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    ENZYMATIC DEPROTECTION OF AMINES AND HYDROXIDES
    2.
    发明申请
    ENZYMATIC DEPROTECTION OF AMINES AND HYDROXIDES 审中-公开
    氨基酸和羟基的酶促抑制

    公开(公告)号：WO02053724A3

    公开(公告)日：2003-01-16

    申请号：PCT/US0149115

    申请日：2001-12-18

    Applicant: SQUIBB BRISTOL MYERS CO ,  PATEL RAMESH ,  BRZOZOWSKI DAVID ,  NANDURI VENKATA B

    Inventor： PATEL RAMESH ,  BRZOZOWSKI DAVID ,  NANDURI VENKATA B

    IPC: C12Q1/04 ,  C12N1/00 ,  C12N1/20 ,  C12P13/00 ,  C12P13/04 ,  C12P17/00 ,  C12P17/10 ,  C12P41/00 ,  C12R1/01 ,  C12N9/78

    CPC classification number: C12P41/007 ,  C12P17/00 ,  C12P17/10 ,  C12P41/004

    Abstract: Provided is a method of deprotecting a hydroxide or amine protected with a group of formula ArC (R)H-(CH2)n-O-C(=O)- where the substituents are as described below, the method comprising: contacting the protected hydroxide or amine with an enzyme effective to remove the protecting group; and recovering the amine. Also provided is a method of isolating a bacteria producing an enzyme effective to remove a protecting group comprising: growing prospective bacteria on a medium having a growth selective amount of an amine compound that is protected as above; and isolating bacteria that grow on said medium.

    Abstract translation: 本发明提供了用下式所示保护的氢氧化物或胺基（H）（R）H（CH 2）n OC（= O） - 基取代的方法，其中取代基如下所述，该方法包括：使被保护的氢氧化物 或胺与有效去除保护基团的酶反应; 并回收胺。 还提供了分离产生有效去除保护基团的酶的细菌的方法，包括：在具有生长选择量的如上所述保护的胺化合物的培养基上培养未来细菌; 并分离在所述培养基上生长的细菌。

    PICHIA PASTORIS FORMATE DEHYDROGENASE AND USES THEREFOR
    3.
    发明申请
    PICHIA PASTORIS FORMATE DEHYDROGENASE AND USES THEREFOR 审中-公开
    PICHIA PASTORIS FORMATE DEHYDROGENASE及其用途

    公开(公告)号：WO03054155A2

    公开(公告)日：2003-07-03

    申请号：PCT/US0240235

    申请日：2002-12-16

    Applicant: SQUIBB BRISTOL MYERS CO ,  GOLDBERG STEVEN L ,  CINO PAUL M ,  PATEL RAMESH N ,  NANDURI VENKATA B ,  JOHNSTON ROBERT M

    Inventor： GOLDBERG STEVEN L ,  CINO PAUL M ,  PATEL RAMESH N ,  NANDURI VENKATA B ,  JOHNSTON ROBERT M

    IPC: C12N9/02 ,  C12P21/04 ,  C12Q1/26 ,  C12N

    CPC classification number: C12N9/0004 ,  C12Q1/26 ,  G01N2333/04

    Abstract: This invention relates to a recombinant Pichia pastoris formate dehydrogenase (FDH) enzyme that catalyzes the oxidation of formate to carbon dioxide and the simultaneous reduction of nicotinamide adenine dinucleotide (NAD+) to its reduced form (NADH). Also related are isolated nucleic acids encoding P. pastoris FDH polypeptides, and fragments and variants thereof, as well as vectors and host cells comprising these nucleic acids. Further related are isolated, recombinant P. pastoris FDH polypeptides, and fragments and variants thereof, and antibodies that specifically bind to P. pastoris FDH polypeptides, fragments, or variants. The invention also relates to methods of obtaining isolated P. pastoris FDH nucleic acids, polypeptides, and antibodies, and methods of using P. pastoris FDH in various reactions for industrial or pharmaceutical applications.

    Abstract translation: 本发明涉及催化甲酸氧化成二氧化碳并同时将烟酰胺腺嘌呤二核苷酸（NAD +）还原为还原形式（NADH）的重组巴斯德毕赤酵母甲酸脱氢酶（FDH）酶。 还涉及编码巴斯德毕赤酵母多肽的分离的核酸及其片段和变体，以及包含这些核酸的载体和宿主细胞。 进一步相关的是分离的，重组的巴斯德毕赤酵母多肽，及其片段和变体，以及特异性结合巴斯德毕赤酵母多肽，片段或变体的抗体。 本发明还涉及获得分离的巴斯德毕赤氏酵母多肽和多肽的抗体的方法，以及在工业或制药的各种反应中使用巴斯德毕赤酵母多肽的方法 应用。

    PICHIA PASTORIS FORMATE DEHYDROGENASE AND USES THEREFOR
    4.
    发明公开
    PICHIA PASTORIS FORMATE DEHYDROGENASE AND USES THEREFOR 审中-公开
    从毕赤酵母甲酸脱氢酶及其用途

    公开(公告)号：EP1463807A4

    公开(公告)日：2006-04-12

    申请号：EP02794274

    申请日：2002-12-16

    Applicant: SQUIBB BRISTOL MYERS CO

    Inventor： GOLDBERG STEVEN L ,  CINO PAUL M ,  PATEL RAMESH N ,  NANDURI VENKATA B ,  JOHNSTON ROBERT M

    IPC: C12N9/02 ,  C12P21/04 ,  C12Q1/26 ,  C12N9/04 ,  C07H21/04 ,  C12N1/20 ,  C12N15/00

    CPC classification number: C12N9/0004 ,  C12Q1/26 ,  G01N2333/04

    Abstract: This invention relates to a recombinant Pichia pastoris formate dehydrogenase (FDH) enzyme that catalyzes the oxidation of formate to carbon dioxide and the simultaneous reduction of nicotinamide adenine dinucleotide (NAD+) to its reduced form (NADH). Also related are isolated nucleic acids encoding P. pastoris FDH polypeptides, and fragments and variants thereof, as well as vectors and host cells comprising these nucleic acids. Further related are isolated, recombinant P. pastoris FDH polypeptides, and fragments and variants thereof, and antibodies that specifically bind to P. pastoris FDH polypeptides, fragments, or variants. The invention also relates to methods of obtaining isolated P. pastoris FDH nucleic acids, polypeptides, and antibodies, and methods of using P. pastoris FDH in various reactions for industrial or pharmaceutical applications.

    Pichia pastoris formate dehydrogenase and uses therefor
    7.
    发明专利
    Pichia pastoris formate dehydrogenase and uses therefor 未知

    公开(公告)号：AU2002359721A8

    公开(公告)日：2003-07-09

    申请号：AU2002359721

    申请日：2002-12-16

    Applicant: SQUIBB BRISTOL MYERS CO

    Inventor： GOLDBERG STEVEN L ,  NANDURI VENKATA B ,  CINO PAUL M ,  PATEL RAMESH N ,  JOHNSTON ROBERT M

    IPC: C12N9/02 ,  C12P21/04 ,  C12Q1/26 ,  C12N9/04 ,  C12N1/20 ,  C12N15/00 ,  C07H21/04

    Abstract: This invention relates to a recombinant Pichia pastoris formate dehydrogenase (FDH) enzyme that catalyzes the oxidation of formate to carbon dioxide and the simultaneous reduction of nicotinamide adenine dinucleotide (NAD+) to its reduced form (NADH). Also related are isolated nucleic acids encoding P. pastoris FDH polypeptides, and fragments and variants thereof, as well as vectors and host cells comprising these nucleic acids. Further related are isolated, recombinant P. pastoris FDH polypeptides, and fragments and variants thereof, and antibodies that specifically bind to P. pastoris FDH polypeptides, fragments, or variants. The invention also relates to methods of obtaining isolated P. pastoris FDH nucleic acids, polypeptides, and antibodies, and methods of using P. pastoris FDH in various reactions for industrial or pharmaceutical applications.

    PICHIA PASTORIS FORMATE DEHYDROGENASE AND USES THEREFOR
    10.
    发明专利
    PICHIA PASTORIS FORMATE DEHYDROGENASE AND USES THEREFOR 未知

    公开(公告)号：AU2002359721A1

    公开(公告)日：2003-07-09

    申请号：AU2002359721

    申请日：2002-12-16

    Applicant: SQUIBB BRISTOL MYERS CO

    Inventor： GOLDBERG STEVEN L ,  CINO PAUL M ,  PATEL RAMESH N ,  NANDURI VENKATA B ,  JOHNSTON ROBERT M

    IPC: C12N9/02 ,  C12P21/04 ,  C12Q1/26

    Abstract: This invention relates to a recombinant Pichia pastoris formate dehydrogenase (FDH) enzyme that catalyzes the oxidation of formate to carbon dioxide and the simultaneous reduction of nicotinamide adenine dinucleotide (NAD+) to its reduced form (NADH). Also related are isolated nucleic acids encoding P. pastoris FDH polypeptides, and fragments and variants thereof, as well as vectors and host cells comprising these nucleic acids. Further related are isolated, recombinant P. pastoris FDH polypeptides, and fragments and variants thereof, and antibodies that specifically bind to P. pastoris FDH polypeptides, fragments, or variants. The invention also relates to methods of obtaining isolated P. pastoris FDH nucleic acids, polypeptides, and antibodies, and methods of using P. pastoris FDH in various reactions for industrial or pharmaceutical applications.

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