公开(公告)号：KR1020130065185A

公开(公告)日：2013-06-19

申请号：KR1020110131931

申请日：2011-12-09

Applicant: 대구한의대학교산학협력단

Inventor： 박성민 ,  유영은 ,  김옥아 ,  강정숙 ,  양재하 ,  김상찬

IPC: A23L3/3472

CPC classification number: A23L3/3472 ,  A23L19/00 ,  A23V2002/00 ,  A23V2250/21

Abstract: PURPOSE: A manufacturing method of a natural food additive containing a Rosa rugosa extract is provided to have an antibacterial property with respect to microorganisms separated from a polluted food. CONSTITUTION: A natural food additive contains a Rosa rugosa extract as an active ingredient. The natural food additive is a natural food preservative, a food antiseptic agent, or a food sterilizing agent. The additive shows a strong anti-biotic activity against Bacillus germ and Paenibacillus genus germ. The additive shows a strong antibiotic activity against a strain selected from the group consisting of CBB6 Bacillus circulans, CBB15 B. benzoevorans, CBB16 B. circulans, CBB3 Paenibacillus sp., and CBB5 Paenibacillus sp. The Rosa rugosa extract is obtained by extracting an extract using a solvent having 1 to 25(v/v) times the amount of a weight of dried Rosa rugosa for about 10 to 96 hours and filtering and concentrating the extract. The solvent is a lower alcohol solvent having C1 to C4 or a mixed solvent of the same and water. The extraction includes enfleurage extraction, reflux cooling extraction, ultrasonic wave extraction, or room temperature extraction.

Abstract translation: 目的：提供含有罗莎蔷薇提取物的天然食品添加剂的制造方法，以对与污染食物分离的微生物具有抗菌性。 构成：天然食品添加剂含有罗莎玫瑰提取物作为活性成分。 天然食品添加剂是天然食品防腐剂，食品防腐剂或食品消毒剂。 添加剂对芽孢杆菌和芽孢杆菌属细菌具有强烈的抗生物活性。 该添加剂显示出对选自CBB6环状芽孢杆菌，CBB15B。苯草甘蓝，CBB16B.环孢素，CBB3 Paenibacillus sp。和CBB5 Paenibacillus sp。的菌株的强抗生素活性。 通过使用具有1〜25（v / v）倍干燥的罗莎酱的重量的溶剂提取提取物约10〜96小时，并过滤并浓缩提取物来获得罗莎蔷薇提取物。 溶剂是具有C1至C4的低级醇溶剂或其混合溶剂和水。 提取包括提取提取，回流冷却提取，超声波提取或室温萃取。

公开(公告)号：KR1020130048302A

公开(公告)日：2013-05-10

申请号：KR1020110113070

申请日：2011-11-02

Applicant: 대구한의대학교산학협력단

Inventor： 박성민 ,  유영은 ,  김옥아 ,  강정숙 ,  양재하 ,  김상찬

IPC: A23L3/3472

CPC classification number: A23L3/3472 ,  A23L19/09

Abstract: PURPOSE: A method of manufacturing a plant-derived antibacterial substance that has a strong antibacterial activity against food poisoning bacteria, safe for the human body, and can be taken as food without repulsion is provided. CONSTITUTION: A natural food additive contains a pomegranate skin extract as an active ingredient. The natural food additive is a natural food preservative, a food decomposition preventing agent, or a food sterilizing agent. The additive has a strong antibacterial activity against bacillus and paenibacillus genus. The additive has a strong antibacterial activity to the strain selected from the group consisting of CBB4 Bacillus sp., CBB5 Bacillus circulans, CBB6 Bacillus sp. CBB11 Bacillus sp., CBB15B. benzoevorans, CBB16 B. circulans, CBB3 Paenibacillus sp. CBB14, and Paenibacillus sp.. The pomegranate skin extract is an extract that is extracted from the skins of fruit, stem, branch, or root of Punica granatum. The pomegranate skin extract is prepared by the following two steps: extracting the extract using a C1-C4 lower alcohol solvent or a mixed solvent of water and the same to an amount of about 1-25 times(v/v) the amount of dried pomegranate skin at room temperature for about 10-96 hours to obtain residue of the extract; and filtering and concentrating the extract.

Abstract translation: 目的：提供一种对食物中毒细菌具有强抗菌活性的植物来源的抗菌物质的制造方法，对人体安全，可作为不排斥食品的食品。 构成：天然食品添加剂含有石榴皮提取物作为活性成分。 天然食品添加剂是天然食品防腐剂，食品分解防止剂或食品消毒剂。 该添加剂对芽孢杆菌属和paenibacillus属具有很强的抗菌活性。 添加剂对选自CBB4芽孢杆菌，CBB5环状芽孢杆菌，CBB6芽孢杆菌属的菌株具有很强的抗菌活性。 CBB11芽孢杆菌，CBB15B。 苯乙草胺，CBB16 B.环孢菌素，CBB3 Paenibacillus sp。 CBB14和Paenibacillus sp ..石榴皮提取物是从Punica granatum的水果，茎，枝或根的皮肤中提取的提取物。 通过以下两个步骤制备石榴皮提取物：使用C1-C4低级醇溶剂或水的混合溶剂萃取提取物，其量为约1-25倍（v / v）的量， 石榴皮肤在室温下进行约10-96小时，以获得提取物的残留物; 并对提取物进行过滤和浓缩。

公开(公告)号：KR1020120077268A

公开(公告)日：2012-07-10

申请号：KR1020100139164

申请日：2010-12-30

Applicant: 대구한의대학교산학협력단

Inventor： 박찬익 ,  김상찬 ,  장정희 ,  안은미

IPC: A61K8/97 ,  A61Q19/02 ,  A61Q19/00

CPC classification number: A61K8/987 ,  A61Q19/02 ,  Y10S514/844

Abstract: PURPOSE: A cosmetic composition containing Urechis unicinctus extract is provided to ensure anti-inflammation and anti-aging and to prevent melanogenesis. CONSTITUTION: A cosmetic composition for anti-inflammation and anti-aging and to prevent melanogenesis contains Urechis unicinctus extract as an active ingredient. The extract is extracted using hot water or alcohol. The alcohol is ethanol. The cosmetic composition is manufactured in the form of a skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisture lotion, massage cream, nutrition cream, moisture cream, hand cream, foundation, essence, pack, soap, cleansing foam, cleansing lotion, cleansing cream, body lotion, or body cleanser.

Abstract translation: 目的：提供含有杜鹃肠杆菌提取物的化妆品组合物，以确保抗炎和抗衰老并防止黑素生成。 构成：用于抗炎和抗衰老并防止黑素生成的化妆品组合物含有乌贼属（Urechis unicinctus）提取物作为活性成分。 提取物用热水或酒精提取。 酒精是乙醇。 化妆品组合物以皮肤洗剂，皮肤柔肤剂，皮肤调色剂，收敛剂，乳液，乳液，湿润剂，按摩霜，营养霜，防湿霜，护手霜，粉底，精华，包装，肥皂，清洁剂的形式制成 泡沫，清洁乳液，清洁霜，身体乳液或身体清洁剂。

公开(公告)号：KR101146861B1

公开(公告)日：2012-05-16

申请号：KR1020100000817

申请日：2010-01-06

Applicant: 대구한의대학교산학협력단

Inventor： 김상찬 ,  최홍식 ,  박숙자 ,  이종록 ,  박원묵 ,  박상미 ,  조미정

IPC: A61K36/48 ,  A61P1/16 ,  A61P1/00

Abstract: PURPOSE: A composition containing Statholobi Caulis extract is provided to reduce H4IIE cytotoxicity induced by cadmium and to protect liver. CONSTITUTION: A pharmaceutical composition for preventing and treating liver disease contains Statholobi Caulis extract as an active ingredient. The Statholobi Caulis extract is a soluble in water including purified water, low alcohol of C1-C4, or mixture solvent thereof. A health food for preventing and treating alcoholic liver diseases contains Statholobi Caulis extract as an active ingredient. The health food is used in the form of powder, granule, tablet, capsule, or beverage.

公开(公告)号：KR1020110120633A

公开(公告)日：2011-11-04

申请号：KR1020100040121

申请日：2010-04-29

Applicant: 대구한의대학교산학협력단

Inventor： 김상찬 ,  이종록 ,  박숙자 ,  조미정 ,  박상미

IPC: A23L19/00

CPC classification number: A23L19/00 ,  A23V2250/21 ,  A23V2300/14 ,  A23V2300/24 ,  A23V2300/50

Abstract: PURPOSE: A processing method of glycyrrhizae radix having the increased content of liquiritigenin is provided to secure an optimal analysis condition for the liquiritigenin from a glycyrrhizae radix extract. CONSTITUTION: A processing method of glycyrrhizae radix having the increased content of liquiritigenin comprises the following steps: processing the glycyrrhizae radix by heating at 150-400 deg C for 1-20 minutes, by acidifying using a weak acid and alcohol mixed solution, or by combining both processes regardless of the order; extracting the glycyrrhizae radix at 0-100 deg C for 1-10 hours using a maceration extraction method, a hot water extraction method, an ultrasonic extraction method, a reflux cooling extraction method, or a heating extraction method for 1-7 times; and filtering and decompress-concentrating the extract to obtain a glycyrrhizae radix extract.

Abstract translation: 目的：提供甘草素含量增加的甘草碱的加工方法，以确保甘草提取物中甘草素的最佳分析条件。 构成：甘草素含量增加的甘草碱的加工方法包括以下步骤：通过在150-400℃加热1-20分钟，通过使用弱酸和醇混合溶液酸化或通过使用弱酸和醇混合溶液进行酸化来加工甘草 无论订单如何组合两个进程; 使用浸提法，热水提取法，超声提取法，回流冷却提取法或加热提取法，在0-100℃下将甘草提取1-10小时; 并对提取物进行过滤和减压浓缩，得到甘草提取物。

公开(公告)号：KR101059359B1

公开(公告)日：2011-08-24

申请号：KR1020080068176

申请日：2008-07-14

Applicant: 대구한의대학교산학협력단

Inventor： 이종록 ,  김상찬 ,  박숙자 ,  조미정 ,  박상미

IPC: A61K36/505

CPC classification number: Y02A50/473

Abstract: 본 발명은 약효가 증강된 현호색 추출물, 그 제조방법 및 그를 함유하는 항균용 조성물에 관한 것으로, 상세하게는 본 발명의 제조방법에 의해 수득된 현호색 추출물은 유효성분인 디하이드로코리달린(dehydrocorydaline)의 함량이 증강되어 여드름의 원인균인
P.

acnes (
Propionibacterium

acnes ) 및 충치의 원인균인 S.
mutans (
Streptococci
mutans )에 대한 증진된 항균 활성을 가지고 있으므로, 충치 및 여드름의 예방 및 치료에 유용하게 이용될 수 있다.
현호색, 디하이드로코리달린, 충치, 여드름

Abstract translation: 本发明涉及一种用于药物的抗微生物组合物增强的延胡索提取物，用（dehydrocorydaline）由本发明的制造方法得到的活性成分制造方法，以及含有它们中，特别的二氢科里的延胡索提取物的方法 痤疮引起致病菌的含量增加

公开(公告)号：KR1020090099945A

公开(公告)日：2009-09-23

申请号：KR1020080025256

申请日：2008-03-19

Applicant: 대구한의대학교산학협력단

Inventor： 김상찬 ,  박숙자 ,  이종록 ,  신정훈 ,  조미정

IPC: A61K36/31 ,  A61P3/04 ,  A61P3/06

Abstract: PURPOSE: A composition for preventing or treating hyperlipidemia or obesity, which contains Raphanus sativus L. extract is provided to significantly reduce the content of lipid, leptin, adiponecting in blood. CONSTITUTION: A pharmaceutical composition for preventing and treating hyperlipidemia or obesity contains Raphanus sativus L. extract as an active ingredient. The Raphanus sativus L. includes dried seed of Raphanus sativus var. hortensis for. raphanistroides Makino or Raphanus raphanistrum L.

Abstract translation: 目的：提供一种用于预防或治疗高脂血症或肥胖症的组合物，其含有Raphanus sativus L.提取物，以显着降低血液中脂质，瘦素，脂肪细胞的含量。 构成：用于预防和治疗高脂血症或肥胖症的药物组合物含有Raphanus sativus L.提取物作为活性成分。 Raphanus sativus L.包括Raphanus sativus var的干种子。 hortensis为。 aph ides L.（Raphanistroides Makino）或Raphanus raphanistrum L.

公开(公告)号：KR1020090068811A

公开(公告)日：2009-06-29

申请号：KR1020070136576

申请日：2007-12-24

Applicant: 대구한의대학교산학협력단

Inventor： 김상찬 ,  박숙자 ,  이종록 ,  양재하

IPC: A61K31/4745 ,  A61K36/505 ,  A61P1/02 ,  A61K8/97

CPC classification number: A61K31/4375 ,  A23L29/035 ,  A23L29/045 ,  A23V2200/312 ,  A61K8/4926 ,  A61K8/97 ,  A61K36/505 ,  A61Q11/00 ,  Y10S514/8995

Abstract: A composition containing extract of Corydalis turtschaninovii or dehydrocorydaline is provided to prevent and treat dental caries and have antibacterial effect to Streptococci mutans. A composition for preventing and treating dental caries contains 0.1-50 weight% of Corydalis turtschaninovii extract or dehydrocorydaline isolated from the extract. The extract of Corydalis turtschaninovii is obtained with water, low alcohol of C1-C4 or its mixture solvent. The extract of Corydalis turtschaninovii is extracted using lump stem, leaves, and flowers of Corydalis turtschaninovii. The composition is used in a form of tooth paste, oral cleaner or oral spray. A health functional food for preventing and improving tooth caries contains Corydalis turtschaninovii extract or dehydrocoryldaline isolated from the extract as an active ingredient. The health functional food is used in a form of powder, granule, tablet, capsule or beverage.

Abstract translation: 提供含有延胡索（Corydalis turtschaninovii）或脱氢钴胺提取物的组合物以预防和治疗龋齿并对链球菌变异链球菌具有抗菌作用。 用于预防和治疗龋齿的组合物含有0.1-50重量％的从提取物分离的延胡索提取物或脱氢卡氨酸。 用水，C1-C4的低级醇或其混合溶剂获得紫茎泽兰提取物。 紫堇提取物采用树枝茎​​，叶，花兰花提取。 组合物以牙膏，口腔清洁剂或口服喷雾剂的形式使用。 用于预防和改善龋齿的健康功能食品包含从提取物中分离的延胡索（Corydalis turtschaninovii）提取物或脱氢肌氨酸作为活性成分。 保健功能食品以粉末，颗粒，片剂，胶囊或饮料的形式使用。

公开(公告)号：KR1020090055243A

公开(公告)日：2009-06-02

申请号：KR1020070122065

申请日：2007-11-28

Applicant: 대구한의대학교산학협력단

Inventor： 김상찬 ,  박숙자 ,  이종록 ,  양재하 ,  조미정 ,  박상미 ,  박은영

IPC: A61K8/97 ,  A61Q19/00 ,  A61K36/505 ,  A61P17/10

Abstract: A composition for improving and treating acne vulgaris, which contains Corydalis turtschaninovii extract or dehydrocorydaline is provided to have antibacterial effect against propionibacterium acnes. A pharmaceutical composition of skin external preparation for improving and treating acne vulgaris comprises 0.1-50 weight% of Corydalis turtschaninovii extract or dehydrocorydaline as an active ingredient. The Corydalis turtschaninovii extract is isolated from stem, leaf, and flower of Corydalis Tuber using one or more solvent selected from water, ethanol, methanol, propanol, butanol, acetone, ethylacetate, hexane, butylenes glycol, propylene glycol and hydrous butylenes glycol, hydrous propylene glycol and hydrous glycerin. The composition is used in a form of cream, gel, patch, ointment, lotion, or cataplasma agent.

Abstract translation: 提供一种用于改善和治疗寻常痤疮的组合物，其含有延胡索提取物或脱氢卡氨酸，以对痤疮丙酸杆菌具有抗菌作用。 用于改善和治疗寻常痤疮的皮肤外用制剂的药物组合物包含0.1-50重量％的延胡索提取物或脱氢卡氨酸作为活性成分。 使用一种或多种选自水，乙醇，甲醇，丙醇，丁醇，丙酮，乙酸乙酯，己烷，丁二醇，丙二醇和含水丁二烯二醇的溶剂，分离出紫茎泽兰提取物的茎，叶和花。 丙二醇和含水甘油。 组合物以霜剂，凝胶剂，贴剂，软膏剂，洗剂或粘膜剂的形式使用。

公开(公告)号：KR100720864B1

公开(公告)日：2007-05-22

申请号：KR1020050056866

申请日：2005-06-29

Applicant: 대구한의대학교산학협력단

Inventor： 서정철 ,  임강현 ,  최호영 ,  최영주 ,  정주호 ,  신동훈 ,  최강덕 ,  양재하 ,  김상찬 ,  한상원

IPC: C12Q1/68

Abstract: 본 발명은 파이로시퀀싱(Pyrosequencing)법에 의한 당귀의 종간 유전자 감별 키트에 관한 것으로써, 상세하게는 중당귀(Angelica sinensis), 일당귀(Angelica acutiloba), 참당귀(Angelica gigas)를 파이로시퀀싱법에 의하여 유전자형을 분석하고, 당귀의 종간 특이성 시퀀싱 프라이머를 고안하여 당귀의 종간 연관성과 유전적 변이를 평가하기 위한 감별 키트에 관한 것이다. 본 발명의 감별 키트를 통하여 당귀의 종을 판별함으로써 정확한 당귀 원료를 공급할 수 있으며, 당귀의 품질관리 방법으로 활용 할 수 있다.
중당귀(Angelica sinensis), 일당귀(Angelica acutiloba), 참당귀(Angelica gigas), 파이로시퀀싱(Pyrosequencing)법, 감별 키트