公开(公告)号：EP1097236A4

公开(公告)日：2006-10-04

申请号：EP99933744

申请日：1999-07-07

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： DONOVAN MARY JO ,  GOLDBERG STEVEN ,  HANSON RONALD L ,  JASS PAUL A ,  LI WEN-SEN ,  PATEL RAMESH N ,  RAMIG KEITH ,  SZARKA LASZLO J ,  VENIT JOHN J

IPC: C12N15/09 ,  C12N1/19 ,  C12N9/06 ,  C12P7/62 ,  C12P13/00 ,  C12P17/04 ,  C12P17/06 ,  C12P41/00 ,  C12R1/01 ,  C12R1/84 ,  C12P13/04 ,  C07C59/185 ,  C07C229/24 ,  C12N1/16 ,  C12N1/20 ,  C12N9/02 ,  C12N15/00 ,  C12N15/70 ,  C12N15/81 ,  C12R1/19

CPC classification number: C12N9/0018 ,  C12P7/62 ,  C12P41/002 ,  C12P41/006

公开(公告)号：EP1109928A4

公开(公告)日：2004-10-13

申请号：EP99945367

申请日：1999-08-31

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： PATEL RAMESH N ,  BANERJEE AMIT ,  NANDURI VENKATA B ,  GOLDBERG STEVEN L ,  JOHNSTON ROBERT M ,  TULLY THOMAS P ,  SZARKA LASZLO J ,  SWAMINATHAN SHANKAR ,  VENIT JOHN J ,  MONIOT JEROME L ,  WINTER WILLIAM J ,  ANDERSON NEAL G ,  LUST DAVID A ,  CRISPINO GERARD ,  SRIVASTAVA SUSHIL

IPC: C12N15/09 ,  A61K38/00 ,  C07D513/04 ,  C07K5/062 ,  C07K5/078 ,  C07K14/81 ,  C12N1/20 ,  C12N1/21 ,  C12N9/06 ,  C12N9/10 ,  C12P17/18 ,  C12R1/01 ,  C12R1/38 ,  C12R1/465 ,  C07K5/06 ,  C12N15/52 ,  C12P21/02

CPC classification number: C07K5/06139 ,  A61K38/00 ,  C07K14/8103 ,  C12N9/1096

公开(公告)号：SG54139A1

公开(公告)日：1998-11-16

申请号：SG1996001983

申请日：1994-06-10

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： HANSON RONALD L ,  SZARKA LASZLO J ,  PATEL RAMESH N

IPC: C12N1/20 ,  C07D305/14 ,  C12N9/14 ,  C12N9/18 ,  C12P17/02 ,  C12Q1/04 ,  C12R1/01

Abstract: An enzymatic hydrolysis method, wherein one or more C-10 acyloxy-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups. Also provided is an enzymatic esterification method, wherein one or more C-10 hydroxyl-bearing taxanes are contacted with an acylating agent and an enzyme or microorganism capable of esterifying said hydroxyl groups to form acyloxy groups. Further provided is an enzymatic hydrolysis method, wherein one or more C-13 acyloxy-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups. The methods are especially useful for the preparation of compounds which may be employed as intermediates in the preparation of taxanes such as taxol.

公开(公告)号：HK1002013A1

公开(公告)日：1998-07-24

申请号：HK98100696

申请日：1998-01-27

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： HANSON RONALD L ,  PATEL RAMESH N ,  SZARKA LASZLO J

IPC: C12N1/20 ,  C12N9/24 ,  C12P17/02 ,  C12P19/60 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/34 ,  C12R1/01 ,  C12R1/07 ,  C12R1/09 ,  C12R1/265 ,  C12P ,  C12N ,  C12Q

Abstract: An enzymatic hydrolysis method, wherein one or more C-7 sugar, preferably C-7 xylosyl-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said sugar groups to hydroxyl groups.

公开(公告)号：FI950137A

公开(公告)日：1995-07-14

申请号：FI950137

申请日：1995-01-12

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： HANSON RONALD L ,  PATEL RAMESH N ,  SZARKA LASZLO J

IPC: C12N1/20 ,  C12N9/24 ,  C12P17/02 ,  C12P19/60 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/34 ,  C12R1/01 ,  C12R1/07 ,  C12R1/09 ,  C12R1/265 ,  C12N

Abstract: An enzymatic hydrolysis method, wherein one or more C-7 sugar, preferably C-7 xylosyl-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said sugar groups to hydroxyl groups.

公开(公告)号：FI950137A0

公开(公告)日：1995-01-12

申请号：FI950137

申请日：1995-01-12

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： HANSON RONALD L ,  PATEL RAMESH N ,  SZARKA LASZLO J

IPC: C12N1/20 ,  C12N9/24 ,  C12P17/02 ,  C12P19/60 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/34 ,  C12R1/01 ,  C12R1/07 ,  C12R1/09 ,  C12R1/265 ,  C12N

Abstract: An enzymatic hydrolysis method, wherein one or more C-7 sugar, preferably C-7 xylosyl-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said sugar groups to hydroxyl groups.

公开(公告)号：AU5044393A

公开(公告)日：1994-05-19

申请号：AU5044393

申请日：1993-11-04

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： PATEL RAMESH N ,  SZARKA LASZLO J ,  BANERJEE AMIT ,  MCNAMEE CLYDE G

IPC: A61K31/18 ,  A61P9/00 ,  C07C311/08 ,  C07C311/21 ,  C12P13/02 ,  C12P41/00 ,  C12R1/01 ,  C12R1/645 ,  C12P7/02 ,  C12P11/00 ,  C12P13/00

Abstract: The present invention concerns a process for the stereoselective enzymatic reduction of keto group-containing compounds such as N-(4-(2-chloroacetyl)phenyl)methanesulfonamido to form the corresponding hydroxyl-group containing compound. The process is selective for the D(+) enantiomer and is catalyzed by enzymes such as oxido-reductase or dehydrogense, or by microorganisms such as Hansenula, Rhodococcus, or Norcardia species.

公开(公告)号：AU2003203698B2

公开(公告)日：2004-06-10

申请号：AU2003203698

申请日：2003-03-11

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： PATEL RAMESH N ,  WENSEN LI ,  JASS PAUL A ,  RAMIG KEITH ,  HANSON RONALD L ,  GOLDBERG STEVEN ,  DONOVAN MARY JO ,  VENIT JOHN J ,  SZARKA LASZLO J

IPC: C12P007/00

公开(公告)号：FI112377B

公开(公告)日：2003-11-28

申请号：FI942794

申请日：1994-06-13

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： HANSON RONALD L ,  PATEL RAMESH N ,  SZARKA LASZLO J

IPC: C12N1/20 ,  C07D305/14 ,  C12N9/14 ,  C12N9/18 ,  C12P17/02 ,  C12Q1/04 ,  C12R1/01 ,  C12N9/00

Abstract: An enzymatic hydrolysis method, wherein one or more C-10 acyloxy-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups. Also provided is an enzymatic esterification method, wherein one or more C-10 hydroxyl-bearing taxanes are contacted with an acylating agent and an enzyme or microorganism capable of esterifying said hydroxyl groups to form acyloxy groups. Further provided is an enzymatic hydrolysis method, wherein one or more C-13 acyloxy-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups. The methods are especially useful for the preparation of compounds which may be employed as intermediates in the preparation of taxanes such as taxol.

公开(公告)号：GR3032990T3

公开(公告)日：2000-07-31

申请号：GR20000400690

申请日：2000-03-17

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： HANSON RONALD L ,  PATEL RAMESH N ,  SZARKA LASZLO J

IPC: C12N1/20 ,  C07D305/14 ,  C12N9/14 ,  C12N9/18 ,  C12P17/02 ,  C12Q1/04 ,  C12R1/01

Abstract: An enzymatic hydrolysis method, wherein one or more C-10 acyloxy-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups. Also provided is an enzymatic esterification method, wherein one or more C-10 hydroxyl-bearing taxanes are contacted with an acylating agent and an enzyme or microorganism capable of esterifying said hydroxyl groups to form acyloxy groups. Further provided is an enzymatic hydrolysis method, wherein one or more C-13 acyloxy-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups. The methods are especially useful for the preparation of compounds which may be employed as intermediates in the preparation of taxanes such as taxol.