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23 records (took 0.026 seconds)

    1.
    发明专利
    未知

    公开(公告)号：DE3869163D1

    公开(公告)日：1992-04-23

    申请号：DE3869163

    申请日：1988-03-09

    Applicant: HOFFMANN LA ROCHE

    Inventor： KLOETZER WILHELM PROF DR ,  MONTAVON MARC DR ,  MUESSNER RENATE DR ,  SINGEWALD NICOLAS

    IPC: C07D233/56 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/417 ,  A61P3/00 ,  A61P29/00 ,  C07D233/61 ,  C07D233/64 ,  C07D233/80 ,  C07D233/84 ,  C07D233/88 ,  C07D521/00

    Abstract: Imidazole derivatives of the formula I wherein R1 and R2 each is lower alkyl, X is a residue of the formula R3 is hydrogen and R4 is hydrogen or lower alkyl or R3 and R4 taken together are an additional carbon-nitrogen bond; R5 is hydrogen or lower alkyl; R6 is hydrogen, lower alkyl, lower alkylthio or a residue of the formula -NR7R8; and R7 and R8 each is lower alkyl or taken together with the nitrogen atom are a 5- or 6-membered saturated heterocycle; and pharmaceutically acceptable acid addition salts thereof are described. The compounds of formula I possess valuable pharmacodynamic properties, especially inflammation-inhibiting and edema-inhibiting properties, so that they can be used for the control or prevention of illnesses, especially for the control or prevention of inflammations and edemas.

    IMIDAZOLE DERIVATIVES
    3.
    发明专利
    IMIDAZOLE DERIVATIVES 未知

    公开(公告)号：AU613349B2

    公开(公告)日：1991-08-01

    申请号：AU1353288

    申请日：1988-03-21

    Applicant: HOFFMANN LA ROCHE

    Inventor： KLOTZER WILHELM ,  MONTAVON MARC ,  MUSSNER RENATE ,  SINGEWALD NICOLAS

    IPC: C07D233/56 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/417 ,  A61P3/00 ,  A61P29/00 ,  C07D233/61 ,  C07D233/64 ,  C07D233/80 ,  C07D233/84 ,  C07D233/88 ,  C07D521/00

    Abstract: Imidazole derivatives of the formula I wherein R1 and R2 each is lower alkyl, X is a residue of the formula R3 is hydrogen and R4 is hydrogen or lower alkyl or R3 and R4 taken together are an additional carbon-nitrogen bond; R5 is hydrogen or lower alkyl; R6 is hydrogen, lower alkyl, lower alkylthio or a residue of the formula -NR7R8; and R7 and R8 each is lower alkyl or taken together with the nitrogen atom are a 5- or 6-membered saturated heterocycle; and pharmaceutically acceptable acid addition salts thereof are described. The compounds of formula I possess valuable pharmacodynamic properties, especially inflammation-inhibiting and edema-inhibiting properties, so that they can be used for the control or prevention of illnesses, especially for the control or prevention of inflammations and edemas.

    IMIDAZOLE DERIVATIVES
    4.
    发明专利
    IMIDAZOLE DERIVATIVES 未知

    公开(公告)号：AU1353288A

    公开(公告)日：1988-09-22

    申请号：AU1353288

    申请日：1988-03-21

    Applicant: HOFFMANN LA ROCHE

    Inventor： KLOTZER WILHELM ,  MONTAVON MARC ,  MUSSNER RENATE ,  SINGEWALD NICOLAS

    IPC: C07D233/56 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/417 ,  A61P3/00 ,  A61P29/00 ,  C07D233/61 ,  C07D233/64 ,  C07D233/80 ,  C07D233/84 ,  C07D233/88 ,  C07D521/00

    Abstract: Imidazole derivatives of the formula I wherein R1 and R2 each is lower alkyl, X is a residue of the formula R3 is hydrogen and R4 is hydrogen or lower alkyl or R3 and R4 taken together are an additional carbon-nitrogen bond; R5 is hydrogen or lower alkyl; R6 is hydrogen, lower alkyl, lower alkylthio or a residue of the formula -NR7R8; and R7 and R8 each is lower alkyl or taken together with the nitrogen atom are a 5- or 6-membered saturated heterocycle; and pharmaceutically acceptable acid addition salts thereof are described. The compounds of formula I possess valuable pharmacodynamic properties, especially inflammation-inhibiting and edema-inhibiting properties, so that they can be used for the control or prevention of illnesses, especially for the control or prevention of inflammations and edemas.

    6.
    发明专利
    未知

    公开(公告)号：NO881199D0

    公开(公告)日：1988-03-18

    申请号：NO881199

    申请日：1988-03-18

    Applicant: HOFFMANN LA ROCHE

    Inventor： KLOETZER WILHELM ,  MONTAVON MARC ,  MUESSNER RENATE ,  SINGEWALD NICOLAS

    IPC: A61K31/415 ,  C07D233/56 ,  A61K31/4164 ,  A61K31/417 ,  A61P3/00 ,  A61P29/00 ,  C07D233/61 ,  C07D233/64 ,  C07D233/80 ,  C07D233/84 ,  C07D233/88 ,  C07D521/00 ,  C07D233/00

    Abstract: Imidazole derivatives of the formula I wherein R1 and R2 each is lower alkyl, X is a residue of the formula R3 is hydrogen and R4 is hydrogen or lower alkyl or R3 and R4 taken together are an additional carbon-nitrogen bond; R5 is hydrogen or lower alkyl; R6 is hydrogen, lower alkyl, lower alkylthio or a residue of the formula -NR7R8; and R7 and R8 each is lower alkyl or taken together with the nitrogen atom are a 5- or 6-membered saturated heterocycle; and pharmaceutically acceptable acid addition salts thereof are described. The compounds of formula I possess valuable pharmacodynamic properties, especially inflammation-inhibiting and edema-inhibiting properties, so that they can be used for the control or prevention of illnesses, especially for the control or prevention of inflammations and edemas.

    7.
    发明专利
    未知

    公开(公告)号：NO170215C

    公开(公告)日：1992-09-23

    申请号：NO881199

    申请日：1988-03-18

    Applicant: HOFFMANN LA ROCHE

    Inventor： KLOETZER WILHELM ,  MONTAVON MARC ,  MUESSNER RENATE ,  SINGEWALD NICOLAS

    IPC: A61K31/415 ,  A61K31/4164 ,  C07D233/56 ,  A61K31/417 ,  A61P3/00 ,  A61P29/00 ,  C07D233/61 ,  C07D233/64 ,  C07D233/80 ,  C07D233/84 ,  C07D233/88 ,  C07D521/00 ,  C07D413/04

    Abstract: Imidazole derivatives of the formula I wherein R1 and R2 each is lower alkyl, X is a residue of the formula R3 is hydrogen and R4 is hydrogen or lower alkyl or R3 and R4 taken together are an additional carbon-nitrogen bond; R5 is hydrogen or lower alkyl; R6 is hydrogen, lower alkyl, lower alkylthio or a residue of the formula -NR7R8; and R7 and R8 each is lower alkyl or taken together with the nitrogen atom are a 5- or 6-membered saturated heterocycle; and pharmaceutically acceptable acid addition salts thereof are described. The compounds of formula I possess valuable pharmacodynamic properties, especially inflammation-inhibiting and edema-inhibiting properties, so that they can be used for the control or prevention of illnesses, especially for the control or prevention of inflammations and edemas.

    10.
    发明专利
    未知

    公开(公告)号：PT87025A

    公开(公告)日：1988-04-01

    申请号：PT8702588

    申请日：1988-03-18

    Applicant: HOFFMANN LA ROCHE

    Inventor： KLOTZER WILHELM ,  MONTAVON MARC ,  MUSSNER RENATE ,  SINGEWALD NICOLAS

    IPC: A61K31/415 ,  A61K31/4164 ,  C07D233/56 ,  A61K31/417 ,  A61P3/00 ,  A61P29/00 ,  C07D233/61 ,  C07D233/64 ,  C07D233/80 ,  C07D233/84 ,  C07D233/88 ,  C07D521/00 ,  C07D233/54 ,  A61K31/41

    Abstract: Imidazole derivatives of the formula I wherein R1 and R2 each is lower alkyl, X is a residue of the formula R3 is hydrogen and R4 is hydrogen or lower alkyl or R3 and R4 taken together are an additional carbon-nitrogen bond; R5 is hydrogen or lower alkyl; R6 is hydrogen, lower alkyl, lower alkylthio or a residue of the formula -NR7R8; and R7 and R8 each is lower alkyl or taken together with the nitrogen atom are a 5- or 6-membered saturated heterocycle; and pharmaceutically acceptable acid addition salts thereof are described. The compounds of formula I possess valuable pharmacodynamic properties, especially inflammation-inhibiting and edema-inhibiting properties, so that they can be used for the control or prevention of illnesses, especially for the control or prevention of inflammations and edemas.

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