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51.发明专利
公开(公告)号：UA117490C2
公开(公告)日：2018-08-10
申请号：UAA201601395
申请日：2014-07-22
Applicant: SERVIER LAB , VERNALIS R&D LTD
Inventor： DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , CHEN I-JEN , WALMSLEY CLAIRE , DODSWORTH MARK , MEISSNER JOHANNES W G , BROUGH PAUL , FEJES IMRE , TATAI JANOS , NYERGES MIKLOS , KOTSCHY ANDRAS , SZLAVIK ZOLTAN , GENESTE OLIVIER , LE TIRAN ARNAUD , LE DIGUARHER THIERRY , HENLIN JEAN-MICHEL , STARCK JEROME-BENOIT , GUILLOUZIC ANNE-FRANCOISE
IPC: C07D401/14 , A61K31/4709 , A61K31/4725 , A61P35/00 , A61P37/00 , C07D401/10 , C07D405/14 , C07D409/14 , C07D471/04
Abstract: Сполукиформули (І): , (I) де Het, R3, R4, R5, R7, R8, R9, Т, р, p', q та q' єтакими, яквизначенов описі.
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52.发明专利
公开(公告)号：ME02922B
公开(公告)日：2018-04-20
申请号：MEP2017272
申请日：2014-07-22
Applicant: VERNALIS R&D LTD , SERVIER LAB
Inventor： LE TIRAN ARNAUD , LE DIGUARHER THIERRY , STARCK JÉRÔME-BENOÎT , HENLIN JEAN-MICHEL , DE NANTEUIL GUILLAUME , GENESTE OLIVIER , DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , CHEN I-JEN
IPC: A61K31/4709 , A61K31/4985 , A61P35/00 , A61P37/00 , C07D471/04 , C07D487/04 , C07D519/00
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公开(公告)号：SG10201800580XA
公开(公告)日：2018-03-28
申请号：SG10201800580X
申请日：2014-07-22
Applicant: SERVIER LAB , VERNALIS R&D LTD
Inventor： LE TIRAN ARNAUD , LE DIGUARHER THIERRY , STARCK JÉRÔME-BENOÎT , HENLIN JEAN-MICHEL , DE NANTEUIL GUILLAUME , GENESTE OLIVIER , DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , CHEN I-JEN
Abstract: Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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公开(公告)号：MD4551B1
公开(公告)日：2018-02-28
申请号：MD20140073
申请日：2014-07-15
Applicant: SERVIER LAB , VERNALIS R&D LTD
Inventor： LE TIRAN ARNAUD , LE DIGUARHER THIERRY , STARCK JÉRÔME-BENOÎT , HENLIN JEAN-MICHEL , GUILLOUZIC ANNE-FRANÇOISE , DE NANTEUIL GUILLAUME , GENESTE OLIVIER , DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , CHEN I-JEN
IPC: A61K31/675 , C07D471/00 , A61P35/00 , C07F9/09 , C07F9/6558 , C07F9/6561
Abstract: Invenţia se referă la compuşii cu formula (I):unde X, Y, A1, A2, Ra, Rb, Rc, Rd, R3, R4, T şi R5 sunt definiţi în descrierea invenţiei, totodată R4 reprezintă un fenil sau piridin-5-il, substituit în poziţia para cu o grupare fosfat, preferabil cu gruparea -OPO(O-Na+)(O-Na+).Invenţia se referă, de asemenea, la un procedeu de obţinere a compuşilor cu formula (I), la compoziţii farmaceutice, care conţin un compus cu formula (I) sau o sare de adiţie a acestuia cu un acid sau o bază acceptabilă farmaceutic, şi la utilizarea compoziţiilor farmaceutice în fabricarea medicamentelor pentru tratarea cancerului, maladiilor autoimune şi ale sistemului imunitar.
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公开(公告)号：CU24315B1
公开(公告)日：2018-02-08
申请号：CU20140081
申请日：2014-07-07
Applicant: SERVIER LAB , VERNALIS R&D LTD
Inventor： CHEN I JEN , DAVIDSON JAMES EDWARD PAUL , DE NANTEUIL GUILLAUME , DURAND DIDIER , FEJES IMRE , GENESTE OLIVIER , GUILLOUZIC ANNE FRANÇOISE , HENLIN JEAN MICHEL , LE DIGUARHER THIERRY , LE TIRAN ARNAUD , MURRAY JAMES BROOKE , NYERGES MIKLOS , STARCK JEROME BENOÎT , TATAI JANOS
IPC: A61K31/40 , A61P35/00 , C07D207/34 , C07D403/14
Abstract: wherein A1, A2, R3, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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Patent Agency Ranking56.发明专利
公开(公告)号：MD4490C1
公开(公告)日：2018-01-31
申请号：MD20140084
申请日：2013-01-23
Applicant: SERVIER LAB , VERNALIS R&D LTD
Inventor： LE DIGUARHER THIERRY , CASARA PATRICK , STARCK JÉRÔME-BENOÎT , HENLIN JEAN-MICHEL , DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , GRAHAM CHRISTOPHER JOHN , CHEN I-JEN , GENESTE OLIVIER , HICKMAN JOHN , DEPIL STÉPHANE , LE TIRAN ARNAUD , NYERGES MIKLOS , DE NANTEUIL GUILLAUME
IPC: C07D471/00 , A61K31/407 , A61K31/4353 , A61K31/436 , A61P35/00 , A61P37/00 , C07D471/04 , C07D487/04 , C07D491/052
Abstract: Invenţia se referă la noi compuşi indolizinici care pot fi utilizaţi în tratamentul bolilor oncologice şi celor legate de apoptoză.Se revendică compuşi cu formula (I) şi un procedeu de obţinere a lor:unde Ra, Rb, Rc, Rd, R1, R2, R3, R4, R5,, X, Y şi Het sunt definiţi în descriere.De asemenea se revendică compoziţii farmaceutice care conţin un compus cu formula (I) sau o sare de adiţie a acestuia cu un acid sau o bază acceptabilă farmaceutic; şi utilizarea compoziţiilor farmaceutice respective în fabricarea medicamentelor.Revendicări: 24
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公开(公告)号：DK3024833T3
公开(公告)日：2017-12-18
申请号：DK14758605
申请日：2014-07-22
Applicant: SERVIER LAB , VERNALIS (R&D) LTD
Inventor： LETIRAN ARNAUD , HENLIN JEAN-MICHEL , DE NANTEUIL GUILLAUME , DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , CHEN I-JEN , GENESTE OLIVIER , LE DIGUARHER THIERRY , STARCK JÉRÔME-BENOÎT
IPC: C07D471/04 , A61K31/4709 , A61K31/4985 , A61P35/00 , A61P37/00 , C07D487/04 , C07D519/00
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公开(公告)号：LT3024833T
公开(公告)日：2017-10-25
申请号：LT14758605
申请日：2014-07-22
Applicant: SERVIER LAB , VERNALIS (R&D) LTD
Inventor： LE TIRAN ARNAUD , LE DIGUARHER THIERRY , STARCK JÉROME-BENOIT , HENLIN JEAN-MICHEL , DE NANTEUIL GUILLAUME , GENESTE OLIVIER , DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , CHEN I-JEN
IPC: C07D471/04 , A61K31/4709 , A61K31/4985 , A61P35/00 , A61P37/00 , C07D487/04 , C07D519/00
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公开(公告)号：PL2829539T3
公开(公告)日：2017-08-31
申请号：PL14178016
申请日：2014-07-22
Applicant: SERVIER LAB , VERNALIS (R&D) LTD
Inventor： LE TIRAN ARNAUD , LE DIGUARHER THIERRY , STARCK JÉRÔME-BENOÎT , HENLIN JEAN-MICHEL , GUILLOUZIC ANNE-FRANÇOISE , DE NANTEUIL GUILLAUME , GENESTE OLIVIER , FEJES IMRE , TATAI JANOS , NYERGES MIKLOS , DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , CHEN I-JEN , DURAND DIDIER
IPC: C07D401/14 , A61K31/4709 , A61P35/00 , A61P37/00 , C07D401/10 , C07D405/14 , C07D471/04 , C07D491/10 , C07D498/04
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公开(公告)号：HK1222394A1
公开(公告)日：2017-06-30
申请号：HK16110596
申请日：2016-09-06
Applicant: SERVIER LAB
Inventor： LE TIRAN ARNAUD , LE DIGUARHER THIERRY , STARCK JRME-BENOT , HENLIN JEAN-MICHEL , DE NANTEUIL GUILLAUME , GENESTE OLIVIER , DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , CHEN I-JEN
IPC: A61K20060101 , C07D20060101 , A61P20060101
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