中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

140 records (took 0.033 seconds)

    CYTOPROTECTIVE THEREAPEUTIC AGENTS FOR THE PREVENTION OF REPERFUSION INJURY FOLLOWING ISCHEMIC STROKE
    62.
    发明申请
    CYTOPROTECTIVE THEREAPEUTIC AGENTS FOR THE PREVENTION OF REPERFUSION INJURY FOLLOWING ISCHEMIC STROKE 审中-公开
    细胞防护剂在预防缺血性脑卒中再灌注损伤中的作用

    公开(公告)号：WO2007005990A3

    公开(公告)日：2007-11-08

    申请号：PCT/US2006026257

    申请日：2006-06-30

    Applicant: ROSALIND FRANKLIN UNIVERSITY O ,  PETERSON DARRYL R

    Inventor： PETERSON DARRYL R

    IPC: A61K38/05 ,  A61K38/06

    CPC classification number: A61K38/05 ,  A61K38/49

    Abstract: The present invention relates generally to the use of ?-glutamyl antioxidants, particularly ?-glutamyl-cysteine, as cytoprotective agents to prevent reperfusion injury (i.e., hemorrhagic transformation) of the blood-brain barrier during reperfusion following an ischemic stroke. The ?-glutamyl antioxidants can be used alone or used in combination with an agent which inhibits the reverse movement of Na/Ca exchange in the blood-brain barrier such as 2-[2-[4-(4-nitrobenzyloxy)phenyl]ethyl]isothiourea methanesulphonate (KB-R7943).

    Abstract translation: 本发明一般涉及β-谷氨酰抗氧化剂，特别是γ-谷氨酰半胱氨酸作为细胞保护剂在预防缺血性中风再灌注期间预防血脑屏障的再灌注损伤（即出血性转化）中的用途。 γ-谷氨酰抗氧化剂可以单独使用或与抑制血脑屏障中Na / Ca交换逆向运动的试剂例如2- [2- [4-（4-硝基苄氧基）苯基]乙基 ]异硫脲甲磺酸盐（KB-R7943）。

    REGULATION OF CCN2 BY CCN3 AND ITS THERAPEUTIC AND DIAGNOSTIC POTENTIAL IN FIBROSIS, SCLEROSIS AND OTHER DISEASES
    64.
    发明申请
    REGULATION OF CCN2 BY CCN3 AND ITS THERAPEUTIC AND DIAGNOSTIC POTENTIAL IN FIBROSIS, SCLEROSIS AND OTHER DISEASES 审中-公开
    CCN3对CCN2的调节作用及其在纤维化，硬化症和其他疾病中的治疗和诊断潜力

    公开(公告)号：WO2006074452A2

    公开(公告)日：2006-07-13

    申请号：PCT/US2006000833

    申请日：2006-01-10

    Applicant: ROSALIND FRANKLIN UNIVERSITY O ,  RISER BRUCE L

    Inventor： RISER BRUCE L ,  PERBAL BERNARD

    IPC: A61K48/00

    CPC classification number: C07K14/4702 ,  A61K48/00

    Abstract: The present invention discloses a role of CCN3 in diseases associated with the overexpression of CCN2, which include but are not limited to kidney disease, fibrosis, and cancer. The full length CCN3 protein or fragments thereof or isoforms (or combinations) of CCN3 are involved in these diseases. The isolated and purified CCN3 protein or its fragments or isoforms (or combinations) of CCN3 can be potentially used in the treatment or prevention of these diseases by regulating the expression and/or activity of the CCN2 protein. The level of CCN3 in tissue or body fluids can also be used to predict, diagnose and/or follow the progression of diseases as well as to determine the effectiveness of therapeutic intervention.

    Abstract translation: 本发明公开了CCN3​​在与CCN2过表达相关的疾病中的作用，所述疾病包括但不限于肾病，纤维化和癌症。 全长CCN3蛋白或其片段或CCN3的同种型（或组合）参与这些疾病。 通过调节CCN2蛋白的表达和/或活性，分离和纯化的CCN3蛋白或其片段或CCN3的同种型（或组合）可以用于治疗或预防这些疾病。 组织或体液中的CCN3水平也可用于预测，诊断和/或跟踪疾病的进展以及确定治疗干预的有效性。

    Durability test system for repetitive loading of a prosthetic socket
    65.
    发明授权
    Durability test system for repetitive loading of a prosthetic socket 有权

    公开(公告)号：US12279979B2

    公开(公告)日：2025-04-22

    申请号：US17936539

    申请日：2022-09-29

    Applicant: Rosalind Franklin University of Medicine & Science

    Inventor： Sai V. Yalla ,  Sunjung Kim ,  Noah J. Rosenblatt

    IPC: A61F2/76 ,  G01N3/06 ,  G01N3/08 ,  G01N3/32

    Abstract: The present disclosure relates to a system for repetitive loading of a prosthetic socket to test the durability of the prosthetic socket. The system includes a base and a load cell coupled to the base. The system further includes a first coupling mechanism positioned vertically above the load cell, and a second coupling mechanism positioned vertically above the first coupling mechanism. The first coupling mechanism is configured to be removably coupled to a first end of the prosthetic socket, and the second coupling mechanism is configured to be removably coupled to a second end of the prosthetic socket. The system further includes a rod having a first end and a second end opposite the first end. The first end of the rod is coupled to the second coupling mechanism. The system further includes a motor coupled to the second end of the rod, a support structure extending vertically from the base, and an actuator coupled to the support structure such that the actuator is positioned vertically above the second coupling mechanism. The system further includes a curved rail coupled to the actuator and positioned between the actuator and the second coupling mechanism. The curved rail is configured to contact the second coupling mechanism along an arc defined by the curved rail such that the second coupling mechanism moves along the arc when the motor moves the rod.

    Mobile sensor system and methods for use
    67.
    发明授权
    Mobile sensor system and methods for use 有权

    公开(公告)号：US10729370B2

    公开(公告)日：2020-08-04

    申请号：US14964690

    申请日：2015-12-10

    Applicant: Rosalind Franklin University of Medicine and Science

    Inventor： Fang Lin ,  Sai V. Yalla

    IPC: A61B5/00 ,  A61B3/113 ,  A61B5/11

    Abstract: The present disclosure provides a system including one or more sensors, a mounting system configured to removeably mount a computing device such that a camera of the computing device is positioned facing an eye of a subject, and a control system. The control system is configured to (a) receive sensor data from the one or more sensors, (b) determine whether the sensor data is indicative of balance instability of the subject, (c) track a position of the eye of the subject to assess vestibular dysfunction, (d) determine whether the camera data is indicative of vestibular dysfunction of the subject, and (e) in response to (i) the sensor data being indicative of balance instability of the subject and/or (ii) the camera data being indicative of vestibular dysfunction of the subject, display an indication of symptoms that are characteristic of a traumatic brain injury or concussion.

Patent Agency Ranking