm : EP0030294,P12,F1 in which R represents hydrogen or a readily hydrolyzable ester group, as well as of salts of these compounds and hydrates of these compounds or of their salts by reating a halide of general formula II see diagramm : EP0030294,P12,F2 in which R has the significance given above and Y represents a halogen atom, or a salt of this compound with thiourea and, if desired, converting a compound of formula I obtained into a salt or hydrate or into a hydrate of this salt, characterized in that X signifies one of the groups see diagramm : EP0030294,P13,F3 in which R' represents hydrogen or a readily hydrolysable ether group.