公开(公告)号：US20240061735A1

公开(公告)日：2024-02-22

申请号：US18450305

申请日：2023-08-15

Applicant: University of Connecticut

Inventor： Peter Watson ,  Emmanouil Anagnostou ,  Diego Cerrai ,  Wei Zhang ,  William Hughes ,  William Taylor ,  Amvrossios Bagtzoglou

IPC: G06F11/00

CPC classification number: G06F11/004 ,  G06F2201/81

Abstract: Systems and methods for assessing the resilience of an infrastructural system. The system includes a computer program product stored on non-transitory machine-readable media. The media includes machine executable instructions for implementing a method for assessing the resilience of an infrastructural system. The method includes receiving, from an interface, scenario specific data regarding conditions for the infrastructural system; processing the scenario specific data to determine a vulnerability metric for a probability of failure for a component of the infrastructural system; determining, based on the vulnerability metric, an in-situ failure risk of the infrastructural system incorporating a complexity of environmental conditions; determining, based on the vulnerability metric, a recommended maintenance task for the component of the infrastructural system; and providing the in-situ failure risk of the infrastructural system and the recommended maintenance task for the component to the interface.

公开(公告)号：US11898000B2

公开(公告)日：2024-02-13

申请号：US16919339

申请日：2020-07-02

Applicant: University of Connecticut

Inventor： Gregory A. Sotzing

IPC: C08G61/12 ,  H01G4/18

CPC classification number: C08G61/124 ,  H01G4/18 ,  C08G2261/3342 ,  C08G2261/418 ,  C08G2261/60 ,  C08G2261/90

Abstract: All organic, dielectric polymers with high discharge efficiency at elevated operation temperatures are reported.

公开(公告)号：US20240009085A1

公开(公告)日：2024-01-11

申请号：US18474544

申请日：2023-09-26

Applicant: UNIVERSITY OF CONNECTICUT ,  CONNECTICUT CHILDREN'S MEDICAL CENTER

Inventor： Christine Finck ,  Liisa Kuhn ,  Kelly A. Burke ,  Todd Jensen

IPC: A61J15/00

CPC classification number: A61J15/0003 ,  A61J15/0049 ,  A61M2025/1061

Abstract: A nasogastic device and method is provided, including a first flexible tube having a distal end configured to be threaded through the nose of a patient, down the esophagus and into the stomach for enteral feeding, a second flexible tube disposed adjacent to the first tube having a distal end proximate to the distal end of the first flexible tube, the distal end of the second tube configured to terminate inside the esophagus for delivery of liquids to the esophagus or for sampling of the local environment, an inflatable balloon configured around the first and second flexible tubes, the inflatable balloon disposed proximal to the distal end of the first and second flexible tubes, a third flexible tube in fluid communication with the balloon configured to inflate the inflatable balloon; and a fourth flexible tube having a distal end portion communicating with an exterior portion of the inflatable balloon, the fourth tube configured to transport suspensions or solutions of materials, such as therapeutic molecules into a space exterior to the inflatable balloon; and an elastomeric sleeve surround the inflatable balloon and around the fourth flexible tube which is used to control delivery of therapeutic suspensions of solutions of materials to the exterior of the device to the adjacent esophagheal tissue.

公开(公告)号：US20240002956A1

公开(公告)日：2024-01-04

申请号：US18037361

申请日：2021-11-17

Applicant: UNIVERSITY OF CONNECTICUT

Inventor： XIONG DING ,  CHANGCHUN LIU

IPC: C12Q1/6844 ,  C12N9/22

CPC classification number: C12Q1/6844 ,  C12N9/22 ,  C12N2310/20

Abstract: The disclosure provides materials and methods for detection of pathogens. In particular, the disclosure provides primers and compositions for detection of viral pathogens, such as SARS-CoV-2. In addition, the disclosure provides a warm-start digital CRISPR assay for detection of viral pathogens, including SARS-CoV-2.

公开(公告)号：US20230404765A1

公开(公告)日：2023-12-21

申请号：US18251984

申请日：2021-10-07

Applicant: UNIVERSITY OF CONNECTICUT

Inventor： Thanh Duc Nguyen ,  Thi Tra Nguyen

IPC: A61F2/38 ,  A61L27/26 ,  A61L27/36

CPC classification number: A61F2/38 ,  A61L27/26 ,  A61L27/3654 ,  A61F2002/2864

Abstract: Methods and systems of osteoarthritis treatment. One method includes providing a cartilage hydrogel, the cartilage hydrogel including piezoelectric nano-fibers of Poly-L-lactide (PLLA). The method also includes injecting the cartilage hydrogel into a cartilage defect. The method also includes applying an ultrasonic treatment to the cartilage defect. The method also includes, in response to applying the ultrasonic treatment to the cartilage defect, converting a mechanical impact of the ultrasonic treatment into an electrical charge from the piezoelectric nano-fibers of PLLA and providing, in response to the electrical charge from the piezoelectric nano-fibers of PLLA, chondrogenesis differentiation for cartilage regeneration for the cartilage defect.

公开(公告)号：US11833254B2

公开(公告)日：2023-12-05

申请号：US17332258

申请日：2021-05-27

Applicant: University of Connecticut

Inventor： Raman Bahal ,  Mu-Ping Nieh ,  Armin Tahmasbi Rad ,  Shipra Malik

IPC: A61K9/127 ,  A61K9/51 ,  A61K47/24 ,  A61K47/34 ,  A61K47/26 ,  A61K47/42 ,  A61K9/14

CPC classification number: A61K9/5123 ,  A61K9/1271 ,  A61K9/1274 ,  A61K9/146 ,  A61K9/5146 ,  A61K9/5192 ,  A61K47/24 ,  A61K47/26 ,  A61K47/34 ,  A61K47/42

Abstract: A self-assembled discoidal PNA delivery vehicle includes a zwitterionic short chain diacyl lipid, a zwitterionic long chain diacyl lipid, a charged long chain diacyl lipid, a PEGylated lipid of the formula distearoyl phosphoethanolamine (DSPE)-PEGn-TG, and an encapsulated PNA molecule with a defined molar ratio of the zwitterionic long chain diacyl lipid and the charged long chain diacyl lipid to the short chain diacyl lipid, the molar ratio of the charged long chain diacyl lipid to the zwitterionic long chain diacyl lipid, molar % of the PEGylated lipid to all lipids, and ratio of PNA to lipid. Also described are method of self-assembling the discoidal PNA delivery vehicle and methods of enhancing cellular uptake of PNA using the discoidal PNA delivery vehicle.

公开(公告)号：US20230372475A1

公开(公告)日：2023-11-23

申请号：US18247962

申请日：2022-09-02

Applicant: UNIVERSITY OF CONNECTICUT ,  EASTERN VIRGINIA MEDICAL SCHOOL

Inventor： Vivek Agrahari ,  Gustavo Fabian Doncel ,  Thanh Duc Nguyen ,  Feng Lin ,  Khanh Tran ,  Onkar Nath Singh

IPC: A61K39/39 ,  A61K9/127 ,  A61K47/54 ,  A61K47/26 ,  A61K39/395 ,  A61K39/215 ,  A61K9/00

CPC classification number: A61K39/39 ,  A61K9/1272 ,  A61K47/543 ,  A61K47/26 ,  A61K39/39591 ,  A61K39/215 ,  A61K9/0021 ,  A61K2039/53

Abstract: Described herein are compositions and methods for stabilizing RNA and protein antigens for long-term storage and use in transdermal microneedle patches, methods for filling microneedles, and methods of use. A stabilized RNA vaccine composition comprises: a complex of RNA with one or more cationic polymers; and one or more cationic lipid entities. A method for stabilizing RNA comprises: forming a complex comprising the RNA with one or more cationic polymers; mixing the complex with one or more cationic lipid entities comprising liposomes or lipid nanoparticles to form a lipid mixture; and drying the lipid mixture under vacuum. The compositions and methods may be employed in the preparation of vaccine medicaments.

公开(公告)号：US20230322862A1

公开(公告)日：2023-10-12

申请号：US18165809

申请日：2023-02-07

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION ,  UNIVERSITY OF CONNECTICUT

Inventor： Ajit Vikram ,  Kaikobad Irani ,  Ravinder Reddy Gaddam ,  Raman Bahal ,  Karishma Dhuri

IPC: C07K14/00 ,  C12N15/113 ,  A61K38/00

CPC classification number: C07K14/003 ,  C12N15/113 ,  A61K38/00

Abstract: Disclosed are compounds and methods for the treatment of diseases or disorders associated with expression of miR-122. More specifically, γ peptide nucleic acid (γPNA) inhibitors of miR-122 and methods of using the same are disclosed.

公开(公告)号：US20230302433A1

公开(公告)日：2023-09-28

申请号：US18143559

申请日：2023-05-04

Applicant: University of Connecticut

Inventor： Pu-Xian Gao ,  Son Hoang

IPC: B01J21/06 ,  B01D53/86 ,  B01J23/42 ,  B01J35/00 ,  B01J35/02 ,  B01J35/04 ,  B01J35/06 ,  B01J37/02 ,  B01J37/10 ,  B01J37/34

CPC classification number: B01J21/063 ,  B01D53/865 ,  B01J23/42 ,  B01J35/0006 ,  B01J35/0013 ,  B01J35/023 ,  B01J35/04 ,  B01J35/06 ,  B01J37/0217 ,  B01J37/10 ,  B01J37/344 ,  B01D2255/1021 ,  B01D2255/20707 ,  B01D2258/012 ,  B01D2259/4566 ,  B82Y30/00

Abstract: Metal oxide nanoarrays, such as titanium oxide nanoarrays, having a platinum group metal dispersed thereon and methods of making such nanoarrays are described. The platinum group metal can be dispersed on the metal oxide nanoarray as single atoms. The nanoarrays can be used to catalyze oxidation of combustion exhaust.

公开(公告)号：US20230272405A1

公开(公告)日：2023-08-31

申请号：US18012143

申请日：2021-06-22

Applicant: University of Connecticut

Inventor： Paulo Henrique Verardi ,  Brittany Jasperse ,  Caitlin M. O’Connell ,  Yuxiang Wang

IPC: C12N15/62 ,  C07K14/005 ,  C12N15/86 ,  A61K39/12 ,  A61P31/14

CPC classification number: C12N15/625 ,  A61K39/12 ,  A61P31/14 ,  C07K14/005 ,  C12N15/86 ,  A61K2039/5258

Abstract: Disclosed herein are flavivirus signal peptide mutants useful for enhancing the production and secretion of flavivirus envelope (E) viral proteins or virus-like proteins. Also disclosed herein are methods of vaccinating subjects (e.g., human subjects) against a flavivirus comprising administering an expression vector, wherein the expression vector comprises a polynucleotide, and a fusion polypeptide comprising an engineered signal peptide and a flavivirus envelope (E) protein