公开(公告)号：GB2433987A

公开(公告)日：2007-07-11

申请号：GB0700616

申请日：2007-01-12

Applicant: INTEL CORP

Inventor： KOO TAE-WOONG ,  BERLIN ANDREW ,  SALSMAN KEN ,  OSTROVSKY BRIAN

IPC: C12Q1/68 ,  G01N21/35

Abstract: Provided herein are methods and systems for detecting biomolecular binding events using gigahertz or terahertz radiation. The methods and systems use low-energy spectroscopy to detect biomolecular binding events between molecules in an aqueous solution. The detected biomolecular binding events include, for example, nucleic acid hybridizations, antibody/antigen binding, and receptor/ligand binding.

公开(公告)号：GB2427469A

公开(公告)日：2006-12-27

申请号：GB0614242

申请日：2004-12-28

Applicant: INTEL CORP

Inventor： SU XING ,  ZHANG JINGWU ,  SUN LEI ,  BERLIN ANDREW

IPC: G01N33/543 ,  G01N21/65

Abstract: Composite organic-inorganic nanoclusters (COINs) are provided that produce surface-enhanced Raman signals (SERS) when excited by a laser. The nanoclusters include metal particles and a Raman-active organic compound. The metal required for achieving a suitable SERS signal is inherent in the nanocluster and a wide variety of Raman-active organic compounds and combinations thereof can be incorporated into the nanocluster. In addition, polymeric microspheres containing the nanoclusters and methods of making them are also provided. The nanoclusters and microspheres can be used, for example, in assays for multiplex detection of biological molecules.

公开(公告)号：AT346297T

公开(公告)日：2006-12-15

申请号：AT03770419

申请日：2003-09-24

Applicant: INTEL CORP

Inventor： SU XING ,  CHAN SELENA ,  KOO TAE-WOONG ,  YAMAKAWA MINEO ,  BERLIN ANDREW

IPC: C12Q1/68 ,  G01N33/543 ,  G01B7/34

Abstract: The present methods and apparatus concern the detection and/or identification of target analytes using probe molecules. In various embodiments of the invention, the probes or analytes are attached to one or more cantilevers. Binding of a probe to an analyte results in deflection of the cantilever, detected by a detection unit. A counterbalancing force may be applied to restore the cantilever to its original position. The counterbalancing force may be magnetic, electrical or radiative. The detection unit and the mechanism generating the counterbalancing force may be operably coupled to an information processing and control unit, such as a computer. The computer may regulate a feedback loop that maintains the cantilever in a fixed position by balancing the deflecting force and the counterbalancing force. The concentration of analytes in a sample may be determined from the magnitude of the counterbalancing force required to maintain the cantilever in a fixed position.

公开(公告)号：AU2003304573A1

公开(公告)日：2005-06-17

申请号：AU2003304573

申请日：2003-10-31

Applicant: INTEL CORP

Inventor： SU XING ,  BERLIN ANDREW

IPC: G01N33/48 ,  G01N33/50 ,  G01N33/53 ,  G01N33/58 ,  G01N33/68 ,  G06F19/00 ,  C12Q1/68 ,  G01N33/66

Abstract: The methods and apparatus, disclosed herein are of use for sequencing and/or identifying proteins, polypeptides and/or peptides. Proteins containing labeled amino acid residues may be synthesized and passed through nanopores. A detector operably coupled to a nanopore may detect labeled amino acid residues as they pass through the nanopore. Distance maps for each type of labeled amino acid residue may be compiled. The distance maps may be used to sequence and/or identify the protein. Apparatus of use for protein sequencing and/or identification is also disclosed herein. In alternative methods, other types of analytes may be analyzed by the same techniques.

公开(公告)号：AU2003278903A1

公开(公告)日：2004-04-19

申请号：AU2003278903

申请日：2003-09-24

Applicant: INTEL CORP

Inventor： YAMAKAWA MINEO ,  BERLIN ANDREW ,  SU XING ,  CHAN SELENA ,  KOO TAE-WOONG

IPC: C12Q1/68 ,  G01N33/543 ,  G01B7/34

Abstract: The present methods and apparatus concern the detection and/or identification of target analytes using probe molecules. In various embodiments of the invention, the probes or analytes are attached to one or more cantilevers. Binding of a probe to an analyte results in deflection of the cantilever, detected by a detection unit. A counterbalancing force may be applied to restore the cantilever to its original position. The counterbalancing force may be magnetic, electrical or radiative. The detection unit and the mechanism generating the counterbalancing force may be operably coupled to an information processing and control unit, such as a computer. The computer may regulate a feedback loop that maintains the cantilever in a fixed position by balancing the deflecting force and the counterbalancing force. The concentration of analytes in a sample may be determined from the magnitude of the counterbalancing force required to maintain the cantilever in a fixed position.

公开(公告)号：AU2003223269A1

公开(公告)日：2003-09-29

申请号：AU2003223269

申请日：2003-03-11

Applicant: INTEL CORP

Inventor： SUNDARARAJAN NARAYAN ,  YAMAKAWA MINEO ,  SU XING ,  BERLIN ANDREW ,  KOO TAE-WOONG ,  CHAN SELENA

IPC: G01N21/65 ,  B01L3/00 ,  C12M1/00 ,  C12Q1/68 ,  G01N33/543

Abstract: The methods and apparatus disclosed herein concern nucleic acid sequencing by enhanced Raman spectroscopy. In certain embodiments of the invention, nucleotides are covalently attached to Raman labels before incorporation into a nucleic acid 13 . Exonuclease 15 treatment of the labeled nucleic acid 13 results in the release of labeled nucleotides 16, 130, which are detected by Raman spectroscopy. In alternative embodiments of the invention, nucleotides 16, 130 released from a nucleic acid 13 by exonuclease 15 treatment are covalently cross-linked to silver or gold nanoparticles 140 and detected by surface enhanced Raman spectroscopy (SERS), surface enhanced resonance Raman spectroscopy (SERFS) and/or coherent anti-Stokes Raman spectroscopy (CARS). Other embodiments of the invention concern apparatus 10, 100, 210 for nucleic acid sequencing.