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61.发明专利
公开(公告)号：AU3544593A
公开(公告)日：1993-09-30
申请号：AU3544593
申请日：1993-03-26
Applicant: SERVIER LAB
Inventor： YOUS SAID , LESIEUR DANIEL , GUARDIOLA-LEMAITRE BEATRICE , ADAM GERARD , RENARD PIERRE , CAIGNARD DANIEL-HENRI
IPC: A61K31/135 , A61K31/16 , A61K31/215 , A61P17/00 , A61P25/00 , A61P37/00 , A61P43/00 , C07C233/05 , C07C233/58 , C07C233/60 , C07C233/63 , C07C275/24 , C07D295/10 , C07C233/08 , C07C233/47 , C07C233/48 , A61K31/495 , A61K31/535 , A61K31/03 , C07C233/16 , C07C275/26 , C07D295/15
Abstract: The invention relates to the compounds of general formula (I): in which R, R1, R2 and R3 are as defined in the description, to their optical isomers, and to their addition salts with a pharmaceutically acceptable base. Medicaments.
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公开(公告)号：PL1466604T3
公开(公告)日：2008-03-31
申请号：PL04290918
申请日：2004-04-07
Applicant: SERVIER LAB
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公开(公告)号：CA2419934C
公开(公告)日：2008-01-15
申请号：CA2419934
申请日：2001-07-16
Applicant: SERVIER LAB
Inventor： DESCAMPS-FRANCOIS CAROLE , YOUS SAID , RENARD PIERRE , DELAGRANGE PHILIPPE , LESIEUR DANIEL , BENNEJEAN CAROLINE , GUILLAUMET GERALD , VIAUD MARIE-CLAUDE , DA COSTA HERVE
IPC: C07C233/18 , C07D333/58 , A61K31/165 , A61K31/235 , A61K31/335 , A61K31/343 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/4045 , A61K31/437 , A61P3/04 , A61P3/10 , A61P15/00 , A61P25/00 , A61P25/04 , A61P25/16 , A61P25/20 , A61P25/28 , A61P35/00 , C07C209/16 , C07C231/12 , C07C233/60 , C07D209/08 , C07D209/20 , C07D307/68 , C07D307/79 , C07D307/81 , C07D333/54 , C07D471/04
Abstract: L'invention concerne les composés de formule (I): dans laquelle: B représent e un atome d'hydrogène ou un groupement COOR, CONRR', ou alkyle (C1-C6) substitué par un groupement COOR, CONRR' ou OR; G1 représente une chaîne X'- (CH2)n-X-(CH2)m-X''- dans laquelle X, X', X'', n et m sont tels que définis dans la description; Cy représente un groupement de formule (II) ou (III): ; G2 représente une chaîne alkylène telle que définie dans la description; et A représente un groupement NRCOR', NRCSR', CONRR', CSNRR', NRCONR'R'', OU NRCSNRR''.
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公开(公告)号：PT1466604E
公开(公告)日：2007-12-21
申请号：PT04290918
申请日：2004-04-07
Applicant: SERVIER LAB
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65.发明专利
公开(公告)号：PL195613B1
公开(公告)日：2007-10-31
申请号：PL34404899
申请日：1999-05-10
Applicant: SERVIER LAB
Inventor： LESIEUR DANIEL , KLUPSCH FREDERIQUE , GUILLAUMET GERALD , VIAUD MARIE-CLAUDE , LANGLOIS MICHEL , BENNEJEAN CAROLINE , RENARD PIERRE , DELAGRANGE PHILIPPE
IPC: C07C233/43 , C07D295/12 , A61K31/16 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/18 , A61K31/19 , A61K31/27 , A61K31/341 , A61K31/343 , A61K31/352 , A61K31/357 , A61K31/381 , A61K31/382 , A61K31/4025 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/4184 , A61K31/423 , A61K31/435 , A61K31/4355 , A61K31/436 , A61K31/4365 , A61K31/437 , A61K31/4402 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/4453 , A61K31/453 , A61K31/454 , A61K31/473 , A61K31/5355 , A61K31/5375 , A61K31/5377 , A61K31/55 , A61P1/00 , A61P3/06 , A61P3/10 , A61P5/02 , A61P9/00 , A61P15/08 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P35/00 , A61P43/00 , C07C233/36 , C07C233/40 , C07C233/62 , C07C233/65 , C07C237/48 , C07C271/20 , C07C271/30 , C07C275/24 , C07C275/40 , C07C311/45 , C07C311/46 , C07C317/32 , C07C323/40 , C07C323/41 , C07C323/44 , C07C323/62 , C07D207/26 , C07D207/27 , C07D209/08 , C07D209/14 , C07D209/16 , C07D209/18 , C07D209/20 , C07D209/60 , C07D209/90 , C07D213/70 , C07D221/08 , C07D221/10 , C07D233/42 , C07D233/84 , C07D235/06 , C07D235/14 , C07D261/20 , C07D295/18 , C07D307/68 , C07D307/77 , C07D307/81 , C07D307/85 , C07D307/92 , C07D311/58 , C07D311/60 , C07D311/92 , C07D319/18 , C07D319/20 , C07D333/20 , C07D333/38 , C07D333/40 , C07D333/50 , C07D333/56 , C07D333/58 , C07D333/64 , C07D333/74 , C07D335/06 , C07D335/08 , C07D401/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/12 , C07D409/06 , C07D471/04 , C07D471/14 , C07D491/04 , C07D491/048 , C07D491/052 , C07D493/04 , C07D495/04 , C07D495/14 , C07D521/00
Abstract: The invention concerns compounds of formula (I): R-A-R' wherein: A is as defined in the description; R represents a group (V), (VI), (VII) or (VIII), where E, Q, R 1 , R 2 , R 3 , v and R 4 are as defined in the description; R' represents a -(CH 2 )t-R 5 group wherein t and R 5 are as defined in the description.
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Patent Agency Ranking66.发明专利
公开(公告)号：EA008250B1
公开(公告)日：2007-04-27
申请号：EA200500720
申请日：2003-11-04
Applicant: SERVIER LAB
Inventor： POISSONNIER-DURIEUX SOPHIE , YOUS SAID , LESIEUR DANIEL , BENNEJEAN CAROLINE , DELAGRANGE PHILIPPE , RENARD PIERRE
IPC: C07C233/18 , A61K31/16 , A61K31/40 , A61P1/00 , A61P3/00 , A61P3/04 , A61P3/10 , A61P9/10 , A61P15/18 , A61P25/00 , A61P35/00 , A61P37/02 , C07C233/36 , C07C233/60 , C07D207/26 , C07D207/27
Abstract: Соединенияформулы (I)вкоторой:АпредставляетсобойгруппировкуRпредставляетсобойалкоксигруппу,Rимеетзначения, указанныев описании,рпредставляетсобой 1, 2 или 3.Лекарственныесредства.
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67.发明专利
公开(公告)号：EA007714B1
公开(公告)日：2006-12-29
申请号：EA200400409
申请日：2004-04-08
Applicant: SERVIER LAB
Inventor： POISSONNIER-DURIEUX SOPHIE , WALLEZ VALERIE , GASNEREAU ANNE , YOUS SAID , LESIEUR DANIEL , DELAGANGE PHILIPPE , RENARD PIERRE , BENNEJEAN CAROLINE , BOUTIN JEAN-ALBERT , AUDINOT VALERIE
IPC: C07D217/14 , A61K31/472 , A61P1/00 , A61P3/02 , A61P3/04 , A61P3/10 , A61P9/00 , A61P15/00 , A61P25/00 , A61P25/02 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P35/00 , A61P37/02 , A61P43/00 , C07D217/16 , C07D217/24
Abstract: Соединенияформулы (I)вкоторой n принимаетзначения 1, 2 или 3,АпредставляетсобойгруппуилигруппуX представляетсобой N или NR,Rпредставляетсобойалкокси, циклоалкилоксиилициклоалкилалкилоксигруппу. Лекарственныесредства.
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公开(公告)号：NZ539631A
公开(公告)日：2006-10-27
申请号：NZ53963103
申请日：2003-11-04
Applicant: SERVIER LAB
Inventor： POISSONNIER-DURIEUX SOPHIE , YOUS SAID , LESIEUR DANIEL , BENNEJEAN CAROLINE , DELAGRANGE PHILIPPE , RENARD PIERRE
IPC: A61P1/00 , A61P3/00 , A61P3/04 , A61P3/10 , A61P9/10 , A61P15/18 , A61P25/00 , A61P35/00 , A61P37/02 , C07C233/18 , C07C233/36 , C07C233/60 , C07D207/26 , C07D207/27 , A61K31/16 , A61K31/40 , C07C233/11 , C07D213/46 , C07D223/08
Abstract: Phenylnapthalene derivative compounds of formula (I) are disclosed, wherein the variables are as defined in the specification. Also disclosed are pharmaceutical compositions of the compounds of formula (I) for use in the manufacture of medicaments for the treatment of sleep disorders, stress, anxiety, seasonal affective disorders or severe depression, cardiovascular pathologies, pathologies of the digestive system, insomnia and fatigue due to jetlag, schizophrenia, panic attacks, melancholia, appetite disorders, obesity, insomnia, psychotic disorders, epilepsy, diabetes, Parkinson's disease, senile dementia, various disorders associated with normal or pathological ageing, migraine, memory losses, Alzheimer's disease, cerebral circulation disorders, and also sexual dysfunctions, and as inhibitors of ovulation, immunomodulators and in the treatment of cancers.
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公开(公告)号：DE69933149D1
公开(公告)日：2006-10-19
申请号：DE69933149
申请日：1999-05-10
Applicant: SERVIER LAB
Inventor： LESIEUR DANIEL , KLUPSCH FREDERIQUE , GUILLAUMET GERALD , VIAUD MARIE-CLAUDE , LANGLOIS MICHEL , BENNEJEAN CAROLINE , RENARD PIERRE , DELAGRANGE PHILIPPE
IPC: C07C233/36 , C07D295/12 , A61K31/16 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/18 , A61K31/19 , A61K31/27 , A61K31/341 , A61K31/343 , A61K31/352 , A61K31/357 , A61K31/381 , A61K31/382 , A61K31/4025 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/4184 , A61K31/423 , A61K31/435 , A61K31/4355 , A61K31/436 , A61K31/4365 , A61K31/437 , A61K31/4402 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/4453 , A61K31/453 , A61K31/454 , A61K31/473 , A61K31/5355 , A61K31/5375 , A61K31/5377 , A61K31/55 , A61P1/00 , A61P3/06 , A61P3/10 , A61P5/02 , A61P9/00 , A61P15/08 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P35/00 , A61P43/00 , C07C233/40 , C07C233/43 , C07C233/62 , C07C233/65 , C07C237/48 , C07C271/20 , C07C271/30 , C07C275/24 , C07C275/40 , C07C311/46 , C07C317/32 , C07C323/40 , C07C323/41 , C07C323/44 , C07C323/62 , C07D207/26 , C07D207/27 , C07D209/08 , C07D209/14 , C07D209/16 , C07D209/18 , C07D209/20 , C07D209/60 , C07D209/90 , C07D213/70 , C07D221/08 , C07D221/10 , C07D233/42 , C07D233/84 , C07D235/06 , C07D235/14 , C07D261/20 , C07D295/18 , C07D307/68 , C07D307/77 , C07D307/81 , C07D307/92 , C07D311/58 , C07D311/60 , C07D311/92 , C07D319/18 , C07D319/20 , C07D333/20 , C07D333/38 , C07D333/40 , C07D333/50 , C07D333/56 , C07D333/58 , C07D333/74 , C07D335/06 , C07D335/08 , C07D401/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/12 , C07D409/06 , C07D471/04 , C07D471/14 , C07D491/04 , C07D491/048 , C07D491/052 , C07D493/04 , C07D495/04 , C07D495/14 , C07D521/00
Abstract: The invention concerns compounds of formula (I): R-A-R' wherein: A is as defined in the description; R represents a group (V), (VI), (VII) or (VIII), where E, Q, R 1 , R 2 , R 3 , v and R 4 are as defined in the description; R' represents a -(CH 2 )t-R 5 group wherein t and R 5 are as defined in the description.
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公开(公告)号：DE69933147D1
公开(公告)日：2006-10-19
申请号：DE69933147
申请日：1999-05-10
Applicant: SERVIER LAB
Inventor： LESIEUR DANIEL , KLUPSCH FREDERIQUE , GUILLAUMET GERALD , VIAUD MARIE-CLAUDE , LANGLOIS MICHEL , BENNEJEAN CAROLINE , RENARD PIERRE , DELAGRANGE PHILIPPE
IPC: C07C233/43 , C07D295/12 , A61K31/16 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/18 , A61K31/19 , A61K31/27 , A61K31/341 , A61K31/343 , A61K31/352 , A61K31/357 , A61K31/381 , A61K31/382 , A61K31/4025 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/4184 , A61K31/423 , A61K31/435 , A61K31/4355 , A61K31/436 , A61K31/4365 , A61K31/437 , A61K31/4402 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/4453 , A61K31/453 , A61K31/454 , A61K31/473 , A61K31/5355 , A61K31/5375 , A61K31/5377 , A61K31/55 , A61P1/00 , A61P3/06 , A61P3/10 , A61P5/02 , A61P9/00 , A61P15/08 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P35/00 , A61P43/00 , C07C233/36 , C07C233/40 , C07C233/62 , C07C233/65 , C07C237/48 , C07C271/20 , C07C271/30 , C07C275/24 , C07C275/40 , C07C311/37 , C07C311/46 , C07C317/32 , C07C323/40 , C07C323/41 , C07C323/44 , C07C323/62 , C07D207/26 , C07D207/27 , C07D209/08 , C07D209/14 , C07D209/16 , C07D209/18 , C07D209/20 , C07D209/60 , C07D209/90 , C07D213/70 , C07D221/08 , C07D221/10 , C07D233/42 , C07D233/84 , C07D235/06 , C07D235/14 , C07D261/20 , C07D295/18 , C07D307/68 , C07D307/77 , C07D307/81 , C07D307/85 , C07D307/92 , C07D311/58 , C07D311/60 , C07D311/92 , C07D319/18 , C07D319/20 , C07D333/20 , C07D333/38 , C07D333/40 , C07D333/50 , C07D333/56 , C07D333/58 , C07D333/74 , C07D335/06 , C07D335/08 , C07D401/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/12 , C07D409/06 , C07D471/04 , C07D471/14 , C07D491/04 , C07D491/048 , C07D491/052 , C07D493/04 , C07D495/04 , C07D495/14 , C07D521/00
Abstract: The invention concerns compounds of formula (I): R-A-R' wherein: A is as defined in the description; R represents a group (V), (VI), (VII) or (VIII), where E, Q, R 1 , R 2 , R 3 , v and R 4 are as defined in the description; R' represents a -(CH 2 )t-R 5 group wherein t and R 5 are as defined in the description.
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