公开(公告)号：US20230323562A1

公开(公告)日：2023-10-12

申请号：US18193483

申请日：2023-03-30

Applicant: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Jungwon PARK ,  Kunwoo PARK

IPC: C30B29/16 ,  C30B1/02 ,  C30B29/68

CPC classification number: C30B29/16 ,  C30B29/68 ,  C30B1/026

Abstract: A ferroelectric thin film and a forming method thereof are provided. The method of forming a ferroelectric thin film according to embodiments of the present invention comprises forming a sacrificial seed layer on a first substrate, forming a ferroelectric thin film on the sacrificial seed layer, and transferring the ferroelectric thin film to a second substrate. The ferroelectric thin film according to embodiments of the present invention is formed by the method.

公开(公告)号：US20230322821A1

公开(公告)日：2023-10-12

申请号：US18023920

申请日：2021-08-25

Applicant: INSTITUTE FOR BASIC SCIENCE ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sungwoo HONG ,  Jaebong JANG ,  Hangyeol CHOI ,  Myojeong KIM

IPC: C07F9/30 ,  A61K47/68

CPC classification number: C07F9/304 ,  A61K47/6889

Abstract: The present disclosure relates to a quinolinone derivative compound selectively binding to cysteine, an amino acid- or peptide-conjugate thereof, and an antibody-drug conjugate comprising same. Since a conjugate with high chemoselectivity and high yield is formed through a radical pathway induced by visible light, the present disclosure can be applied in various ways to bioconjugation.

公开(公告)号：US20230211011A1

公开(公告)日：2023-07-06

申请号：US17800990

申请日：2021-02-22

Applicant: INSTITUTE FOR BASIC SCIENCE ,  UNIST(ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY)

Inventor： Bartosz Grzybowski ,  Kristiana Kandere-Grybowska ,  Magdalena Borkowaska ,  Marta Siek ,  Diana Kolygina

IPC: A61K47/69 ,  A61K33/242 ,  A61K33/26 ,  A61K33/00 ,  A61K47/54 ,  A61P35/00

CPC classification number: A61K47/6929 ,  A61K33/242 ,  A61K33/26 ,  A61K33/00 ,  A61K47/54 ,  A61K47/548 ,  A61K47/542 ,  A61P35/00

Abstract: The present invention relates to a mixed-charge nanoparticle for inducing selective death of cancer cells and a use thereof. The mixed-charge nanoparticle of the present invention is localized and crystallized specifically in cancer cell lysosomes through a pH-dependent aggregation behavior due to the balance between positively charged ligands and negatively charged ligands on the surface thereof and can induce lysosomal membrane permeabilization (LMP) and lysosomal cell death mediated thereby, like cationic amphiphilic drugs (CADs) Exhibiting a cancer cell-specific death effect, the nanoparticles of the present invention can surmount the limited medical use of conventional cationic nanoparticles due to the non-specific cytotoxicity thereof. Particularly, the nanoparticles of the present invention do not exhibit toxicity to the human body and normal cells, thus finding useful applications in medical and medicinal uses such as for prevention and treatment of solid cancer, blood cancer, and tumors.

公开(公告)号：US20220387939A1

公开(公告)日：2022-12-08

申请号：US17751503

申请日：2022-05-23

Applicant: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Dae-Hyeong KIM ,  Taeghwan Hyeon ,  Dongjun Jung ,  Chaehong Lim ,  Hyung Joon Shim

IPC: B01D69/12 ,  B01D71/02 ,  B01D71/62

Abstract: A nanomembrane and a forming method thereof are provided. The nanomembrane according to embodiments of the present invention comprises an elastomer layer and nanostructures disposed on the elastomer layer. The method for forming a nanomembrane according to embodiments of the present invention comprises forming a nanocomposite solution comprising nanostructures and an elastomer solution, forming an elastomer solution layer by providing the nanocomposite solution on a first solvent, and forming an elastomer layer by drying the elastomer solution layer, and forming a nanomembrane comprising the elastomer layer and the nanostructures bonded to the elastomer layer. The nanocomposite solution is formed by mixing the nanostructures and the elastomer solution with a second solvent, and the elastomer solution is formed by mixing elastomer and a third solvent.

公开(公告)号：US20220259583A1

公开(公告)日：2022-08-18

申请号：US17674743

申请日：2022-02-17

Applicant: UIF (University Industry Foundation), Yonsei University ,  Institute for Basic Science

Inventor： Jin Woo CHEON ,  Jae Hyun LEE ,  Jung Uk LEE

IPC: C12N13/00

Abstract: The magnetic particle for modulating the activity of cells according to an exemplary embodiment of the present invention is capable of specifically binding to a bioactive material, and includes a core and a plurality of nanoparticles disposed on the surface of the core, and may generate a torque of 10 pN·nm or more when a rotating magnetic field of 5 mT is applied.

公开(公告)号：US11369770B2

公开(公告)日：2022-06-28

申请号：US16335762

申请日：2017-09-22

Applicant: INSTITUTE FOR BASIC SCIENCE

Inventor： Hee-Sup Shin ,  Charles Francois Vincent Latchoumane ,  Jan Born

IPC: A61M21/00 ,  A61N1/36 ,  A61N5/06 ,  A61N7/00 ,  A61N2/00

Abstract: The present invention relates to a brain stimulating device and, particularly, relates to a brain stimulating device comprising: a brainwave measurement unit for outputting a brainwave signal; and a stimulation unit for applying spindle-like stimulation to a brain in accordance with the generation of slow oscillation included in the brainwave signal. The brain stimulating device according to the present invention can reinforce memory or reduce memory deterioration due to dementia. Also, the brain stimulating device according to the present invention can reinforce hippocampus-dependent memory. Further, a portable device according to the present invention can control and monitor the brain stimulating device. Moreover, a method for assessing the performance of the brain stimulating device according to the present invention can assess the performance of the brain stimulating device.

公开(公告)号：US20220168717A1

公开(公告)日：2022-06-02

申请号：US17676078

申请日：2022-02-18

Applicant: INSTITUTE FOR BASIC SCIENCE ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sukbok CHANG ,  Seung Youn HONG ,  Yoon Su PARK ,  Yeongyu HWANG ,  Yeong Bum KIM

IPC: B01J31/22 ,  C07D207/267 ,  C07D209/46 ,  C07D209/52 ,  C07D209/54 ,  C07D209/56 ,  C07D209/70 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04 ,  C07F17/02 ,  C07J43/00

Abstract: The present invention relates to a novel metal complex, a method for producing same, and a method for producing a gamma-lactam compound using same, and the metal complex according to the present invention is used as a catalyst for producing a gamma-lactam compound and can efficiently produce a gamma-lactam compound with an excellent yield and excellent selectivity.

公开(公告)号：US20220140418A1

公开(公告)日：2022-05-05

申请号：US17518327

申请日：2021-11-03

Applicant: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  INSTITUTE FOR BASIC SCIENCE ,  THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY (IAC)

Inventor： Yung-Eun Sung ,  Jungjin Park ,  Jae-Hyuk Park ,  Jong Sig Lee ,  Chunjoong Kim ,  Shin-Yeong Kim

IPC: H01M10/6572 ,  G01N23/2251 ,  H01M10/615 ,  H01M10/613 ,  H01M10/052

Abstract: An in-situ X-ray analysis apparatus includes: a potentiostat connected to an in-situ electrochemical cell and configured to control a voltage, current, and time of the in-situ electrochemical cell, or to record voltage, current, resistance, capacity, and time information of the in-situ electrochemical cell; an X-ray analysis apparatus configured to obtain X-ray diffraction information of the in-situ electrochemical cell; and a controller connected to the X-ray analysis apparatus and the potentiostat and configured to provide or receive a signal to or from each of the X-ray analysis apparatus and the potentiostat.

公开(公告)号：US20220117903A1

公开(公告)日：2022-04-21

申请号：US17422414

申请日：2020-01-16

Applicant: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Taeghwan HYEON ,  Soohong LEE ,  Jonghoon KIM ,  Okkyu PARK ,  Nohyun LEE

IPC: A61K9/51 ,  A61P35/00 ,  A61K47/68 ,  A61K47/69

Abstract: A drug delivery system and a drug delivery method are provided. The drug delivery system comprises a nanoparticle to which a first functional group is bound and drug is loaded, an antibody to which a second functional group to react with the first functional group is bound, and a carrier cell comprising an antigen protein to bind to the antibody. The drug delivery method comprises injecting a nanoparticle to which a first functional group is bound and drug is loaded, and an antibody to which a second functional group to react with the first functional group is bound into a living body, and binding the antibody to an antigen protein of a carrier cell present in the living body, and binding the nanoparticle to the antibody by reaction of the first functional group and the second functional group.

公开(公告)号：US20210402004A1

公开(公告)日：2021-12-30

申请号：US17291246

申请日：2019-11-05

Applicant: Seoul National University R&DB Foundation ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Taeghwan HYEON ,  Sungjoong LEE ,  Min SOH ,  Boomin CHOI

IPC: A61K47/69

Abstract: A nanoparticle structure and method of forming the same are provided. The nanoparticle structure comprises a metal oxide nanoparticle. The metal oxide nanoparticle may comprise ceria and zirconia. The nanoparticle structure may further comprise an antibody connected to the metal oxide nanoparticle. The method comprises forming a metal oxide nanoparticle. The method may further comprise connecting an antibody to the metal oxide nanoparticle.