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1.发明专利
公开(公告)号：SI2844739T1
公开(公告)日：2019-11-29
申请号：SI201331572
申请日：2013-04-30
Applicant: UNIV HEALTH NETWORK
Inventor： KELLER GORDON , NOSTRO MARIA CRISTINA , HOLTZINGER AUDREY , SARANGI FARIDA
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2.发明专利
公开(公告)号：CA3101021A1
公开(公告)日：2019-12-05
申请号：CA3101021
申请日：2019-05-30
Applicant: UNIV HEALTH NETWORK
Inventor： NOSTRO MARIA CRISTINA , SARANGI FARIDA , KORYTNIKOV ROMAN , MCGAUGH EMILY , POON FRANKIE HOI CHUN
Abstract: Methods and compositions are provided for producing PDX1+/NKX6-1+ pancreatic progenitor cells from a PDX1+ endodermal cell population. The method comprises contacting the endodermal cell population with an EGF component and tankyrase inhibitor that binds to an adenosine subsite of a tankyrase enzyme, to induce the differentiation of at least a portion of the PDX1+ endodermal cell population into PDX1+NKX6-1+ pancreatic progenitor cells.
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3.发明专利
公开(公告)号：AU2013255031C1
公开(公告)日：2018-12-06
申请号：AU2013255031
申请日：2013-04-30
Applicant: UNIV HEALTH NETWORK
Inventor： KELLER GORDON , NOSTRO MARIA CRISTINA , HOLTZINGER AUDREY , SARANGI FARIDA
Abstract: Methods and compositions for producing NKX6-1+ pancreatic progenitor cells and/or insulin producing cells from an endodermal cell population, the method comprising contacting the endodermal cell population with an EGF component, a Nicotinamide component and/or a Noggin component, optionally a combination of at least one EGF component and at least one nicotinamide component to induce the differentiation of at least one endodermal cell into a NKX6-1+ pancreatic progenitor cell, the combination optionally further comprising at least one Noggin component.
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4.发明公开METHODS AND COMPOSITIONS FOR GENERATING PANCREATIC PROGENITORS AND FUNCTIONAL BETA CELLS FROM hPSCs 审中-公开方法和组合物胰脏前体和功能性β细胞FROM HPSCS
公开(公告)号：EP2844739A4
公开(公告)日：2015-12-02
申请号：EP13784648
申请日：2013-04-30
Applicant: UNIV HEALTH NETWORK
Inventor： KELLER GORDON , NOSTRO MARIA CRISTINA , HOLTZINGER AUDREY , SARANGI FARIDA
CPC classification number: C12N5/0678 , A61K35/39 , C12N5/0676 , C12N2500/38 , C12N2501/11 , C12N2501/115 , C12N2501/119 , C12N2501/155 , C12N2501/385 , C12N2501/40 , C12N2501/415 , C12N2502/28 , C12N2506/02 , C12N2506/45
Abstract: Methods and compositions for producing NKX6-1+ pancreatic progenitor cells and/or insulin producing cells from an endodermal cell population, the method comprising contacting the endodermal cell population with an EGF component, a Nicotinamide component and/or a Noggin component, optionally a combination of at least one EGF component and at least one nicotinamide component to induce the differentiation of at least one endodermal cell into a NKX6-1+ pancreatic progenitor cell, the combination optionally further comprising at least one Noggin component.
Abstract translation: 方法和组合物，用于从内胚层细胞群体生产NKX6-1 +胰腺祖细胞和/或胰岛素产生细胞，所述方法包括用在EGF成分，烟酰胺组分和/或组件，头蛋白，任选的组合接触的内胚层细胞群 中的至少一个EGF成分和至少一种烟酰胺组分以诱导至少一个内胚层细胞分化成胰腺祖细胞NKX6-1 +，所述组合任选地进一步包含至少一种组分头蛋白。
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公开(公告)号：ES2747967T3
公开(公告)日：2020-03-12
申请号：ES13784648
申请日：2013-04-30
Applicant: UNIV HEALTH NETWORK
Inventor： KELLER GORDON , NOSTRO MARIA CRISTINA , HOLTZINGER AUDREY , SARANGI FARIDA
Abstract: Un procedimiento para producir células progenitoras pancreáticas NKX6-1+ a partir de una población de células endodérmicas, comprendiendo el procedimiento poner en contacto a la población de células endodérmicas con una combinación de 1) al menos un componente de EGF seleccionado a partir de EGF, un conjugado activo de EGF y un fragmento activo de EGF; y 2) nicotinamida o una sal de la misma para inducir la diferenciación de al menos una porción de la población de células endodérmicas en células progenitoras.
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Patent Agency Ranking
公开(公告)号：HK1254968A1
公开(公告)日：2019-08-02
申请号：HK18114075
申请日：2018-11-05
Applicant: UNIV HEALTH NETWORK
Inventor： KELLER GORDON , NOSTRO MARIA CRISTINA , HOLTZINGER AUDREY , SARANGI FARIDA
IPC: C12N20060101 , C12Q20060101
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7.发明专利
公开(公告)号：CA2871795A1
公开(公告)日：2013-11-07
申请号：CA2871795
申请日：2013-04-30
Applicant: UNIV HEALTH NETWORK
Inventor： KELLER GORDON , NOSTRO MARIA CRISTINA , HOLTZINGER AUDREY , SARANGI FARIDA
Abstract: Methods and compositions for producing NKX6-1+ pancreatic progenitor cells and/or insulin producing cells from an endodermal cell population, the method comprising contacting the endodermal cell population with an EGF component, a Nicotinamide component and/or a Noggin component, optionally a combination of at least one EGF component and at least one nicotinamide component to induce the differentiation of at least one endodermal cell into a NKX6-1+ pancreatic progenitor cell, the combination optionally further comprising at least one Noggin component.
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8.发明专利
公开(公告)号：HUE046271T2
公开(公告)日：2020-02-28
申请号：HUE13784648
申请日：2013-04-30
Applicant: UNIV HEALTH NETWORK
Inventor： KELLER GORDON , NOSTRO MARIA CRISTINA , HOLTZINGER AUDREY , SARANGI FARIDA
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9.发明专利
公开(公告)号：HRP20191677T1
公开(公告)日：2019-12-13
申请号：HRP20191677
申请日：2019-09-17
Applicant: UNIV HEALTH NETWORK
Inventor： KELLER GORDON , NOSTRO MARIA CRISTINA , HOLTZINGER AUDREY , SARANGI FARIDA
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10.发明专利
公开(公告)号：LT2844739T
公开(公告)日：2019-10-10
申请号：LT13784648
申请日：2013-04-30
Applicant: UNIV HEALTH NETWORK
Inventor： KELLER GORDON , NOSTRO MARIA CRISTINA , HOLTZINGER AUDREY , SARANGI FARIDA
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