公开(公告)号：GR3018521T3

公开(公告)日：1996-03-31

申请号：GR950403656

申请日：1995-12-21

Applicant: CIBA GEIGY AG

Inventor： ODINK KAREL GERRIT ,  TARCSAY LAJOS ,  BRUEGGEN JOSEF ,  WIESENDANGER WALTER ,  CERLETTI NICO ,  SORG CLEMENS ,  DEWOLF-PEETERS CHRISTIANE ,  DELABIE JAN

IPC: G01N33/53 ,  A61K38/00 ,  A61K39/395 ,  A61P29/00 ,  C07K14/435 ,  C07K14/52 ,  C07K16/00 ,  C07K16/24 ,  C07K16/30 ,  C07K19/00 ,  C12N1/21 ,  C12N15/19 ,  C12P21/00 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  C12R1/91 ,  G01N33/577 ,  A61K38/19 ,  G01N33/68

Abstract: The invention concerns polypeptides with an apparent molecular weight of around 160 kD which are mediators or precursors for mediators of inflammation, derivatives thereof such as mutants and fragments, processes for their preparation, DNAs and hybrid vectors coding for said polypeptides and derivatives and host cells transformed with such hybrid vectors, polyclonal and monoclonal antibodies specific for said polypeptides or their derivatives and antibody derivatives as well as diagnostic and therapeutic methods for inflammatory conditions and Hodgkin lymphomas.

公开(公告)号：ES2081960T3

公开(公告)日：1996-03-16

申请号：ES90810481

申请日：1990-06-26

Applicant: CIBA GEIGY AG

Inventor： ODINK KAREL GERRIT ,  TARCSAY LAJOS ,  BRUEGGEN JOSEF ,  WIESENDANGER WALTER ,  CERLETTI NICO ,  SORG CLEMENS

IPC: G01N33/53 ,  A61K38/00 ,  A61K39/395 ,  A61P29/00 ,  C07K14/435 ,  C07K14/52 ,  C07K16/00 ,  C07K16/24 ,  C07K16/30 ,  C07K19/00 ,  C12N1/21 ,  C12N15/19 ,  C12P21/00 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  C12R1/91 ,  G01N33/577 ,  A61K38/19 ,  G01N33/68

Abstract: The invention concerns polypeptides with an apparent molecular weight of around 160 kD which are mediators or precursors for mediators of inflammation, derivatives thereof such as mutants and fragments, processes for their preparation, DNAs and hybrid vectors coding for said polypeptides and derivatives and host cells transformed with such hybrid vectors, polyclonal and monoclonal antibodies specific for said polypeptides or their derivatives and antibody derivatives as well as diagnostic and therapeutic methods for inflammatory conditions and Hodgkin lymphomas.

公开(公告)号：DK0412050T3

公开(公告)日：1996-01-29

申请号：DK90810481

申请日：1990-06-26

Applicant: CIBA GEIGY AG

Inventor： TARCSAY LAJOS ,  ODINK KAREL GERRIT ,  CERLETTI NICO ,  BRUEGGEN JOSEF ,  WIESENDANGER WALTER ,  SORG CLEMENS ,  DEWOLF-PEETERS CHRISTIANE ,  DELABIE JAN

IPC: G01N33/53 ,  A61K38/00 ,  A61K39/395 ,  A61P29/00 ,  C07K14/435 ,  C07K14/52 ,  C07K16/00 ,  C07K16/24 ,  C07K16/30 ,  C07K19/00 ,  C12N1/21 ,  C12N15/19 ,  C12P21/00 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  C12R1/91 ,  G01N33/577 ,  A61K37/02 ,  G01N33/68

Abstract: The invention concerns polypeptides with an apparent molecular weight of around 160 kD which are mediators or precursors for mediators of inflammation, derivatives thereof such as mutants and fragments, processes for their preparation, DNAs and hybrid vectors coding for said polypeptides and derivatives and host cells transformed with such hybrid vectors, polyclonal and monoclonal antibodies specific for said polypeptides or their derivatives and antibody derivatives as well as diagnostic and therapeutic methods for inflammatory conditions and Hodgkin lymphomas.

公开(公告)号：NO167746C

公开(公告)日：1991-12-04

申请号：NO832691

申请日：1983-07-22

Applicant: CIBA GEIGY AG

Inventor： HARTMANN ALBERT ,  TARCSAY LAJOS ,  WACKER OSKAR ,  BASCHANG GERHARD

IPC: A61K31/70 ,  A61K38/00 ,  A61K38/14 ,  A61K38/17 ,  A61P31/12 ,  A61P35/00 ,  C07H15/00 ,  C07K1/113 ,  C07K9/00 ,  C07K14/52 ,  C07K14/53 ,  C07K14/535

Abstract: The compounds of the formula I (I) in which each of R1, R4 and R6, independently of the others, represents hydrogen or lower alkanoyl, R2 represents C1-4-alkyl, hydroxymethyl or phenyl, R3 represents hydrogen or methyl, R5 represents hydrogen or C1-3-alkyl, R7 represents C1-3-alkyl that is unsubstituted or substituted by hydroxy, mercapto or methylthio, R8 represents hydrogen or lower alkyl, X represents oxygen or the group NH, Y represents C1-4-alkylidene, and each of R9 and R10, independently of the other, represents C11-17-alkyl or C11-17-alkenyl, and their salts, have an immunostimulating activeity.

公开(公告)号：CA2020303A1

公开(公告)日：1991-01-06

申请号：CA2020303

申请日：1990-07-03

Applicant: CIBA GEIGY AG

Inventor： ODINK KAREL GERRIT ,  TARCSAY LAJOS ,  BRUEGGEN JOSEF ,  WIESENDANGER WALTER ,  CERLETTI NICO ,  SORG CLEMENS ,  DEWOLF-PEETERS CHRISTIANE ,  DELABIE JAN

IPC: G01N33/53 ,  A61K38/00 ,  A61K39/395 ,  A61P29/00 ,  C07K14/435 ,  C07K14/52 ,  C07K16/00 ,  C07K16/24 ,  C07K16/30 ,  C07K19/00 ,  C12N1/21 ,  C12N15/19 ,  C12P21/00 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  C12R1/91 ,  G01N33/577 ,  C12N5/10 ,  A61K38/19

Abstract: 4- 17645/+ Novel cytokines of the disclosure The invention concerns polypeptides with an apparent molecular weight of around 160 kD which are mediators or precursors for mediators of inflammation, derivatives thereof such as mutants and fragments, processes for their preparation, DNAs and hybrid vectors coding for said polypeptides and derivatives and host cells transformed with such hybrid vectors, polyclonal and monoclonal antibodies specific for said polypeptides or their derivatives and antibody derivatives as well as diagnostic and therapeutic methods for inflammatory conditions and Hodgkin lymphomas.

公开(公告)号：PT85849B

公开(公告)日：1990-07-31

申请号：PT8584987

申请日：1987-10-01

Applicant: CIBA GEIGY AG

Inventor： SORG CLEMENS ,  ODINK KAREL GERRIT ,  BRUGEN JOSEF ,  WIESENDANGER WALTER ,  CERLETTI NICO ,  TARCSAY LAJOS ,  CLERC ROGER

IPC: G01N33/50 ,  A61K38/00 ,  A61P29/00 ,  C07H21/04 ,  C07K1/20 ,  C07K1/22 ,  C07K14/52 ,  C07K14/54 ,  C07K14/545 ,  C07K16/00 ,  C07K16/24 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/19 ,  C12N15/85 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  C12R1/865 ,  C12R1/91 ,  G01N33/53 ,  G01N33/577 ,  A61K37/02 ,  C07K3/20 ,  C12N5/12 ,  C12N15/10 ,  C12N15/71 ,  C12N15/73 ,  G01N33/68

公开(公告)号：NO921024L

公开(公告)日：1988-04-05

申请号：NO921024

申请日：1992-03-17

Applicant: CIBA GEIGY AG

Inventor： ODINK KAREL GERRIT ,  CLERC ROGER ,  CERLETTI NICO ,  BRUEGGEN JOSEF ,  TARCSAY LAJOS ,  SORG CLEMENS ,  WIESENDANGER WALTER

IPC: C12N5/12 ,  C12N15/00 ,  C12N15/12 ,  C12P21/08 ,  G01N33/577 ,  C07K15/28

公开(公告)号：FI874287A

公开(公告)日：1988-04-04

申请号：FI874287

申请日：1987-09-30

Applicant: CIBA GEIGY AG

Inventor： ODINK KAREL GERRIT ,  CLERC ROGER ,  CERLETTI NICO ,  BRUEGGEN JOSEF ,  TARCSAY LAJOS ,  SORG CLEMENS ,  WIESENDANGER WALTER

IPC: G01N33/50 ,  A61K38/00 ,  A61P29/00 ,  C07H21/04 ,  C07K1/20 ,  C07K1/22 ,  C07K14/52 ,  C07K14/54 ,  C07K14/545 ,  C07K16/00 ,  C07K16/24 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/19 ,  C12N15/85 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  C12R1/865 ,  C12R1/91 ,  G01N33/53 ,  G01N33/577 ,  C12P

公开(公告)号：PT85849A

公开(公告)日：1987-11-01

申请号：PT8584987

申请日：1987-10-01

Applicant: CIBA GEIGY AG

Inventor： ODINK KAREL GERRIT ,  CLERO ROGER ,  CERLETTI NICO ,  BRUEGGEN JOSEF ,  WIESENDANGER WALTER ,  TARCSAY LAJOS ,  SORG CLEMENS

IPC: G01N33/50 ,  A61K38/00 ,  A61P29/00 ,  C07H21/04 ,  C07K1/20 ,  C07K1/22 ,  C07K14/52 ,  C07K14/54 ,  C07K14/545 ,  C07K16/00 ,  C07K16/24 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/19 ,  C12N15/85 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  C12R1/865 ,  C12R1/91 ,  G01N33/53 ,  G01N33/577 ,  C07K7/10

公开(公告)号：DK517787D0

公开(公告)日：1987-10-02

申请号：DK517787

申请日：1987-10-02

Applicant: CIBA GEIGY AG

Inventor： ODINK KAREL GERRIT ,  CLERC ROGER ,  CERLETTI NICO ,  BRUEGGEN JOSEF ,  TARCSAY LAJOS ,  SORG CLEMENS ,  WIESENDANGER WALTER

IPC: G01N33/50 ,  A61K38/00 ,  A61P29/00 ,  C07H21/04 ,  C07K1/20 ,  C07K1/22 ,  C07K14/52 ,  C07K14/54 ,  C07K14/545 ,  C07K16/00 ,  C07K16/24 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/19 ,  C12N15/85 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  C12R1/865 ,  C12R1/91 ,  G01N33/53 ,  G01N33/577 ,  C07K7/10 ,  C07K13/00 ,  C07K15/06 ,  C12N1/16 ,  C12N1/20 ,  C12N5/00 ,  C12N15/00