公开(公告)号：EP2665809B1

公开(公告)日：2018-01-10

申请号：EP12736463.6

申请日：2012-01-18

Applicant: CJ Cheiljedang Corporation

Inventor： LEE, Kwang Ho ,  LEE, Keun Chul ,  LEE, Seok Myung ,  HWANG, Young Bin

IPC: C12N1/21 ,  C12N9/10 ,  C12N9/12 ,  C12P13/08 ,  C12P13/04 ,  C12P13/22

CPC classification number: C12N15/70 ,  C07K14/245 ,  C12N9/1007 ,  C12N9/1205 ,  C12P13/04 ,  C12P13/08 ,  C12P13/227 ,  C12Y201/01 ,  C12Y207/01023

Abstract: A microorganism of the genus Escherichia having enhanced L-amino acid productivity, wherein the microorganism is transformed to have an enhanced NAD kinase activity and an inactivated activity of an enzyme having an amino acid sequence of SEQ ID NO: 2 encoded by tehB gene and a method for producing L-amino acids using the microorganism of the genus Escherichia.

公开(公告)号：EP3191592A1

公开(公告)日：2017-07-19

申请号：EP15767598.4

申请日：2015-09-09

Applicant: Novartis AG

Inventor： MAVRAKIS, Konstantinos John ,  MCDONALD, Earl III ,  STEGMEIER, Frank Peter

IPC: C12N15/113 ,  G01N33/574 ,  A61K31/713 ,  A61P35/00

CPC classification number: C12N15/1137 ,  A61K31/7088 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/40 ,  C07K2317/76 ,  C12N2310/14 ,  C12N2320/10 ,  C12N2320/31 ,  C12Y201/01 ,  G01N33/574 ,  G01N33/57496 ,  G01N2800/52

Abstract: The invention provides novel personalized therapies, kits, transmittable forms of information and methods for use in treating patients having cancer, wherein the cancer is MTAP-deficient and/or MTA-accumulating and thus amenable to therapeutic treatment with a PRMT5 inhibitor. Kits, methods of screening for candidate PRMT5 inhibitors, and associated methods of treatment are also provided.

Abstract translation: 本发明提供了用于治疗患有癌症的患者的新型个性化疗法，试剂盒，可传递形式的信息和方法，其中所述癌症是MTAP-缺陷型和/或MTA-积累型并因此适合用PRMT5抑制剂进行治疗性治疗。 还提供了试剂盒，筛选候选PRMT5抑制剂的方法以及相关的治疗方法。

公开(公告)号：EP3110975A1

公开(公告)日：2017-01-04

申请号：EP15754498.2

申请日：2015-02-27

Applicant: Igenomx International Genomics Corporation

Inventor： BROWN, Keith

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  A61K31/7056 ,  A61K31/7072 ,  A61K38/45 ,  A61K49/0054 ,  C12Q1/6809 ,  C12Q1/6869 ,  C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2600/178 ,  C12Y201/01 ,  G06F19/00 ,  G16H15/00 ,  Y02A90/26 ,  C12Q2525/161 ,  C12Q2525/179 ,  C12Q2525/185 ,  C12Q2525/191 ,  C12Q2535/122 ,  C12Q2537/165

Abstract: Methods and compositions related to the use of Mobile Element Insertions and their adjacent genomic sequences. Methods using MEIs as markers for cellular proliferation, as targets for pharmaceuticals, as markers for tissue fingerprinting and in related methods and compositions are disclosed herein. Methods and compositions relate to the detection, treatment and ongoing monitoring of cell proliferation events, cancer, and deleterious effects of mobile elements in aging, and to the selection, use and monitoring of the success of treatment regimens to address these conditions.

Abstract translation: 与使用移动元件插入物及其相邻基因组序列相关的方法和组合物。 本文公开了使用MEI作为细胞增殖的标志物，作为药物的靶标，作为组织指纹图谱的标记物以及相关方法和组合物的方法。 方法和组成涉及检测，治疗和持续监测细胞增殖事件，癌症和移动因素在衰老中的有害作用，以及选择，使用和监测治疗方案成功解决这些病症。

公开(公告)号：US20240240209A1

公开(公告)日：2024-07-18

申请号：US18556152

申请日：2022-04-20

Applicant: Agency for Science, Technology and Research ,  Institut National De Recherche Pour L' Agriculture, L'Alimentation Et L'Environment ,  Centre National De La Recherche Scientifique ,  Institut National Des Sciences Appliquées De Toulouse

Inventor： Xixian CHEN ,  Congqiang ZHANG ,  Rehka T ,  Sudha SHUKAL ,  Derek SMITH ,  Isabelle ANDRÉ ,  Esque JEREMY

IPC: C12P7/26 ,  C12N9/10 ,  C12N9/78 ,  C12N15/52 ,  C12N15/70 ,  C12P41/00

CPC classification number: C12P7/26 ,  C12N9/1007 ,  C12N9/78 ,  C12N15/52 ,  C12N15/70 ,  C12P41/00 ,  C12Y201/01 ,  C12Y201/01067 ,  C12Y305/04028 ,  C12N2800/101

Abstract: Synthesis of enantiopure cis-α-irone from a renewable carbon source Disclosed herein are natural and synthetic enzymes capable of performing a method of producing cis-α-irone. The method comprises providing an enzyme capable of converting psi-ionone to cis-α-irone; and contacting the enzyme and psi-ionone under suitable conditions to produce cis-α-irone. The enzyme may be a methyltransferase from Streptomyces albireticuli (SaMT), a promiscuous bifunctional methyltransferase/cyclase (pMT1) enzyme from Streptomyces, or a modified pMT1 enzyme with at least one substitution. The enzymes allow the in-vivo and in-vitro production of cis-α-irone including the use of glucose as feedstock for the biotransformation into cis-α-irone.

公开(公告)号：US20240043892A1

公开(公告)日：2024-02-08

申请号：US18345379

申请日：2023-06-30

Applicant: Arcturus Therapeutics, Inc.

Inventor： Maher ALAYYOUBI ,  Kyoung-Joo Jenny CHOI ,  Timothy Wayne LUGER, II

IPC: C12P19/34 ,  C12N9/10 ,  C12N9/12

CPC classification number: C12P19/34 ,  C12N9/1007 ,  C12Y201/01 ,  C12N9/1247 ,  C12Y207/07006

Abstract: Disclosed herein are methods of producing transcribed RNA product with increased yield and reduced dsRNA impurities.

公开(公告)号：US20230287362A1

公开(公告)日：2023-09-14

申请号：US18183815

申请日：2023-03-14

Applicant: The Regents of the University of Colorado, a body corporate ,  The Regents of the University of California

Inventor： Aaron Whiteley ,  Hannah Ledvina ,  Kevin Corbett ,  Qiaozhen Ye ,  Yajie Gu

IPC: C12N9/12 ,  C07K16/10 ,  C12N9/10

CPC classification number: C12N9/1241 ,  C07K16/10 ,  C12N9/1007 ,  C12Y201/01 ,  C12N9/1077 ,  C12Y204/02038 ,  C07K2319/30

Abstract: The invention describes the discovery and novel application of a bacterial ubiquitin transferase (Cap2). Specifically, the invention describes the novel activity of the enzyme Cap2 which is capable of creating a specific fusion between two proteins implementing a standalone catalytic mechanism to create the fusion.

公开(公告)号：US20230220443A1

公开(公告)日：2023-07-13

申请号：US16488421

申请日：2018-02-20

Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE

Inventor： Emmanuel Sebastien BURGOS ,  David SHECHTER

IPC: C12Q1/48 ,  G01N21/76 ,  C12Q1/34

CPC classification number: C12Q1/48 ,  C12Y201/01 ,  C12Y305/04 ,  G01N21/76 ,  C12Q1/34

Abstract: Methods and kits are disclosed for measuring activity of a methyltransferase or a radical SAM enzyme or for screening for an inhibitor of a methyltransferase or a radical SAM enzyme, where the methods and kits comprise, respectively, deaminase TM0936 for a MTase coupled assay and deaminase PA3170 for a radical SAM coupled assay.

公开(公告)号：US20180030484A1

公开(公告)日：2018-02-01

申请号：US15488320

申请日：2017-04-14

Applicant: Genomatica, Inc.

Inventor： Anthony P. Burgard ,  Robin E. Osterhout ,  Stephen J. Van Dien ,  Cara Ann Tracewell ,  Priti Pharkya ,  Stefan Andrae

IPC: C12P7/18 ,  C08G69/26 ,  C08G63/66 ,  C08G63/12 ,  C08G63/06 ,  C12N9/10 ,  C12P19/02 ,  C12P7/24 ,  C08G18/32 ,  C12N9/88 ,  C12N9/04 ,  C12N9/06 ,  C07D207/12

CPC classification number: C12P7/18 ,  C07D207/12 ,  C08G18/3206 ,  C08G63/06 ,  C08G63/12 ,  C08G63/66 ,  C08G69/26 ,  C12N9/0006 ,  C12N9/0028 ,  C12N9/1007 ,  C12N9/88 ,  C12P7/24 ,  C12P19/02 ,  C12Y101/01224 ,  C12Y101/01244 ,  C12Y101/02007 ,  C12Y105/0102 ,  C12Y201/01 ,  C12Y201/0109 ,  C12Y402/01 ,  Y02P20/52

Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 1,4-butanediol (BDO). Also provided herein are methods for using such an organism to produce BDO.

公开(公告)号：US20170327805A1

公开(公告)日：2017-11-16

申请号：US15415431

申请日：2017-01-25

Applicant: The General Hospital Corporation

Inventor： J. Keith Joung ,  Shengdar Tsai

IPC: C12N9/22 ,  C12N15/10 ,  C12N15/11 ,  C12N2310/20

CPC classification number: C12N15/102 ,  C07K14/005 ,  C07K14/195 ,  C07K2319/00 ,  C07K2319/01 ,  C07K2319/80 ,  C12N9/0071 ,  C12N9/1007 ,  C12N9/16 ,  C12N9/22 ,  C12N9/96 ,  C12N15/01 ,  C12N15/1031 ,  C12N15/11 ,  C12N15/63 ,  C12N15/85 ,  C12N2310/20 ,  C12N2710/00033 ,  C12N2770/00033 ,  C12N2800/80 ,  C12Y114/11 ,  C12Y201/01 ,  C12Y301/00 ,  C12Y301/21004

Abstract: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.

公开(公告)号：US20170198318A1

公开(公告)日：2017-07-13

申请号：US15389849

申请日：2016-12-23

Applicant: NATIONAL UNIVERSITY OF TAINAN ,  BIO-JOURDENESS INTERNATIONAL GROUP CO., LTD.

Inventor： TE-SHENG CHANG ,  YA-TING TSAI ,  HSIOU-YU DING ,  CHIEN-MIN CHIANG

IPC: C12P17/06 ,  A61K8/49 ,  A61Q19/02

CPC classification number: C12P17/06 ,  A61K8/498 ,  A61Q19/02 ,  C12Y201/01

Abstract: A method of manufacturing methoxy-isoflavones by biotransformation and a use thereof are revealed herein. The method comprises the steps of synthesizing a nucleic acid sequence including a SpOMT2884 gene ofStreptomyces peucetius; cloning the nucleic acid sequence into an expression vector to form a cyclic recombinant plasmid; transforming the cyclic recombinant plasmid into a microbial expression system (Escherichia coli); and incubating the microbial expression system in a medium containing 8-hydroxydaidzeins therein for generating methoxy-isoflavones.