公开(公告)号：ES2724198T3

公开(公告)日：2019-09-09

申请号：ES11819236

申请日：2011-08-26

Applicant: UNIV HEALTH NETWORK

Inventor： KELLER GORDON ,  CRAFT APRIL M ,  DUBOIS NICOLE C

IPC: C12N5/077 ,  C12N5/0775 ,  C12Q1/04 ,  C12Q1/68 ,  G01N33/567

Abstract: Un método de enriquecimiento de una población de células para células cardiomiocitos y células progenitoras de cardiomiocitos, que comprende: (a) proporcionar la población de células de la que tiene que aislarse las células cardiomiocitos y las células progenitoras de cardiomiocitos; y (b) obtener una población enriquecida de cardiomiocitos y células progenitoras de cardiomiocitos basándose en la expresión de SIRPA aislando células que expresan SIRPA de la población; en el que la población de células comprende una población de células madre pluripotentes humanas inducidas para diferenciase en células cardiomiocitos y células progenitoras de cardiomiocitos.

公开(公告)号：AU2018202355B2

公开(公告)日：2019-07-25

申请号：AU2018202355

申请日：2018-04-04

Applicant: UNIV HEALTH NETWORK

Inventor： KELLER GORDON ,  ZUNIGA-PFLUCKER JUAN CARLOS ,  KENNEDY MARION J ,  STURGEON CHRISTOPHER MICHAEL ,  DITADI ANDREA ,  AWONG GENEVE SHEANDRA

IPC: C12N5/0789 ,  A61K38/00

Abstract: There is described herein a method of enriching a population of stem cells for hematopoietic progenitors. The method comprises inducing hematopoietic differentiation in a population of human embryonic stem cells or human induced pluripotent stem cells; sorting the population based on expression of CD43 and at least one of CD34, CD31 and CD144; and selecting a fraction that is at least one of CD34*CD43-, CD31*CD43- and CD144*CD43-. Also provided are populations of hematopoietic progenitors obtained by the methods described herein.

公开(公告)号：DK2609194T3

公开(公告)日：2019-05-06

申请号：DK11819236

申请日：2011-08-26

Applicant: UNIV HEALTH NETWORK

Inventor： KELLER GORDON ,  DUBOIS NICOLE C ,  CRAFT APRIL M

IPC: C12N5/077 ,  C12N5/0775 ,  C12Q1/04 ,  G01N33/567

公开(公告)号：HK1248270A1

公开(公告)日：2018-10-12

申请号：HK18107486

申请日：2018-06-08

Applicant: UNIV HEALTH NETWORK

Inventor： KELLER GORDON ,  PROTZE STEPHANIE

IPC: A61K20060101 ,  C12N20060101 ,  A61P20060101

公开(公告)号：HK1219293A1

公开(公告)日：2017-03-31

申请号：HK16107222

申请日：2016-06-22

Applicant: UNIV HEALTH NETWORK

Inventor： KELLER GORDON ,  CRAFT APRIL M M

IPC: A61K20060101 ,  C12N20060101 ,  A61P20060101 ,  C12Q20060101 ,  G01N20060101

公开(公告)号：SG10201603901UA

公开(公告)日：2016-07-28

申请号：SG10201603901U

申请日：2011-08-26

Applicant: UNIV HEALTH NETWORK

Inventor： KELLER GORDON ,  CRAFT APRIL M ,  DUBOIS NICOLE C

公开(公告)号：IN10053DEN2014A

公开(公告)日：2015-08-14

申请号：IN10053DEN2014

申请日：2014-11-27

Applicant: UNIV HEALTH NETWORK

Inventor： KELLER GORDON ,  NOSTRO MARIA CRISTINA ,  HOLTZINGER AUDREY ,  SARANGI FARIDA

IPC: C12N5/071 ,  C12N5/02 ,  C12N5/073

Abstract: Methods and compositions for producing NKX6 1+ pancreatic progenitor cells and/or insulin producing cells from an endodermal cell population , the method comprising contacting the endodermal cell population with an EGF component, a Nicotinamide component and/or a Noggin component , optionally a combination of at least one EGF component and at least one nicotinamide component to induce the differentiation of at least one endodermal cell into a NKX6 1+ pancreatic progenitor cell, the combination optionally further comprising at least one Noggin component.

公开(公告)号：AU2013255031A1

公开(公告)日：2014-12-04

申请号：AU2013255031

申请日：2013-04-30

Applicant: UNIV HEALTH NETWORK

Inventor： KELLER GORDON ,  NOSTRO MARIA CRISTINA ,  HOLTZINGER AUDREY ,  SARANGI FARIDA

IPC: C12N5/071 ,  C12N5/02 ,  C12N5/073 ,  C12P21/02

Abstract: Methods and compositions for producing NKX6-1+ pancreatic progenitor cells and/or insulin producing cells from an endodermal cell population, the method comprising contacting the endodermal cell population with an EGF component, a Nicotinamide component and/or a Noggin component, optionally a combination of at least one EGF component and at least one nicotinamide component to induce the differentiation of at least one endodermal cell into a NKX6-1+ pancreatic progenitor cell, the combination optionally further comprising at least one Noggin component.

公开(公告)号：SG188306A1

公开(公告)日：2013-04-30

申请号：SG2013014303

申请日：2011-08-26

Applicant: UNIV HEALTH NETWORK

Inventor： KELLER GORDON ,  CRAFT APRIL M ,  DUBOIS NICOLE C

Abstract: The present invention relates to methods for enriching pluripotent stem cell-derived cardiomyocyte progenitor cells and cardiomyocyte cells based on SIRPA expression.