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    하이드록시아파타이트를 함유한 조직공학용 다공성 생분해고분자 지지체 및 이의 제조방법
    3.
    发明授权
    하이드록시아파타이트를 함유한 조직공학용 다공성 생분해고분자 지지체 및 이의 제조방법 有权
    含有组氨酸工程的羟基磷酸酯的可生物降解多孔聚合物的制备方法

    公开(公告)号：KR100794174B1

    公开(公告)日：2008-01-14

    申请号：KR1020060113227

    申请日：2006-11-16

    Applicant: 한국과학기술연구원

    Inventor： 한동근 ,  박귀덕 ,  손준식 ,  정현정

    IPC: C08J9/00 ,  C08J7/00 ,  A61L31/00

    Abstract: A method for preparing a biodegradable porous polymer scaffold having hydroxyapatite on the surface is provided to produce the biodegradable porous polymer scaffolds having improved cell affinity and osteoconductivity in a simple and effective manner. A method for preparing a biodegradable porous polymer scaffold having hydroxyapatite on the surface includes the steps of: (1) graft-polymerizing a functional group-containing hydrophilic monomer on the surface of a biodegradable porous polymer scaffold; and (2) immersing the obtained functional group-containing polymer scaffold in a simulated body fluid solution to form hydroxyapatite on the surface of the scaffold. The functional group-containing hydrophilic monomer is selected from the group consisting of organic acids having carboxylic acids at the terminals, monomers having phosphoric acids at the terminals, and mixtures thereof.

    Abstract translation: 提供了一种在表面上制备具有羟基磷灰石的可生物降解的多孔聚合物支架的方法，以简单且有效的方式制备具有改善的细胞亲和力和骨传导性的可生物降解的多孔聚合物支架。 一种在表面上制备具有羟基磷灰石的可生物降解的多孔聚合物支架的方法包括以下步骤：（1）在可生物降解的多孔聚合物支架的表面上接枝聚合含官能团的亲水单体; 和（2）将获得的含官能团的聚合物支架浸入模拟的体液溶液中以在支架的表面上形成羟基磷灰石。 含官能团的亲水性单体选自末端具有羧酸的有机酸，末端具有磷酸的单体及其混合物。

    조직공학용 생분해성 이중기공 고분자 지지체의 제조 방법
    4.
    发明授权
    조직공학용 생분해성 이중기공 고분자 지지체의 제조 방법 失效
    生物可降解双组分聚合物组合物的组织工程制备方法

    公开(公告)号：KR100673498B1

    公开(公告)日：2007-01-24

    申请号：KR1020050100632

    申请日：2005-10-25

    Applicant: 한국과학기술연구원

    Inventor： 한동근 ,  안광덕 ,  정현정 ,  박귀덕

    IPC: C08J9/26 ,  C08J9/00

    CPC classification number: A61L27/56 ,  A61L27/18 ,  A61L27/58 ,  C08L67/04

    Abstract: Provided is a method for preparing biodegradable dual pore polymer scaffolds for tissue engineering, wherein the prepared scaffold has high surface area and high porosity, and thus is effective in regenerating all biological tissues and organs. The method for preparing biodegradable dual pore polymer scaffolds for tissue engineering comprises the steps of: (1) preparing a polymer sample by leaving a polymer solution including biodegradable polymer, a fizzy mixture of carbonates and organic acids, and a solvent alone at a temperature of -196‹C to room temperature to evaporate solvent; and (2) putting the prepared polymer sample into an aqueous mixture solution of water and alcohol and expanding the sample to be dried. The polymer sample of the step (1) is obtained by dissolving the biodegradable polymer in a solvent/non-solvent mixture solution and then thereto adding the fizzy mixture to be homogeneously mixed, or dissolving the biodegradable polymer in organic solvent and then thereto adding the fizzy mixture in different sizes to be homogeneously mixed. In the solvent/non-solvent mixture solution, the solvent is an organic solvent in which the biodegradable polymer is soluble, and the non-solvent is a solvent in which the polymer is insoluble and which is miscible with only the organic solvent.

    Abstract translation: 提供了一种用于组织工程制备可生物降解的双孔聚合物支架的方法，其中所制备的支架具有高表面积和高孔隙率，因此有效地再生所有生物组织和器官。 制备用于组织工程的可生物降解的双孔聚合物支架的方法包括以下步骤：（1）通过在包含可生物降解的聚合物，碳酸盐和有机酸的混合物和单独的溶剂的温度下留下聚合物溶液来制备聚合物样品 -196℃至室温以蒸发溶剂; 和（2）将制备的聚合物样品放入水和醇的混合水溶液中并使待干燥的样品膨胀。 步骤（1）的聚合物样品通过将可生物降解的聚合物溶解在溶剂/非溶剂混合溶液中，然后加入均匀混合的发泡混合物，或将可生物降解的聚合物溶解在有机溶剂中，然后加入 不同大小的混合物均匀混合。 在溶剂/非溶剂混合溶液中，溶剂是其中可生物降解聚合物可溶的有机溶剂，非溶剂是其中聚合物不溶性且仅与有机溶剂混溶的溶剂。

    생리 활성 물질이 결합된 조직 재생용 다공성 생분해성고분자 지지체 및 이의 제조방법
    7.
    发明授权
    생리 활성 물질이 결합된 조직 재생용 다공성 생분해성고분자 지지체 및 이의 제조방법 失效
    생리활성물질이결합된조직재생용다공성생분해성고분자지지체및이의제조방생

    公开(公告)号：KR100654329B1

    公开(公告)日：2006-12-08

    申请号：KR1020050116036

    申请日：2005-11-30

    Applicant: 한국과학기술연구원

    Inventor： 한동근 ,  안광덕 ,  정현정

    IPC: C08J9/00 ,  C08J9/224

    Abstract: Provided are a porous biodegradable polymer support for the regeneration of tissue which is excellent in cell affinity such as cell adhesion and cell differentiation, and its preparation method. The porous biodegradable polymer support comprises a porous biodegradable polymer support which has a pore size of 5-500 micrometers, a surface area per unit volume of 10-20 cm^3/g and a porosity of 85-98 % and whose surface is modified with a hydrophilic monomer; and a bioactive material which is located on the surface of the porous biodegradable polymer support. Preferably the hydrophilic monomer is selected from the group consisting of acrylic acid, maleic acid, itaconic acid, aconitic acid and their mixture; and the bioactive material is a ligand peptide or a growth factor.

    Abstract translation: 本发明提供用于细胞亲和性优异的组织如细胞粘附和细胞分化的组织再生的多孔生物可降解聚合物载体及其制备方法。 多孔可生物降解聚合物载体包含多孔可生物降解聚合物载体，其孔尺寸为5-500微米，每单位体积表面积为10-20立方公分/克，孔隙率为85-98％，其表面改性 用亲水单体; 以及位于多孔生物可降解聚合物载体表面上的生物活性材料。 优选亲水性单体选自丙烯酸，马来酸，衣康酸，乌头酸及其混合物; 生物活性物质是配体肽或生长因子。

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