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    코지산 유도체 제조 방법
    61.
    发明公开
    코지산 유도체 제조 방법 审中-实审
    制备醇酸衍生物的方法

    公开(公告)号：KR1020130026626A

    公开(公告)日：2013-03-14

    申请号：KR1020110089286

    申请日：2011-09-02

    Applicant: (주)아모레퍼시픽

    Inventor： 노호식 ,  백흥수 ,  우병영 ,  김연준 ,  신송석 ,  박영호

    IPC: C07D407/12 ,  C07D407/14 ,  A61K8/49 ,  A61Q19/02

    Abstract: PURPOSE: A method for preparing a kojic acid derivative is provided to obtain a high purity kojic acid derivative by reacting halogenated kojic acid, which is the product of substituting a halogen element for a hydroxyl group of a hydroxyl methyl group, with benzoate or cinnamate. CONSTITUTION: A method for preparing a kojic acid derivative of chemical formula 1 comprises a step of reacting halogenated kojic acid with benzoate or cinnamate under the presence of acid. In chemical formula 1, R_1 is -CH_2- or -CH_2CH_2-; and R_2 is -C(O)OCH_2- or -CH=CHC(O)OCH_2-.

    Abstract translation: 目的：提供制备曲酸衍生物的方法，通过将卤代醇酸（羟基甲基的羟基取代卤素）与苯甲酸酯或肉桂酸酯反应得到高纯度曲酸衍生物。 构成：制备化学式1的曲酸衍生物的方法包括在酸存在下使卤代曲酸与苯甲酸酯或肉桂酸酯反应的步骤。 在化学式1中，R 1是-CH 2 - 或-CH 2 CH 2 - ; 和R 2是-C（O）OCH 2 - 或-CH = CHC（O）OCH 2 - 。

    효소 처리 감태 추출물을 포함하는 피부 미백용 조성물
    62.
    发明公开
    효소 처리 감태 추출물을 포함하는 피부 미백용 조성물 审中-实审
    用于皮肤刺激的组合物，包括通过酶处理的ECKLONIA CAVA的提取物

    公开(公告)号：KR1020130017159A

    公开(公告)日：2013-02-20

    申请号：KR1020110079436

    申请日：2011-08-10

    Applicant: (주)아모레퍼시픽

    Inventor： 노호식 ,  김연준 ,  홍용덕 ,  남미희 ,  신송석 ,  박영호

    IPC: A61K8/97 ,  A61Q19/02 ,  A61K36/03 ,  A61P17/00

    Abstract: PURPOSE: A composition containing an Ecklonia cava extract treated with an enzyme and a method for manufacturing the same are provided to suppress tyrosinase and melanogenesis. CONSTITUTION: A composition for skin whitening contains 0.001-20 wt% of an Ecklonia cava extract treated with an enzyme as an active ingredient. The enzyme is a cell wall degrading enzyme including celluclast or protease including pectinase. The composition is a cosmetic composition or a pharmaceutical composition. A method for preparing the composition comprises: a step of treating Ecklonia cava with an enzyme; and a step of extracting the enzyme-treated Ecklonia cava with water, an organic solvent, or a mixture thereof.

    Abstract translation: 目的：提供含有用酶处理的Ecklonia cava提取物及其制备方法的组合物以抑制酪氨酸酶和黑素生成。 构成：用于皮肤美白的组合物含有用酶作为活性成分处理的Ecklonia cava提取物的0.001-20重量％。 酶是细胞壁降解酶，包括果胶酶或蛋白酶，包括果胶酶。 该组合物是化妆品组合物或药物组合物。 一种制备该组合物的方法包括：用酶处理Ecklonia cava的步骤; 以及用水，有机溶剂或其混合物提取经酶处理的埃克氏杆菌的一个步骤。

    신규 벤조산아미드 화합물
    63.
    发明公开
    신규 벤조산아미드 화합물 有权
    新颖的苯甲酸化合物

    公开(公告)号：KR1020130015954A

    公开(公告)日：2013-02-14

    申请号：KR1020110078309

    申请日：2011-08-05

    Applicant: (주)아모레퍼시픽

    Inventor： 주영협 ,  백흥수 ,  이창석 ,  최수정 ,  노호식 ,  박미영 ,  신송석 ,  임경민 ,  박영호

    IPC: C07C235/46 ,  C07C235/48 ,  A61K8/42 ,  A61Q19/02

    CPC classification number: A61K8/42 ,  A61Q19/00 ,  A61Q19/02 ,  C07C235/46 ,  C07C235/48 ,  C07C2603/74

    Abstract: PURPOSE: A benzoic acid amide compound is provided to have excellent a skin-whitening effect without side effects by suppressing melanin generation and decreasing tyrosinase activity. CONSTITUTION: A benzoic acid amide compound, an isomer thereof, pharmaceutically-acceptable salt thereof, a prodrug thereof, a hydrate thereof, or a solvate thereof is represented by chemical formula 1. In the chemical formula 1: each of R1, R3, and R4 is independently selected from hydrogen, hydroxy, C1-C5 alkoxy, C3-C6 cycloalkoxy, aryloxy, and C1-C15 haloalkoxy; R2 is selected from hydrogen, C1-C5 alkyl, C3-C6 cycloalkyl, aryl, and C1-C5 haloalkyl; and n is an integer from 1-5.

    Abstract translation: 目的：提供苯甲酸酰胺化合物以通过抑制黑色素产生和降低酪氨酸酶活性而具有优异的美白效果而没有副作用。 构成：化学式1表示苯甲酸酰胺化合物，其异构体，药学上可接受的盐，其前药，其水合物或其溶剂合物。在化学式1中，R1，R3和 R 4独立地选自氢，羟基，C 1 -C 5烷氧基，C 3 -C 6环烷氧基，芳氧基和C 1 -C 15卤代烷氧基; R2选自氢，C1-C5烷基，C3-C6环烷基，芳基和C1-C5卤代烷基; n为1-5的整数。

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