公开(公告)号：BR0201697A

公开(公告)日：2003-05-06

申请号：BR0201697

申请日：2002-05-14

Applicant: SERVIER LAB

Inventor： NANTEUIL GUILLAUME DE ,  PORTEVIN BERNARD ,  BENOIST ALAIN ,  LEVENS NIGEL ,  NOSJEAN OLIVIER ,  HUSSON-ROBERT BERNADETTE ,  BOULANGER MICHELLE

IPC: C07D295/10 ,  A61K31/40 ,  A61K31/426 ,  A61P3/04 ,  A61P3/08 ,  A61P3/10 ,  C07D207/16 ,  C07D277/04 ,  C07D277/06 ,  C07D295/185 ,  C07K5/02 ,  C07D207/06

Abstract: Alpha amino acid derivatives (I), their optical isomers and addition salts, are new. Alpha amino acid derivatives of formula (I), their optical isomers and addition salts, are new: A = five-membered heterocycle, optionally substituted by a cyano group; Ak = 1-6C alkylene; X = single bond or phenylene; R1, R2, R4 = H or 1-6C alkyl; Y = NR4 or CH-NO2; R3 = NO2 or CN; and provided that: (i) when Y is CH-NO2, then R3 may further be 1-6C alkyl; and (ii) when A is unsubstituted, then Ak is propylene, X is a bond, Y is NH and R3 is NO2, are excluded.

公开(公告)号：HU0204354A2

公开(公告)日：2003-04-28

申请号：HU0204354

申请日：2001-02-01

Applicant: SERVIER LAB

Inventor： BENNEJEAN CAROLINE ,  BLANC-DELMAS ELODIE ,  BOUTIN JEAN ALBERT ,  DACQUET CATHERINE ,  DEPREUX PATRICK ,  GUILLAUMET GERALD ,  LESIEUR DANIEL ,  LEVENS NIGEL ,  RENARD PIERRE ,  YOUS SAID

IPC: A61K31/423 ,  A61K31/428 ,  A61K31/437 ,  A61K31/4439 ,  A61P1/00 ,  A61P1/04 ,  A61P1/14 ,  A61P1/18 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P5/00 ,  A61P9/00 ,  A61P9/10 ,  A61P9/14 ,  A61P13/00 ,  A61P13/12 ,  A61P15/00 ,  A61P17/06 ,  A61P19/10 ,  A61P21/00 ,  A61P21/04 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07B61/00 ,  C07D263/58 ,  C07D277/68 ,  C07D417/06 ,  C07D471/04 ,  C07D498/04

Abstract: Compounds of formula (I): wherein: X represents an oxygen or a sulphur or CH 2 or R 1 and R 2 represent a hydrogen atom, or a group as defined in the description, A represents an alkylene chain as described in the description, B is as defined in the description, R 3 and R 4 represent a hydrogen atom or a group as defined in the description, D represents an optionally substituted benzene, optionally substituted pyrazine, optionally substituted pyrimidine or optionally substituted pyridazine and medicinal products containing the same which are useful in treating or preventing melatoninergic disorders.

公开(公告)号：DK1044970T3

公开(公告)日：2003-04-22

申请号：DK00401039

申请日：2000-04-14

Applicant: SERVIER LAB

Inventor： FAUCHERE JEAN-LUC ,  ORTUNO JEAN-CLAUDE ,  DUHAULT JACQUES ,  BOUTIN JEAN ALBERT ,  LEVENS NIGEL

IPC: C07D249/08 ,  A61K31/4196 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4439 ,  A61K31/501 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P9/12 ,  A61P15/00 ,  A61P15/10 ,  A61P25/00 ,  A61P25/08 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D249/12 ,  C07D249/14 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

Abstract: 1,2,4-Triazolylamino-substituted carboxamide or hydrazide derivatives (I) are new. Triazole derivatives of formula G-NH-A- CO-NH-(NH)n-W-Z (I) and their enantiomers, diastereoisomers and acid or base addition salts are new. G = 1,2,4-triazolyl group of formula (G1)-(G4); n = 0 or 1; W = CO, S, SO or SO2; Z, R1 = alkyl or (all optionally substituted) aryl, heteroaryl, aralkyl, aralkenyl, aralkynyl, heteroaralkyl, heteroaralkenyl or heteroaralkynyl; A = -A2-, -A1-A-2-, -A2-A1- or -A1-A2-A1-; A1 = alkylene; A2 = phenylene, naphthylene, cycloalkylene or heteroarylene (all optionally substituted); R = H or as Z. Alkyl or alkylene groups have 1-6C; alkenyl/alkynyl groups have 2-6C and 1-3 double/triple bonds; cycloalkylene groups have 3-6C; aryl groups are phenyl, naphthyl, biphenylyl, dihydronaphthyl or tetrahydronaphthyl; heteroaryl moieties are 5-11 membered, mono- or bicyclic and unsaturated or partially unsaturated, and contain 1-4 of O, S and N as heteroatoms; arylene or heteroarylene moieties are the divalent analogs of arylene and heteroarylene respectively; optionally substituted, in the case of aryl, aralkyl, heteroaryl and heteroaralkyl, indicates that the groups are optionall ring-substituted by 1-5 of alkyl, alkoxy, halo, OH, perhaloalkyl, NO2, NH2, mono- or dialkylamino, 1-6C acyl, CONH2, mono- or di-alkylaminocarbonyl, 1-6C acylamino, alkoxycarbonyl, CHO, COOH, SO3H, CN, aminoalkyl, mono- or dialkylaminoalkyl, thioalkyl, alkylthioalkyl, hydroxyalkyl or alkoxyalkyl; optionally substituted, in the case of phenylene, naphthylene and heteroarylene, indicates that the groups are optionally substituted by 1-3 of alkyl, alkoxy, halo, OH, perhaloalkyl, NO2, NH2, mono- or dialkylamino, 1-6C acyl, CHO, COOH, alkoxycarbonyl, CONH2, mono- or di-alkylaminocarbonyl, 1-6C acylamino or CN. An Independent claim is included for the preparation of (I).

公开(公告)号：SK8772002A3

公开(公告)日：2003-01-09

申请号：SK8772002

申请日：2002-06-18

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  FOURQUEZ JEAN-MARIE ,  LEVENS NIGEL ,  NOSJEAN OLIVIER ,  BOULANGER MICHELLE ,  HUSSON-ROBERT BERNADETTE

IPC: A61K31/16 ,  C07D295/18 ,  A61K31/397 ,  A61K31/40 ,  A61K31/403 ,  A61K31/426 ,  A61K31/4453 ,  A61K31/5375 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  C07C237/14 ,  C07D205/04 ,  C07D207/18 ,  C07D207/20 ,  C07D209/02 ,  C07D209/52 ,  C07D277/04 ,  C07D277/22 ,  C07D295/185 ,  C07C229/00

Abstract: A compound of formula (I):wherein:represents an optionally substituted saturated carbon ring having from 4 to 8 ring members,R1 and R4, which may be identical or different, each represents hydrogen or acyl,R2 and R3, which may be identical or different, each represents hydrogen or alkyl,R5 and R6, which may be identical or different, each represents hydrogen or alkyl, or R5 and R6 together, with the nitrogen atom carrying them, form an optionally substituted nitrogen-containing heterocycle,stereoisomers thereof, and also addition salts thereof with a pharmaceutically acceptable acid.Medicinal products containing the same which are useful for treatment of glucose intolerance or of disorders associated with hyperglycaemia.

公开(公告)号：SK11162002A3

公开(公告)日：2003-01-09

申请号：SK11162002

申请日：2001-02-01

Applicant: SERVIER LAB

Inventor： LESIEUR DANIEL ,  BLANC-DELMAS ELODIE ,  YOUS SAID ,  DEPREUX PATRICK ,  GUILLAUMET GERALD ,  DACQUET CATHERINE ,  LEVENS NIGEL ,  BOUTIN JEAN ALBERT ,  BENNEJEAN CAROLINE ,  RENARD PIERRE

IPC: A61K31/423 ,  A61K31/428 ,  A61K31/437 ,  A61K31/4439 ,  A61P1/00 ,  A61P1/04 ,  A61P1/14 ,  A61P1/18 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P5/00 ,  A61P9/00 ,  A61P9/10 ,  A61P9/14 ,  A61P13/00 ,  A61P13/12 ,  A61P15/00 ,  A61P17/06 ,  A61P19/10 ,  A61P21/00 ,  A61P21/04 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07B61/00 ,  C07D263/58 ,  C07D277/68 ,  C07D417/06 ,  C07D471/04 ,  C07D498/04 ,  A61K31/4353

Abstract: Compounds of formula (I): wherein: X represents an oxygen or a sulphur or CH 2 or R 1 and R 2 represent a hydrogen atom, or a group as defined in the description, A represents an alkylene chain as described in the description, B is as defined in the description, R 3 and R 4 represent a hydrogen atom or a group as defined in the description, D represents an optionally substituted benzene, optionally substituted pyrazine, optionally substituted pyrimidine or optionally substituted pyridazine and medicinal products containing the same which are useful in treating or preventing melatoninergic disorders.

公开(公告)号：BR0200982A

公开(公告)日：2002-12-31

申请号：BR0200982

申请日：2002-03-27

Applicant: SERVIER LAB

Inventor： DE NANTEUIL GUILLAUME ,  PORTEVIN BERNARD ,  BENOIST ALAIN ,  LEVENS NIGEL ,  NOSJEAN OLIVIER ,  HUSSON-ROBERT BERNADETTE

IPC: C07D295/18 ,  A61K31/40 ,  A61K31/4178 ,  A61K31/426 ,  A61K31/5377 ,  A61K38/00 ,  A61P1/00 ,  A61P1/02 ,  A61P3/04 ,  A61P3/10 ,  A61P31/18 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00 ,  C07B57/00 ,  C07D207/16 ,  C07D231/04 ,  C07D233/06 ,  C07D233/48 ,  C07D277/04 ,  C07D277/06 ,  C07D277/10 ,  C07D295/22 ,  C07D403/12 ,  C07K5/062 ,  C07K5/078 ,  C07K5/087 ,  C07K5/097 ,  C07D207/08 ,  A61P35/04

Abstract: Sulfonated amino acid derivatives (I), their optical isomers and acid addition salts, are new. Sulfonated amino acid derivatives (I), their optical isomers and acid addition salts, are new. ring A = a 5 membered nitrogen heterocycle that may be substituted by cyano; R1 = H, 1-6C alkyl or acyl, prolyl, alanyl, histidylprolyl, or phenylalanylprolyl; Ak = 1-6C alkylene or heteroalkylene; X = a bond or phenylene optionally substituted by one or more groups selected from halogens, 1-6C alkyl, alkoxy or polyhaloalkyl, or OH; R2 = 1-6C alkyl (optionally substituted by one or more groups selected from aryl, 1-6C alkylsulfonyl, 3-7C cycloalkylsulfonyl, 3-7C cycloalkyl, and halogen), 3-10C cycloalkyl, or a group -NR2aR2b; R2a and R2b = H, 1-6C alkyl, or together with the N atom they form a nitrogen heterocycle; Y = -NR3, -NH-CH=N-, -C(=NH)-NH-, or -NR4-C(=NR5)-NR6-; R3 = H, 1-6C alkyl, 3-7C cycloalkyl, or aryl; R4, R5, R6 = H, 1-6C alkyl; or R4 and R6 together, or R5 and R6 together = imidazolidine or dihydrobenzimidazole in which the term nitrogen heterocycle encompasses a monocyclic saturated ring of 5 - 7 members having 1 - 3 heteroatoms at least one of which is N and others may be N, O or S, and the term 1-6c alkylene encompasses a group that may be straight or branched and one methylene group may be replaced by an atom or O or S.

公开(公告)号：NO20022891A

公开(公告)日：2002-12-19

申请号：NO20022891

申请日：2002-06-17

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  FOURQUEZ JEAN-MARIE ,  LEVENS NIGEL ,  HUSSON-ROBERT BERNADETTE ,  NOSJEAN OLIVIER ,  BOULANGER MICHELLE

IPC: C07D295/18 ,  A61K31/16 ,  A61K31/397 ,  A61K31/40 ,  A61K31/403 ,  A61K31/426 ,  A61K31/4453 ,  A61K31/5375 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  C07C237/14 ,  C07D205/04 ,  C07D207/18 ,  C07D207/20 ,  C07D209/02 ,  C07D209/52 ,  C07D277/04 ,  C07D277/22 ,  C07D295/185 ,  C07D207/02

CPC classification number: C07C237/14 ,  C07C2601/08 ,  C07C2601/14 ,  C07D205/04 ,  C07D207/20 ,  C07D209/52 ,  C07D277/04 ,  C07D295/185

公开(公告)号：AU4882202A

公开(公告)日：2002-12-19

申请号：AU4882202

申请日：2002-06-18

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOULANGER MICHELLE ,  NOSJEAN OLIVIER ,  HUSSON-ROBERT BERNADETTE ,  LEVENS NIGEL ,  FOURQUEZ JEAN-MARIE

IPC: C07D295/18 ,  A61K31/16 ,  A61K31/397 ,  A61K31/40 ,  A61K31/403 ,  A61K31/426 ,  A61K31/4453 ,  A61K31/5375 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  C07C237/14 ,  C07D205/04 ,  C07D207/18 ,  C07D207/20 ,  C07D209/02 ,  C07D209/52 ,  C07D277/04 ,  C07D277/22 ,  C07D295/185 ,  C07D209/08

Abstract: A compound of formula (I):wherein:represents an optionally substituted saturated carbon ring having from 4 to 8 ring members,R1 and R4, which may be identical or different, each represents hydrogen or acyl,R2 and R3, which may be identical or different, each represents hydrogen or alkyl,R5 and R6, which may be identical or different, each represents hydrogen or alkyl, or R5 and R6 together, with the nitrogen atom carrying them, form an optionally substituted nitrogen-containing heterocycle,stereoisomers thereof, and also addition salts thereof with a pharmaceutically acceptable acid.Medicinal products containing the same which are useful for treatment of glucose intolerance or of disorders associated with hyperglycaemia.

公开(公告)号：PL353910A1

公开(公告)日：2002-11-18

申请号：PL35391002

申请日：2002-05-15

Applicant: SERVIER LAB

Inventor： DE NANTEUIL GUILLAUME ,  PORTEVIN BERNARD ,  BENOIST ALAIN ,  LEVENS NIGEL ,  NOSJEAN OLIVIER ,  HUSSON-ROBERT BERNADETTE ,  BOULANGER MICHELLE

IPC: A61K31/40 ,  A61K31/426 ,  A61P3/04 ,  A61P3/08 ,  C07D295/10 ,  A61P3/10 ,  C07D207/16 ,  C07D277/04 ,  C07D277/06 ,  C07D295/185 ,  C07K5/02 ,  C07D207/06 ,  A61K31/401

Abstract: Alpha amino acid derivatives (I), their optical isomers and addition salts, are new. Alpha amino acid derivatives of formula (I), their optical isomers and addition salts, are new: A = five-membered heterocycle, optionally substituted by a cyano group; Ak = 1-6C alkylene; X = single bond or phenylene; R1, R2, R4 = H or 1-6C alkyl; Y = NR4 or CH-NO2; R3 = NO2 or CN; and provided that: (i) when Y is CH-NO2, then R3 may further be 1-6C alkyl; and (ii) when A is unsubstituted, then Ak is propylene, X is a bond, Y is NH and R3 is NO2, are excluded.

公开(公告)号：NO20022285A

公开(公告)日：2002-11-18

申请号：NO20022285

申请日：2002-05-14

Applicant: SERVIER LAB

Inventor： NANTEUIL GUILLAUME DE ,  PORTEVIN BERNARD ,  BENOIST ALAIN ,  LEVENS NIGEL ,  NOSJEAN OLIVIER ,  HUSSON-ROBERT BERNADETTE ,  BOULANGER MICHELLE

IPC: C07D295/10 ,  A61K31/40 ,  A61K31/426 ,  A61P3/04 ,  A61P3/08 ,  A61P3/10 ,  C07D207/16 ,  C07D277/04 ,  C07D277/06 ,  C07D295/185 ,  C07K5/02

CPC classification number: C07D295/185 ,  C07D207/16 ,  C07D277/04 ,  C07D277/06 ,  Y02P20/55