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    METHOD FOR THE PRODUCTION OF (S)-3-METHYLAMINO-1-(THIEN-2-YL)PROPAN-1-OL
    61.
    发明专利
    METHOD FOR THE PRODUCTION OF (S)-3-METHYLAMINO-1-(THIEN-2-YL)PROPAN-1-OL 未知

    公开(公告)号：CA2493451A1

    公开(公告)日：2004-02-12

    申请号：CA2493451

    申请日：2003-07-31

    Applicant: BASF AG

    Inventor： STUERMER RAINER

    IPC: C07D333/20 ,  C07B57/00

    Abstract: The invention relates to a method for the production of enantiomer-pure (S)- 3- methylamino-1-(thien-2-yl)propan-1-ol of formula (II-S) by obtaining (S)-3- hydroxy-3-thien-2-ylproipionitril from its enantiomer mixture with the R- isomer and by subsequently reacting (S)-3-hydroxy-3-thien-2-ylpropionitril with hydrogen and methylamine in the presence of a catalyst in order to obta in (II-S).

    62.
    发明专利
    未知

    公开(公告)号：AT240932T

    公开(公告)日：2003-06-15

    申请号：AT99118428

    申请日：1999-09-17

    Applicant: BASF AG

    Inventor： STUERMER RAINER ,  KLATT MARTIN JOCHEN ,  BOERMER ARMIN ,  HOLZ JENS ,  VOSS GUDRUN

    IPC: B01J31/24 ,  C07B53/00 ,  C07B61/00 ,  C07C67/297 ,  C07C67/31 ,  C07C69/67 ,  C07C69/675 ,  C07C69/732

    Abstract: Enantiomerically pure beta -hydroxyesters (I) are prepared by asymmetric hydrogenation of a beta -hydroxyester (II) over a ruthenium complex catalyst (III) containing an optically active bidentate bis-phospholane ligand. Preparation of enantiomerically pure beta -hydroxyesters (I) involves reacting a beta -hydroxyester (II) with hydrogen in presence of a ruthenium complex catalyst of formula (III): LRuX2 (III) X = halo, acetate, allyl, methallyl, 2-phenylallyl, perchlorate, trifluoroacetate, tetrafluoroborate, hexafluoroantimonate, hexafluorophosphate, hexafluoroarsenate or trichloroacetate; L = bidentate bis-phospholane ligand of formula (A) : Y = bridging group providing 1-5C between the two P atoms; R1 = H, 1-6C alkyl, aryl, alkaryl or Si(R2)3; R2 = alkyl or aryl; m = 0 and R3 = OR4; or m = 1 and R3 = H; R4 = as R1.

    64.
    发明专利
    未知

    公开(公告)号：AT225398T

    公开(公告)日：2002-10-15

    申请号：AT99931239

    申请日：1999-07-02

    Applicant: BASF AG

    Inventor： STUERMER RAINER

    IPC: C12N9/96 ,  C08G18/32 ,  C08G18/83 ,  C12N11/02 ,  C12N11/08 ,  C12P41/00

    Abstract: Enzyme-containing polymers are prepared by an anhydrous process of direct reaction of an enzyme in organic solution with crosslinking organic compounds having terminal reactive groups. In a first step, the enzyme is reacted in an organic solvent with a bifunctional monomer such as p-phenylene diisocyanate, 4-methyl-m-phenylene diisocyanate or 4,4'-methylenebisphenyl diisocyanate, and in a second step a bifunctional amine such as N-phenylethylenediamine, 1,6-diaminohexane, N,N'-diethyl-ethylenediamine or 1,4-diaminobutane is added. The enzyme-containing polymers are used as catalysts in chemical reactions such as acylation or enantioselective acylation of alcohols.

    New butynol I esterase, for stereospecific hydrolysis or transesterification of esters, to produce optically active reaction products
    66.
    发明专利
    New butynol I esterase, for stereospecific hydrolysis or transesterification of esters, to produce optically active reaction products 未知

    公开(公告)号：DE10042892A1

    公开(公告)日：2002-03-14

    申请号：DE10042892

    申请日：2000-08-31

    Applicant: BASF AG

    Inventor： HAUER BERNHARD ,  FRIEDRICH THOMAS ,  NUEBLING CHRISTOPH ,  STUERMER RAINER

    IPC: C12N1/21 ,  C12N9/16 ,  C12P41/00 ,  C12N9/14 ,  C07K14/21 ,  C12N15/63

    Abstract: A protein (I) with butynol I esterase (BIE) activity comprising at least one of 4 partial sequence polypeptides (S1-4) and their functional equivalents, is new. A protein (I) with butynol I esterase (BIE) activity comprises at least one of 4 partial sequence polypeptides (S1-4) and their functional equivalents. Independent claims are also included for the following: (1) polynucleotides (II) that encode (I), and complementary polynucleotides and sequences that hybridize to them; (2) an expression cassette (EC) comprising at least one (II), operably linked to regulators; (3) a recombinant vector for transforming eukaryotic or prokaryotic hosts, containing (II) or EC; (4) preparation of (I) by culturing organisms that produce (I), either endogenously or after transformation; (5) (I) produced by the method in (4); Pseudomonas glumae Lu2023 (DSM 13176), or its variants or mutants; (6) microorganisms containing the vector of (4); (7) method for enantioselective ester hydrolysis or transesterification using (I); and (8) optically active alcohols, carboxylic acids or esters prepared using (I). Phe-Ile-Glu-Thr-Leu-Gly-Leu-Glu-Arg-Pro-Val-Leu-Val-Gly-His-Ser-Leu-Gl y-Gly-Ala-Ile-Ala-Leu-Ala-Val-Gly-Leu-Asp-Tyr-Pro-Glu-Arg (S1) Ile-Ala-Leu-Ile-Ala-Pro-Leu-Thr-His-Thr-Glu-Thr-Glu-Pro (S2) Gly-Gly-Gly-Met-Met-Gly-Leu-Arg-Pro-Glu-Ala-Phe-Tyr-Ala-Ala-Ser-Ser-As p-Leu-Val (S3) Ala-Ile-Asp-Ala-Ile-Phe-Ala-Pro-Glu-Pro-Val (S4)

    69.
    发明专利
    未知

    公开(公告)号：AT208786T

    公开(公告)日：2001-11-15

    申请号：AT96924832

    申请日：1996-07-01

    Applicant: BASF AG

    Inventor： FISCHER DAVID ,  LANGHAUSER FRANZ ,  STUERMER RAINER ,  KERTH JUERGEN ,  SCHWEIER GUENTHER ,  BRINTZINGER HANS-HERBERT ,  SCHMIDT KATRIN

    IPC: C07F17/00

    Abstract: PCT No. PCT/EP96/02869 Sec. 371 Date Jan. 8, 1998 Sec. 102(e) Date Jan. 8, 1998 PCT Filed Jan. 7, 1996 PCT Pub. No. WO97/03081 PCT Pub. Date Jan. 30, 1997In a process for converting the achiral meso form or the racemate of an ansa-metallocene complex or a mixture thereof into one of its enantiomers, the conversion is carried out photochemically in the presence of an enantiomerically pure auxiliary reagent.

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