公开(公告)号：BR9907112A

公开(公告)日：2000-10-24

申请号：BR9907112

申请日：1999-01-23

Applicant: BASF AG

Inventor： BAUCKE DORIT ,  LAUNGE UDO ,  MACK HELMUT ,  SEITZ WERNER ,  HOFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED

IPC: A61K38/00 ,  A61P1/18 ,  A61P7/02 ,  A61P11/06 ,  A61P17/04 ,  A61P19/02 ,  A61P27/16 ,  A61P29/00 ,  C07K5/06 ,  C07K5/065 ,  A61K38/05

Abstract: Novel five-membered heterocyclic amidines, their preparation and use as competitive inhibitors of trypsin-like serine proteases, especially thrombin and kininogenases such as kallikrein. Pharmaceutical compositions which contain the compounds as active ingredients, and use of the compounds as thrombin inhibitors, anticoagulants and antiinflammatory agents.

公开(公告)号：NO20003814A

公开(公告)日：2000-07-25

申请号：NO20003814

申请日：2000-07-25

Applicant: BASF AG

Inventor： BAUCKE DORIT ,  LANGE UDO ,  MACK HELMUT ,  SEITZ WERNER ,  HOEFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED

IPC: A61K38/00 ,  A61P1/18 ,  A61P7/02 ,  A61P11/06 ,  A61P17/04 ,  A61P19/02 ,  A61P27/16 ,  A61P29/00 ,  C07K5/06 ,  C07K5/065 ,  C07K5/08 ,  A61K38/06

CPC classification number: C07K5/06191 ,  A61K38/00 ,  C07K5/06078

公开(公告)号：AT189458T

公开(公告)日：2000-02-15

申请号：AT95941015

申请日：1995-11-25

Applicant: BASF AG

Inventor： BOEHM HANS JOACHIM ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  HOEFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED ,  ZIERKE THOMAS

IPC: A61K38/00 ,  A61K38/05 ,  A61K38/55 ,  A61P7/02 ,  C07K5/06 ,  C07K5/062 ,  C07K5/065 ,  C07K5/072 ,  C07K5/087

公开(公告)号：ZA986064B

公开(公告)日：2000-01-10

申请号：ZA986064

申请日：1998-07-09

Applicant: BASF AG

Inventor： SUBKOWSKI THOMAS ,  HORNBERGER WILFRIED

IPC: A61K38/00 ,  A61K39/395 ,  A61P7/02 ,  A61P7/04 ,  A61P39/02 ,  C07K16/00 ,  C07K16/40 ,  C12N5/10 ,  C12N15/02 ,  C12P21/08 ,  G01N33/573 ,  C07K ,  A61K ,  G01N

Abstract: Ancrod-specific monoclonal antibodies, antibody fragments, mixtures or derivatives thereof are used in pharmaceutical preparations and in diagnosis. Cells which express these antibodies, antibody fragments, mixtures or derivatives thereof are also disclosed.

公开(公告)号：BG103096A

公开(公告)日：1999-09-30

申请号：BG10309699

申请日：1999-01-19

Applicant: BASF AG

Inventor： BAUCKE DORIT ,  LANGE UDO ,  MACK HELMUT ,  SEITZ WERNER ,  ZIERKE THOMAS ,  HOEFFKEN HANS W ,  HORNBERGER WILFRIED

IPC: A61K38/00 ,  A61K38/05 ,  A61P7/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  C07K5/06 ,  C07K5/062 ,  C07K5/065

Abstract: The invention relates to compounds with the formulawhere A,B,E & D have the meanings listed in the description, aswell as to their preparation. These compounds can be used for thetreatment of diseases.7 claims

公开(公告)号：SK899A3

公开(公告)日：1999-06-11

申请号：SK899

申请日：1997-07-29

Applicant: BASF AG

Inventor： BAUCKE DORIT ,  LANGE UDO ,  MACK HELMUT ,  SEITZ WERNER ,  ZIERKE THOMAS ,  HOFFKEN HANS W ,  HORNBERGER WILFRIED

IPC: A61K38/00 ,  A61K38/05 ,  A61P7/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  C07K5/06 ,  C07K5/062 ,  C07K5/065

Abstract: PCT No. PCT/EP97/04104 Sec. 371 Date Feb. 10, 1999 Sec. 102(e) Date Feb. 10, 1999 PCT Filed Jul. 29, 1997 PCT Pub. No. WO98/06741 PCT Pub. Date Feb. 19, 1998Compounds of the formula where A, B, E and D have the meanings indicated in the description, and their preparation are described. The substances are suitable for controlling diseases.

公开(公告)号：NO990667L

公开(公告)日：1999-04-12

申请号：NO990667

申请日：1999-02-12

Applicant: BASF AG

Inventor： BAUCKE DORIT ,  LANGE UDO ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  ZIERKE THOMAS ,  HOEFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED

IPC: A61K31/40 ,  A61K31/44 ,  A61K38/00 ,  A61K38/05 ,  A61P1/18 ,  A61P7/02 ,  A61P11/02 ,  A61P11/06 ,  A61P17/00 ,  A61P19/02 ,  A61P29/00 ,  A61P43/00 ,  C07D207/22 ,  C07D211/78 ,  C07K5/00 ,  C07K5/02 ,  C07K5/083

Abstract: Compounds of the formula Iwhere R, R1, R2, R3, R4, R5 and R6, and l, m and n have the meanings stated in the description, and their preparation are described. The novel compounds are suitable for controlling diseases.

公开(公告)号：NZ288591A

公开(公告)日：1999-02-25

申请号：NZ28859195

申请日：1995-06-06

Applicant: BASF AG

Inventor： BOHM HANS-JOACHIM ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  HOFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED

IPC: A61K31/40 ,  A61K38/00 ,  A61K38/05 ,  A61K38/55 ,  A61K47/48 ,  A61P7/02 ,  C07C279/00 ,  C07D205/04 ,  C07D207/06 ,  C07D207/16 ,  C07D207/48 ,  C07D211/60 ,  C07K5/06 ,  C07K5/065 ,  C07K5/072 ,  C07K5/078 ,  C07D205/00

Abstract: Compounds of the formula and the salts thereof with physiologically tolerated acids and the stereoisomers thereof, in which the substituents have the meanings stated in the description, are described. Also disclosed are intermediates for their preparation. The compounds are suitable for controlling diseases.

公开(公告)号：NO990662A

公开(公告)日：1999-02-12

申请号：NO990662

申请日：1999-02-12

Applicant: BASF AG

Inventor： BAUCKE DORIT ,  LANGE UDO ,  MACK HELMUT ,  SEITZ WERNER ,  ZIERKE THOMAS ,  HOEFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED

IPC: A61K38/00 ,  A61K38/05 ,  A61P7/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  C07K5/06 ,  C07K5/062 ,  C07K5/065

CPC classification number: C07K5/06078 ,  A61K38/00

公开(公告)号：AU8540698A

公开(公告)日：1999-02-08

申请号：AU8540698

申请日：1998-06-23

Applicant: BASF AG

Inventor： SUBKOWSKI THOMAS ,  HORNBERGER WILFRIED

IPC: A61K38/00 ,  A61K39/395 ,  A61P7/02 ,  A61P7/04 ,  A61P39/02 ,  C07K16/00 ,  C07K16/40 ,  C12N5/10 ,  C12N15/02 ,  C12P21/08 ,  G01N33/573

Abstract: Ancrod-specific monoclonal antibodies, antibody fragments, mixtures or derivatives thereof are used in pharmaceutical preparations and in diagnosis. Cells which express these antibodies, antibody fragments, mixtures or derivatives thereof are also disclosed.