公开(公告)号：EP2095374A2

公开(公告)日：2009-09-02

申请号：EP07871543.0

申请日：2007-11-20

Applicant: LOMA LINDA UNIVERSITY MEDICAL CENTER

Inventor： BUSH, David A.

IPC: G21K5/08

CPC classification number: A61N5/10 ,  A41C3/00 ,  A61B6/0435 ,  A61N5/1049 ,  A61N2005/1097

Abstract: According to the improved systems and methods described herein, a patient may be immobilized so that one or both breasts are returned to a known position. Additionally, the improved systems and methods reduce respiratory movement of the breasts. Thus, the immobilization devices and techniques described herein provide accurate and reproducible breast positioning while simultaneously reducing respiratory motion.

公开(公告)号：EP2069375A2

公开(公告)日：2009-06-17

申请号：EP07843470.1

申请日：2007-09-28

Applicant: LOMA LINDA UNIVERSITY

Inventor： LI, Fengchun ,  ESCHER, Alan, P.

IPC: C07H21/02 ,  C07H21/04 ,  A61K31/70 ,  A01N43/04

CPC classification number: C12N5/0602 ,  A61K31/7088 ,  A61K35/12 ,  A61K39/001 ,  A61K2035/122 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/531

Abstract: Mammalian host cells for use in a cell-mediated transfection process, which contain an RNAi molecule and an expression vector for a pro-apoptotic protein. The method includes inducing apoptotic cell (AC) death in mammalian cells that contain an RNAi molecule capable of down-regulating a chosen target gene. Living cells expressing the target gene are then exposed to the ACs. The ACs are processed by the living cells, and the RNAi molecule in the ACs down-regulates the expression of the target gene in living cells.

公开(公告)号：EP1446989B1

公开(公告)日：2007-03-21

申请号：EP02789303.1

申请日：2002-10-28

Applicant: LOMA LINDA UNIVERSITY MEDICAL CENTER

Inventor： MOYERS, Michael, F.

IPC: H05G1/00 ,  A61B6/04 ,  A61B6/08

CPC classification number: A61B6/0421 ,  A61B6/0407 ,  A61B6/0457 ,  A61N5/1049 ,  A61N5/1069 ,  A61N2005/1087

Abstract: A device (10) for aligning a patient for delivering a plurality of radiation beams comprising a patient support surface (12), a coarse alignment subsystem (14) connected to the patient support surface, and a fine alignment subsystem connected to the patient support surface (16). A method of aligning a patient for delivering a plurality of radiation beams from a plurality of device positions comprising compensating for flexion of a radiation beam delivery device within a gantry during movement of the radiation beam delivery device from a first device position to a second device position by using a set of predetermined data describing the flexion behavior of the radiation beam delivery device so that the target tissue within the patient is placed at the beamline center for the radiation beam delivery device at the second device position.

公开(公告)号：EP1737987A2

公开(公告)日：2007-01-03

申请号：EP04821356.5

申请日：2004-12-08

Applicant: LOMA LINDA UNIVERSITY

Inventor： DUERKSEN-HUGHES, Penelope J. ,  FILIPPOVA, Maria ,  FODOR, Istvan

IPC: C12Q1/70

CPC classification number: C12Q1/705 ,  C12Q1/70 ,  C12Q2525/143

Abstract: A DNA virus in a sample is detected by contacting the sample with host cells that have been transiently transfected with a reporter sequence under the control of a virus-specific promoter, and then detecting the reporter.

公开(公告)号：EP1737465A1

公开(公告)日：2007-01-03

申请号：EP05737742.6

申请日：2005-04-18

Applicant: LOMA LINDA UNIVERSITY

Inventor： BALDWIN, Dalton D.

IPC: A61K31/53 ,  A61K31/495 ,  A61K31/497 ,  A61K31/44 ,  A61K31/40

CPC classification number: A61K31/40 ,  A61K31/44 ,  A61K31/495 ,  A61K31/497 ,  A61K31/519 ,  A61K31/53 ,  A61K2300/00

Abstract: A method of decreasing renal ischemic damage comprising a) identifying an organism having a kidney that is susceptible to renal ischemic damage from an ischemic event; and b) administering to the organism one or more than one effective dose of an agent prior to the ischemic event; where administering to the organism the one or more than one effective dose of the agent serves to at least partially protect the organism's kidney from damage during a subsequent ischemic event. A composition for decreasing renal ischemic damage comprising one or more than one phosphodiesterase inhibitor, and one or more than one HMG-CoA reductase inhibitor.

公开(公告)号：EP1513456B1

公开(公告)日：2006-10-11

申请号：EP03742029.6

申请日：2003-06-16

Applicant: LOMA LINDA UNIVERSITY MEDICAL CENTER

Inventor： ZHU, Yong, Hua ,  KIRSCH, Wolff, M.

IPC: A61B17/00 ,  A61B17/02

CPC classification number: A61B17/085 ,  A61B17/00491 ,  A61B17/0057 ,  A61B17/0206 ,  A61B17/10 ,  A61B17/3439 ,  A61B2017/00637 ,  A61B2017/0065 ,  A61B2017/00654 ,  A61B2017/00659 ,  A61B2090/037 ,  A61M25/00 ,  H04N7/08 ,  H04N7/088

Abstract: A method and apparatus for closing a vascular wound includes a guidewire and/or other surgical implement extending from the wound. A hemostatic material is advanced over the surgical implement and into contact with an area of the blood vessel surrounding the wound. The surgical implement is removed. Blood soaks the hemostatic material, and blood clotting is facilitated by the hemostatic agent within the material. A sealing layer of adhesive can be applied to the hemostatic material, confining the blood flow to the material. Thus, the vascular puncture wound is sealed by natural blood clot formation.

公开(公告)号：EP1414503B1

公开(公告)日：2006-09-06

申请号：EP02752499.0

申请日：2002-07-19

Applicant: LOMA LINDA UNIVERSITY MEDICAL CENTER

Inventor： KIRSCH, Wolff, M.

IPC: A61L15/42 ,  A61F13/02

CPC classification number: A61L24/0015 ,  A61B17/085 ,  A61B2017/081 ,  A61F13/023 ,  A61F13/0246 ,  A61L2/00 ,  A61L15/58 ,  A61L24/06 ,  C08L35/04

Abstract: The present invention provides a wound approximation device and method for safely applying cyanoacrylate or other adhesives to skin lacerations. The wound approximation device comprises a resilient sheet and an opening, wherein the opening is of a sufficient size such that it surrounds a skin wound and exposes a margin of skin surrounding the wound when the resilient sheet in a streched form is placed against the skin, and wherein a portion of the resilient sheet adjacent to the opening and opposite to a side of the resilient sheet to be placed against the skin comprises a substance which does not form a strong bond with a wound-sealing adhesive used to seal the wound.

公开(公告)号：EP1638491A2

公开(公告)日：2006-03-29

申请号：EP04776473.3

申请日：2004-06-14

Applicant: LOMA LINDA UNIVERSITY MEDICAL CENTER

Inventor： ZHU, Yong, Hua ,  Yang, Chang Zheng ,  KIRSCH, Wolff, M. ,  Shen, Qun-Dong ,  Hu, Yong ,  DICKSON, Cindy

IPC: A61F13/00

CPC classification number: A61K9/70 ,  A61B17/0057 ,  A61B17/06166 ,  A61B2017/00884 ,  A61B2017/00898 ,  A61K47/36 ,  A61L15/225 ,  A61L26/0052 ,  A61L26/0066 ,  A61L2300/232 ,  A61L2300/402 ,  A61L2300/404 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/418 ,  A61L2300/45 ,  A61L2300/622 ,  A61L2400/04 ,  C08L5/08

Abstract: This invention relates to deployable hemostatic materials comprising chitosan fibers upon which hemostatic microporous polysaccharide microspheres and a medicament or biologically active substance are deposited. The hemostatic materials are suitable for use in controlling active bleeding from artery and vein lacerations, sealing femoral artery punctures, and controlling oozing from tissue.

公开(公告)号：EP1585578A1

公开(公告)日：2005-10-19

申请号：EP03814903.5

申请日：2003-12-22

Applicant: LOMA LINDA UNIVERSITY MEDICAL CENTER

Inventor： BELOUSSOV, Alexandre ,  BAUMANN, Michael, A. ,  OLSEN, Howard, B. ,  SALEM, Dana

IPC: A61N5/10

CPC classification number: A61N5/1048 ,  A61N5/10 ,  A61N5/1077 ,  A61N5/1079 ,  A61N2005/1074 ,  A61N2005/1087 ,  G06F19/00 ,  H05H7/00

Abstract: In a complex, multi-processor software controlled system, such as proton beam therapy system (PBTS), it may be important to provide treatment configurable parameters that are easily modified by an authorized user to prepare the software controlled systems for various modes of operation. This particular invention relates to a configuration management system for the PBTS that utilizes a database to maintain data and configuration parameters and also to generate and distribute system control files that can be used by the PBTS for treatment delivery. The use of system control files reduces the adverse effects of single point failures in the database by allowing the PBTS to function independently from the database. The PBTS accesses the data, parameters, and control settings from the database through the system control files, which insures that the data and configuration parameters are accessible when and if single point failures occur with respect to the database.

公开(公告)号：EP1254250B1

公开(公告)日：2005-03-23

申请号：EP01906690.1

申请日：2001-01-25

Applicant: LOMA LINDA UNIVERSITY

Inventor： SHABAHANG, Shahrokh ,  SZALAY, Aladar, A. ,  YU, Yong

IPC: C12Q1/02 ,  C12Q1/22 ,  C12N1/20

CPC classification number: C12Q1/025 ,  C12Q1/04 ,  C12Q1/18 ,  G01N33/5088

Abstract: A method for evaluating whether a material will allow bacteria to pass through the material comprising providing bacteria which are modified to produce a first detectable signal, placing the bacteria on a first side of the material being evaluated, and determining whether the first signal is present on a second side of the material. A method for the evaluation of a material to determine whether the material is susceptible to bacterial contamination or colonization comprising providing bacteria which are modified to produce a first detectable signal, exposing the material being evaluated to the bacteria and determining whether the first signal is present on the material.