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    SINGLE-PULS COHERENT ANTI-STOKES RAMAN SCATTERING MICROSCOPY AND SPECTROSCOPY
    61.
    发明申请
    SINGLE-PULS COHERENT ANTI-STOKES RAMAN SCATTERING MICROSCOPY AND SPECTROSCOPY 审中-公开
    单脉冲相干反射拉曼散射显微镜和光谱

    公开(公告)号：WO2004068126A1

    公开(公告)日：2004-08-12

    申请号：PCT/IL2004/000083

    申请日：2004-01-29

    Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY LTD. ,  SILBERBERG, Yaron ,  DUDOVICH, Nirit ,  ORON, Dan

    Inventor： SILBERBERG, Yaron ,  DUDOVICH, Nirit ,  ORON, Dan

    IPC: G01N21/65

    CPC classification number: G01N21/65 ,  G01N2021/653 ,  G01N2021/656

    Abstract: A method and system are presented for producing an output coherent anti-stokes Raman scattering (CARS) signal of a medium. The method comprises generation of a unitary optical excitation pulse that carries a pump photon, a Stokes photon and a probe photon; and inducing a CARS process in the medium by exciting the medium by the at least one such unitary optical excitation pulse. Strong coherent non resonant background, a major problem in single-pulse CARS, is reduced by orders of magnitude by using phase-only pulse shaping or completely supressed by using phase-and-polarisation shaped pulses.

    Abstract translation: 提出了一种用于产生介质的输出相干反斯托克斯拉曼散射（CARS）信号的方法和系统。 该方法包括产生携带泵浦光子，斯托克斯光子和探针光子的单一光学激发脉冲; 以及通过所述至少一个这样的整体光激励脉冲激发介质，在所述介质中引发CARS过程。 单脉冲CARS的主要问题是强相干非共振背景通过使用相位脉冲整形或通过使用相位偏振形状的脉冲完全抑制而减少数量级。

    A GUIDED RADIATION RECEIVER ASSEMBLY AND A RADIATION DELIVERY WAVEGUIDE FOR USE THEREWITH
    64.
    发明申请
    A GUIDED RADIATION RECEIVER ASSEMBLY AND A RADIATION DELIVERY WAVEGUIDE FOR USE THEREWITH 审中-公开
    指导辐射接收装置及其使用的辐射传送波形

    公开(公告)号：WO1996012979A1

    公开(公告)日：1996-05-02

    申请号：PCT/US1995013110

    申请日：1995-10-20

    Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD. ,  RYCUS, Avigail ,  YOGEV, Amnon

    Inventor： YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD. ,  RYCUS, Avigail

    IPC: G02B06/20

    CPC classification number: G02B6/032 ,  F24S23/12 ,  G02B6/26 ,  Y02E10/40

    Abstract: A transparent radiation delivery waveguide (3) and a guided radiation receiver assembly (1, 7) using the same, which assembly comprises a first transparent medium (6) with a first refraction index n1, a receiver chamber (1) having an aperture (2) and holding a second transparent medium (7) having a second refraction index n2, and the transparent radiation delivery waveguide (3) having a third refraction index n3 substantially equal to or greater than n1. The radiation delivery waveguide (3) consists of a transparent vessel (9) holding a transparent liquid medium (10) and has a first radiation intake portion in optical contact with the first transparent medium (6) and held tightly within the aperture (2) of the receiver chamber (1), and a second, tapered radiation delivery portion of non-circular cross-sectional shape, projecting into the receiver chamber (1).

    Abstract translation: 透明辐射传送波导（3）和使用其的导向辐射接收器组件（1,7），该组件包括具有第一折射率n1的第一透明介质（6），具有孔径的接收器腔室（1） 2）并且保持具有第二折射率n2的第二透明介质（7），并且具有基本上等于或大于n1的第三折射率n3的透明辐射传送波导（3）。 辐射传送波导（3）由保持透明液体介质（10）的透明容器（9）组成，并且具有与第一透明介质（6）光学接触并且紧密地保持在孔（2）内的第一辐射入口部分， 和一个非圆形横截面形状的第二锥形辐射传送部分，突出到接受腔室（1）中。

    DELIVERY OF RADIATION FROM A TRANSPARENT MEDIUM
    65.
    发明申请
    DELIVERY OF RADIATION FROM A TRANSPARENT MEDIUM 审中-公开
    从透明介质传送辐射

    公开(公告)号：WO1995029415A1

    公开(公告)日：1995-11-02

    申请号：PCT/US1995004915

    申请日：1995-04-20

    Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY LTD. ,  KARNI, Jacob ,  RIES, Horold ,  SEGAL, Akiba ,  KRUPKIN, Vladimir ,  YOGEV, Amnon

    Inventor： YEDA RESEARCH AND DEVELOPMENT COMPANY LTD.

    IPC: G02B06/26

    CPC classification number: G02B6/262 ,  F24S20/20 ,  F24S23/12 ,  G02B6/26 ,  G02B6/4298 ,  Y02E10/41

    Abstract: Extraction of guided radiation from a waveguide (3) into a receiver chamber (1). The radiation arrives via a transparent medium and is extracted into the receiver chamber (1) holding a medium having smaller refraction index than the transparent medium, via a delivery waveguide (3) whose refraction index is equal to or greater than that of the transparent medium. The delivery waveguide (3) has a tapering radiation (5) delivery portion of non-circular cross sectional shape which projects into the receiver chamber (1).

    Abstract translation: 将引导的辐射从波导（3）提取到接收器室（1）中。 辐射经由透明介质到达，并通过其折射率等于或大于透明介质的折射率的输送波导（3）被提取到保持具有比透明介质更小的折射率的介质的接收器室（1） 。 输送波导（3）具有突出到接收器室（1）中的非圆形横截面形状的锥形辐射（5）输送部分。

    INHIBITOR OF LYMPHOCYTE RESPONSE AND IMMUNE-RELATED DISEASE
    66.
    发明申请
    INHIBITOR OF LYMPHOCYTE RESPONSE AND IMMUNE-RELATED DISEASE 审中-公开
    淋巴细胞反应和免疫相关疾病的抑制剂

    公开(公告)号：WO1992004049A1

    公开(公告)日：1992-03-19

    申请号：PCT/US1991006434

    申请日：1991-09-05

    Applicant: RIJKSUNIVERSITEIT TE UTRECHT ,  YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD. ,  DE STAAT DER NEDERLANDEN vertegenwoordigd door de ,  VAN EDEN, Willem ,  WAUBEN, Marca, H.M. ,  VAN DER ZEE, Ruurd ,  BOOG, Claire, J., P. ,  COHEN, Irun, R.

    Inventor： RIJKSUNIVERSITEIT TE UTRECHT ,  YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD. ,  DE STAAT DER NEDERLANDEN vertegenwoordigd door de

    IPC: A61K39/00

    CPC classification number: C07K14/35 ,  A61K38/00 ,  C07K14/4703

    Abstract: Peptides having at least seven amino acids, preferably up to 20 amino acids, and most preferably 7 to 9 amino acids, comprising an amino acid sequence which corresponds to positions 180-186 of the Mycobacterium tuberculosis protein hsp 65 having the formula TFGLQLE, but differing therefrom by one to three amino acid substitutions in the positions 181-183, are disclosed. These peptides inhibit antigen recognition by T lymphocytes, such as recognition of hsp 65, and are capable of protecting a subject from an immune-related disease, such as autoimmune arthritis and to prevent rejection of a transplanted organ or tissue. Single amino acid substitutions, in particular with alanine, at positions corresponding to hsp 65 positions 183 and 181 are preferred. T cell lines specific for the above peptides and their use in treating or preventing immune-related disease is also disclosed.

    Abstract translation: 具有至少七个氨基酸，优选至多20个氨基酸，最优选7-9个氨基酸的肽，其包含对应于具有式TFGLQLE的结核分枝杆菌蛋白hsp65的位置180-186的氨基酸序列，但不同 公开了181-183位1-3个氨基酸取代。 这些肽抑制T淋巴细胞的抗原识别，例如hsp65的识别，并且能够保护受试者免受免疫相关疾病，例如自身免疫性关节炎，并防止移植的器官或组织的排斥。 单个氨基酸取代，特别是丙氨酸，在对应于hsp65位置183和181的位置是优选的。 还公开了对上述肽特异性的T细胞系及其在治疗或预防免疫相关疾病中的用途。

    METHOD AND SYSTEM FOR DETERMINING DEPTH PROFILING
    69.
    发明公开
    METHOD AND SYSTEM FOR DETERMINING DEPTH PROFILING 审中-公开
    方法和系统测定低调

    公开(公告)号：EP2350625A2

    公开(公告)日：2011-08-03

    申请号：EP09760620.6

    申请日：2009-10-22

    Applicant: Yeda Research And Development Company Ltd.

    Inventor： COHEN, Hagai

    IPC: G01N23/227

    CPC classification number: H01J37/26 ,  G01N23/2273 ,  G01N23/2276

    Abstract: The present invention relates to a novel system and method for the determination of depth profiling with improved accuracy and reliability. The method comprises obtaining spectroscopic data from the sample while under at least two different electrical conditions of the sample, the spectroscopic data comprising a signal of charged particles emitted from the sample, and being indicative of a change in amplitude, spectral position and spectral shape of the signal from the sample while under different electrical conditions of the sample, the change being indicative of the compositional profile and spatial distribution for at least one chemical element in the sample along a direction through the sample.

    DEVICE FOR IN SITU PRODUCTION AND TOPICAL ADMINISTRATION OF ALLICIN
    70.
    发明公开
    DEVICE FOR IN SITU PRODUCTION AND TOPICAL ADMINISTRATION OF ALLICIN 审中-公开
    DEVICE原位生产和大蒜素局部给药

    公开(公告)号：EP2276460A2

    公开(公告)日：2011-01-26

    申请号：EP09726853.6

    申请日：2009-03-26

    Applicant: Yeda Research And Development Company Ltd.

    Inventor： MIRELMAN, David ,  RABINKOV, Aharon

    IPC: A61K9/00 ,  A61K9/70 ,  A61K36/8962 ,  A61K31/255

    CPC classification number: A61K9/0036 ,  A61K9/0014 ,  A61K9/7084

    Abstract: The present invention relates to a drug delivery device that is useful for topical treatment of various infections such as skin and nail, or vaginal infections. More specifically, the invention provides a device for topical administration of allicin to an infection site, comprising either one solid carrier or two adjacent solid carriers, dry alliin and dry alliinase, wherein either a mixture of said dry alliin and dry alliinase is contained within said one solid carrier or dry alliin and dry alliinase are each separately contained within each one of said two adjacent solid carriers, whereby in contact with the infection site and a wetting agent, the alliinase acts on the alliin and allicin is produced in situ and administered to the infection site

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