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公开(公告)号：WO2010096418A3
公开(公告)日：2012-06-14
申请号：PCT/US2010024377
申请日：2010-02-17
Applicant: UCB PHARMA SA , LAWSON ALASTAIR DAVID GRIFFITHS , NESBITT ANDREW MALCOLM , POPPLEWELL ANDREW GEORGE , SHAW STEPHEN GRAHAM , SHPEKTOR DIANA , ZHANG YI
Inventor： LAWSON ALASTAIR DAVID GRIFFITHS , NESBITT ANDREW MALCOLM , POPPLEWELL ANDREW GEORGE , SHAW STEPHEN GRAHAM , SHPEKTOR DIANA , ZHANG YI
IPC: C07K16/28 , A61K39/395 , C07K16/00
CPC classification number: C07K16/2878 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/70578 , C07K2317/24 , C07K2317/33 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of human OX40, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
Abstract translation: 本发明涉及对人OX40的抗原决定簇具有特异性的抗体分子，抗体分子的治疗用途以及产生所述抗体分子的方法。
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公开(公告)号：WO2011015349A3
公开(公告)日：2011-04-21
申请号：PCT/EP2010004770
申请日：2010-08-04
Applicant: UCB PHARMA SA , KENDA BENOIT , MATAGNE ALAIN
Inventor： KENDA BENOIT , MATAGNE ALAIN
IPC: A61K31/4178 , A61P25/00 , A61P25/28
CPC classification number: A61K31/4178
Abstract: A compound having an affinity to a SV2 protein for the treatment of a condition associated with enhancement or improvement of the cognitive ability or to counteract cognitive decline of a mammal. For example, a compound which is covered by formula (I) R1 is an halogen atom, preferably, a chlorine or a fluorine atom; n is equal to 1, 2 or 3; and R2 is cyano.
Abstract translation: 对SV2蛋白具有亲和力的化合物，用于治疗与增强或改善认知能力有关的病症或抵抗哺乳动物的认知衰退。 例如，式（I）R 1所覆盖的化合物是卤素原子，优选氯或氟原子; n等于1,2或3; R2为氰基。
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公开(公告)号：WO2009081105A2
公开(公告)日：2009-07-02
申请号：PCT/GB2008004171
申请日：2008-12-17
Applicant: UCB PHARMA SA , ALLEN DANIEL REES , BUCKLEY GEORGE MARTIN , BUERLI ROLAND , DAVENPORT RICHARD JOHN , KINSELLA NATASHA , LOCK CHRISTOPHER JAMES , LOWE CHRISTOPHER , MACK STEPHEN ROBERT , PITT WILLIAM ROSS , RATCLIFFE ANDREW JAMES , RICHARD MARIANNA DILANI , SABIN VERITY MARGARET , SHARPE ANDREW , TAIT LAURA JANE , WARRELOW GRAHAM JOHN , WILLIAMS SOPHIE CAROLINE
Inventor： ALLEN DANIEL REES , BUCKLEY GEORGE MARTIN , BUERLI ROLAND , DAVENPORT RICHARD JOHN , KINSELLA NATASHA , LOCK CHRISTOPHER JAMES , LOWE CHRISTOPHER , MACK STEPHEN ROBERT , PITT WILLIAM ROSS , RATCLIFFE ANDREW JAMES , RICHARD MARIANNA DILANI , SABIN VERITY MARGARET , SHARPE ANDREW , TAIT LAURA JANE , WARRELOW GRAHAM JOHN , WILLIAMS SOPHIE CAROLINE
IPC: C07D401/14 , A61K31/395 , A61P35/00 , C07D403/06 , C07D403/12 , C07D403/14 , C07D409/14 , C07D413/14 , C07D473/34 , C07D473/36
CPC classification number: C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D409/14 , C07D413/14 , C07D473/34 , C07D473/36
Abstract: A series of heteroaryl-substituted quinoxaline and quinoline derivatives, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.
Abstract translation: 因此，作为PI3激酶的选择性抑制剂的一系列杂芳基取代的喹喔啉和喹啉衍生物在医学中是有益的，例如在治疗炎症，自身免疫，心血管，神经退行性，代谢性，肿瘤学，伤害感受性或眼科疾病中。
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公开(公告)号：WO2008133722A3
公开(公告)日：2009-03-19
申请号：PCT/US2007084280
申请日：2007-11-09
Applicant: UCB PHARMA SA , LATHAM JOHN , WINKLER DAVID G
Inventor： LATHAM JOHN , WINKLER DAVID G
IPC: C07K16/22
CPC classification number: C07K16/18 , C07K16/22 , C07K2317/56 , C07K2317/565
Abstract: Compositions and methods relating to sclerostin binding agents, such as antibodies and polypeptides capable of binding to sclerostin, are provided.
Abstract translation: 提供了与硬骨素结合剂（例如能够结合硬化蛋白的抗体和多肽）相关的组合物和方法。
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公开(公告)号：WO2008061013A2
公开(公告)日：2008-05-22
申请号：PCT/US2007084276
申请日：2007-11-09
Applicant: AMGEN INC , UCB PHARMA SA , ROBINSON MARTYN KIM , PASZTY CHRISTOPHER J , HENRY ALISTAIR JAMES , LAWSON ALISTAIR , POPPLEWELL ANDY
Inventor： ROBINSON MARTYN KIM , PASZTY CHRISTOPHER J , HENRY ALISTAIR JAMES , LAWSON ALISTAIR , POPPLEWELL ANDY
IPC: C07K16/00
CPC classification number: C07K16/18 , C07K16/22 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: Compositions and methods relating to sclerostin binding agents, such as antibodies and polypeptides capable of binding to sclerostin, are provided.
Abstract translation: 提供了与硬骨素结合剂（例如能够结合硬化蛋白的抗体和多肽）相关的组合物和方法。
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Patent Agency Ranking66.发明申请ANTI-TNF ALPHA ANTIBODIES WHICH SELECTIVELY INHIBIT TNF ALPHA SIGNALLING THROUGH THE p55R 审中-公开通过p55R选择性抑制TNF ALPHA信号的抗TNF ALPHA抗体
公开(公告)号：WO2006056779A3
公开(公告)日：2007-07-05
申请号：PCT/GB2005004511
申请日：2005-11-24
Applicant: UCB PHARMA SA , BROWN DEREK THOMAS , KIRBY HISHANI , FINNEY HELENE MARGARET , LAWSON ALASTAIR DAVID GRIFFITH
Inventor： BROWN DEREK THOMAS , KIRBY HISHANI , FINNEY HELENE MARGARET , LAWSON ALASTAIR DAVID GRIFFITH
IPC: C07K16/24 , A61K39/395 , A61P37/06
CPC classification number: C07K16/241 , C07K2317/56 , C07K2317/76
Abstract: Anti-TNFa antibodies which selectively inhibit TNFa signalling through the p55R. In particular anti-TNFa antibodies which selectively inhibit TNFa signalling through the p55R relative to the p75R.
Abstract translation: 通过p55R选择性抑制TNFa信号传导的抗TNFα抗体。 特别是抗TNFa抗体，其通过p55R相对于p75R选择性地抑制TNFa信号转导。
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67.发明申请
公开(公告)号：WO2006056412A8
公开(公告)日：2007-05-31
申请号：PCT/EP2005012509
申请日：2005-11-23
Applicant: UCB PHARMA SA , SCHLUMMER BJOERN , SCHOLZ ULRICH , SMITH IAN
Inventor： SCHLUMMER BJOERN , SCHOLZ ULRICH , SMITH IAN
IPC: C07D495/04
CPC classification number: C07D495/04
Abstract: The invention relates to a novel process for the Pdcatalysed formation of C-N bonds between an aryl halide or an aryloxysulphonyl compound and an amine in specific solvent systems, and also to the use of these solvent systems for C-N couplings.
Abstract translation: 本发明涉及在特定溶剂体系中芳基卤化物或芳氧基磺酰基化合物与胺之间的C-N键的Pd催化形成的新方法，以及这些溶剂体系用于C-N偶联的新方法。
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公开(公告)号：WO2013068563A9
公开(公告)日：2014-06-19
申请号：PCT/EP2012072325
申请日：2012-11-09
Applicant: UCB PHARMA SA
Inventor： ADAMS RALPH , BHATTA PALLAVI , HEYWOOD SAM PHILLIP , HUMPHREYS DAVID PAUL
CPC classification number: C07K16/18 , A61K39/3955 , A61K2039/505 , C07K16/2866 , C07K16/2878 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2317/624 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of human OX40, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
Abstract translation: 本发明涉及对人OX40的抗原决定簇具有特异性的抗体分子，抗体分子的治疗用途以及产生所述抗体分子的方法。
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公开(公告)号：WO2012164406A3
公开(公告)日：2013-01-17
申请号：PCT/IB2012001705
申请日：2012-06-04
Applicant: UCB PHARMA SA , MCLOUGHLIN MARTIN J
Inventor： MCLOUGHLIN MARTIN J
CPC classification number: A61M5/14546 , A61M5/1452 , A61M5/158 , A61M5/172 , A61M5/20 , A61M5/3129 , A61M5/3134 , A61M5/3137 , A61M5/31511 , A61M5/3202 , A61M5/3204 , A61M5/3213 , A61M5/326 , A61M5/5086 , A61M2005/206 , A61M2005/3139 , A61M2005/3152 , A61M2005/3215 , A61M2202/04 , A61M2205/27 , A61M2205/276 , A61M2205/33 , A61M2205/50 , A61M2205/502 , A61M2205/505 , A61M2205/583 , A61M2205/584 , A61M2205/586 , A61M2205/8206 , F04C2270/0421
Abstract: Provided is a cassette unit suitable for use with an auto-injector having an electrically powered drive unit. The cassette unit has a housing defining a cassette unit housing cavity and a needle projection aperture. The cassette unit housing cavity is arranged for receipt of a syringe. The syringe has a barrel for containing a volume of a liquid drug formulation, the barrel defining a flange at the rear end thereof and a forward shoulder at the forward end thereof; a hollow needle at a front end of the barrel, the hollow needle defining a needle tip; and a plunger that is axially movable within the barrel. The cassette unit includes, in contact with the plunger and axially movable within the barrel, a plunger slaving part arranged such that when a drive load is applied to a rear drive-receiving face thereof the drive load is evenly transmitted to the plunger.
Abstract translation: 提供了适用于具有电动驱动单元的自动注射器的盒单元。 盒单元具有限定盒单元容纳腔和针投影孔的壳体。 盒单元容纳腔被布置成用于接收注射器。 注射器具有用于容纳一定体积的液体药物制剂的筒，所述筒在其后端处限定凸缘，在其前端具有前肩; 在筒的前端处的中空针，中空针限定针尖; 以及在筒体内可轴向移动的柱塞。 盒单元包括与柱塞接触并在筒内可轴向移动的柱塞从动部件，其布置成使得当驱动负载施加到后驱动接收面时，驱动负载均匀地传递到柱塞。
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公开(公告)号：WO2012164404A2
公开(公告)日：2012-12-06
申请号：PCT/IB2012001507
申请日：2012-06-04
Applicant: UCB PHARMA SA , MCLOUGHLIN MARTIN J
Inventor： MCLOUGHLIN MARTIN J
IPC: A61M5/31
CPC classification number: A61M5/14546 , A61M5/1452 , A61M5/158 , A61M5/172 , A61M5/20 , A61M5/3129 , A61M5/3134 , A61M5/3137 , A61M5/31511 , A61M5/3202 , A61M5/3204 , A61M5/3213 , A61M5/326 , A61M5/5086 , A61M2005/206 , A61M2005/3139 , A61M2005/3152 , A61M2005/3215 , A61M2202/04 , A61M2205/27 , A61M2205/276 , A61M2205/33 , A61M2205/50 , A61M2205/502 , A61M2205/505 , A61M2205/583 , A61M2205/584 , A61M2205/586 , A61M2205/8206 , F04C2270/0421
Abstract: Provided is a cassette unit suitable for use with an auto-injector having an electrically powered drive unit. The cassette unit has a housing defining a cassette unit housing cavity and a needle projection aperture. The housing cavity is arranged for receipt of a syringe suitable for delivery of a drug to a patient. The syringe has a barrel for containing a volume of a liquid drug formulation, the barrel defining a flange at the rear end thereof and a forward shoulder at the forward end thereof. The cassette unit includes one or more shoulder support features for supporting the forward shoulder of the syringe. In use, the one or more shoulder support features act to direct a major part of an applied load path to travel through the shoulder at the forward end of the syringe and lesser load to pass through the flange at the rear end thereof.
Abstract translation: 提供了适用于具有电动驱动单元的自动注射器的盒单元。 盒单元具有限定盒单元容纳腔和针投影孔的壳体。 壳体空腔设置成接收适于将药物递送到患者的注射器。 注射器具有用于容纳一定体积的液体药物制剂的桶，所述筒在其后端限定凸缘，在其前端具有前肩。 盒单元包括用于支撑注射器的前肩的一个或多个肩部支撑特征。 在使用中，一个或多个肩部支撑特征用于引导施加的负载路径的主要部分在注射器的前端穿过肩部，并且较小的负载在其后端穿过凸缘。
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