公开(公告)号：DK246878A

公开(公告)日：1978-12-04

申请号：DK246878

申请日：1978-06-02

Applicant: HOFFMANN LA ROCHE

Inventor： MONTAVON M ,  REINER R

IPC: A61K20060101 ,  A61K31/54 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07B20060101 ,  C07D20060101 ,  C07D279/08 ,  C07D499/00 ,  C07D501/04 ,  C07D501/20 ,  C07D501/36 ,  C07D501/40 ,  C07D501/46 ,  C07D

公开(公告)号：HRP930529B1

公开(公告)日：1996-12-31

申请号：HRP930529

申请日：1993-03-26

Applicant: HOFFMANN LA ROCHE

Inventor： MONTAVON M ,  REINER R

IPC: A61K31/545 ,  C07D501/22

公开(公告)号：YU45256B

公开(公告)日：1992-05-28

申请号：YU74485

申请日：1985-05-06

Applicant: HOFFMANN LA ROCHE

Inventor： MONTAVON M ,  RIENER R

IPC: C07D501/04 ,  A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07C20060101 ,  C07D20060101 ,  C07D501/00 ,  C07D501/16 ,  C07D501/22 ,  C07D501/36 ,  C07D501/46 ,  C07D501/56 ,  C07D501/60

公开(公告)号：YU40388A

公开(公告)日：1990-02-28

申请号：YU40388

申请日：1988-03-01

Applicant: HOFFMANN LA ROCHE

Inventor： KLOETZER W ,  MONTAVON M ,  MUESSNER R ,  SINGEWALD N

IPC: A61K31/415 ,  A61K31/4164 ,  C07D233/56 ,  A61K31/417 ,  A61P3/00 ,  A61P29/00 ,  C07D233/61 ,  C07D233/64 ,  C07D233/80 ,  C07D233/84 ,  C07D233/88 ,  C07D521/00

Abstract: Imidazole derivatives of the formula I wherein R1 and R2 each is lower alkyl, X is a residue of the formula R3 is hydrogen and R4 is hydrogen or lower alkyl or R3 and R4 taken together are an additional carbon-nitrogen bond; R5 is hydrogen or lower alkyl; R6 is hydrogen, lower alkyl, lower alkylthio or a residue of the formula -NR7R8; and R7 and R8 each is lower alkyl or taken together with the nitrogen atom are a 5- or 6-membered saturated heterocycle; and pharmaceutically acceptable acid addition salts thereof are described. The compounds of formula I possess valuable pharmacodynamic properties, especially inflammation-inhibiting and edema-inhibiting properties, so that they can be used for the control or prevention of illnesses, especially for the control or prevention of inflammations and edemas.

公开(公告)号：YU42485B

公开(公告)日：1988-10-31

申请号：YU123379

申请日：1979-05-25

Applicant: HOFFMANN LA ROCHE

Inventor： MONTAVON M ,  REINER R

IPC: C07D501/04 ,  A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07C20060101 ,  C07D20060101 ,  C07D501/00 ,  C07D501/16 ,  C07D501/22 ,  C07D501/36 ,  C07D501/46 ,  C07D501/56 ,  C07D501/60

公开(公告)号：YU74585A

公开(公告)日：1987-12-31

申请号：YU74585

申请日：1985-05-06

Applicant: HOFFMANN LA ROCHE

Inventor： MONTAVON M ,  REINER R

IPC: C07D501/04 ,  A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07C20060101 ,  C07D20060101 ,  C07D501/00 ,  C07D501/16 ,  C07D501/22 ,  C07D501/36 ,  C07D501/46 ,  C07D501/56 ,  C07D501/60

公开(公告)号：SE437522B

公开(公告)日：1985-03-04

申请号：SE7904682

申请日：1979-05-29

Applicant: HOFFMANN LA ROCHE

Inventor： MONTAVON M ,  REINER R

IPC: C07D501/04 ,  A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07C20060101 ,  C07D20060101 ,  C07D501/00 ,  C07D501/16 ,  C07D501/22 ,  C07D501/36 ,  C07D501/46 ,  C07D501/56 ,  C07D501/60

公开(公告)号：NZ191003A

公开(公告)日：1984-05-31

申请号：NZ19100379

申请日：1979-07-13

Applicant: HOFFMANN LA ROCHE

Inventor： MONTAVON M ,  REINER R

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D501/36 ,  C07D501/46 ,  C07D501/56 ,  C07D501

Abstract: There is presented cephalosporin derivatives which are the readily hydrolysable esters and ethers of compounds of the general formula (I) wherein R represents furyl, thienyl or phenyl optionally substituted by halogen, hydroxy, lower alkoxy or lower alkyl, R1 represents lower alkyl or aminocarbonylmethyl and X represents a group of the formula in which one of the two symbols R2 and R3 represents hydrogen and the other represents lower alkyl and R4 represents lower alkyl, as well as salts of said esters and ethers and hydrates of said esters, ethers and salts.

公开(公告)号：YU123379A

公开(公告)日：1983-04-30

申请号：YU123379

申请日：1979-05-25

Applicant: HOFFMANN LA ROCHE

Inventor： MONTAVON M ,  REINER R

IPC: C07D501/04 ,  A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07C20060101 ,  C07D20060101 ,  C07D501/00 ,  C07D501/16 ,  C07D501/22 ,  C07D501/36 ,  C07D501/46 ,  C07D501/56 ,  C07D501/60

公开(公告)号：ZA8106068B

公开(公告)日：1983-02-23

申请号：ZA8106068

申请日：1981-09-01

Applicant: HOFFMANN LA ROCHE

Inventor： MONTAVON M ,  REINER R

IPC: C07D249/12 ,  C07D ,  A61K

CPC classification number: C07D249/12