Abstract:
The present invention relates to a polypeptide, which is specifically bound to Annexin A1 to inhibit function, and uses thereof. More specifically, in the present invention, provided is a pharmaceutical composition for preventing, treating and/or diagnosing diseases, which includes polypeptide bound to Annexin A1; an antagonist for the Annexin A1 including the polypeptide; the specific antibody of Annexin A1 or a piece bound to antigen thereof including the polypeptide; and the antagonist and/or the antibody or the antibody or pieces bound to antigen thereof as active ingredients.
Abstract:
The present invention relates to a fusion protein having an annexin A2 binding protein, a p53 protein, and a p18 protein bound, and to a pharmaceutical composition including the fusion protein for preventing or treating a cancer. Provided in an embodiment of the present invention is a fusion protein including an annexin A2 binding protein, a p53 protein or a fragment of the same, and a p18 protein. The fusion protein can additionally include one or more selected from the group consisting of an in vitro stabilization protein, a membrane transfer sequence (MTS) domain, a nucleus-cytoplasm signal domain, ATT, and STOPx2.