公开(公告)号：KR100673498B1

公开(公告)日：2007-01-24

申请号：KR1020050100632

申请日：2005-10-25

Applicant: 한국과학기술연구원

Inventor： 한동근 ,  안광덕 ,  정현정 ,  박귀덕

IPC: C08J9/26 ,  C08J9/00

CPC classification number: A61L27/56 ,  A61L27/18 ,  A61L27/58 ,  C08L67/04

Abstract: Provided is a method for preparing biodegradable dual pore polymer scaffolds for tissue engineering, wherein the prepared scaffold has high surface area and high porosity, and thus is effective in regenerating all biological tissues and organs. The method for preparing biodegradable dual pore polymer scaffolds for tissue engineering comprises the steps of: (1) preparing a polymer sample by leaving a polymer solution including biodegradable polymer, a fizzy mixture of carbonates and organic acids, and a solvent alone at a temperature of -196‹C to room temperature to evaporate solvent; and (2) putting the prepared polymer sample into an aqueous mixture solution of water and alcohol and expanding the sample to be dried. The polymer sample of the step (1) is obtained by dissolving the biodegradable polymer in a solvent/non-solvent mixture solution and then thereto adding the fizzy mixture to be homogeneously mixed, or dissolving the biodegradable polymer in organic solvent and then thereto adding the fizzy mixture in different sizes to be homogeneously mixed. In the solvent/non-solvent mixture solution, the solvent is an organic solvent in which the biodegradable polymer is soluble, and the non-solvent is a solvent in which the polymer is insoluble and which is miscible with only the organic solvent.

Abstract translation: 提供了一种用于组织工程制备可生物降解的双孔聚合物支架的方法，其中所制备的支架具有高表面积和高孔隙率，因此有效地再生所有生物组织和器官。 制备用于组织工程的可生物降解的双孔聚合物支架的方法包括以下步骤：（1）通过在包含可生物降解的聚合物，碳酸盐和有机酸的混合物和单独的溶剂的温度下留下聚合物溶液来制备聚合物样品 -196℃至室温以蒸发溶剂; 和（2）将制备的聚合物样品放入水和醇的混合水溶液中并使待干燥的样品膨胀。 步骤（1）的聚合物样品通过将可生物降解的聚合物溶解在溶剂/非溶剂混合溶液中，然后加入均匀混合的发泡混合物，或将可生物降解的聚合物溶解在有机溶剂中，然后加入 不同大小的混合物均匀混合。 在溶剂/非溶剂混合溶液中，溶剂是其中可生物降解聚合物可溶的有机溶剂，非溶剂是其中聚合物不溶性且仅与有机溶剂混溶的溶剂。