公开(公告)号：HK1097594A1

公开(公告)日：2007-06-29

申请号：HK07103296

申请日：2007-03-28

Applicant: LUMINEX CORP

Inventor： ROTH WAYNE D

IPC: G01N20060101 ,  G01N15/14

Abstract: Various light emitting diode (LED) based measurement systems and methods are provided. One system includes one or more arrays of LEDs arranged along a flow path of a sample. The array(s) are configured to illuminate the sample as the sample moves along the flow path. The system also includes one or more detectors configured to detect light resulting from illumination of the sample by the array(s). One method includes illuminating a microsphere at different positions along a flow path of the microsphere. The method also includes detecting light resulting from the illumination to produce individual output signals corresponding to the illumination at the different positions. The method further includes combining the individual output signals to produce a single output signal having a signal-to-noise ratio that is greater than a signal-to-noise ratio of the individual output signals.

公开(公告)号：CA2623130A1

公开(公告)日：2007-03-29

申请号：CA2623130

申请日：2006-09-21

Applicant: LUMINEX CORP

Inventor： ROTH WAYNE D

IPC: G01N15/14

Abstract: A system configured to acquire and process image data is disclosed. The system comprises an imaging subsystem configured to image, at different wavelength bands, particles disposed within the imaging subsystem and acquire data corresponding to emissions of imaged particles. The system further comprises a storage medium with program instructions which are executable by a processor for storing data acquired for multiple images of the particles, wherein each of the multiple images corresponds to a different wavelength band, selecting a reference image from one of the multiple images and manipulating the coordinates of at least one of the multiple images that is not the reference image such that spots corresponding to the particles within each of the multiple images align with spots in the reference image.

公开(公告)号：CA2553025A1

公开(公告)日：2005-07-28

申请号：CA2553025

申请日：2005-01-13

Applicant: LUMINEX CORP

Inventor： ROTH WAYNE D

IPC: G01N15/14

Abstract: Methods and systems for expanding the dynamic range of a system are provided . One method includes splitting fluorescent light emitted by a particle into multiple light paths having different intensities, detecting the fluorescent light in the multiple light paths with different channels to generate multip le signals, and determining which of the channels is operating in a linear rang e based on the multiple signals. The method also includes altering the signal generated by the channel operating in the linear rang to compensate for the different intensities. Another method includes illuminating a particle in multiple illumination zones with light having different intensities and separately detecting fluorescent light emitted by the particle while located in the multiple illumination zones to generate multiple signals. The method also includes determining which of the signals is located in a linear range and altering the signal located in the linear range to compensate for the different intensities.

公开(公告)号：CA2767108A1

公开(公告)日：2005-02-24

申请号：CA2767108

申请日：2004-08-13

Applicant: LUMINEX CORP

Inventor： ROTH WAYNE D ,  MOORE DOUGLAS E

IPC: G01N15/10 ,  G01N15/14

Abstract: A method for controlling one or more parameters of a flow cytometer type measurement system, is disclosed. The comprises the following steps - measuring a time in which a microsphere (10) travels from a first detection window of the flow cytometer type measurement system to a second detection window of the measurement system; and - altering an applied pressure of the measurement system such that the time is substantially constant.

公开(公告)号：CA2725226C

公开(公告)日：2018-07-24

申请号：CA2725226

申请日：2010-12-13

Applicant: LUMINEX CORP

Inventor： ROTH WAYNE D ,  CALVIN EDWARD A ,  COLLINS CHARLES J ,  DEICHER WILLIAM R ,  KRAGER JARDEN E ,  SCHILFFARTH ADAM R ,  JOHNSON ROSS G ,  BOZARTH COLIN D ,  SELVARAJ VICTOR ,  SMITH ERIC D ,  ARAB NICOLAS F ,  BERNARD BRUCE J C ,  CONNER DONALD A ,  ROACH ROBERT S ,  SMITH DAVID L

IPC: G01N15/00 ,  G01J3/46 ,  G01N21/11 ,  G01N21/13 ,  G01N21/84 ,  H01S5/00 ,  H04N5/335

Abstract: Systems and methods for performing measurements of one or more materials are provided. One system is configured to transfer one or more materials to an imaging volume of a measurement device from one or more storage vessels. Another system is configured to image one or more materials in an imaging volume of a measurement device. An additional system is configured to substantially immobilize one or more materials in an imaging volume of a measurement device. A further system is configured to transfer one or more materials to an imaging volume of a measurement device from one or more storage vessels, to image the one or more materials in the imaging volume, to substantially immobilize the one or more materials in the imaging volume, or some combination thereof.

公开(公告)号：CA2623130C

公开(公告)日：2018-01-09

申请号：CA2623130

申请日：2006-09-21

Applicant: LUMINEX CORP

Inventor： ROTH WAYNE D

IPC: G01N15/14

Abstract: Methods, storage mediums, and systems for image data processing are provided. Embodiments for the methods, storage mediums, and systems include configurations to perform one or more of the following steps: background signal measurement, particle identification using classification dye emission and cluster rejection, inter-image alignment, inter-image particle correlation, fluorescence integration of reporter emission, and image plane normalization.

公开(公告)号：BRPI1010430A2

公开(公告)日：2012-12-18

申请号：BRPI1010430

申请日：2010-12-28

Applicant: LUMINEX CORP

Inventor： ROTH WAYNE D ,  CALVIN EDWARD A ,  COLLINS CHARLES J ,  DEICHER WILLIAM R ,  KRAGER JARDEN E ,  SCHILFFARTH ADAM R ,  JOHNSON ROSS G ,  BOZARTH COLIN D ,  SELVARAJ VICTOR ,  SMITH ERIC D ,  ARAB NICOLAS F ,  BERNARD BRUCE J C ,  CONNER DONALD A ,  ROACH ROBERT S ,  SMITH DAVID L

IPC: G01N21/64

Abstract: Systems and methods for performing measurements of one or more materials are provided. One system is configured to transfer one or more materials to an imaging volume of a measurement device from one or more storage vessels. Another system is configured to image one or more materials in an imaging volume of a measurement device. An additional system is configured to substantially immobilize one or more materials in an imaging volume of a measurement device. A further system is configured to transfer one or more materials to an imaging volume of a measurement device from one or more storage vessels, to image the one or more materials in the imaging volume, to substantially immobilize the one or more materials in the imaging volume, or some combination thereof.

公开(公告)号：AU2010253487A1

公开(公告)日：2011-12-01

申请号：AU2010253487

申请日：2010-12-15

Applicant: LUMINEX CORP

Inventor： COLLINS CHARLES J ,  ROTH WAYNE D ,  CALVIN EDWARD A ,  DEICHER WILLIAM R ,  KRAGER JARDEN E ,  SCHILFFARTH ADAM R ,  JOHNSON ROSS G ,  BOZARTH COLIN D ,  VICTOR SELVARAJ ,  SMITH ERIC D ,  ARAB NICOLAS F ,  BERNARD BRUCE J C ,  CONNER DONALD A ,  ROACH ROBERT S ,  SMITH DAVID L

IPC: G01N15/00 ,  G01N21/64

Abstract: Systems and methods for performing measurements of one or more materials are provided. One system is configured to transfer one or more materials to an imaging volume of a 5 measurement device from one or more storage vessels. Another system is configured to image one or more materials in an imaging volume of a measurement device. An additional system is configured to substantially immobilize one or more materials in an imaging volume of a measurement device. A further system is configured to transfer one or more materials to an imaging volume of a measurement device from one or more storage vessels, to image the one or 10 more materials in the imaging volume, to substantially immobilize the one or more materials in the imaging volume, or some combination thereof.

公开(公告)号：AU2010202161A1

公开(公告)日：2010-06-17

申请号：AU2010202161

申请日：2010-05-27

Applicant: LUMINEX CORP

Inventor： ROTH WAYNE D ,  MOORE DOUGLAS E

IPC: G01N15/14

Abstract: A method for controlling one or more parameters of a flow cytometer type measurement system, is disclosed. The comprises the following steps - measuring a time in which a microsphere (10) travels from a first detection window of the flow cytometer type measurement system to a second detection window of the measurement system; and - altering an applied pressure of the measurement system such that the time is substantially constant.

公开(公告)号：AU2004265989B2

公开(公告)日：2010-03-25

申请号：AU2004265989

申请日：2004-08-13

Applicant: LUMINEX CORP

Inventor： MOORE DOUGLAS E ,  ROTH WAYNE D

IPC: G01N15/14

Abstract: A method for controlling one or more parameters of a flow cytometer type measurement system, is disclosed. The comprises the following steps - measuring a time in which a microsphere (10) travels from a first detection window of the flow cytometer type measurement system to a second detection window of the measurement system; and - altering an applied pressure of the measurement system such that the time is substantially constant.