公开(公告)号：KR870001028B1

公开(公告)日：1987-05-25

申请号：KR830002472

申请日：1983-06-02

Applicant: HOFFMANN LA ROCHE

Inventor： FURLENMEIER ANDRE ,  ISENRING HANS-PETER ,  HOFHEINZ WERNER ,  HUBSCHUERLEN CHRISITIAN NICOLA

IPC: C07D401/12 ,  A61K20060101 ,  A61K31/397 ,  A61K31/41 ,  A61K31/415 ,  A61K31/425 ,  A61K31/433 ,  A61P31/04 ,  B01J23/44 ,  B01J27/13 ,  B01J27/16 ,  C07B61/00 ,  C07D20060101 ,  C07D205/08 ,  C07D205/085 ,  C07D213/55 ,  C07D213/73 ,  C07D231/12 ,  C07D233/88 ,  C07D263/00 ,  C07D263/48 ,  C07D277/00 ,  C07D277/20 ,  C07D277/40 ,  C07D277/74 ,  C07D285/08 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12 ,  C07D419/12 ,  C07D521/00 ,  C07F7/18

公开(公告)号：US3542771A

公开(公告)日：1970-11-24

申请号：US3542771D

申请日：1967-12-29

Applicant: HOFFMANN LA ROCHE

Inventor： FURST ANDOR ,  FURLENMEIER ANDRE ,  LANGEMANN ALBERT ,  WALDVOGEL GUY ,  HOCKS PETER ,  JAGER ALBERT ,  KERB ULRICH ,  WIECHERT RUDOLF

IPC: C07J9/00 ,  C07C173/00

CPC classification number: C07J9/00

公开(公告)号：US3900464A

公开(公告)日：1975-08-19

申请号：US31872872

申请日：1972-12-27

Applicant: HOFFMANN LA ROCHE

Inventor： FURLENMEIER ANDRE ,  LANZ PAUL ,  QUITT PETER ,  VOGLER KARL ,  VOGLER HEIR BY FRANZISKA ,  VOGLER HEIR BY NIKLAUS E ,  VOGLER HEIR BY HEINRICH

IPC: C07D207/32 ,  C07D207/327 ,  C07D209/18 ,  C07D213/55 ,  C07D257/04 ,  C07D307/54 ,  C07D333/24 ,  C07D499/00 ,  C07D499/60 ,  C07D499/46

CPC classification number: C07D207/327 ,  C07D209/18 ,  C07D213/55 ,  C07D257/04 ,  C07D307/54 ,  C07D333/24 ,  C07D499/00 ,  Y02P20/55

Abstract: Novel antibiotic compounds represented by the formula

wherein R is a furyl, pyrrolyl, thienyl, oxazolyl, isoxazolyl, thiazolyl, pyridyl, pyrimidinyl, tetrazolyl or indolyl radical which can be substituted with halogen, C1-C3-alkyl, C1-C3alkoxy or C1-C3-alkylthio and T is a C2-C5-alkyl group, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AND HYDRATES OF SUCH SALTS, A PROCESS FOR THEIR PREPARATION AND NOVEL INTERMEDIATES THEREOF ARE DISCLOSED.

公开(公告)号：US3478065A

公开(公告)日：1969-11-11

申请号：US3478065D

申请日：1967-08-22

Applicant: HOFFMANN LA ROCHE

Inventor： FURST ANDOR ,  FURLENMEIER ANDRE ,  LANGEMANN ALBERT ,  WALDVOGEL GUY ,  HOCKS PETER ,  KERB ULRICH ,  WIECHERT RUDOLF

IPC: C07J1/00 ,  C07J5/00 ,  C07J9/00 ,  C07J31/00 ,  C07J75/00 ,  C07C169/62 ,  C07C167/14 ,  C07C167/28

CPC classification number: C07J31/00 ,  C07J1/00 ,  C07J5/00 ,  C07J9/00 ,  C07J75/00

公开(公告)号：US3886142A

公开(公告)日：1975-05-27

申请号：US31873672

申请日：1972-12-27

Applicant: HOFFMANN LA ROCHE

Inventor： FURLENMEIER ANDRE ,  LANZ PAUL ,  VOGLER KARL ,  ZANETTI GUIDO

IPC: B25C5/02 ,  B25C5/06 ,  C07C51/60 ,  C07D499/00 ,  C07D499/60 ,  F16B15/04 ,  C07D99/16

CPC classification number: F16B15/04 ,  B25C5/0257 ,  B25C5/06 ,  C07C51/60 ,  C07D499/00 ,  Y10S411/92 ,  Y10S514/962 ,  Y10T29/49833 ,  C07C59/70

Abstract: WHEREIN R is halogen, lower alkyl, lower alkoxy, nitro, lower alkoxy-lower alkyl, dilower alkylamino, lower alkyl sulfonylamido, bis-lower alkylsulfonyl amido or lower alkanoyl amido, n is an integer of 0-2 and T is a C2-C5 alkyl group, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AND HYDRATES OF SUCH SALTS, A PROCESS FOR THEIR PREPARATION AND NOVEL INTERMEDIATES THEREFOR ARE DISCLOSED.
Novel antibiotic compounds represented by the formula

D R A W I N G

Abstract translation: 由式WHEREIN R表示的新型抗生素化合物是卤素，低级烷基，低级烷氧基，硝基，低级烷氧基 - 低级烷基，二元烷基氨基，低级烷基磺酰氨基，双 - 低级烷基磺酰基酰氨基或低级烷酰氨基，n是0〜 2和T是C 2 -C 5烷基，其药学上可接受的盐及其水合物，其制备和新型中间体的方法被公开。

公开(公告)号：US3578659A

公开(公告)日：1971-05-11

申请号：US3578659D

申请日：1969-03-28

Applicant: HOFFMANN LA ROCHE

Inventor： BERNDT HANS-DETLEF ,  BUCHSCHACHER PAUL ,  EDER ULRICH ,  FURLENMEIER ANDRE ,  FURST ANDOR ,  KERB ULRICH ,  MULLER MARCEL ,  WIECHERT RUDOLF

IPC: C07J71/00 ,  C07C173/00

CPC classification number: C07J71/0057

Abstract: 18-NOR-14B-PREGNANO-(13,14-F)-HEXAHYDRO-1,4OXAZEPINES AND METHODS FOR THEIR PREPARATION ARE DESCRIBED. THESE COMPOUNDS ARE VALUABLE PHARMACEUTICALS IN THAT THEY EXHIBIT BLOOD PRESSURE REDUCING AND DIURETIC EFFECTS. THEY ALSO POSSESS A POSITIVE INOTROPE AND MYOTROPE ACTIVITY, PROMOTE THE BLOOD FLOW TO BLOOD VESSELS SURROUNDING THE HEART AND ALSO THE STROKE MINUTE VOLUME OF THE HEART.

公开(公告)号：US3547910A

公开(公告)日：1970-12-15

申请号：US3547910D

申请日：1968-02-29

Applicant: HOFFMANN LA ROCHE

Inventor： FURST ANDOR ,  FURLENMEIER ANDRE ,  LANGEMANN ALBERT ,  WALDVOGEL GUY ,  HOCKS PETER ,  KERB ULRICH ,  WIECHERT RUDOLF

IPC: C07J1/00 ,  C07J5/00 ,  C07J7/00 ,  C07J9/00 ,  C07J31/00 ,  C07J75/00 ,  C07C173/00

CPC classification number: C07J31/00 ,  C07J1/00 ,  C07J5/00 ,  C07J7/00 ,  C07J9/00 ,  C07J75/00

公开(公告)号：US3509185A

公开(公告)日：1970-04-28

申请号：US3509185D

申请日：1967-11-13

Applicant: HOFFMANN LA ROCHE

Inventor： SCHAEREN SIDNEY FRANK ,  FURLENMEIER ANDRE

IPC: C07C45/40 ,  C07C45/81 ,  C07C49/757 ,  C07C167/12

CPC classification number: C07C49/757 ,  C07C45/40 ,  C07C45/81

公开(公告)号：US3917584A

公开(公告)日：1975-11-04

申请号：US31873872

申请日：1972-12-27

Applicant: HOFFMANN LA ROCHE

Inventor： FURLENMEIER ANDRE ,  LANZ PAUL ,  VOGLER KARL ,  ZANETTI GUIDO

IPC: C07C51/60 ,  C07D499/00 ,  C07D499/60 ,  C07D499/44

CPC classification number: C07D499/00 ,  C07C51/60 ,  Y02P20/55 ,  C07C59/64

Abstract: Novel antibiotic compounds represented by the formula

wherein R is halogen, lower alkyl, lower alkoxy, lower alkylamino, di-lower alkylamino or lower alkanoylamino, n is an integer of 0-2 and T is a C2-C5 alkyl group, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AND HYDRATES OF SUCH SALTS A PROCESS FOR THEIR PREPARATION AND NOVEL INTERMEDIATES THEREOF ARE DISCLOSED.

Abstract translation: 由式-CH2-COO-CH-CO-NH- ||（R）nT S ANGLE CH3 CH-CHC ANGLE |||CH3 C --- N --- CH PARALLEL | OCOOH表示的新型抗生素化合物其中R 是卤素，低级烷基，低级烷氧基，低级烷基氨基，二低级烷基氨基或低级烷酰基氨基，n是0-2的整数，T是C2-C5烷基，其药学上可接受的盐及其等价物的方法 他们的准备和新闻中介被披露。

公开(公告)号：US3868366A

公开(公告)日：1975-02-25

申请号：US33704073

申请日：1973-03-01

Applicant: HOFFMANN LA ROCHE

Inventor： FURST ANDOR ,  FURLENMEIER ANDRE ,  LANGEMANN ALBERT ,  WALDVOGEL GUY ,  HOCKS PETER ,  KERB ULRICH ,  WIECHERT RUDOLF

IPC: C07J9/00 ,  C07J17/00 ,  C07J71/00 ,  C07C173/00

CPC classification number: C07J71/001 ,  C07J9/00 ,  C07J9/005 ,  C07J17/00 ,  C07J71/0026

Abstract: This invention is directed to processes for the synthesis of 2,3-substituted-5 Beta -H-6-keto steroids which are useful as metamorphosis hormones and are additionally useful as intermediates for the production of other insect hormones.

Abstract translation: 本发明涉及用于合成2,3-取代-5β-H-6-酮类固醇的方法，其可用作变态激素，并且另外可用作生产其它昆虫激素的中间体。