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1.发明授权公开(公告)号：US10668466B2
公开(公告)日：2020-06-02
申请号：US16050105
申请日：2018-07-31
Applicant: BacterioScan LTD
Inventor： Dana A. Marshall , Theodore S. McMinn , Dan Vadim Regelman
Abstract: The present invention is a cuvette assembly for use in optically measuring at least one characteristic of particles within a plurality of liquid samples. The cuvette assembly comprises a main body having internal walls and external walls, and a plurality of cuvettes within the main body at least partially being defined by the internal walls. Each of the plurality of cuvettes has a liquid-input chamber for receiving a respective one of the plurality of liquid samples, a filter, and an optical chamber for receiving a respective filtered liquid sample caused by passing the respective one of the plurality of liquid samples through the filter. Each of the optical chambers includes an entry window for allowing transmission of an input light beam through the filtered liquid sample and an exit window for transmitting a forward scatter signal caused by the particles within the filtered liquid sample.
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公开(公告)号：US20180313753A1
公开(公告)日：2018-11-01
申请号：US16013643
申请日：2018-06-20
Applicant: BacterioScan LTD
Inventor： Dana A. Marshall , Dan Vadim Regelman
CPC classification number: G01N21/51 , G01N21/0303 , G01N2021/513 , G01N2201/0231 , G01N2201/0415
Abstract: An instrument determines a concentration of bacteria in a plurality of fluid samples, and comprises a housing, a rotatable platform, a plurality of fluid containers, a light source, a sensor, and a motor. The rotatable platform is within the housing. The fluid containers are located on the rotatable platform. Each fluid container holds a corresponding one of the plurality of fluid samples, and has an input window and an output window. The light source provides an input beam for transmission into the input windows of the fluid containers and through the corresponding fluid samples. The input beam creates a forward-scatter signal associated with the concentration of bacteria. The motor rotates the rotatable platform so that the input beam sequentially passes through each fluid sample. A sensor within the housing detects the forward-scatter signal exiting from the output window associated with the fluid sample receiving the input beam.
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公开(公告)号：US20200372976A1
公开(公告)日：2020-11-26
申请号：US16947655
申请日：2020-08-11
Applicant: BacterioScan LTD
Inventor： Dana A. Marshall , Theodore S. McMinn , Dan Vadim Regelman
Abstract: An optical measurement instrument is an integrated instrument that includes an optical cavity with a light source, a sample cuvette, and an optical sensor. The instrument can be used for taking measurements of organism concentration in one or more samples. Preferably, the instrument holds multiple, individually-loaded, independent fluid samples and determines bacteria concentration via a forward-scattering signal. The instrument can incorporate onboard incubation to promote bacterial growth in the samples such that, once a certain bacterial concentration is achieved, the higher concentration sample can be used with a mass spectrometer to identify the type of bacteria. The instrument and mass spectrometer can be a part of a network for medical diagnostic testing data where data is stored in a manner that is inherently untainted by patient identifiable information.
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4.发明申请公开(公告)号：US20200290036A1
公开(公告)日：2020-09-17
申请号：US16887792
申请日：2020-05-29
Applicant: BacterioScan LTD
Inventor： Dana A. Marshall , Theodore S. McMinn , Dan Vadim Regelman
Abstract: The present invention is a cuvette assembly for use in optically measuring at least one characteristic of particles within a plurality of liquid samples. The cuvette assembly comprises a main body having internal walls and external walls, and a plurality of cuvettes within the main body at least partially being defined by the internal walls. Each of the plurality of cuvettes has a liquid-input chamber for receiving a respective one of the plurality of liquid samples, a filter, and an optical chamber for receiving a respective filtered liquid sample caused by passing the respective one of the plurality of liquid samples through the filter. Each of the optical chambers includes an entry window for allowing transmission of an input light beam through the filtered liquid sample and an exit window for transmitting a forward scatter signal caused by the particles within the filtered liquid sample.
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公开(公告)号：US10233481B2
公开(公告)日：2019-03-19
申请号：US14959054
申请日：2015-12-04
Applicant: BacterioScan LTD
Inventor： Dana A. Marshall , Theodore S. McMinn , Dan Vadim Regelman
Abstract: An optical measurement instrument is an integrated instrument that includes an optical cavity with a light source, a sample cuvette, and an optical sensor. The light source and sensor are on a bench that is on a translational or rotational mechanical platform such that optical beam can be moved to multiple sample containers. The instrument can be used for taking measurements of organism concentration in multiple samples as a production tool for microbiology. Preferably, the instrument holds multiple, individually-loaded, independent fluid samples and determines bacteria concentration via a forward-scattering signal. The instrument can incorporate onboard incubation to promote bacterial growth in the samples during the test. In another aspect, the instrument can be a part of a network for medical diagnostic testing data where data is stored in a manner that is inherently untainted by patient identifiable information.
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Patent Agency Ranking
公开(公告)号：US10006857B2
公开(公告)日：2018-06-26
申请号：US15005321
申请日：2016-01-25
Applicant: BacterioScan LTD
Inventor： Dana A. Marshall , Dan Vadim Regelman
CPC classification number: G01N21/51 , G01N21/0303 , G01N2021/513 , G01N2201/0231 , G01N2201/0415
Abstract: An instrument determines a concentration of bacteria in a plurality of fluid samples, and comprises a housing, a rotatable platform, a plurality of fluid containers, a light source, a sensor, and a motor. The rotatable platform is within the housing. The fluid containers are located on the rotatable platform. Each fluid container holds a corresponding one of the plurality of fluid samples, and has an input window and an output window. The light source provides an input beam for transmission into the input windows of the fluid containers and through the corresponding fluid samples. The input beam creates a forward-scatter signal associated with the concentration of bacteria. The motor rotates the rotatable platform so that the input beam sequentially passes through each fluid sample. A sensor within the housing detects the forward-scatter signal exiting from the output window associated with the fluid sample receiving the input beam.
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7.发明申请公开(公告)号：US20180333719A1
公开(公告)日：2018-11-22
申请号：US16050105
申请日：2018-07-31
Applicant: BacterioScan LTD
Inventor： Dana A. Marshall , Theodore S. McMinn , Dan Vadim Regelman
Abstract: The present invention is a cuvette assembly for use in optically measuring at least one characteristic of particles within a plurality of liquid samples. The cuvette assembly comprises a main body having internal walls and external walls, and a plurality of cuvettes within the main body at least partially being defined by the internal walls. Each of the plurality of cuvettes has a liquid-input chamber for receiving a respective one of the plurality of liquid samples, a filter, and an optical chamber for receiving a respective filtered liquid sample caused by passing the respective one of the plurality of liquid samples through the filter. Each of the optical chambers includes an entry window for allowing transmission of an input light beam through the filtered liquid sample and an exit window for transmitting a forward scatter signal caused by the particles within the filtered liquid sample.
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8.发明申请System Using Laser-Scatter Measurement Instrument For Organism Identification And Related Network 审中-公开系统使用激光散射测量仪器进行有机体识别和相关网络公开(公告)号：US20160161404A1
公开(公告)日：2016-06-09
申请号：US14959108
申请日：2015-12-04
Applicant: BacterioScan LTD
Inventor： Dana A. Marshall , Theodore S. McMinn , Dan Vadim Regelman
CPC classification number: G16B50/00 , B01L3/50255 , B01L2200/0684 , B01L2300/022 , B01L2300/043 , B01L2300/044 , B01L2300/045 , B01L2300/0672 , B01L2300/0681 , B01L2400/0683 , C12Q1/04 , G01N21/51 , G01N2021/4707 , G01N2021/513 , G01N2201/0612
Abstract: An optical measurement instrument is an integrated instrument that includes an optical cavity with a light source, a sample cuvette, and an optical sensor. The instrument can be used for taking measurements of organism concentration in one or more samples. Preferably, the instrument holds multiple, individually-loaded, independent fluid samples and determines bacteria concentration via a forward-scattering signal. The instrument can incorporate onboard incubation to promote bacterial growth in the samples such that, once a certain bacterial concentration is achieved, the higher concentration sample can be used with a mass spectrometer to identify the type of bacteria. The instrument and mass spectrometer can be a part of a network for medical diagnostic testing data where data is stored in a manner that is inherently untainted by patient identifiable information.
Abstract translation: 光学测量仪器是一种集成的仪器，其包括具有光源的光学腔，样品比色皿和光学传感器。 该仪器可用于测量一个或多个样品中的生物体浓度。 优选地，仪器保持多个单独加载的独立流体样品，并通过前向散射信号确定细菌浓度。 该仪器可以并入板内温育以促进样品中的细菌生长，使得一旦达到一定的细菌浓度，可以用质谱仪使用较高浓度的样品来鉴定细菌的类型。 仪器和质谱仪可以作为用于医疗诊断测试数据的网络的一部分，其中数据以由患者可识别信息固有地保持的方式存储。
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公开(公告)号：US20180348127A1
公开(公告)日：2018-12-06
申请号：US16101046
申请日：2018-08-10
Applicant: BacterioScan LTD
Inventor： Dan Vadim Regelman
CPC classification number: G01N21/51 , E21B47/102 , G01N21/0303 , G01N21/645 , G01N21/6452 , G01N2021/6478 , G02B3/14 , G02B21/16 , G02B21/241 , G02B27/0018
Abstract: The present invention is an optical measurement system for measuring a liquid sample within a well. The system comprises a light source configured to transmit light though the well, a detector configured to measure optical signals derived from the transmitted light, and a tunable optical element. The tunable optical element is positioned between the light source and the well. The tunable optical element is operable to shape the light to compensate for distortions induced by a surface of the liquid sample. The detector is preferably located below the well for receiving a forward scatter signal indicative of at least one characteristic of the particles within the liquid sample.
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10.发明授权公开(公告)号：US10040065B2
公开(公告)日：2018-08-07
申请号：US15425846
申请日：2017-02-06
Applicant: BacterioScan LTD.
Inventor： Dana A. Marshall , Theodore S. McMinn , Dan Vadim Regelman
Abstract: The present invention is a cuvette assembly for use in optically measuring at least one characteristic of particles within a plurality of liquid samples. The cuvette assembly comprises a main body having internal walls and external walls, and a plurality of cuvettes within the main body at least partially being defined by the internal walls. Each of the plurality of cuvettes has a liquid-input chamber for receiving a respective one of the plurality of liquid samples, a filter, and an optical chamber for receiving a respective filtered liquid sample caused by passing the respective one of the plurality of liquid samples through the filter. Each of the optical chambers includes an entry window for allowing transmission of an input light beam through the filtered liquid sample and an exit window for transmitting a forward scatter signal caused by the particles within the filtered liquid sample.
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