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    Interferometric focusing of guide-stars for direct wavefront sensing
    53.
    发明申请
    Interferometric focusing of guide-stars for direct wavefront sensing 有权
    引导星的直接波前感测的干涉聚焦

    公开(公告)号：US20160274355A1

    公开(公告)日：2016-09-22

    申请号：US15166668

    申请日：2016-05-27

    Applicant: The Regents of the University of California

    Inventor： Xiaodong Tao ,  Joel A. Kubby

    IPC: G02B27/00 ,  G02B27/09 ,  G02B21/16 ,  G02B21/36 ,  G01N21/64 ,  G01J9/00

    CPC classification number: G02B27/0068 ,  G01J9/00 ,  G01N21/45 ,  G01N21/49 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/4709 ,  G01N2021/6439 ,  G01N2201/06113 ,  G01N2201/0675 ,  G01N2201/121 ,  G02B21/16 ,  G02B21/244 ,  G02B21/245 ,  G02B21/361 ,  G02B21/365 ,  G02B27/0927

    Abstract: Interferometric focusing (IF), rather than conventional geometric focusing, of excitation light onto a guide-star that is embedded deeply in tissue, increases its fluorescence intensity. The method can extend the depth of wavefront measurement and improve correction inside of tissues because of its ability to suppress both scattering of diffuse light and aberration of ballistic light. The results showed more than two times improvement in SNR and RMS error of the wavefront measurement. Although only ballistic light in the excitation path is corrected, the intensity after wavefront correction increased by 1.5 times. When applying IF to a two-photon microscope with a near infra-red laser, this method would further extend the measurement depth and achieve high SNR for the wavefront sensor.

    Abstract translation: 干涉测深（IF），而不是传统的几何聚焦，激发光到深埋在组织中的引导星，增加其荧光强度。 该方法可以延长波前测量的深度，并改善组织内部的校正，因为其能够抑制漫射光的散射和弹道光的差异。 结果显示波前测量的SNR和RMS误差提高了两倍以上。 虽然激励路径中只有弹道光被校正，波前校正后的强度增加了1.5倍。 当将IF应用于具有近红外激光器的双光子显微镜时，该方法将进一步扩展测量深度并实现波前传感器的高SNR。

    ADAPTIVE OPTICS FOR IMAGING THROUGH HIGHLY SCATTERING MEDIA IN OIL RESERVOIR APPLICATIONS
    54.
    发明申请
    ADAPTIVE OPTICS FOR IMAGING THROUGH HIGHLY SCATTERING MEDIA IN OIL RESERVOIR APPLICATIONS 有权
    通过油藏储存应用中高分辨率介质成像的自适应光学

    公开(公告)号：US20160259156A1

    公开(公告)日：2016-09-08

    申请号：US15061056

    申请日：2016-03-04

    Applicant: Aramco Services Company ,  SAUDI ARABIAN OIL COMPANY ,  BOSTON UNIVERSITY

    Inventor： Thomas Bifano ,  Shannon L. Eichmann ,  Bennett B. Goldberg ,  Mazen Kanj ,  Hari P. Paudel ,  William Shain

    IPC: G02B21/00 ,  G02B21/02

    CPC classification number: G02B21/0028 ,  G01N21/6458 ,  G01N2201/0675 ,  G02B21/002 ,  G02B21/0032 ,  G02B21/0048 ,  G02B21/0076 ,  G02B21/008 ,  G02B21/02 ,  G02B21/367 ,  G02B27/0068

    Abstract: Embodiments of the invention provide an imaging system and method using adaptive optics and optimization algorithms for imaging through highly scattering media in oil reservoir applications and lab-based petroleum research. Two-/multi-photon fluorescence microscopy is used in conjunction with adaptive optics for enhanced imaging and detection capabilities in scattering reservoir media. Advanced fluorescence techniques are used to allow for super-penetration imaging to compensate for aberrations both in and out of the field of interest, extending the depth at which pore geometry can be imaged within a rock matrix beyond the current capability of confocal microscopy. The placement of a Deformable Mirror or Spatial Light Modulator for this application, in which scattering and index mismatch are dominant aberrations, is in an optical plane that is conjugate to the pupil plane of the objective lens in the imaging system. The invention images stationary and dynamic nanoparticles, surfactants, fluid-fluid interfaces and tracers which can be used to study properties such as diffusion, mobility, adhesion, stickiness and wettability within the 3D structure of cores and thin sections.

    Abstract translation: 本发明的实施例提供了一种使用自适应光学和优化算法的成像系统和方法，用于通过油藏应用中的高散射介质和基于实验室的石油研究进行成像。 双光子/多光子荧光显微镜与自适应光学结合使用，用于在散射储层介质中增强成像和检测能力。 先进的荧光技术被用于允许超级穿透成像补偿在感兴趣的领域内外的像差，从而扩展了在几何形状可以在岩石基质内成像超过目前的共聚焦显微镜能力的深度。 在该应用中，散射和折射率失配是主要像差的可变形镜或空间光调制器的放置在与成像系统中的物镜的光瞳平面共轭的光学平面中。 本发明将稳定和动态的纳米颗粒，表面活性剂，流体 - 流体界面和示踪剂图像化，可用于研究核心和薄部分的3D结构内的扩散，迁移率，粘附性，粘性和润湿性等性质。

    OPTICAL MODULE AND OBSERVATION DEVICE
    58.
    发明申请
    OPTICAL MODULE AND OBSERVATION DEVICE 审中-公开
    光学模块和观察装置

    公开(公告)号：US20160054576A1

    公开(公告)日：2016-02-25

    申请号：US14782005

    申请日：2014-03-25

    Applicant: HAMAMATSU PHOTONICS K.K.

    Inventor： Takashi INOUE ,  Hirotoshi TERADA

    IPC: G02B27/28 ,  G02B27/09 ,  G02B5/30 ,  G02B27/00

    CPC classification number: G02B27/283 ,  G01N21/6458 ,  G01N2201/0675 ,  G02B5/3016 ,  G02B21/0032 ,  G02B21/0076 ,  G02B21/0092 ,  G02B27/0025 ,  G02B27/0905

    Abstract: An optical module (1A) includes a polarization beam splitter (10A) having a light splitting surface (11), polarization elements (20, 40), and respectively arranged on an optical path of a first polarization component (L2) transmitted through the light splitting surface (11) and an optical path of a second polarization component (L4) reflected by the light splitting surface (11), a reflective SLM (30) that modulates and reflects the first polarization component (L2) passing through the polarization element (20), and a reflective SLM (50) that modulates and reflects the second polarization component (L4) passing through the polarization element (40). The first modulation light (L3) passing through the polarization element (20) again and then reflected by the light splitting surface (11) and the second modulation light (L5) passing through the polarization element (40) again and then transmitted through the light splitting surface (11) are combined with each other.

    Abstract translation: 光学模块（1A）包括具有光分离表面（11）的偏振分束器（10A），偏振元件（20,40），并且分别布置在透过该光的第一偏振分量（L2）的光路上 分离表面（11）和由所述光分离表面（11）反射的第二偏振分量（L4）的光路;反射SLM（30），其对通过所述偏振元件的所述第一偏振分量（L2）进行调制和反射 20），以及反射SLM（50），其对通过偏振元件（40）的第二偏振分量（L4）进行调制和反射。 再次通过偏振元件（20）的第一调制光（L3），然后再次通过分光表面（11）和第二调制光（L5）反射，然后透过该光 分离表面（11）彼此组合。

    MEMS microdisplay optical imaging and sensor systems for underwater scattering environments
    59.
    发明授权
    MEMS microdisplay optical imaging and sensor systems for underwater scattering environments 有权
    用于水下散射环境的MEMS微显示器光学成像和传感器系统

    公开(公告)号：US08917395B2

    公开(公告)日：2014-12-23

    申请号：US13089715

    申请日：2011-04-19

    Applicant: Fraser Dalgleish ,  Anni Dalgleish ,  Bing Ouyang

    Inventor： Fraser Dalgleish ,  Anni Dalgleish ,  Bing Ouyang

    IPC: G01N21/55 ,  G01N21/47 ,  G01N21/17

    CPC classification number: G01N21/47 ,  G01N2021/1793 ,  G01N2201/0675

    Abstract: An imaging or sensor system comprises a transmitter assembly, a receiver assembly and a control unit. The transmitter assembly defines an outgoing optical beam transmission path with respect to a target surface and the receiver assembly defines a return optical signal transmission path from the target surface. Each of the paths includes transmission through or reflection from at least one microdisplay device comprising a plurality of controllable elements for selective placement in a transmit mode for transmission of light along the transmission paths. A control unit selectively places the microdisplay device elements in the transmission mode.

    Abstract translation: 成像或传感器系统包括发射器组件，接收器组件和控制单元。 发射器组件相对于目标表面限定出射光束传输路径，并且接收器组件限定了来自目标表面的返回光信号传输路径。 每个路径包括从包括多个可控元件的至少一个微显示设备的透射或反射，用于以发射模式选择性地放置以沿着传输路径传输光。 控制单元选择性地将微显示器件元件置于传输模式中。

    Method for Investigating a Specimen Containing Fluorescing Dyes with the Aid of a Microscope
    60.
    发明申请
    Method for Investigating a Specimen Containing Fluorescing Dyes with the Aid of a Microscope 审中-公开
    用显微镜的辅助剂研究含有荧光染料的样品的方法

    公开(公告)号：US20130034913A1

    公开(公告)日：2013-02-07

    申请号：US13648740

    申请日：2012-10-10

    Applicant: LEICA MICROSYSTEMS CMS GMBH

    Inventor： Volker SEYFRIED ,  Werner KNEBEL

    IPC: G01N21/76

    CPC classification number: G02B21/0076 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2201/0675 ,  G02B21/0056 ,  G03H1/0404 ,  G03H1/08 ,  G03H1/0866

    Abstract: In order to investigate a specimen (30) with the aid of a microscope (20), dye particles (40, 42) in the specimen (30) are excited to fluoresce with the aid of a first illumination light beam (24). Fluorescent light proceeding from the specimen (30) is directed via an optical arrangement (34) onto an areal sensor (36), the optical arrangement (34) acting on the fluorescent light in such a way that sub-beams of the fluorescent light interfere with themselves, so that interference patterns produced as a result of the interference are imaged on a sensitive surface of the areal sensor (36) and sensed thereby. Positions of the dye particles (40, 42) within the specimen (30) are ascertained as a function of the interference patterns.

    Abstract translation: 借助于显微镜（20）研究样品（30），借助于第一照明光束（24）激发样品（30）中的染料颗粒（40,42）以发荧光。 从样品（30）进行的荧光通过光学装置（34）引导到面传感器（36）上，光学装置（34）以荧光的子光束干涉 使得由于干扰而产生的干涉图案被成像在面传感器（36）的敏感表面上并被感测。 确定样品（30）内的染料颗粒（40,42）的位置作为干涉图案的函数。

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