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    62.
    发明专利
    未知

    公开(公告)号：DK212285A

    公开(公告)日：1985-11-16

    申请号：DK212285

    申请日：1985-05-14

    Applicant: BASF AG

    Inventor： ERNST HANSGEORG ,  ECKHARDT HEINZ ,  PAUST JOACHIM

    IPC: C07C67/00 ,  C07C241/00 ,  C07C245/08 ,  C07D475/14 ,  C07D ,  C07C

    Abstract: An improved process for the preparation of riboflavin by condensation of a 4,5-dimethyl-N-(D)-ribityl-2-phenylazoaniline derivative with barbituric acid in the presence of an acidic condensing agent in an organic solvent, wherein a 4,5-dimethyl-N-(D)-ribityl-2-(o-alkoxyphenylazo)-aniline of the formula IIa where R is alkyl of 1 to 4 carbon atoms, in particular methyl, is reacted with barbituric acid, as well as the novel intermediates of the formula IIa.

    63.
    发明专利
    未知

    公开(公告)号：DK212285D0

    公开(公告)日：1985-05-14

    申请号：DK212285

    申请日：1985-05-14

    Applicant: BASF AG

    Inventor： ERNST HANSGEORG ,  ECKHARDT HEINZ ,  PAUST JOACHIM

    IPC: C07C67/00 ,  C07C241/00 ,  C07C245/08 ,  C07D475/14 ,  C07D ,  C07C

    Abstract: An improved process for the preparation of riboflavin by condensation of a 4,5-dimethyl-N-(D)-ribityl-2-phenylazoaniline derivative with barbituric acid in the presence of an acidic condensing agent in an organic solvent, wherein a 4,5-dimethyl-N-(D)-ribityl-2-(o-alkoxyphenylazo)-aniline of the formula IIa where R is alkyl of 1 to 4 carbon atoms, in particular methyl, is reacted with barbituric acid, as well as the novel intermediates of the formula IIa.

    64.
    发明专利
    未知

    公开(公告)号：DD210267A5

    公开(公告)日：1984-06-06

    申请号：DD25675883

    申请日：1983-11-16

    Applicant: BASF AG

    Inventor： PAUST JOACHIM ,  LEININGER HARTMUT

    IPC: C07D307/33 ,  C07D307/60

    Abstract: Dihydro-4,4-dimethylfuran-2,3-dione is prepared by oxidation of racemic dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone by a process in which the oxidation is carried out by gradually adding powdered calcium oxide to a solution of racemic dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone and chlorine in the inert organic solvent.

    65.
    发明专利
    未知

    公开(公告)号：DK527283A

    公开(公告)日：1984-05-19

    申请号：DK527283

    申请日：1983-11-17

    Applicant: BASF AG

    Inventor： PAUST JOACHIM ,  LEININGER HARTMUT

    IPC: C07D307/33 ,  C07D307/60 ,  C07D

    Abstract: Dihydro-4,4-dimethylfuran-2,3-dione is prepared by oxidation of racemic dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone by a process in which the oxidation is carried out by gradually adding powdered calcium oxide to a solution of racemic dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone and chlorine in the inert organic solvent.

    68.
    发明专利
    未知

    公开(公告)号：DK1339705T3

    公开(公告)日：2006-10-09

    申请号：DK01990455

    申请日：2001-11-29

    Applicant: BASF AG

    Inventor： KLATT MARTIN JOCHEN ,  PAUST JOACHIM ,  NIEBEL MARKUS

    IPC: C07D339/04

    Abstract: The present invention relates to a process for the preparation of R- and S-lipoic acid and R- and S-dihydrolipoic acid comprising (a) reaction of where MS is SO 2 -R' and R and R' independently of one another are C 1 -C 6 -alkyl, C 3 -C 8 -cycloalkyl, C 3 -C 8 -cycloalkylalkyl, aryl or aralkyl, with sodium sulfide and sulfur in methanol. The invention especially relates to processes for preparing pure R- or S-dihydrolipoic acid, which is either used directly or processed further to give R- and S-lipoic acid. The process also serves for the production of pharmaceuticals. The present invention further relates to a solution of sodium sulfide trihydrate and sulfur in methanol, the sulfur being present in a molar excess over the sodium sulfide trihydrate, and a kit which comprises the solution according to the invention.

    69.
    发明专利
    未知

    公开(公告)号：BR0112848A

    公开(公告)日：2003-06-24

    申请号：BR0112848

    申请日：2001-07-24

    Applicant: BASF AG

    Inventor： KLATT MARTIN JOCHEN ,  NIEBEL MARKUS ,  PAUST JOACHIM

    IPC: A61K31/20 ,  A61P3/10 ,  C07B53/00 ,  C07C303/38 ,  C07C309/66 ,  C07C319/08 ,  C07C319/18 ,  C07C319/28 ,  C07C321/04 ,  C07C323/52 ,  C07D339/04 ,  C07D339/00

    Abstract: Processes for the preparation of R-lipoic acid or S-lipoic acid comprising a process step selected from a) distillation of dihydrolipoic acid, b) reaction of or its stereoisomer, where Ms is SO 2 -R' and R and R' independently of one another is [sic] C 1 -C 6 -alkyl, C 3 -C 8 -cycloalkyl, C 3 -C 8 -cycloalkylalkyl, aryl or aralkyl, with sodium sulfide and sulfur in ethanol and reaction with a complex hydride, (c) the extraction of a protic solution of R-dihydrolipoic acid or S-dihydrolipoic acid with organic solvents at a pH from 9 to 10, or (d) the extraction of R-dihydrolipoic acid or S-dihydrolipoic acid with organic solvents from a protic solution at a pH of 4 to 5, or a combination of one or more of steps (a) to (d), and processes for the preparation of dihydrolipoic acid and the compound 1,6,8 [lacuna] octanetriol.

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