公开(公告)号：JP2004043502A

公开(公告)日：2004-02-12

申请号：JP2003358317

申请日：2003-10-17

Applicant: Basf Ag ,  ビーエーエスエフ アクチェンゲゼルシャフト

Inventor： LEMAIRE HANS-GEORG ,  HILLEN HEINZ ,  MOELLER ACHIM ,  DAUM LOTHAR ,  DOERPER THOMAS ,  SUBKOWSKI THOMAS

IPC: A61K35/22 ,  A61K38/00 ,  A61P7/02 ,  A61P7/04 ,  A61P11/00 ,  A61P19/00 ,  A61P19/02 ,  A61P25/00 ,  A61P29/00 ,  A61P31/04 ,  A61P37/02 ,  A61P37/08 ,  A61P43/00 ,  C07K1/18 ,  C07K1/22 ,  C07K7/08 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/715 ,  C07K16/18

CPC classification number: C07K16/18 ,  A61K38/00 ,  C07K14/7151

Abstract: PROBLEM TO BE SOLVED: To obtain a protein which can neutralize the action of TNFα (tumor necrusis factor α).
SOLUTION: This protein has molecular weight of about 42,000 daltons measured by SDS gel electrophoresis and has at the N-terminus an amino acid sequence; Xaa Thr Pro Tyr Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Arg Glu (Xaa is H, phenylalanine residue (Phe) or an amino acid sequence; Ala Phe, Val Ala Phe, Gln Val Ala Phe, Ala Gln Val Ala Phe, Pro Ala Gln Val Ala Phe or Leu Pro Ala Gln Val Ala Phe), and a mutein is obtained by subjecting the protein having the TNFα suppressing action to a proper substitution, deletion or addition of an amino acid or peptide or the change of a glycoside group without strongly lowering the TNFα suppressing action.
COPYRIGHT: (C)2004,JPO

公开(公告)号：JP2002302500A

公开(公告)日：2002-10-18

申请号：JP2002013319

申请日：2002-01-22

Applicant: BASF AG

Inventor： LEMAIRE HANS-GEORG ,  HILLEN HEINZ ,  MOELLER ACHIM ,  DAUM LOTHAR ,  DOERPER THOMAS ,  SUBKOWSKI THOMAS

IPC: A61K35/22 ,  A61K38/00 ,  A61K38/17 ,  A61K38/19 ,  A61P7/00 ,  A61P7/02 ,  A61P7/04 ,  A61P11/00 ,  A61P19/00 ,  A61P19/02 ,  A61P19/08 ,  A61P25/00 ,  A61P29/00 ,  A61P31/04 ,  A61P37/00 ,  A61P37/02 ,  A61P37/08 ,  A61P43/00 ,  C07K1/18 ,  C07K1/22 ,  C07K7/08 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/525 ,  C07K14/715 ,  C07K16/18

Abstract: PROBLEM TO BE SOLVED: To obtain a protein which can neutralize the action of TNFα. SOLUTION: The protein has a molecular weight of about 42,000 daltons in the first glycosylated form and has at the N-terminus an amino acid sequence; Xaa Thr Pro Tyr Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Arg Glu (Xaa is H, phenylalanine residue (Phe) or an amino acid sequence; Ala Phe, Val Ala Phe, Gln Val Ala Phe, Ala Gln Val Ala Phe, Pro Ala Gln Val Ala Phe or Leu Pro Ala Gln Val Ala Phe), and the protein and a mutein obtained by the proper substitution, deletion or addition of an amino acid or peptide for/ from/or to/the protein or the change of a glycoside group without strongly lowering the action of the protein are used for suppressing the abnormal increase in the TNF-α.

公开(公告)号：WO9902564A3

公开(公告)日：1999-04-01

申请号：PCT/EP9803834

申请日：1998-06-23

Applicant: BASF AG ,  SUBKOWSKI THOMAS ,  HORNBERGER WILFRIED

Inventor： SUBKOWSKI THOMAS ,  HORNBERGER WILFRIED

IPC: A61K38/00 ,  A61K39/395 ,  A61P7/02 ,  A61P7/04 ,  A61P39/02 ,  C07K16/00 ,  C07K16/40 ,  C12N5/10 ,  C12N15/02 ,  C12P21/08 ,  G01N33/573 ,  C12N5/20 ,  G01N33/577

CPC classification number: G01N33/573 ,  A61K38/00 ,  C07K16/40 ,  G01N2333/96433

Abstract: The invention relates to ancrod specific monoclonal antibodies, antibody fragments, mixtures or derivatives thereof and the use thereof in pharmaceutical preparations or in diagnostics. The invention also relates to cells which express said antibodies, antibody fragments and mixtures or derivatives thereof.

Abstract translation: 本发明涉及ancrod特异性单克隆抗体，抗体片段，它们的混合物或衍生物及其在药物制剂或诊断中的用途。 此外，本发明涉及表达这些抗体的细胞，抗体片段，它们的混合物或衍生物。

公开(公告)号：WO2007042487A3

公开(公告)日：2007-05-31

申请号：PCT/EP2006067169

申请日：2006-10-09

Applicant: BASF AG ,  SUBKOWSKI THOMAS ,  LEMAIRE HANS-GEORG ,  KAROS MARVIN ,  HAMMER SUSAN ,  KARL JOERN ,  POSSELT DIETMAR

Inventor： SUBKOWSKI THOMAS ,  LEMAIRE HANS-GEORG ,  KAROS MARVIN ,  HAMMER SUSAN ,  KARL JOERN ,  POSSELT DIETMAR

IPC: C10L1/24 ,  C07K14/37

CPC classification number: C10L1/2475 ,  C10L1/238

Abstract: The invention relates to the use of a hydrophobin or a derivative thereof as an antifoaming agent in additive compositions or in fuels, to a method for defoaming fuels, to an additive and fuel composition containing a hydrophobin or derivative thereof and at least one additional fuel additive, and to a method for producing a fuel composition.

Abstract translation: 本发明涉及使用疏水蛋白的或作为添加剂组合物或燃料消泡剂，用于燃料，燃料和添加剂组合物，包含疏水蛋白或其衍生物和至少一种另外的燃料添加剂的消泡的方法和用于制备燃料组合物的方法其衍生物 ，

公开(公告)号：WO2006082251A3

公开(公告)日：2006-12-28

申请号：PCT/EP2006050719

申请日：2006-02-07

Applicant: BASF AG ,  SUBKOWSKI THOMAS ,  KAROS MARVIN ,  LEMAIRE HANS-GEORG ,  BARG HEIKO ,  BOLLSCHWEILER CLAUS

Inventor： SUBKOWSKI THOMAS ,  KAROS MARVIN ,  LEMAIRE HANS-GEORG ,  BARG HEIKO ,  BOLLSCHWEILER CLAUS

IPC: C07K14/37

CPC classification number: C07K14/37

Abstract: Disclosed are polypeptides of general structural formula (I) X n -C 1 -X 1-50 -C 2 -X 0-5 -C 3 -X 1-100 -C 4 -X 1-100 -C 5 -X 1-50 -C 6 -X 0-5 -C 7 -X 1-50 -C 8 -X m as well as the production and use thereof.

Abstract translation: 结构通式（I）中X _{名词 -C ^{1 X 1-50 -C 2 -X多肽 0-5 -C 3 X 1-100 -C 4 X 1-100 -C 5 X 1-50 -C 6 X 0-5 -C 7 X 1-50 -C 8 X 米，它们的制备和用途。}}

公开(公告)号：WO2006131564A3

公开(公告)日：2007-06-07

申请号：PCT/EP2006063066

申请日：2006-06-09

Applicant: BASF AG ,  SUBKOWSKI THOMAS ,  KAROS MARVIN ,  LEMAIRE HANS-GEORG ,  BARG HEIKO ,  BOLLSCHWEILER CLAUS

Inventor： SUBKOWSKI THOMAS ,  KAROS MARVIN ,  LEMAIRE HANS-GEORG ,  BARG HEIKO ,  BOLLSCHWEILER CLAUS

IPC: C07K14/37

CPC classification number: C07K14/37 ,  C07K2319/00

Abstract: The invention relates to polypeptides of general structural formula (I) X n -C 1 -X 1-50 -C 2 -X 0-5 -C 3 -X P -C 4 -X 1-100 -C 5 -X 1-50 -C 6 -X 0-5 -C 7 -X 1-50 -C 8 -X m , to their production and use thereof.

Abstract translation: 结构通式（I）中X _{名词 -C ^{1 X 1-50 -C 2 -X多肽 0-5 -C 3 X P -C 4 X 1-100 -C 5 X 1-50 -C 6 X 0-5 -C 7 X 1-50 -C 8 XM（I），它们的制备和用途。}}

公开(公告)号：WO2006082253A3

公开(公告)日：2006-12-28

申请号：PCT/EP2006050723

申请日：2006-02-07

Applicant: BASF AG ,  SUBKOWSKI THOMAS ,  KAROS MARVIN ,  BOLLSCHWEILER CLAUS ,  BAUS ULF ,  RUEDIGER PATRICK ,  LANG MICHAEL ,  MONTAG THORSTEN ,  KASPRZYK ALEXANDRA

Inventor： SUBKOWSKI THOMAS ,  KAROS MARVIN ,  BOLLSCHWEILER CLAUS ,  BAUS ULF ,  RUEDIGER PATRICK ,  LANG MICHAEL ,  MONTAG THORSTEN ,  KASPRZYK ALEXANDRA

IPC: C07K14/37

CPC classification number: C07K14/37 ,  B05D5/04 ,  B05D7/12 ,  B05D2201/02 ,  B05D2202/25 ,  B05D2203/24 ,  C03C17/28 ,  C03C2217/76 ,  C07K14/195 ,  C07K17/00 ,  C07K2319/00 ,  C14C13/00

Abstract: Disclosed are a method for coating surfaces with fusion hydrophobins at a pH value of > 4 as well as a surface comprising a coating which contains at least one fusion hydrophobin.

Abstract translation: 一种用pH> 4的融合疏水蛋白涂覆表面的方法和具有包含至少一种融合疏水蛋白的涂层的表面。

公开(公告)号：WO2006034811A3

公开(公告)日：2006-06-22

申请号：PCT/EP2005010239

申请日：2005-09-22

Applicant: BASF AG ,  KAROS MARVIN ,  SUBKOWSKI THOMAS ,  LEMAIRE HANS-GEORG ,  BOLLSCHWEILER CLAUS ,  NUESSLEIN BERNHARD ,  FISCHER REINHARD

Inventor： KAROS MARVIN ,  SUBKOWSKI THOMAS ,  LEMAIRE HANS-GEORG ,  BOLLSCHWEILER CLAUS ,  NUESSLEIN BERNHARD ,  FISCHER REINHARD

IPC: C12Q1/68 ,  C12N9/02

CPC classification number: C12N9/12 ,  A01K2267/0393

Abstract: Method for determining the regulatory properties of a genetic element, which comprises the following steps: a) introducing a DNA molecule having a DNA-I sequence whose regulatory properties are to be determined into a cell, said DNA-I sequence being linked with an additional DNA-II sequence encoding a laccase from Aspergillus nidulans in such a manner that the regulatory elements of the DNA-I sequence control expression of the laccase, b) cultivating the cells obtained in step (a) under conditions allowing expression of the laccase, c) associating the conditions selected under (b) with the regulatory properties of the DNA-I sequence.

Abstract translation: 一种确定遗传元件调控性质的方法，包括以下步骤：a）向细胞中导入具有DNA序列的DNA分子，所述DNA分子的调节特性待测定，所述DNA序列具有DNA序列; 连接编码构巢曲霉漆酶的另一DNA II序列，使得DNA I序列的调节元件控制漆酶的表达，b）在（a）中获得的细胞在 允许漆酶表达，c）将（b）中选择的条件分配给DNA-1序列的调控性质。

公开(公告)号：WO9805360A3

公开(公告)日：1998-05-07

申请号：PCT/EP9703899

申请日：1997-07-21

Applicant: BASF AG ,  KOLTER KARL ,  SUBKOWSKI THOMAS ,  RADITSCH MARTIN ,  SCHEHLMANN VOLKER

Inventor： KOLTER KARL ,  SUBKOWSKI THOMAS ,  RADITSCH MARTIN ,  SCHEHLMANN VOLKER

IPC: A61K9/02 ,  A61K9/06 ,  A61K9/10 ,  A61K9/107 ,  A61K9/14 ,  A61K9/16 ,  A61K9/20 ,  A61K9/28 ,  A61K31/78 ,  A61K33/24 ,  A61K45/06 ,  A61K47/32

CPC classification number: A61K47/32 ,  A61K9/2027 ,  A61K9/2846 ,  A61K31/78 ,  A61K33/24 ,  A61K45/06 ,  A61K2300/00

Abstract: (Meth)acrylic acid copolymers used to increase the permeability of mucous membranes contain as comonomers (meth)acrylic acid esters and/or other radically polymerisable monomers, the molar ratio between (meth)acrylic acid and comonomer varying between 99:1 and 1:99.

公开(公告)号：WO2006136607A3

公开(公告)日：2007-05-31

申请号：PCT/EP2006063485

申请日：2006-06-23

Applicant: BASF AG ,  SUBKOWSKI THOMAS ,  KAROS MARVIN ,  LEMAIRE HANS-GEORG ,  BARG HEIKO ,  BOLLSCHWEILER CLAUS

Inventor： SUBKOWSKI THOMAS ,  KAROS MARVIN ,  LEMAIRE HANS-GEORG ,  BARG HEIKO ,  BOLLSCHWEILER CLAUS

IPC: A61K8/64 ,  A61K8/65 ,  A61K8/66 ,  C07K14/375 ,  C12N15/62

CPC classification number: A61K8/64 ,  A61Q5/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/002 ,  A61Q19/004

Abstract: The invention relates to a cosmetic composition for treating materials containing keratin, mucous membranes and teeth, said composition containing at least one hydrophobin polypeptide sequence (i) X n -C 1 -X 1-50 -C 2 -X 0-5 -C 3 -X p -C 4 -X 1-100 -C 5 -X 1-50 -C 6 -X 0-5 -C 7 -X 1-50 -C 8 -X m (I).

Abstract translation: 用于处理角蛋白材料，粘膜和牙齿的化妆品组合物，其包含至少一种疏水蛋白多肽序列（I）中X _{名词 -C ^{1 X 1-50 -C 2 X 0-5 -C 3 X p -C 4 < / SUP> X 1-100 -C 5 X 1-50 -C 6 -X < SUB> 0-5 -C 7 X 1-50 -C 8 X 米（I）}}