公开(公告)号：US20170113225A1

公开(公告)日：2017-04-27

申请号：US15301765

申请日：2015-04-07

Applicant: James Richard HOWELL ,  Benjamin Masterman WEBSTER

Inventor： James Richard HOWELL ,  Benjamin Masterman WEBSTER

IPC: B01L7/00 ,  G01N21/27

CPC classification number: B01L7/52 ,  B01L9/06 ,  B01L2300/02 ,  B01L2300/041 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/0681 ,  B01L2300/0832 ,  B01L2300/087 ,  B01L2300/123 ,  B01L2300/1805 ,  B01L2300/1822 ,  B01L2300/1827 ,  G01N21/0332 ,  G01N21/272 ,  G01N2201/0231 ,  G01N2201/0846

Abstract: A chemical and/or biochemical apparatus (10) for receiving a plurality of reaction vessels in which chemical and/or biochemical reactions may take place includes a thermal mount (14) having a plurality of wells (26) for receiving the reaction vessels (12), a thermal module (16) having a first side thermally coupled to the thermal mount (14), a first heat sink (18) thermally coupled to a second side of the thermal module, the heat sink (18) having a body and a plurality of thermally conductive fins (32) extending outwards from the body of the first heat sink (18), and a printed circuit board (54) having electronic components for controlling at least the thermal module (16), an excitation light source (62), and a light sensor (52). A first set of light waveguides (60) is provided for delivering excitation light to a reaction vessel, and a second set of light waveguides (38) is provided for receiving light from a reaction vessel and for delivering the light to the light sensor (52). The first heat sink (18) comprises an interior space (5) and the printed circuit board (54), the excitation light source (62), the light sensor (52) and the light waveguides (38, 60) are arranged within the interior space (5).

公开(公告)号：US20160237477A1

公开(公告)日：2016-08-18

申请号：US15138869

申请日：2016-04-26

Applicant: WaferGen, Inc.

Inventor： Victor Joseph ,  Amjad Huda ,  Alnoor Shivji ,  Jie Zhou

IPC: C12Q1/68 ,  H01L27/144 ,  H01L31/024 ,  B01L3/00 ,  H01L31/0203 ,  H01L31/18 ,  G01N21/01 ,  B01L7/00 ,  H01L31/105 ,  H01L31/0232

CPC classification number: C12Q1/686 ,  B01L3/50851 ,  B01L3/50853 ,  B01L7/52 ,  B01L7/54 ,  B01L2200/0689 ,  B01L2300/044 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0819 ,  B01L2300/0829 ,  B01L2300/18 ,  B01L2300/1822 ,  B01L2300/1827 ,  B82Y30/00 ,  C12Q1/6806 ,  C12Q1/6844 ,  G01N21/01 ,  G01N21/0332 ,  G01N21/6408 ,  G01N21/6452 ,  G01N21/76 ,  G01N35/0099 ,  G01N2021/6417 ,  G01N2021/6484 ,  G01N2035/0405 ,  G01N2201/0231 ,  H01L27/1443 ,  H01L31/0203 ,  H01L31/02325 ,  H01L31/024 ,  H01L31/105 ,  H01L31/18 ,  C12Q2565/501

Abstract: The present invention provides miniaturized instruments for conducting chemical reactions where control of the reaction temperature is desired or required. Specifically, this invention provides chips and optical systems for performing and monitoring temperature-dependent chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost amplification of nucleic acids.

公开(公告)号：US20160216204A1

公开(公告)日：2016-07-28

申请号：US15005321

申请日：2016-01-25

Applicant: BacterioScan LTD

Inventor： Dana A. Marshall ,  Dan Vadim Regelman

IPC: G01N21/51 ,  G01N21/03 ,  C12Q1/06

CPC classification number: G01N21/51 ,  G01N21/0303 ,  G01N2021/513 ,  G01N2201/0231 ,  G01N2201/0415

Abstract: An instrument determines a concentration of bacteria in a plurality of fluid samples, and comprises a housing, a rotatable platform, a plurality of fluid containers, a light source, a sensor, and a motor. The rotatable platform is within the housing. The fluid containers are located on the rotatable platform. Each fluid container holds a corresponding one of the plurality of fluid samples, and has an input window and an output window. The light source provides an input beam for transmission into the input windows of the fluid containers and through the corresponding fluid samples. The input beam creates a forward-scatter signal associated with the concentration of bacteria. The motor rotates the rotatable platform so that the input beam sequentially passes through each fluid sample. A sensor within the housing detects the forward-scatter signal exiting from the output window associated with the fluid sample receiving the input beam.

Abstract translation: 仪器确定多个流体样品中细菌的浓度，并且包括壳体，可旋转平台，多个流体容器，光源，传感器和马达。 可旋转平台位于外壳内。 流体容器位于可旋转平台上。 每个流体容器保持多个流体样本中的相应的一个，并且具有输入窗口和输出窗口。 光源提供输入光束，用于传输到流体容器的输入窗口并通过相应的流体样品。 输入光束产生与细菌浓度相关联的前向散射信号。 马达旋转可旋转平台，使得输入光束顺序地通过每个流体样品。 壳体内的传感器检测从与接收输入光束的流体样品相关联的输出窗口离开的前向散射信号。

公开(公告)号：US20160216199A1

公开(公告)日：2016-07-28

申请号：US14805221

申请日：2015-07-21

Applicant: H2Optx Inc.

Inventor： Rudolf J. Hofmeister ,  Donald A. Ice ,  Scott W. Tandy

IPC: G01N21/25 ,  B01D46/42 ,  B01D46/00 ,  G01N33/15 ,  G01N1/06

CPC classification number: G01J3/42 ,  B01D46/0002 ,  B01D46/42 ,  G01J3/00 ,  G01J3/0267 ,  G01J3/0291 ,  G01J3/06 ,  G01J3/10 ,  G01J3/44 ,  G01N1/06 ,  G01N21/01 ,  G01N21/25 ,  G01N21/253 ,  G01N21/33 ,  G01N21/3504 ,  G01N21/3577 ,  G01N21/65 ,  G01N23/00 ,  G01N33/15 ,  G01N35/10 ,  G01N2021/0106 ,  G01N2201/0231

Abstract: The present disclosure generally relates to systems, devices and methods for analyzing and processing samples or analytes. In one example configuration, a method of analyzing an analyte includes shaving a first layer of a plurality of layers of an analyte to expose a first surface of an analyte. The method includes positioning the first surface of the analyte over a window of a hyperspectral analyzation subassembly. The method further includes scanning the first surface of the analyte by the hyperspectral analyzation subassembly to obtain information regarding the analyte proximate the first surface. Other systems, devices and methods are disclosed herein.

Abstract translation: 本公开一般涉及用于分析和处理样品或分析物的系统，装置和方法。 在一个示例性配置中，分析分析物的方法包括剃刮分析物的多个层的第一层以暴露分析物的第一表面。 该方法包括将分析物的第一表面定位在高光谱分析子组件的窗口上。 该方法还包括通过高光谱分析子组件扫描分析物的第一表面以获得关于第一表面附近的分析物的信息。 本文公开了其它系统，装置和方法。

公开(公告)号：US20160138082A1

公开(公告)日：2016-05-19

申请号：US14857379

申请日：2015-09-17

Applicant: WaferGen, Inc.

Inventor： Victor Joseph ,  Amjad Huda ,  Alnoor Shivji ,  Jie Zhou

IPC: C12Q1/68 ,  B01L7/00 ,  B01L3/00

CPC classification number: C12Q1/686 ,  B01L3/50851 ,  B01L3/50853 ,  B01L7/52 ,  B01L7/54 ,  B01L2200/0689 ,  B01L2300/044 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0819 ,  B01L2300/0829 ,  B01L2300/18 ,  B01L2300/1822 ,  B01L2300/1827 ,  B82Y30/00 ,  C12Q1/6806 ,  C12Q1/6844 ,  G01N21/01 ,  G01N21/0332 ,  G01N21/6408 ,  G01N21/6452 ,  G01N21/76 ,  G01N35/0099 ,  G01N2021/6417 ,  G01N2021/6484 ,  G01N2035/0405 ,  G01N2201/0231 ,  H01L27/1443 ,  H01L31/0203 ,  H01L31/02325 ,  H01L31/024 ,  H01L31/105 ,  H01L31/18 ,  C12Q2565/501

Abstract: The present invention provides miniaturized instruments for conducting chemical reactions where control of the reaction temperature is desired or required. Specifically, this invention provides chips and optical systems for performing and monitoring temperature-dependent chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost amplification of nucleic acids.

公开(公告)号：US20160060681A1

公开(公告)日：2016-03-03

申请号：US14554863

申请日：2014-11-26

Applicant: Electronics and Telecommunications Research Institute

Inventor： Kwang Hyo CHUNG ,  Jin Tae KIM ,  Yo Han CHOI ,  Choon Gi CHOI ,  Hong Kyw CHOI ,  Young Jun YU ,  Doo Hyeb YOUN ,  Jin Sik CHOI

IPC: C12Q1/68 ,  G01N21/64 ,  B01L7/00

CPC classification number: C12Q1/686 ,  B01L7/52 ,  B01L2200/12 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/1827 ,  G01N21/6486 ,  G01N2201/0231 ,  H05B3/145 ,  H05B3/42 ,  H05B2203/013 ,  H05B2203/037

Abstract: Provided is a gene amplifying and detecting device. The gene amplifying and detecting device includes: a gene amplifying chip including a chamber formed therein; a reaction solution filled in the chamber and including a fluorescent material; a light source located at one side of the gene amplifying chip; a light detector located at the other side of the gene amplifying chip; and a graphene heater formed on an inner surface or outer surface of the gene amplifying chip so as to heat the reaction solution.

Abstract translation: 提供了一种基因放大和检测装置。 基因扩增和检测装置包括：基因放大芯片，其包括形成在其中的腔室; 填充在所述室中并包括荧光材料的反应溶液; 位于基因放大芯片一侧的光源; 位于基因放大芯片另一侧的光检测器; 以及形成在基因放大芯片的内表面或外表面上的石墨烯加热剂，以加热反应溶液。

公开(公告)号：US08901502B2

公开(公告)日：2014-12-02

申请号：US13751613

申请日：2013-01-28

Applicant: KROHNE Optosens GmbH

Inventor： Gert Sinn ,  Thomas Fritsch

IPC: G01T1/20 ,  G01N21/64

CPC classification number: G01N21/64 ,  B01L2300/18 ,  B01L2300/1822 ,  G01N21/6486 ,  G01N2201/0231

Abstract: A device (1) is provided for determining at least one parameter of a medium which has a sensor device (2) and an electronic device (3). To provide such a device with a cooling system for at least a portion of its components, the sensor device (2) and/or the electronic device (3) are arranged at least partly in at least one inner space (4, 5) of a housing (6). A passage (7) borders the inner space (4, 5) and a cooling chamber (8) through which a cooling medium can flow is arranged in proximity of the passage (7).

Abstract translation: 提供了一种用于确定具有传感器装置（2）和电子装置（3）的介质的至少一个参数的装置（1）。 为了为这种装置提供用于其部件的至少一部分的冷却系统，传感器装置（2）和/或电子装置（3）至少部分地布置在至少一个内部空间（4,5）中， 一个房屋（6）。 与通道（7）相邻的通道（7）与内部空间（4,5）和冷却室（8）相接触，冷却介质可以流过冷却室。

公开(公告)号：US08767060B2

公开(公告)日：2014-07-01

申请号：US11925085

申请日：2007-10-26

Applicant: Joshua Lynn Scott ,  Marjorie L. Buerkle ,  James J. Delmonico ,  Thomas W. Karpen ,  Joseph V. Lopez

Inventor： Joshua Lynn Scott ,  Marjorie L. Buerkle ,  James J. Delmonico ,  Thomas W. Karpen ,  Joseph V. Lopez

IPC: A61B1/04 ,  H04N13/00

CPC classification number: G02B23/2476 ,  G01N21/88 ,  G01N21/954 ,  G01N29/043 ,  G01N29/326 ,  G01N2201/0221 ,  G01N2201/0231 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/0634 ,  G01N2201/0693 ,  G01N2201/0694 ,  G01N2201/0826 ,  G03B2205/0046 ,  G03B2205/0053 ,  H01L2924/0002 ,  H01L2924/00

Abstract: An inspection apparatus can include a handset and an elongated inspection tube extending from the handset. For reduction of heat energy radiating from one or more components of the apparatus, the apparatus can include a particularly designed heat sink assembly.

Abstract translation: 检查装置可以包括手机和从手机延伸的细长检查管。 为了减少从设备的一个或多个部件辐射的热能，该设备可以包括特别设计的散热器组件。

公开(公告)号：US20130243657A1

公开(公告)日：2013-09-19

申请号：US13988083

申请日：2011-10-19

Applicant: Keiko Yoshikawa ,  Hajime Yamazaki

Inventor： Keiko Yoshikawa ,  Hajime Yamazaki

IPC: G01N21/17

CPC classification number: G01N21/17 ,  F21Y2115/10 ,  G01N21/272 ,  G01N2021/3181 ,  G01N2035/00346 ,  G01N2201/0231 ,  G01N2201/0624 ,  G01N2201/0695 ,  G01N2201/1211

Abstract: An automatic analyzing apparatus which can make an adjustment to a target temperature so as to stabilize the light intensity of an LED and also can make the adjustment to that temperature in a short time is provided. The automatic analyzing apparatus in which an LED is used for a light source 114 includes a temperature adjusting mechanism 201 for the LED, and the temperature adjusting mechanism 201 includes a metal member 202 provided with the light source 114, a pair of metal pipes (water-flowing pipes) 203 buried in the metal member 202 and allowing constant-temperature bath water to flow therein, and pins (small metal piece members) 204 bringing only a heat-generating lead 252 of the light source 114 into direct contact with the metal member 202. Therefore, the temperature adjusting mechanism 201 can make an adjustment to a target temperature so as to stabilize the light intensity of the LED, and the adjustment to that temperature can be made in a short time.

Abstract translation: 一种自动分析装置，其可以对目标温度进行调节，以稳定LED的光强度，并且还可以在短时间内对该温度进行调节。 其中LED用于光源114的自动分析装置包括用于LED的温度调节机构201，温度调节机构201包括设置有光源114的金属构件202，一对金属管（水 埋入金属构件202中并允许恒温槽水流入其中的引脚（小金属构件）204，仅使光源114的发热引线252与金属直接接触 因此，温度调节机构201可以调节目标温度以稳定LED的光强度，并且可以在短时间内对该温度进行调节。

公开(公告)号：US20120107949A1

公开(公告)日：2012-05-03

申请号：US12393427

申请日：2009-02-26

Applicant: Jeffrey Haas ,  Douglas Haas

Inventor： Jeffrey Haas ,  Douglas Haas

IPC: G01N21/75

CPC classification number: G01N1/02 ,  G01N21/78 ,  G01N25/00 ,  G01N33/22 ,  G01N33/227 ,  G01N33/94 ,  G01N35/00009 ,  G01N35/00722 ,  G01N2001/022 ,  G01N2001/028 ,  G01N2035/00425 ,  G01N2035/0091 ,  G01N2035/0097 ,  G01N2201/0231 ,  Y10T436/25375

Abstract: A portable chemical analytical apparatus to analyze a test swipe having a base; a chemically treated pad containing the swiped sample positioned in a white zone above the base; and a tab attached to one side of the base. The apparatus includes a heater to warm the test swipe to a predetermined temperature; a clamp to secure the test swipe to the heater; one or more pumps to dispense one or more chemicals onto the test swipe from a disposable cartridge; a fan to remove chemical vapors rising a predetermined distance from the test swipe; and a camera to capture an image of the test swipe for un-biased automated analysis, and displayed on an LCD screen.

Abstract translation: 一种用于分析具有基底的测试滑动的便携式化学分析装置; 化学处理的垫，其包含位于基底上方的白色区域中的被擦拭的样品; 以及附接到基座的一侧的突片。 该装置包括加热器，以将测试滑动加热至预定温度; 用于将测试滑动固定到加热器的夹具; 一个或多个泵将一种或多种化学品从一次性药筒分配到测试刷卡上; 用于去除从测试滑动上升预定距离的化学气体的风扇; 以及相机捕获测试滑动的图像以进行无偏压的自动分析，并显示在LCD屏幕上。