公开(公告)号：CY2205B1

公开(公告)日：2002-11-08

申请号：CY0000060

申请日：2000-12-19

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： HANSON RONALD L ,  PATEL RAMESH N ,  SZARKA LASZLO J

IPC: C12N1/20 ,  C07D305/14 ,  C12N9/14 ,  C12N9/18 ,  C12P17/02 ,  C12Q1/04 ,  C12R1/01

Abstract: An enzymatic hydrolysis method, wherein one or more C-10 acyloxy-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups. Also provided is an enzymatic esterification method, wherein one or more C-10 hydroxyl-bearing taxanes are contacted with an acylating agent and an enzyme or microorganism capable of esterifying said hydroxyl groups to form acyloxy groups. Further provided is an enzymatic hydrolysis method, wherein one or more C-13 acyloxy-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups. The methods are especially useful for the preparation of compounds which may be employed as intermediates in the preparation of taxanes such as taxol.

公开(公告)号：PT629701E

公开(公告)日：2000-06-30

申请号：PT94108957

申请日：1994-06-10

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： PATEL RAMESH N ,  HANSON RONALD L ,  SZARKA LASZLO J

IPC: C12N1/20 ,  C07D305/14 ,  C12N9/14 ,  C12N9/18 ,  C12P17/02 ,  C12Q1/04 ,  C12R1/01

Abstract: An enzymatic hydrolysis method, wherein one or more C-10 acyloxy-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups. Also provided is an enzymatic esterification method, wherein one or more C-10 hydroxyl-bearing taxanes are contacted with an acylating agent and an enzyme or microorganism capable of esterifying said hydroxyl groups to form acyloxy groups. Further provided is an enzymatic hydrolysis method, wherein one or more C-13 acyloxy-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups. The methods are especially useful for the preparation of compounds which may be employed as intermediates in the preparation of taxanes such as taxol.

公开(公告)号：CA2342792A1

公开(公告)日：2000-03-16

申请号：CA2342792

申请日：1999-08-31

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： GOLDBERG STEVEN L ,  NANDURI VENKATA B ,  BANERJEE AMIT ,  JOHNSTON ROBERT M ,  SWAMINATHAN SHANKAR ,  ANDERSON NEAL G ,  CRISPINO GERARD ,  LUST DAVID A ,  MONIOT JEROME L ,  PATEL RAMESH N ,  WINTER WILLIAM J ,  VENIT JOHN J ,  SRIVASTAVA SUSHIL ,  SZARKA LASZLO J ,  TULLY THOMAS P

IPC: C12N15/09 ,  A61K38/00 ,  C07D513/04 ,  C07K5/062 ,  C07K5/078 ,  C07K14/81 ,  C12N1/20 ,  C12N1/21 ,  C12N9/06 ,  C12N9/10 ,  C12P17/18 ,  C12R1/01 ,  C12R1/38 ,  C12R1/465 ,  C12N15/54 ,  C12P21/00 ,  C12P21/02 ,  C07K5/06 ,  C12N5/10

Abstract: The present invention concerns an enzymatic oxidative deamination process of a dipeptide monomer to prepare an intermediate useful to prepare compounds having endopeptidase and angiotensin converting enzyme inhibition activity.

公开(公告)号：AU5252499A

公开(公告)日：2000-03-14

申请号：AU5252499

申请日：1999-08-03

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： HANSON RONALD L ,  PATEL RAMESH N

IPC: C12N9/18 ,  C07D305/14 ,  C12P15/00 ,  C12P17/02 ,  C12R1/01 ,  C12N9/00

Abstract: A process useful for the preparation of intermediates in synthesis or semi-synthesis of paclitaxel analogs wherein a starting taxane such as 10-deacetylbaccatin III is deacetylated at the C-4 position using a microorganism or an enzyme derived therefrom to provide 4-deacetyltaxanes, such as 4,10-dideacetylbaccatin III.

公开(公告)号：AT189001T

公开(公告)日：2000-02-15

申请号：AT94108957

申请日：1994-06-10

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： HANSON RONALD L ,  PATEL RAMESH N ,  SZARKA LASZLO J

IPC: C12N1/20 ,  C07D305/14 ,  C12N9/14 ,  C12N9/18 ,  C12P17/02 ,  C12Q1/04 ,  C12R1/01 ,  C12R1/365

Abstract: An enzymatic hydrolysis method, wherein one or more C-10 acyloxy-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups. Also provided is an enzymatic esterification method, wherein one or more C-10 hydroxyl-bearing taxanes are contacted with an acylating agent and an enzyme or microorganism capable of esterifying said hydroxyl groups to form acyloxy groups. Further provided is an enzymatic hydrolysis method, wherein one or more C-13 acyloxy-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups. The methods are especially useful for the preparation of compounds which may be employed as intermediates in the preparation of taxanes such as taxol.

公开(公告)号：AU1015695A

公开(公告)日：1995-07-27

申请号：AU1015695

申请日：1995-01-12

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： HANSON RONALD L ,  PATEL RAMESH N ,  SZARKA LASZLO J

IPC: C12N1/20 ,  C12N9/24 ,  C12P17/02 ,  C12P19/60 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/34 ,  C12R1/01 ,  C12R1/07 ,  C12R1/09 ,  C12R1/265 ,  C12P19/56

Abstract: An enzymatic hydrolysis method, wherein one or more C-7 sugar, preferably C-7 xylosyl-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said sugar groups to hydroxyl groups.

公开(公告)号：AU6743394A

公开(公告)日：1995-01-27

申请号：AU6743394

申请日：1994-07-13

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： PATEL RAMESH N

IPC: C07D205/08 ,  C07D405/04 ,  C12P17/04 ,  C12P17/16 ,  C12P41/00 ,  C07C229/34

Abstract: Methods for the enzymatic resolution of mixtures of enantiomers, such as beta -lactam compounds, which may be employed as intermediates in the preparation of taxanes bearing a C-13 sidechain containing a heterocyclic or cycloalkyl group, the latter useful in the pharmaceutical field.

公开(公告)号：FI943326A

公开(公告)日：1995-01-15

申请号：FI943326

申请日：1994-07-12

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： PATEL RAMESH N

IPC: C07D205/08 ,  C07D405/04 ,  C12P17/04 ,  C12P17/16 ,  C12P41/00

Abstract: Methods for the enzymatic resolution of mixtures of enantiomers, such as beta -lactam compounds, which may be employed as intermediates in the preparation of taxanes bearing a C-13 sidechain containing a heterocyclic or cycloalkyl group, the latter useful in the pharmaceutical field.

公开(公告)号：AU6478094A

公开(公告)日：1994-12-22

申请号：AU6478094

申请日：1994-06-17

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： PATEL RAMESH N ,  BANERJEE AMIT ,  MCNAMEE CLYDE ,  BRZOZOWSKI DAVID ,  SZARKA LASZLO J

IPC: C07D311/22 ,  C07D311/70 ,  C07D493/04 ,  C12P17/18 ,  C12P41/00 ,  C07D311/58

Abstract: An enzymatic process for the preparation of chiral epoxides, monohydroxy or dihydroxy compounds of formula by the stereoselective epoxidation or hydroxylation of benzopyrans of formula or resolution of compounds of formula The compounds of formula I and II are intermediates useful in the preparation of pyranyl cyanoguanidine derivatives.

公开(公告)号：CZ303884B6

公开(公告)日：2013-06-12

申请号：CZ2003758

申请日：2001-07-20

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： PATEL RAMESH N ,  CHU LINDA

IPC: C12P7/02 ,  C12P13/02 ,  C07D301/26 ,  C07D303/36 ,  C12P13/00 ,  C12R1/01 ,  C12S99/00

Abstract: Stereoselektivní zpusob prípravy (3S,2R)-1-halogen-2-hydroxy-3-(chránených)amino-4-substituovaných butanu vzorce I, kde Hal je halogen, R je vybrán ze skupiny sestávající z alkylu, substituovaného alkylu, arylu a substituovaného arylu a R.sub.1.n. je chránicí skupina aminové funkcní skupiny, pri nemz se (3S)-1-halogen-2-oxo-3-(chránený)amino-4-substituovaný butan vzorce II, kde Hal, R a R.sub.1.n. mají výse uvedený význam, uvádí do styku s mikroorganismem schopným katalyzovat stereoselektivní redukci slouceniny vzorce II, vybraným ze skupiny sestávající z Rhodococcus erythropolis ATCC 4277, Rhodococcus erythropolis DSM 6971 a Rhodococcus sp. ATCC 21227, Rhodococcus erythropolis ATCC 27854 a Brevi-bacterium sp. ATCC 19653 za takových podmínek, ze se uskutecní redukce a získá se uvedená sloucenina vzorce I.